Peringatan Keamanan

The acute intravenous LD50 in the adult female mouse and rabbit was about 8.0 g/kg and greater than 1.0 g/kg, respectively. The acute intraperitoneal LD50 in the adult rat was greater than 10.0 g/kg.

Cefoxitin

DB01331

small molecule approved

Deskripsi

Cefoxitin is a semi-synthetic, broad-spectrum cepha antibiotic for intravenous administration. It is derived from cephamycin C, which is produced by Streptomyces lactamdurans.

Struktur Molekul 2D

Berat 427.452
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The half-life after an intravenous dose is 41 to 59 minutes.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Minimal (approximately 85 percent of cefoxitin is excreted unchanged by the kidneys over a 6-hour period).

Rute Eliminasi

Approximately 85 percent of cefoxitin is excreted unchanged by the kidneys over a 6-hour period, resulting in high urinary concentrations. Cefoxitin passes into pleural and joint fluids and is detectable in antibacterial concentrations in bile.

Interaksi Obat

795 Data
Probenecid The serum concentration of Cefoxitin can be increased when it is combined with Probenecid.
Foscarnet The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Foscarnet.
Mannitol The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Cefoxitin.
Tenofovir disoproxil Cefoxitin may increase the nephrotoxic activities of Tenofovir disoproxil.
Tenofovir alafenamide Cefoxitin may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir Cefoxitin may increase the nephrotoxic activities of Tenofovir.
Cyclosporine The risk or severity of nephrotoxicity can be increased when Cyclosporine is combined with Cefoxitin.
Icosapent The risk or severity of nephrotoxicity can be increased when Icosapent is combined with Cefoxitin.
Cefotiam The risk or severity of nephrotoxicity can be increased when Cefotiam is combined with Cefoxitin.
Mesalazine The risk or severity of nephrotoxicity can be increased when Mesalazine is combined with Cefoxitin.
Cefmenoxime The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefoxitin.
Cefmetazole The risk or severity of nephrotoxicity can be increased when Cefmetazole is combined with Cefoxitin.
Indomethacin The risk or severity of nephrotoxicity can be increased when Indomethacin is combined with Cefoxitin.
Triamterene The risk or severity of nephrotoxicity can be increased when Triamterene is combined with Cefoxitin.
Cefpiramide The risk or severity of nephrotoxicity can be increased when Cefpiramide is combined with Cefoxitin.
Loracarbef The risk or severity of nephrotoxicity can be increased when Loracarbef is combined with Cefoxitin.
Cefalotin The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Cefoxitin.
Nabumetone The risk or severity of nephrotoxicity can be increased when Nabumetone is combined with Cefoxitin.
Ketorolac The risk or severity of nephrotoxicity can be increased when Ketorolac is combined with Cefoxitin.
Tenoxicam The risk or severity of nephrotoxicity can be increased when Tenoxicam is combined with Cefoxitin.
Celecoxib The risk or severity of nephrotoxicity can be increased when Celecoxib is combined with Cefoxitin.
Cefotaxime The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Cefoxitin.
Tolmetin The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Cefoxitin.
Rofecoxib The risk or severity of nephrotoxicity can be increased when Rofecoxib is combined with Cefoxitin.
Fenoprofen The risk or severity of nephrotoxicity can be increased when Fenoprofen is combined with Cefoxitin.
Valdecoxib The risk or severity of nephrotoxicity can be increased when Valdecoxib is combined with Cefoxitin.
Diclofenac The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Cefoxitin.
Sulindac The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Cefoxitin.
Bacitracin The risk or severity of nephrotoxicity can be increased when Bacitracin is combined with Cefoxitin.
Amphotericin B The risk or severity of nephrotoxicity can be increased when Amphotericin B is combined with Cefoxitin.
Cephaloglycin The risk or severity of nephrotoxicity can be increased when Cephaloglycin is combined with Cefoxitin.
Adefovir dipivoxil The risk or severity of nephrotoxicity can be increased when Adefovir dipivoxil is combined with Cefoxitin.
Pentamidine The risk or severity of nephrotoxicity can be increased when Pentamidine is combined with Cefoxitin.
Mefenamic acid The risk or severity of nephrotoxicity can be increased when Mefenamic acid is combined with Cefoxitin.
Naproxen The risk or severity of nephrotoxicity can be increased when Naproxen is combined with Cefoxitin.
Sulfasalazine The risk or severity of nephrotoxicity can be increased when Sulfasalazine is combined with Cefoxitin.
Phenylbutazone The risk or severity of nephrotoxicity can be increased when Phenylbutazone is combined with Cefoxitin.
Meloxicam The risk or severity of methemoglobinemia can be increased when Cefoxitin is combined with Meloxicam.
Carprofen The risk or severity of nephrotoxicity can be increased when Carprofen is combined with Cefoxitin.
Tacrolimus The risk or severity of nephrotoxicity can be increased when Tacrolimus is combined with Cefoxitin.
Etacrynic acid The risk or severity of nephrotoxicity can be increased when Etacrynic acid is combined with Cefoxitin.
Ceforanide The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cefoxitin.
Salicylic acid The risk or severity of nephrotoxicity can be increased when Salicylic acid is combined with Cefoxitin.
Acetylsalicylic acid The risk or severity of nephrotoxicity can be increased when Acetylsalicylic acid is combined with Cefoxitin.
Hydrochlorothiazide The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Cefoxitin.
Balsalazide The risk or severity of nephrotoxicity can be increased when Balsalazide is combined with Cefoxitin.
Cefditoren The risk or severity of nephrotoxicity can be increased when Cefditoren is combined with Cefoxitin.
Atazanavir The risk or severity of nephrotoxicity can be increased when Atazanavir is combined with Cefoxitin.
Colistimethate The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Cefoxitin.
Cefuroxime The risk or severity of nephrotoxicity can be increased when Cefuroxime is combined with Cefoxitin.
Cefapirin The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Cefoxitin.
Cefprozil The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Cefoxitin.
Olsalazine The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Olsalazine.
Lumiracoxib The risk or severity of nephrotoxicity can be increased when Lumiracoxib is combined with Cefoxitin.
Cefamandole The risk or severity of nephrotoxicity can be increased when Cefamandole is combined with Cefoxitin.
Cefazolin The risk or severity of nephrotoxicity can be increased when Cefazolin is combined with Cefoxitin.
Cefonicid The risk or severity of nephrotoxicity can be increased when Cefonicid is combined with Cefoxitin.
Cefoperazone The risk or severity of nephrotoxicity can be increased when Cefoperazone is combined with Cefoxitin.
Ceftizoxime The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Ceftizoxime.
Magnesium salicylate The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Magnesium salicylate.
Salsalate The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Salsalate.
Choline magnesium trisalicylate The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Choline magnesium trisalicylate.
Cefepime The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Cefepime.
Cefacetrile The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Cefacetrile.
Cefpodoxime The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Cefpodoxime.
Antrafenine The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Antrafenine.
Aminophenazone The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Aminophenazone.
Antipyrine The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Antipyrine.
Tiaprofenic acid The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Tiaprofenic acid.
Lopinavir The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Lopinavir.
Etoricoxib The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Etoricoxib.
Hydrolyzed Cephalothin The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Hydrolyzed Cephalothin.
Cephalothin Group The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Cephalothin Group.
Oxyphenbutazone The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Oxyphenbutazone.
Latamoxef The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Latamoxef.
Nimesulide The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Nimesulide.
Benoxaprofen The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Benoxaprofen.
Metamizole The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Metamizole.
Zomepirac The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Zomepirac.
Ceftobiprole The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Ceftobiprole.
Cimicoxib The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Cimicoxib.
Ceftaroline fosamil The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Ceftaroline fosamil.
Lornoxicam The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Lornoxicam.
Zaltoprofen The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Zaltoprofen.
Azapropazone The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Azapropazone.
Parecoxib The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Parecoxib.
Salicylamide The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Salicylamide.
Kebuzone The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Kebuzone.
Isoxicam The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Isoxicam.
Indoprofen The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Indoprofen.
Ibuproxam The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Ibuproxam.
Floctafenine The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Floctafenine.
Fenbufen The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Fenbufen.
Etofenamate The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Etofenamate.
Epirizole The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Epirizole.
Cefaloridine The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Cefaloridine.
Cefminox The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Cefminox.
Dexibuprofen The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Dexibuprofen.
Droxicam The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Droxicam.
Tolfenamic acid The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Tolfenamic acid.

