Peringatan Keamanan

Limited data are available with regard to overdosage in humans. The most likely manifestations are hypotension, which may be severe, hyperkalaemia, hyponatraemia and renal impairment with metabolic acidosis. Treatment should be mainly symptomatic and supportive.

Cilazapril

DB01340

small molecule approved

Deskripsi

Cilazapril is an ACE inhibtor class drug used in the treatment of hypertension and heart failure. It belongs to the angiotensin-converting enzyme inhibitors (ACE inhibitors) class of drugs. It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat. It is branded as Inhibace in Canada and other countries, Vascace and Dynorm in a number of European countries, among many other names. None of these varieties are available in the United States.

Struktur Molekul 2D

Berat 417.4986
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Half-lives for the periods 1 to 4 hours and 1 to 7 days after the intravenous administration of 2.5 mg cilazaprilat are 0.90 and 46.2 hours respectively.
Volume Distribusi -
Klirens (Clearance) Total clearance is 12.3 L/h and renal clearance is 10.8 L/h. The total urinary recovery of cilazaprilat following the oral administration of 2.5 mg cilazapril is 52.6%.

Absorpsi

Maximum plasma concentrations of cilazaprilat are reached within two hours after administration of cilazapril.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Cilazaprilat is eliminated unchanged by the kidneys. The total urinary recovery of cilazaprilat after intravenous administration of 2.5 mg is 91%.

Interaksi Makanan

1 Data
  • 1. Take with or without food. Food decreases absorption, but not to a clinically significant extent.

Interaksi Obat

848 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Cilazapril is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Cilazapril is combined with Levodopa.
Risperidone Cilazapril may increase the hypotensive activities of Risperidone.
Alfuzosin Alfuzosin may increase the hypotensive activities of Cilazapril.
Amifostine Cilazapril may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Cilazapril.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Cilazapril.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Cilazapril.
Obinutuzumab Cilazapril may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Cilazapril.
Rituximab Cilazapril may increase the hypotensive activities of Rituximab.
Desmopressin Desmopressin may decrease the antihypertensive activities of Cilazapril.
Phentermine Phentermine may decrease the antihypertensive activities of Cilazapril.
Midodrine Midodrine may decrease the antihypertensive activities of Cilazapril.
Isoetharine Isoetharine may decrease the antihypertensive activities of Cilazapril.
Methysergide Methysergide may decrease the antihypertensive activities of Cilazapril.
Atomoxetine Atomoxetine may decrease the antihypertensive activities of Cilazapril.
Etomidate Etomidate may decrease the antihypertensive activities of Cilazapril.
Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Cilazapril.
Dihydroergotamine Dihydroergotamine may decrease the antihypertensive activities of Cilazapril.
Protriptyline Protriptyline may decrease the antihypertensive activities of Cilazapril.
Methylergometrine Methylergometrine may decrease the antihypertensive activities of Cilazapril.
Norepinephrine Norepinephrine may decrease the antihypertensive activities of Cilazapril.
Mirtazapine Mirtazapine may decrease the antihypertensive activities of Cilazapril.
Phenylephrine Phenylephrine may decrease the antihypertensive activities of Cilazapril.
Phenylpropanolamine Phenylpropanolamine may decrease the antihypertensive activities of Cilazapril.
Promazine Promazine may decrease the antihypertensive activities of Cilazapril.
Droperidol Droperidol may decrease the antihypertensive activities of Cilazapril.
Buspirone Buspirone may decrease the antihypertensive activities of Cilazapril.
Nortriptyline Nortriptyline may decrease the antihypertensive activities of Cilazapril.
Amoxapine Amoxapine may decrease the antihypertensive activities of Cilazapril.
Doxapram Doxapram may decrease the antihypertensive activities of Cilazapril.
Atropine Atropine may decrease the antihypertensive activities of Cilazapril.
Lisuride Lisuride may decrease the antihypertensive activities of Cilazapril.
Metaraminol Metaraminol may decrease the antihypertensive activities of Cilazapril.
Trazodone Trazodone may decrease the antihypertensive activities of Cilazapril.
Epinephrine Epinephrine may decrease the antihypertensive activities of Cilazapril.
Ergotamine Ergotamine may decrease the antihypertensive activities of Cilazapril.
Nicergoline Nicergoline may decrease the antihypertensive activities of Cilazapril.
Methoxamine Methoxamine may decrease the antihypertensive activities of Cilazapril.
Propiomazine Propiomazine may decrease the antihypertensive activities of Cilazapril.
Alfentanil Alfentanil may decrease the antihypertensive activities of Cilazapril.
Fentanyl Fentanyl may decrease the antihypertensive activities of Cilazapril.
Orciprenaline Orciprenaline may decrease the antihypertensive activities of Cilazapril.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Cilazapril.
Dobutamine Dobutamine may decrease the antihypertensive activities of Cilazapril.
Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Cilazapril.
Benzphetamine Benzphetamine may decrease the antihypertensive activities of Cilazapril.
Ritodrine Ritodrine may decrease the antihypertensive activities of Cilazapril.
Terbutaline Terbutaline may decrease the antihypertensive activities of Cilazapril.
Bitolterol Bitolterol may decrease the antihypertensive activities of Cilazapril.
Almotriptan Almotriptan may decrease the antihypertensive activities of Cilazapril.
Diethylpropion Diethylpropion may decrease the antihypertensive activities of Cilazapril.
Salmeterol Salmeterol may decrease the antihypertensive activities of Cilazapril.
Naratriptan Naratriptan may decrease the antihypertensive activities of Cilazapril.
Rizatriptan Rizatriptan may decrease the antihypertensive activities of Cilazapril.
Formoterol Formoterol may decrease the antihypertensive activities of Cilazapril.
Dopamine Dopamine may decrease the antihypertensive activities of Cilazapril.
Frovatriptan Frovatriptan may decrease the antihypertensive activities of Cilazapril.
Albuterol Salbutamol may decrease the antihypertensive activities of Cilazapril.
Methoxyflurane Methoxyflurane may decrease the antihypertensive activities of Cilazapril.
Ergoloid mesylate Ergoloid mesylate may decrease the antihypertensive activities of Cilazapril.
Isoprenaline Isoprenaline may decrease the antihypertensive activities of Cilazapril.
Arbutamine Arbutamine may decrease the antihypertensive activities of Cilazapril.
Dutasteride Dutasteride may decrease the antihypertensive activities of Cilazapril.
Nefazodone Nefazodone may decrease the antihypertensive activities of Cilazapril.
Desipramine Desipramine may decrease the antihypertensive activities of Cilazapril.
Pergolide Pergolide may decrease the antihypertensive activities of Cilazapril.
Finasteride Finasteride may decrease the antihypertensive activities of Cilazapril.
Ergometrine Ergometrine may decrease the antihypertensive activities of Cilazapril.
Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Cilazapril.
Arformoterol Arformoterol may decrease the antihypertensive activities of Cilazapril.
Fenoterol Fenoterol may decrease the antihypertensive activities of Cilazapril.
Pirbuterol Pirbuterol may decrease the antihypertensive activities of Cilazapril.
Ephedra sinica root Ephedra sinica root may decrease the antihypertensive activities of Cilazapril.
Ephedrine Ephedrine may decrease the antihypertensive activities of Cilazapril.
Mephentermine Mephentermine may decrease the antihypertensive activities of Cilazapril.
Procaterol Procaterol may decrease the antihypertensive activities of Cilazapril.
Yohimbine Yohimbine may decrease the antihypertensive activities of Cilazapril.
Methotrimeprazine Methotrimeprazine may decrease the antihypertensive activities of Cilazapril.
Clenbuterol Clenbuterol may decrease the antihypertensive activities of Cilazapril.
Bambuterol Bambuterol may decrease the antihypertensive activities of Cilazapril.
MMDA MMDA may decrease the antihypertensive activities of Cilazapril.
Midomafetamine Midomafetamine may decrease the antihypertensive activities of Cilazapril.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Cilazapril.
4-Methoxyamphetamine 4-Methoxyamphetamine may decrease the antihypertensive activities of Cilazapril.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Cilazapril.
Tenamfetamine Tenamfetamine may decrease the antihypertensive activities of Cilazapril.
Chlorphentermine Chlorphentermine may decrease the antihypertensive activities of Cilazapril.
Dextroamphetamine Dextroamphetamine may decrease the antihypertensive activities of Cilazapril.
Metamfetamine Metamfetamine may decrease the antihypertensive activities of Cilazapril.
Phendimetrazine Phendimetrazine may decrease the antihypertensive activities of Cilazapril.
Solifenacin Solifenacin may decrease the antihypertensive activities of Cilazapril.
Periciazine Periciazine may decrease the antihypertensive activities of Cilazapril.
Acepromazine Acepromazine may decrease the antihypertensive activities of Cilazapril.
Thioproperazine Thioproperazine may decrease the antihypertensive activities of Cilazapril.
Zuclopenthixol Zuclopenthixol may decrease the antihypertensive activities of Cilazapril.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Cilazapril.
1-benzylimidazole 1-benzylimidazole may decrease the antihypertensive activities of Cilazapril.
Lysergic acid diethylamide Lysergic acid diethylamide may decrease the antihypertensive activities of Cilazapril.

