Ceftizoxime

DB01332

small molecule approved withdrawn

Deskripsi

A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.

Struktur Molekul 2D

Berat 383.403
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi The mean apparent volume of distribution ranges between 15 - 28L.[A192942]
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Ceftizoxime is not metabolized and is excreted virtually unchanged by the kidneys in 24 hours.

Rute Eliminasi

Excreted virtually unchanged by the kidneys in 24 hours.

Interaksi Obat

884 Data
Probenecid The serum concentration of Ceftizoxime can be increased when it is combined with Probenecid.
Foscarnet The risk or severity of nephrotoxicity can be increased when Ceftizoxime is combined with Foscarnet.
Mannitol The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Ceftizoxime.
Tenofovir disoproxil Ceftizoxime may increase the nephrotoxic activities of Tenofovir disoproxil.
Tenofovir alafenamide Ceftizoxime may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir Ceftizoxime may increase the nephrotoxic activities of Tenofovir.
Aspartame The excretion of Ceftizoxime can be decreased when combined with Aspartame.
Pravastatin The excretion of Ceftizoxime can be decreased when combined with Pravastatin.
Aminohippuric acid The excretion of Ceftizoxime can be decreased when combined with Aminohippuric acid.
Lansoprazole The excretion of Ceftizoxime can be decreased when combined with Lansoprazole.
Zidovudine The excretion of Ceftizoxime can be decreased when combined with Zidovudine.
Guanidine The excretion of Ceftizoxime can be decreased when combined with Guanidine.
Enalapril The excretion of Ceftizoxime can be decreased when combined with Enalapril.
Oxytetracycline The excretion of Ceftizoxime can be decreased when combined with Oxytetracycline.
Leucovorin The excretion of Ceftizoxime can be decreased when combined with Leucovorin.
Esomeprazole The excretion of Ceftizoxime can be decreased when combined with Esomeprazole.
Dinoprostone The excretion of Ceftizoxime can be decreased when combined with Dinoprostone.
Famotidine The excretion of Ceftizoxime can be decreased when combined with Famotidine.
Minocycline The excretion of Ceftizoxime can be decreased when combined with Minocycline.
Novobiocin The excretion of Ceftizoxime can be decreased when combined with Novobiocin.
Benzylpenicillin The excretion of Ceftizoxime can be decreased when combined with Benzylpenicillin.
Melatonin The excretion of Ceftizoxime can be decreased when combined with Melatonin.
Ouabain The excretion of Ceftizoxime can be decreased when combined with Ouabain.
Rosuvastatin The excretion of Ceftizoxime can be decreased when combined with Rosuvastatin.
Succinic acid The excretion of Succinic acid can be decreased when combined with Ceftizoxime.
Citrulline The excretion of Citrulline can be decreased when combined with Ceftizoxime.
Cefdinir The excretion of Cefdinir can be decreased when combined with Ceftizoxime.
Fluorescein The excretion of Fluorescein can be decreased when combined with Ceftizoxime.
Hydrocortisone The excretion of Hydrocortisone can be decreased when combined with Ceftizoxime.
Quinapril The excretion of Quinapril can be decreased when combined with Ceftizoxime.
Fexofenadine The excretion of Fexofenadine can be decreased when combined with Ceftizoxime.
Captopril The excretion of Captopril can be decreased when combined with Ceftizoxime.
Tazobactam The excretion of Tazobactam can be decreased when combined with Ceftizoxime.
Cyclic adenosine monophosphate The excretion of Cyclic adenosine monophosphate can be decreased when combined with Ceftizoxime.
Cholic Acid The excretion of Cholic Acid can be decreased when combined with Ceftizoxime.
Glutaric Acid The excretion of Glutaric Acid can be decreased when combined with Ceftizoxime.
Oxalic Acid The excretion of Oxalic Acid can be decreased when combined with Ceftizoxime.
Taurocholic acid The excretion of Taurocholic acid can be decreased when combined with Ceftizoxime.
Ellagic acid The excretion of Ellagic acid can be decreased when combined with Ceftizoxime.
Avibactam The excretion of Avibactam can be decreased when combined with Ceftizoxime.
Eluxadoline The excretion of Eluxadoline can be decreased when combined with Ceftizoxime.
Silibinin The excretion of Silibinin can be decreased when combined with Ceftizoxime.
Relebactam The excretion of Relebactam can be decreased when combined with Ceftizoxime.
Liotrix The excretion of Ceftizoxime can be decreased when combined with Liotrix.
Cilastatin The excretion of Ceftizoxime can be decreased when combined with Cilastatin.
trans-2-hydroxycinnamic acid The excretion of Ceftizoxime can be decreased when combined with trans-2-hydroxycinnamic acid.
Benzoic acid The excretion of Ceftizoxime can be decreased when combined with Benzoic acid.
Caprylic acid The excretion of Ceftizoxime can be decreased when combined with Caprylic acid.
Ataluren The excretion of Ceftizoxime can be decreased when combined with Ataluren.
Teriflunomide The excretion of Ceftizoxime can be decreased when combined with Teriflunomide.
Dabrafenib The excretion of Ceftizoxime can be decreased when combined with Dabrafenib.
Dolutegravir The excretion of Ceftizoxime can be decreased when combined with Dolutegravir.
Lenvatinib The excretion of Ceftizoxime can be decreased when combined with Lenvatinib.
Cabotegravir The excretion of Ceftizoxime can be decreased when combined with Cabotegravir.
Pradigastat The excretion of Ceftizoxime can be decreased when combined with Pradigastat.
Enasidenib The excretion of Ceftizoxime can be decreased when combined with Enasidenib.
Oseltamivir The excretion of Oseltamivir can be decreased when combined with Ceftizoxime.
Pantoprazole The excretion of Ceftizoxime can be decreased when combined with Pantoprazole.
Liothyronine The excretion of Ceftizoxime can be decreased when combined with Liothyronine.
Conjugated estrogens The excretion of Ceftizoxime can be decreased when combined with Conjugated estrogens.
Piperacillin The excretion of Piperacillin can be decreased when combined with Ceftizoxime.
Trifluridine The excretion of Trifluridine can be decreased when combined with Ceftizoxime.
Allopurinol The excretion of Allopurinol can be decreased when combined with Ceftizoxime.
Cimetidine The excretion of Ceftizoxime can be decreased when combined with Cimetidine.
Piroxicam The excretion of Ceftizoxime can be decreased when combined with Piroxicam.
Methotrexate The excretion of Ceftizoxime can be decreased when combined with Methotrexate.
Cephalexin The excretion of Ceftizoxime can be decreased when combined with Cephalexin.
Valaciclovir The excretion of Valaciclovir can be decreased when combined with Ceftizoxime.
Levocarnitine The excretion of Levocarnitine can be decreased when combined with Ceftizoxime.
Tetracycline The excretion of Ceftizoxime can be decreased when combined with Tetracycline.
Estradiol The excretion of Estradiol can be decreased when combined with Ceftizoxime.
Acyclovir The excretion of Ceftizoxime can be decreased when combined with Acyclovir.
Cefaclor The excretion of Ceftizoxime can be decreased when combined with Cefaclor.
Ranitidine The excretion of Ranitidine can be decreased when combined with Ceftizoxime.
Bumetanide The excretion of Ceftizoxime can be decreased when combined with Bumetanide.
Ganciclovir The excretion of Ceftizoxime can be decreased when combined with Ganciclovir.
Ketoprofen The excretion of Ceftizoxime can be decreased when combined with Ketoprofen.
Ibuprofen The excretion of Ceftizoxime can be decreased when combined with Ibuprofen.
Cefadroxil The excretion of Ceftizoxime can be decreased when combined with Cefadroxil.
Ceftriaxone The excretion of Ceftizoxime can be decreased when combined with Ceftriaxone.
Gemfibrozil The excretion of Ceftizoxime can be decreased when combined with Gemfibrozil.
Sitagliptin The excretion of Sitagliptin can be decreased when combined with Ceftizoxime.
Ceftibuten The excretion of Ceftibuten can be decreased when combined with Ceftizoxime.
Topiroxostat The excretion of Ceftizoxime can be decreased when combined with Topiroxostat.
Doripenem The excretion of Doripenem can be decreased when combined with Ceftizoxime.
Saxagliptin The excretion of Saxagliptin can be decreased when combined with Ceftizoxime.
Baricitinib The serum concentration of Baricitinib can be increased when it is combined with Ceftizoxime.
Apalutamide The excretion of Ceftizoxime can be decreased when combined with Apalutamide.
Dronedarone The excretion of Ceftizoxime can be decreased when combined with Dronedarone.
Dexamethasone The excretion of Dexamethasone can be decreased when combined with Ceftizoxime.
Favipiravir The excretion of Ceftizoxime can be decreased when combined with Favipiravir.
Polythiazide The excretion of Polythiazide can be decreased when combined with Ceftizoxime.
Prednisolone phosphate The excretion of Prednisolone phosphate can be decreased when combined with Ceftizoxime.
Tafamidis The excretion of Ceftizoxime can be decreased when combined with Tafamidis.
Dexamethasone acetate The excretion of Dexamethasone acetate can be decreased when combined with Ceftizoxime.
Linezolid The excretion of Ceftizoxime can be decreased when combined with Linezolid.
Acamprosate The excretion of Acamprosate can be decreased when combined with Ceftizoxime.
Cyclosporine The risk or severity of nephrotoxicity can be increased when Cyclosporine is combined with Ceftizoxime.
Icosapent The risk or severity of nephrotoxicity can be increased when Icosapent is combined with Ceftizoxime.
Cefotiam The excretion of Ceftizoxime can be decreased when combined with Cefotiam.

