Cefradine

DB01333

small molecule approved

Deskripsi

A semi-synthetic cephalosporin antibiotic.

Struktur Molekul 2D

Berat 349.405
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Over 90 percent of the drug is excreted unchanged in the urine within six hours.

Interaksi Makanan

1 Data
  • 1. Take with or without food.

Interaksi Obat

1053 Data
Aripiprazole The metabolism of Aripiprazole can be increased when combined with Cefradine.
Aripiprazole lauroxil The metabolism of Aripiprazole lauroxil can be increased when combined with Cefradine.
Probenecid The serum concentration of Cefradine can be increased when it is combined with Probenecid.
Foscarnet The risk or severity of nephrotoxicity can be increased when Cefradine is combined with Foscarnet.
Mannitol The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Cefradine.
Tenofovir disoproxil Cefradine may increase the nephrotoxic activities of Tenofovir disoproxil.
Tenofovir alafenamide The serum concentration of Tenofovir alafenamide can be increased when it is combined with Cefradine.
Tenofovir Cefradine may increase the nephrotoxic activities of Tenofovir.
Ifosfamide The metabolism of Ifosfamide can be increased when combined with Cefradine.
Perampanel The metabolism of Perampanel can be increased when combined with Cefradine.
Warfarin The metabolism of Warfarin can be increased when combined with Cefradine.
Acenocoumarol The metabolism of Acenocoumarol can be increased when combined with Cefradine.
(R)-warfarin The metabolism of (R)-warfarin can be increased when combined with Cefradine.
R,S-Warfarin alcohol The metabolism of R,S-Warfarin alcohol can be increased when combined with Cefradine.
S,R-Warfarin alcohol The metabolism of S,R-Warfarin alcohol can be increased when combined with Cefradine.
(S)-Warfarin The metabolism of (S)-Warfarin can be increased when combined with Cefradine.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefradine.
Triamterene The risk or severity of nephrotoxicity can be increased when Triamterene is combined with Cefradine.
Etacrynic acid The risk or severity of nephrotoxicity can be increased when Etacrynic acid is combined with Cefradine.
Hydrochlorothiazide The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Cefradine.
Atazanavir The risk or severity of nephrotoxicity can be increased when Atazanavir is combined with Cefradine.
Icosapent The risk or severity of nephrotoxicity can be increased when Icosapent is combined with Cefradine.
Cefotiam The risk or severity of nephrotoxicity can be increased when Cefotiam is combined with Cefradine.
Mesalazine The risk or severity of nephrotoxicity can be increased when Mesalazine is combined with Cefradine.
Cefmenoxime The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefradine.
Cefmetazole The risk or severity of nephrotoxicity can be increased when Cefmetazole is combined with Cefradine.
Indomethacin The risk or severity of nephrotoxicity can be increased when Indomethacin is combined with Cefradine.
Cidofovir The risk or severity of nephrotoxicity can be increased when Cidofovir is combined with Cefradine.
Cefpiramide The risk or severity of nephrotoxicity can be increased when Cefpiramide is combined with Cefradine.
Ceftazidime The risk or severity of nephrotoxicity can be increased when Ceftazidime is combined with Cefradine.
Loracarbef The risk or severity of nephrotoxicity can be increased when Loracarbef is combined with Cefradine.
Cefalotin The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Cefradine.
Nabumetone The risk or severity of nephrotoxicity can be increased when Nabumetone is combined with Cefradine.
Ketorolac The risk or severity of nephrotoxicity can be increased when Ketorolac is combined with Cefradine.
Tenoxicam The risk or severity of nephrotoxicity can be increased when Tenoxicam is combined with Cefradine.
Celecoxib The risk or severity of nephrotoxicity can be increased when Celecoxib is combined with Cefradine.
Cefotaxime The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Cefradine.
Tolmetin The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Cefradine.
Rofecoxib The risk or severity of nephrotoxicity can be increased when Rofecoxib is combined with Cefradine.
Piroxicam The risk or severity of nephrotoxicity can be increased when Piroxicam is combined with Cefradine.
Cephalexin The risk or severity of nephrotoxicity can be increased when Cephalexin is combined with Cefradine.
Fenoprofen The risk or severity of nephrotoxicity can be increased when Fenoprofen is combined with Cefradine.
Valaciclovir The risk or severity of nephrotoxicity can be increased when Valaciclovir is combined with Cefradine.
Valdecoxib The risk or severity of nephrotoxicity can be increased when Valdecoxib is combined with Cefradine.
Diclofenac The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Cefradine.
Sulindac The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Cefradine.
Bacitracin The risk or severity of nephrotoxicity can be increased when Bacitracin is combined with Cefradine.
Amphotericin B The risk or severity of nephrotoxicity can be increased when Amphotericin B is combined with Cefradine.
Cephaloglycin The risk or severity of nephrotoxicity can be increased when Cephaloglycin is combined with Cefradine.
Flurbiprofen The risk or severity of nephrotoxicity can be increased when Flurbiprofen is combined with Cefradine.
Adefovir dipivoxil The risk or severity of nephrotoxicity can be increased when Adefovir dipivoxil is combined with Cefradine.