Target Protein

Angiotensin-converting enzyme ACE

Referensi & Sumber

Synthesis reference: Attwood, M. R.; Hassall, C. H.; Kr?Hn, A.; Lawton, G.; Redshaw, S. (1986). "The design and synthesis of the Angiotensin Converting Enzyme inhibitor Cilazapril and related bicyclic compounds". Journal of the Chemical Society, Perkin Transactions 1: 1011. doi:10.1039/P19860001011
Artikel (PubMed)
  • PMID: 2434790
    Fasanella d'Amore T, Bussien JP, Nussberger J, Waeber B, Turini GA, Brunner HR, Kler L, Francis RJ: Effects of single doses of the converting enzyme inhibitor cilazapril in normal volunteers. J Cardiovasc Pharmacol. 1987 Jan;9(1):26-31.

Contoh Produk & Brand

Produk: 36 • International brands: 5
Produk
  • Apo-cilazapril
    Tablet • 1 mg • Oral • Canada • Generic • Approved
  • Apo-cilazapril
    Tablet • 2.5 mg • Oral • Canada • Generic • Approved
  • Apo-cilazapril
    Tablet • 5 mg • Oral • Canada • Generic • Approved
  • Apo-cilazapril/hctz
    Tablet • - • Oral • Canada • Generic • Approved
  • Cilazapril
    Tablet • 5 mg • Oral • Canada • Approved
  • Cilazapril
    Tablet • 1 mg • Oral • Canada • Approved
  • Cilazapril
    Tablet • 2.5 mg • Oral • Canada • Approved
  • Cilazapril
    Tablet • 1.0 mg • Oral • Canada • Approved
Menampilkan 8 dari 36 produk.
International Brands
  • Dynorm — Roche
  • Inhibestril — Teva
  • Vascace — Roche
  • Zapril — Mylan
  • Zobox — Hemofarm

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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