Target Protein

D-alanyl-D-alanine carboxypeptidase DacC dacC
D-alanyl-D-alanine carboxypeptidase DacA dacA
D-alanyl-D-alanine endopeptidase pbpG
D-alanyl-D-alanine carboxypeptidase DacB dacB
Penicillin-binding protein 1A mrcA
Penicillin-binding protein 1B mrcB
Peptidoglycan synthase FtsI ftsI
Penicillin-binding protein 3 pbp3
Penicillin-binding protein 1b pbp1b
Penicillin-binding protein 2a pbp2a
Penicillin-binding protein 1A pbpA
Penicillin-binding protein 2B penA

Referensi & Sumber

Synthesis reference: Pandurang Deshpande, Bhausaheb Khadangale, "Process for the preparation of cefoxitin." U.S. Patent US20060252928, issued November 09, 2006.

Contoh Produk & Brand

Produk: 46 • International brands: 3
Produk
  • Cefoxitin
    Injection, powder, for solution • 10 g/1 • Intravenous • US • Generic • Approved
  • Cefoxitin
    Injection, powder, for solution • 1 g/1 • Intravenous • US • Generic • Approved
  • Cefoxitin
    Injection, powder, for solution • 2 g/1 • Intravenous • US • Generic • Approved
  • Cefoxitin
    Injection, powder, for solution • 1 g/10mL • Intravenous • US • Generic • Approved
  • Cefoxitin
    Injection, powder, for solution • 2 g/10mL • Intravenous • US • Generic • Approved
  • Cefoxitin
    Injection, powder, for solution • 10 g/100mL • Intravenous • US • Generic • Approved
  • Cefoxitin
    Injection, powder, for solution • 1 g/1 • Intravenous • US • Generic • Approved
  • Cefoxitin
    Injection, powder, for solution • 2 g/1 • Intravenous • US • Generic • Approved
Menampilkan 8 dari 46 produk.
International Brands
  • Cefoctin — Teva
  • Cenomicin — Daiichi-Seiyaku
  • Mefoxitin — Merck

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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