Peringatan Keamanan

Overdose symptoms may include confusion, irritability, trouble thinking or concentrating, muscle weakness, or trouble breathing.

Tolevamer

DB01344

small molecule approved investigational

Deskripsi

Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, HIV.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) none
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Not absorbed following oral administration.

Metabolisme

none

Rute Eliminasi

Feces.

Interaksi Makanan

2 Data
  • 1. Avoid multivalent ions.
  • 2. Take on an empty stomach.

Interaksi Obat

63 Data
Magnesium oxide The risk or severity of adverse effects can be increased when Tolevamer is combined with Magnesium oxide.
Sodium bicarbonate The risk or severity of adverse effects can be increased when Tolevamer is combined with Sodium bicarbonate.
Aluminum hydroxide The risk or severity of adverse effects can be increased when Tolevamer is combined with Aluminum hydroxide.
Calcium carbonate The risk or severity of adverse effects can be increased when Tolevamer is combined with Calcium carbonate.
Magaldrate The risk or severity of adverse effects can be increased when Tolevamer is combined with Magaldrate.
Magnesium hydroxide The risk or severity of adverse effects can be increased when Tolevamer is combined with Magnesium hydroxide.
Magnesium trisilicate The risk or severity of adverse effects can be increased when Tolevamer is combined with Magnesium trisilicate.
Magnesium carbonate The risk or severity of adverse effects can be increased when Tolevamer is combined with Magnesium carbonate.
Bismuth subnitrate The risk or severity of adverse effects can be increased when Tolevamer is combined with Bismuth subnitrate.
Magnesium silicate The risk or severity of adverse effects can be increased when Tolevamer is combined with Magnesium silicate.
Aluminium acetoacetate The risk or severity of adverse effects can be increased when Tolevamer is combined with Aluminium acetoacetate.
Hydrotalcite The risk or severity of adverse effects can be increased when Tolevamer is combined with Hydrotalcite.
Magnesium peroxide The risk or severity of adverse effects can be increased when Tolevamer is combined with Magnesium peroxide.
Almasilate The risk or severity of adverse effects can be increased when Tolevamer is combined with Almasilate.
Aluminium glycinate The risk or severity of adverse effects can be increased when Tolevamer is combined with Aluminium glycinate.
Aloglutamol The risk or severity of adverse effects can be increased when Tolevamer is combined with Aloglutamol.
Calcium silicate The risk or severity of adverse effects can be increased when Tolevamer is combined with Calcium silicate.
Aluminium phosphate The risk or severity of adverse effects can be increased when Tolevamer is combined with Aluminium phosphate.
Thyrotropin alfa Tolevamer can cause a decrease in the absorption of Thyrotropin alfa resulting in a reduced serum concentration and potentially a decrease in efficacy.
Liothyronine Tolevamer can cause a decrease in the absorption of Liothyronine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Levothyroxine Tolevamer can cause a decrease in the absorption of Levothyroxine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Liotrix Tolevamer can cause a decrease in the absorption of Liotrix resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tiratricol Tolevamer can cause a decrease in the absorption of Tiratricol resulting in a reduced serum concentration and potentially a decrease in efficacy.
Thyroid, porcine Tolevamer can cause a decrease in the absorption of Thyroid, porcine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Digoxin The risk or severity of Cardiac Arrhythmia can be increased when Tolevamer is combined with Digoxin.
Acetyldigitoxin The risk or severity of Cardiac Arrhythmia can be increased when Tolevamer is combined with Acetyldigitoxin.
Deslanoside The risk or severity of Cardiac Arrhythmia can be increased when Tolevamer is combined with Deslanoside.
Ouabain The risk or severity of Cardiac Arrhythmia can be increased when Tolevamer is combined with Ouabain.
Digitoxin The risk or severity of Cardiac Arrhythmia can be increased when Tolevamer is combined with Digitoxin.
Oleandrin The risk or severity of Cardiac Arrhythmia can be increased when Tolevamer is combined with Oleandrin.
Cymarin The risk or severity of Cardiac Arrhythmia can be increased when Tolevamer is combined with Cymarin.
Proscillaridin The risk or severity of Cardiac Arrhythmia can be increased when Tolevamer is combined with Proscillaridin.
Metildigoxin The risk or severity of Cardiac Arrhythmia can be increased when Tolevamer is combined with Metildigoxin.
Lanatoside C The risk or severity of Cardiac Arrhythmia can be increased when Tolevamer is combined with Lanatoside C.
Gitoformate The risk or severity of Cardiac Arrhythmia can be increased when Tolevamer is combined with Gitoformate.
Acetyldigoxin The risk or severity of Cardiac Arrhythmia can be increased when Tolevamer is combined with Acetyldigoxin.
Peruvoside The risk or severity of Cardiac Arrhythmia can be increased when Tolevamer is combined with Peruvoside.
Meloxicam The risk or severity of adverse effects can be increased when Meloxicam is combined with Tolevamer.
Lithium citrate The absorption of Lithium citrate can be decreased when combined with Tolevamer.
Lithium carbonate The absorption of Lithium carbonate can be decreased when combined with Tolevamer.
Lithium hydroxide The absorption of Lithium hydroxide can be decreased when combined with Tolevamer.
Cimetidine The therapeutic efficacy of Tolevamer can be decreased when used in combination with Cimetidine.
Nizatidine The therapeutic efficacy of Tolevamer can be decreased when used in combination with Nizatidine.
Ranitidine The therapeutic efficacy of Tolevamer can be decreased when used in combination with Ranitidine.
Famotidine The therapeutic efficacy of Tolevamer can be decreased when used in combination with Famotidine.
Methantheline The therapeutic efficacy of Tolevamer can be decreased when used in combination with Methantheline.
Metiamide The therapeutic efficacy of Tolevamer can be decreased when used in combination with Metiamide.
Roxatidine acetate The therapeutic efficacy of Tolevamer can be decreased when used in combination with Roxatidine acetate.
Lafutidine The therapeutic efficacy of Tolevamer can be decreased when used in combination with Lafutidine.
Lavoltidine The therapeutic efficacy of Tolevamer can be decreased when used in combination with Lavoltidine.
Niperotidine The therapeutic efficacy of Tolevamer can be decreased when used in combination with Niperotidine.
Pantoprazole The therapeutic efficacy of Tolevamer can be decreased when used in combination with Pantoprazole.
Omeprazole The therapeutic efficacy of Tolevamer can be decreased when used in combination with Omeprazole.
Lansoprazole The therapeutic efficacy of Tolevamer can be decreased when used in combination with Lansoprazole.
Esomeprazole The therapeutic efficacy of Tolevamer can be decreased when used in combination with Esomeprazole.
Rabeprazole The therapeutic efficacy of Tolevamer can be decreased when used in combination with Rabeprazole.
Dexlansoprazole The therapeutic efficacy of Tolevamer can be decreased when used in combination with Dexlansoprazole.
Dexrabeprazole The therapeutic efficacy of Tolevamer can be decreased when used in combination with Dexrabeprazole.
Sodium zirconium cyclosilicate The therapeutic efficacy of Tolevamer can be decreased when used in combination with Sodium zirconium cyclosilicate.
Aluminium The therapeutic efficacy of Tolevamer can be decreased when used in combination with Aluminium.
Vonoprazan The therapeutic efficacy of Tolevamer can be decreased when used in combination with Vonoprazan.
Technetium Tc-99m oxidronate Tolevamer may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent.
Tegoprazan The therapeutic efficacy of Tolevamer can be decreased when used in combination with Tegoprazan.

