Pipecuronium

DB01338

small molecule approved

Deskripsi

Pipecuronium is a piperazinyl androstane derivative which is a non-depolarizing neuromuscular blocking agent.

Struktur Molekul 2D

Berat 602.8912
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Pipecuronium has an approximate half-life of 87 minutes.[A263237]
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1264 Data
Buprenorphine Pipecuronium may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Pipecuronium.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Pipecuronium.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Pipecuronium.
Hydrocodone Pipecuronium may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Pipecuronium.
Magnesium sulfate The therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Pipecuronium may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Pipecuronium may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Pipecuronium.
Mirtazapine Pipecuronium may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Pipecuronium.
Orphenadrine Pipecuronium may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Pipecuronium may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Pipecuronium.
Pramipexole Pipecuronium may increase the sedative activities of Pramipexole.
Ropinirole Pipecuronium may increase the sedative activities of Ropinirole.
Rotigotine Pipecuronium may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Pipecuronium.
Sodium oxybate The risk or severity of CNS depression can be increased when Pipecuronium is combined with Sodium oxybate.
Suvorexant Pipecuronium may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Pipecuronium.
Thalidomide Pipecuronium may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Pipecuronium may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Capreomycin The therapeutic efficacy of Pipecuronium can be increased when used in combination with Capreomycin.
Cyclosporine The therapeutic efficacy of Pipecuronium can be increased when used in combination with Cyclosporine.
Doxycycline The therapeutic efficacy of Pipecuronium can be increased when used in combination with Doxycycline.
Lymecycline The therapeutic efficacy of Pipecuronium can be increased when used in combination with Lymecycline.
Framycetin The therapeutic efficacy of Pipecuronium can be increased when used in combination with Framycetin.
Clomocycline The therapeutic efficacy of Pipecuronium can be increased when used in combination with Clomocycline.
Quinine The therapeutic efficacy of Pipecuronium can be increased when used in combination with Quinine.
Vancomycin The therapeutic efficacy of Pipecuronium can be increased when used in combination with Vancomycin.
Tigecycline The therapeutic efficacy of Pipecuronium can be increased when used in combination with Tigecycline.
Oxytetracycline The therapeutic efficacy of Pipecuronium can be increased when used in combination with Oxytetracycline.
Chloroquine The therapeutic efficacy of Pipecuronium can be increased when used in combination with Chloroquine.
Demeclocycline The therapeutic efficacy of Pipecuronium can be increased when used in combination with Demeclocycline.
Tobramycin The therapeutic efficacy of Pipecuronium can be increased when used in combination with Tobramycin.
Tetracycline The therapeutic efficacy of Pipecuronium can be increased when used in combination with Tetracycline.
Gentamicin The therapeutic efficacy of Pipecuronium can be increased when used in combination with Gentamicin.
Etacrynic acid The therapeutic efficacy of Pipecuronium can be increased when used in combination with Etacrynic acid.
Metacycline The therapeutic efficacy of Pipecuronium can be increased when used in combination with Metacycline.
Netilmicin The therapeutic efficacy of Pipecuronium can be increased when used in combination with Netilmicin.
Neomycin The therapeutic efficacy of Pipecuronium can be increased when used in combination with Neomycin.
Streptomycin The therapeutic efficacy of Pipecuronium can be increased when used in combination with Streptomycin.
Colistimethate The therapeutic efficacy of Pipecuronium can be increased when used in combination with Colistimethate.
Kanamycin The therapeutic efficacy of Pipecuronium can be increased when used in combination with Kanamycin.
Rolitetracycline The therapeutic efficacy of Pipecuronium can be increased when used in combination with Rolitetracycline.
Magnesium oxide The therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium oxide.
Magnesium cation The therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium cation.
Paromomycin The therapeutic efficacy of Pipecuronium can be increased when used in combination with Paromomycin.
Lincomycin The therapeutic efficacy of Pipecuronium can be increased when used in combination with Lincomycin.
Ribostamycin The therapeutic efficacy of Pipecuronium can be increased when used in combination with Ribostamycin.
Geneticin The therapeutic efficacy of Pipecuronium can be increased when used in combination with Geneticin.
Apramycin The therapeutic efficacy of Pipecuronium can be increased when used in combination with Apramycin.
Gentamicin C1a The therapeutic efficacy of Pipecuronium can be increased when used in combination with Gentamicin C1a.
Neamine The therapeutic efficacy of Pipecuronium can be increased when used in combination with Neamine.