Pentamidine The risk or severity of nephrotoxicity can be increased when Pentamidine is combined with Cefradine.
Etodolac The risk or severity of nephrotoxicity can be increased when Etodolac is combined with Cefradine.
Mefenamic acid The risk or severity of nephrotoxicity can be increased when Mefenamic acid is combined with Cefradine.
Acyclovir The risk or severity of nephrotoxicity can be increased when Acyclovir is combined with Cefradine.
Naproxen The risk or severity of nephrotoxicity can be increased when Naproxen is combined with Cefradine.
Sulfasalazine The risk or severity of nephrotoxicity can be increased when Sulfasalazine is combined with Cefradine.
Phenylbutazone The risk or severity of nephrotoxicity can be increased when Phenylbutazone is combined with Cefradine.
Meloxicam The risk or severity of methemoglobinemia can be increased when Cefradine is combined with Meloxicam.
Carprofen The risk or severity of nephrotoxicity can be increased when Carprofen is combined with Cefradine.
Cefaclor The risk or severity of nephrotoxicity can be increased when Cefaclor is combined with Cefradine.
Diflunisal The risk or severity of nephrotoxicity can be increased when Diflunisal is combined with Cefradine.
Bumetanide The risk or severity of nephrotoxicity can be increased when Bumetanide is combined with Cefradine.
Ceforanide The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cefradine.
Salicylic acid The risk or severity of nephrotoxicity can be increased when Salicylic acid is combined with Cefradine.
Meclofenamic acid The risk or severity of nephrotoxicity can be increased when Meclofenamic acid is combined with Cefradine.
Acetylsalicylic acid The risk or severity of nephrotoxicity can be increased when Acetylsalicylic acid is combined with Cefradine.
Carboplatin The risk or severity of nephrotoxicity can be increased when Carboplatin is combined with Cefradine.
Oxaprozin The risk or severity of nephrotoxicity can be increased when Oxaprozin is combined with Cefradine.
Ketoprofen The risk or severity of nephrotoxicity can be increased when Ketoprofen is combined with Cefradine.
Balsalazide The risk or severity of nephrotoxicity can be increased when Balsalazide is combined with Cefradine.
Ibuprofen The risk or severity of nephrotoxicity can be increased when Ibuprofen is combined with Cefradine.
Cefditoren The risk or severity of nephrotoxicity can be increased when Cefditoren is combined with Cefradine.
Colistimethate The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Cefradine.
Cefuroxime The risk or severity of nephrotoxicity can be increased when Cefuroxime is combined with Cefradine.
Cefapirin The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Cefradine.
Cefadroxil The risk or severity of nephrotoxicity can be increased when Cefadroxil is combined with Cefradine.
Cefprozil The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Cefradine.
Ceftriaxone The risk or severity of nephrotoxicity can be increased when Ceftriaxone is combined with Cefradine.
Olsalazine The risk or severity of nephrotoxicity can be increased when Cefradine is combined with Olsalazine.
Lumiracoxib The risk or severity of nephrotoxicity can be increased when Lumiracoxib is combined with Cefradine.
Cefamandole The risk or severity of nephrotoxicity can be increased when Cefamandole is combined with Cefradine.
Cefazolin The risk or severity of nephrotoxicity can be increased when Cefazolin is combined with Cefradine.
Cefonicid The risk or severity of nephrotoxicity can be increased when Cefonicid is combined with Cefradine.
Cefoperazone The risk or severity of nephrotoxicity can be increased when Cefoperazone is combined with Cefradine.
Cefotetan The risk or severity of nephrotoxicity can be increased when Cefotetan is combined with Cefradine.
Cefoxitin The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Cefradine.
Ceftizoxime The risk or severity of nephrotoxicity can be increased when Ceftizoxime is combined with Cefradine.
Ceftibuten The risk or severity of nephrotoxicity can be increased when Cefradine is combined with Ceftibuten.
Aceclofenac The risk or severity of nephrotoxicity can be increased when Cefradine is combined with Aceclofenac.
Benzydamine The risk or severity of nephrotoxicity can be increased when Cefradine is combined with Benzydamine.
Dexketoprofen The risk or severity of nephrotoxicity can be increased when Cefradine is combined with Dexketoprofen.
Propacetamol The risk or severity of nephrotoxicity can be increased when Cefradine is combined with Propacetamol.
Cefroxadine The risk or severity of nephrotoxicity can be increased when Cefradine is combined with Cefroxadine.
Alclofenac The risk or severity of nephrotoxicity can be increased when Cefradine is combined with Alclofenac.
Magnesium salicylate The risk or severity of nephrotoxicity can be increased when Cefradine is combined with Magnesium salicylate.
Salsalate The risk or severity of nephrotoxicity can be increased when Cefradine is combined with Salsalate.
Choline magnesium trisalicylate The risk or severity of nephrotoxicity can be increased when Cefradine is combined with Choline magnesium trisalicylate.
Cefepime The risk or severity of nephrotoxicity can be increased when Cefradine is combined with Cefepime.
Cefacetrile The risk or severity of nephrotoxicity can be increased when Cefradine is combined with Cefacetrile.