Target Protein

Potassium

Referensi & Sumber

Synthesis reference: Chris Ho, Jugminder Chawla, Hitesh R. Bhagat, "Polystyrene sulfonate polymer tablets, their preparation and use." U.S. Patent US20080299198, issued December 04, 2008.

Contoh Produk & Brand

Produk: 52 • International brands: 2
Produk
  • Jamp Calcium Polystyrene Sulfonate
    Powder, for suspension • 999 mg / g • Oral; Rectal • Canada • Generic • Approved
  • Jamp Sodium Polystyrene Sulfonate
    Powder, for suspension • 1 g / g • Oral; Rectal • Canada • Generic • Approved
  • K-exit Poudre
    Powder, for solution • 100 % • Oral; Rectal • Canada • Approved
  • Kayexalate
    Powder, for suspension • 4.1 meq/1g • Oral; Rectal • US • Approved
  • Kayexalate
    Powder, for suspension • 4.1 meq/1g • Oral; Rectal • US • Approved
  • Kayexalate
    Powder, for suspension • 4.1 meq/1g • Oral; Rectal • US • Approved
  • Kayexalate
    Powder, for suspension • 1 g / g • Oral; Rectal • Canada • Approved
  • Kionex
    Powder, for suspension • 4.1 meq/1g • Oral; Rectal • US • Generic • Approved
Menampilkan 8 dari 52 produk.
International Brands
  • Resonium A
  • Sorbisterit

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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