Arbekacin The therapeutic efficacy of Pipecuronium can be increased when used in combination with Arbekacin.
Viomycin The therapeutic efficacy of Pipecuronium can be increased when used in combination with Viomycin.
Puromycin The therapeutic efficacy of Pipecuronium can be increased when used in combination with Puromycin.
Magnesium hydroxide The therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium hydroxide.
Magnesium trisilicate The therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium trisilicate.
Magnesium chloride The therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium chloride.
Magnesium acetate tetrahydrate The therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium acetate tetrahydrate.
Magnesium carbonate The therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium carbonate.
Magnesium citrate The therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium citrate.
Magnesium glycinate The therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium glycinate.
Magnesium Aluminum Silicate The therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium Aluminum Silicate.
Dihydrostreptomycin The therapeutic efficacy of Pipecuronium can be increased when used in combination with Dihydrostreptomycin.
Hygromycin B The therapeutic efficacy of Pipecuronium can be increased when used in combination with Hygromycin B.
Sisomicin The therapeutic efficacy of Pipecuronium can be increased when used in combination with Sisomicin.
Plazomicin The therapeutic efficacy of Pipecuronium can be increased when used in combination with Plazomicin.
Magnesium silicate The therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium silicate.
Penimepicycline The therapeutic efficacy of Pipecuronium can be increased when used in combination with Penimepicycline.
Magnesium aspartate The therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium aspartate.
Isepamicin The therapeutic efficacy of Pipecuronium can be increased when used in combination with Isepamicin.
Magnesium gluconate The therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium gluconate.
Magnesium orotate The therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium orotate.
Magnesium phosphate The therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium phosphate.
Magnesium acetate The therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium acetate.
Procainamide The therapeutic efficacy of Pipecuronium can be increased when used in combination with Procainamide.
Mecamylamine The therapeutic efficacy of Pipecuronium can be increased when used in combination with Mecamylamine.
Quinidine The therapeutic efficacy of Pipecuronium can be increased when used in combination with Quinidine.
Dantrolene The therapeutic efficacy of Pipecuronium can be increased when used in combination with Dantrolene.
Piperacillin The therapeutic efficacy of Pipecuronium can be increased when used in combination with Piperacillin.
Magnesium stearate The therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium stearate.
Colistin The therapeutic efficacy of Pipecuronium can be increased when used in combination with Colistin.
Aclidinium The risk or severity of adverse effects can be increased when Pipecuronium is combined with Aclidinium.
Mianserin Mianserin may increase the anticholinergic activities of Pipecuronium.
Mirabegron The risk or severity of urinary retention can be increased when Pipecuronium is combined with Mirabegron.
Potassium chloride The risk or severity of gastrointestinal ulceration can be increased when Pipecuronium is combined with Potassium chloride.
Pramlintide The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Pipecuronium.
Secretin porcine The therapeutic efficacy of Secretin porcine can be decreased when used in combination with Pipecuronium.
Tiotropium The risk or severity of adverse effects can be increased when Pipecuronium is combined with Tiotropium.
Topiramate The risk or severity of hyperthermia and oligohydrosis can be increased when Pipecuronium is combined with Topiramate.
Umeclidinium The risk or severity of adverse effects can be increased when Pipecuronium is combined with Umeclidinium.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Pipecuronium.
Glycopyrronium The risk or severity of adverse effects can be increased when Pipecuronium is combined with Glycopyrronium.
Dipyridamole The therapeutic efficacy of Pipecuronium can be decreased when used in combination with Dipyridamole.
Ephedrine Pipecuronium may increase the neuromuscular blocking activities of Ephedrine.
Sar9, Met (O2)11-Substance P Pipecuronium may increase the neuromuscular blocking activities of Sar9, Met (O2)11-Substance P.

Target Protein

Neuronal acetylcholine receptor subunit alpha-2 CHRNA2
Muscarinic acetylcholine receptor M2 CHRM2
Muscarinic acetylcholine receptor M3 CHRM3

Referensi & Sumber

Artikel (PubMed)
  • PMID: 10223167
    Atherton DP, Hunter JM: Clinical pharmacokinetics of the newer neuromuscular blocking drugs. Clin Pharmacokinet. 1999 Mar;36(3):169-89. doi: 10.2165/00003088-199936030-00001.

Contoh Produk & Brand

Produk: 1 • International brands: 0
Produk
  • Arduan
    Injection • 10 mg/1 • Intravenous • US • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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