Saprisartan is an AT1 receptor antagonist. It is based on medications of losartan's prototypical chemical structure. The mode of (functional) AT1 receptor antagonism has been characterized as insurmountable/noncompetitive for saprisartan. It is very likely that slow dissociation kinetics from the AT1 receptor underlie insurmountable antagonism A14009.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Alfuzosin | Alfuzosin may increase the hypotensive activities of Saprisartan. |
| Aliskiren | The risk or severity of hyperkalemia can be increased when Aliskiren is combined with Saprisartan. |
| Amifostine | Saprisartan may increase the hypotensive activities of Amifostine. |
| Canagliflozin | The risk or severity of hypotension, hyperkalemia, and reduced intravascular volume can be increased when Canagliflozin is combined with Saprisartan. |
| Diazoxide | Diazoxide may increase the hypotensive activities of Saprisartan. |
| Drospirenone | The risk or severity of hyperkalemia can be increased when Saprisartan is combined with Drospirenone. |
| Eplerenone | The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Saprisartan. |
| Semuloparin | The risk or severity of hyperkalemia can be increased when Semuloparin is combined with Saprisartan. |
| Lithium citrate | The serum concentration of Lithium citrate can be increased when it is combined with Saprisartan. |
| Lithium carbonate | The serum concentration of Lithium carbonate can be increased when it is combined with Saprisartan. |
| Lithium hydroxide | The serum concentration of Lithium hydroxide can be increased when it is combined with Saprisartan. |
| Methylphenidate | Methylphenidate may decrease the antihypertensive activities of Saprisartan. |
| Dexmethylphenidate | Dexmethylphenidate may decrease the antihypertensive activities of Saprisartan. |
| Obinutuzumab | Saprisartan may increase the hypotensive activities of Obinutuzumab. |
| Pentoxifylline | Pentoxifylline may increase the hypotensive activities of Saprisartan. |
| Rituximab | Saprisartan may increase the hypotensive activities of Rituximab. |
| Tolvaptan | The risk or severity of hyperkalemia can be increased when Tolvaptan is combined with Saprisartan. |
| Trimethoprim | The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Saprisartan. |
| Desmopressin | Desmopressin may decrease the antihypertensive activities of Saprisartan. |
| Phentermine | Phentermine may decrease the antihypertensive activities of Saprisartan. |
| Midodrine | Midodrine may decrease the antihypertensive activities of Saprisartan. |
| Eletriptan | Eletriptan may decrease the antihypertensive activities of Saprisartan. |
| Isoetharine | Isoetharine may decrease the antihypertensive activities of Saprisartan. |
| Methysergide | Methysergide may decrease the antihypertensive activities of Saprisartan. |
| Cabergoline | Cabergoline may decrease the antihypertensive activities of Saprisartan. |
| Atomoxetine | Atomoxetine may decrease the antihypertensive activities of Saprisartan. |
| Etomidate | Etomidate may decrease the antihypertensive activities of Saprisartan. |
| Zolmitriptan | Zolmitriptan may decrease the antihypertensive activities of Saprisartan. |
| Dihydroergotamine | Dihydroergotamine may decrease the antihypertensive activities of Saprisartan. |
| Amitriptyline | Amitriptyline may decrease the antihypertensive activities of Saprisartan. |
| Protriptyline | Protriptyline may decrease the antihypertensive activities of Saprisartan. |
| Methylergometrine | Methylergometrine may decrease the antihypertensive activities of Saprisartan. |
| Norepinephrine | Norepinephrine may decrease the antihypertensive activities of Saprisartan. |
| Mirtazapine | Mirtazapine may decrease the antihypertensive activities of Saprisartan. |
| Phenylephrine | Phenylephrine may decrease the antihypertensive activities of Saprisartan. |
| Phenylpropanolamine | Phenylpropanolamine may decrease the antihypertensive activities of Saprisartan. |
| Promazine | Promazine may decrease the antihypertensive activities of Saprisartan. |
| Droperidol | Droperidol may decrease the antihypertensive activities of Saprisartan. |
| Buspirone | Buspirone may decrease the antihypertensive activities of Saprisartan. |
| Nortriptyline | Nortriptyline may decrease the antihypertensive activities of Saprisartan. |
| Amoxapine | Amoxapine may decrease the antihypertensive activities of Saprisartan. |
| Doxapram | Doxapram may decrease the antihypertensive activities of Saprisartan. |
| Atropine | Atropine may decrease the antihypertensive activities of Saprisartan. |
| Lisuride | Lisuride may decrease the antihypertensive activities of Saprisartan. |
| Metaraminol | Metaraminol may decrease the antihypertensive activities of Saprisartan. |
| Trazodone | Trazodone may decrease the antihypertensive activities of Saprisartan. |