Target Protein

Penicillin-binding protein 1A mrcA
Penicillin-binding protein 1B mrcB
Peptidoglycan transpeptidase
D-alanyl-D-alanine carboxypeptidase DacC dacC

Referensi & Sumber

Synthesis reference: Norio Ohnishi, Rinta Ibuki, "Method for preparing stable crystals of salt of Ceftizoxime." U.S. Patent US4390694, issued October, 1981.
Artikel (PubMed)
  • PMID: 3888599
    Richards DM, Heel RC: Ceftizoxime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1985 Apr;29(4):281-329. doi: 10.2165/00003495-198529040-00001.

Contoh Produk & Brand

Produk: 11 • International brands: 1
Produk
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    Injection, powder, lyophilized, for solution • 1 g/1 • Intravenous • US • Approved
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  • Cefizox
    Solution • 1 g/50mL • Intravenous • US • Approved
  • Cefizox
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  • Cefizox
    Injection, powder, lyophilized, for solution • 500 mg/1 • Intramuscular; Intravenous • US • Approved
  • Cefizox
    Injection, powder, lyophilized, for solution • 1 g/1 • Intramuscular; Intravenous • US • Approved
  • Cefizox
    Injection, powder, lyophilized, for solution • 2 g/1 • Intramuscular; Intravenous • US • Approved
  • Cefizox
    Injection, powder, lyophilized, for solution • 1 g/1 • Intramuscular; Intravenous • US • Approved
Menampilkan 8 dari 11 produk.
International Brands
  • Epocelin — Choseido Pharmaceutical

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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