Target Protein

Penicillin-binding protein 1A mrcA

Referensi & Sumber

Synthesis reference: Dennis Heemskerk, Anja Gerarda Hogenboom, Carlos Lenhardt, Harold Moody, Theodorus Johannes Godfried Maria Dooren, "Process for the preparation of cephradine." U.S. Patent US20060189802, issued August 24, 2006.
Artikel (PubMed)
  • PMID: 4572639
    Neiss ES: Cephradine--a summary of preclinical studies and clinical pharmacology. J Ir Med Assoc. 1973 Mar 24;Suppl:1-12.

Contoh Produk & Brand

Produk: 4 • International brands: 6
Produk
  • Velosef
    Capsule, gelatin coated • 250 mg/1 • Oral • US • Generic • Approved
  • Velosef
    Capsule, gelatin coated • 500 mg/1 • Oral • US • Generic • Approved
  • Velosef
    Suspension • 125 mg/5mL • Oral • US • Approved
  • Velosef
    Suspension • 250 mg/5mL • Oral • US • Approved
International Brands
  • Anspor
  • Eskacef
  • Intracef — Beximco Pharma
  • Lebac — Square pharmaceuticals Ltd.
  • Reocef — Rephco Pharmaceuticals Ltd.
  • Sefril — ACME laboratories Ltd.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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