| Epinephrine | Epinephrine may decrease the antihypertensive activities of Saprisartan. |
| Sumatriptan | Sumatriptan may decrease the antihypertensive activities of Saprisartan. |
| Ergotamine | Ergotamine may decrease the antihypertensive activities of Saprisartan. |
| Nicergoline | Nicergoline may decrease the antihypertensive activities of Saprisartan. |
| Methoxamine | Methoxamine may decrease the antihypertensive activities of Saprisartan. |
| Trimipramine | Trimipramine may decrease the antihypertensive activities of Saprisartan. |
| Risperidone | Risperidone may decrease the antihypertensive activities of Saprisartan. |
| Propiomazine | Propiomazine may decrease the antihypertensive activities of Saprisartan. |
| Alfentanil | Alfentanil may decrease the antihypertensive activities of Saprisartan. |
| Fentanyl | Fentanyl may decrease the antihypertensive activities of Saprisartan. |
| Orciprenaline | Orciprenaline may decrease the antihypertensive activities of Saprisartan. |
| Phenmetrazine | Phenmetrazine may decrease the antihypertensive activities of Saprisartan. |
| Trifluoperazine | Trifluoperazine may decrease the antihypertensive activities of Saprisartan. |
| Dobutamine | Dobutamine may decrease the antihypertensive activities of Saprisartan. |
| Pseudoephedrine | Pseudoephedrine may decrease the antihypertensive activities of Saprisartan. |
| Benzphetamine | Benzphetamine may decrease the antihypertensive activities of Saprisartan. |
| Ritodrine | Ritodrine may decrease the antihypertensive activities of Saprisartan. |
| Terbutaline | Terbutaline may decrease the antihypertensive activities of Saprisartan. |
| Flupentixol | Flupentixol may decrease the antihypertensive activities of Saprisartan. |
| Bitolterol | Bitolterol may decrease the antihypertensive activities of Saprisartan. |
| Quinidine | Quinidine may decrease the antihypertensive activities of Saprisartan. |
| Almotriptan | Almotriptan may decrease the antihypertensive activities of Saprisartan. |
| Diethylpropion | Diethylpropion may decrease the antihypertensive activities of Saprisartan. |
| Salmeterol | Salmeterol may decrease the antihypertensive activities of Saprisartan. |
| Naratriptan | Naratriptan may decrease the antihypertensive activities of Saprisartan. |
| Rizatriptan | Rizatriptan may decrease the antihypertensive activities of Saprisartan. |
| Formoterol | Formoterol may decrease the antihypertensive activities of Saprisartan. |
| Dopamine | Dopamine may decrease the antihypertensive activities of Saprisartan. |
| Frovatriptan | Frovatriptan may decrease the antihypertensive activities of Saprisartan. |
| Albuterol | Salbutamol may decrease the antihypertensive activities of Saprisartan. |
| Methoxyflurane | Methoxyflurane may decrease the antihypertensive activities of Saprisartan. |
| Ergoloid mesylate | Ergoloid mesylate may decrease the antihypertensive activities of Saprisartan. |
| Isoprenaline | Isoprenaline may decrease the antihypertensive activities of Saprisartan. |
| Arbutamine | Arbutamine may decrease the antihypertensive activities of Saprisartan. |
| Dutasteride | Dutasteride may decrease the antihypertensive activities of Saprisartan. |
| Doxepin | Doxepin may decrease the antihypertensive activities of Saprisartan. |
| Nefazodone | Nefazodone may decrease the antihypertensive activities of Saprisartan. |
| Desipramine | Desipramine may decrease the antihypertensive activities of Saprisartan. |
| Pergolide | Pergolide may decrease the antihypertensive activities of Saprisartan. |
| Finasteride | Finasteride may decrease the antihypertensive activities of Saprisartan. |
| Ergometrine | Ergometrine may decrease the antihypertensive activities of Saprisartan. |
| Lisdexamfetamine | Lisdexamfetamine may decrease the antihypertensive activities of Saprisartan. |
| Paliperidone | Paliperidone may decrease the antihypertensive activities of Saprisartan. |
| Arformoterol | Arformoterol may decrease the antihypertensive activities of Saprisartan. |
| Fenoterol | Fenoterol may decrease the antihypertensive activities of Saprisartan. |
| Pirbuterol | Pirbuterol may decrease the antihypertensive activities of Saprisartan. |
| Ephedra sinica root | Ephedra sinica root may decrease the antihypertensive activities of Saprisartan. |
| Ephedrine | Ephedrine may decrease the antihypertensive activities of Saprisartan. |
| Mephentermine | Mephentermine may decrease the antihypertensive activities of Saprisartan. |
| Procaterol | Procaterol may decrease the antihypertensive activities of Saprisartan. |
| Yohimbine | Yohimbine may decrease the antihypertensive activities of Saprisartan. |
| Methotrimeprazine | Methotrimeprazine may decrease the antihypertensive activities of Saprisartan. |
| Clenbuterol | Clenbuterol may decrease the antihypertensive activities of Saprisartan. |
| Bambuterol | Bambuterol may decrease the antihypertensive activities of Saprisartan. |