Peringatan Keamanan

Symptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting.

Cefoperazone

DB01329

small molecule approved investigational

Deskripsi

Cefoperazone is a semisynthetic broad-spectrum cephalosporin proposed to be effective against Pseudomonas infections. It is a third-generation antiobiotic agent and it is used in the treatment of various bacterial infections caused by susceptible organisms in the body, including respiratory tract infections, peritonitis, skin infections, endometritis, and bacterial septicemia. While its clinical use has been discontinued in the U.S., cefoperazone is available in several European countries most commonly under the product name, Sulperazon.

Struktur Molekul 2D

Berat 645.67
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The mean serum half-life is approximately 2.0 hours, independent of the route of administration.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

No significant quanitity of metabolites have been identified in urine.

Rute Eliminasi

Cefoperazone is excreted mainly in the bile.

Interaksi Makanan

1 Data
  • 1. Avoid alcohol. Ingesting alcohol with cefoperazone may precipitate a disulfuram like reaction including symptoms such as flushing, tachycardia, sweating, and headache.

Interaksi Obat

834 Data
Probenecid The serum concentration of Cefoperazone can be increased when it is combined with Probenecid.
Foscarnet The risk or severity of nephrotoxicity can be increased when Cefoperazone is combined with Foscarnet.
Mannitol The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Cefoperazone.
Tenofovir disoproxil Cefoperazone may increase the nephrotoxic activities of Tenofovir disoproxil.
Tenofovir alafenamide Cefoperazone may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir Cefoperazone may increase the nephrotoxic activities of Tenofovir.
Succinic acid The excretion of Succinic acid can be decreased when combined with Cefoperazone.
Citrulline The excretion of Citrulline can be decreased when combined with Cefoperazone.
Aminohippuric acid The excretion of Aminohippuric acid can be decreased when combined with Cefoperazone.
Cefdinir The excretion of Cefdinir can be decreased when combined with Cefoperazone.
Leucovorin The excretion of Leucovorin can be decreased when combined with Cefoperazone.
Fluorescein The excretion of Fluorescein can be decreased when combined with Cefoperazone.
Quinapril The excretion of Quinapril can be decreased when combined with Cefoperazone.
Dinoprostone The excretion of Dinoprostone can be decreased when combined with Cefoperazone.
Famotidine The excretion of Famotidine can be decreased when combined with Cefoperazone.
Benzylpenicillin The excretion of Benzylpenicillin can be decreased when combined with Cefoperazone.
Rosuvastatin The excretion of Rosuvastatin can be decreased when combined with Cefoperazone.
Captopril The excretion of Captopril can be decreased when combined with Cefoperazone.
Tazobactam The excretion of Tazobactam can be decreased when combined with Cefoperazone.
Cyclic adenosine monophosphate The excretion of Cyclic adenosine monophosphate can be decreased when combined with Cefoperazone.
Cholic Acid The excretion of Cholic Acid can be decreased when combined with Cefoperazone.
Glutaric Acid The excretion of Glutaric Acid can be decreased when combined with Cefoperazone.
Oxalic Acid The excretion of Oxalic Acid can be decreased when combined with Cefoperazone.
Ellagic acid The excretion of Ellagic acid can be decreased when combined with Cefoperazone.
Avibactam The excretion of Avibactam can be decreased when combined with Cefoperazone.
Eluxadoline The excretion of Eluxadoline can be decreased when combined with Cefoperazone.
Silibinin The excretion of Silibinin can be decreased when combined with Cefoperazone.
Relebactam The excretion of Relebactam can be decreased when combined with Cefoperazone.
Oseltamivir The excretion of Oseltamivir can be decreased when combined with Cefoperazone.
Piperacillin The excretion of Piperacillin can be decreased when combined with Cefoperazone.
Trifluridine The excretion of Trifluridine can be decreased when combined with Cefoperazone.
Allopurinol The excretion of Allopurinol can be decreased when combined with Cefoperazone.
Cephalexin The excretion of Cephalexin can be decreased when combined with Cefoperazone.
Valaciclovir The excretion of Valaciclovir can be decreased when combined with Cefoperazone.
Levocarnitine The excretion of Levocarnitine can be decreased when combined with Cefoperazone.
Acyclovir The excretion of Acyclovir can be decreased when combined with Cefoperazone.
Cefaclor The excretion of Cefaclor can be decreased when combined with Cefoperazone.
Bumetanide The excretion of Bumetanide can be decreased when combined with Cefoperazone.
Ceftibuten The excretion of Ceftibuten can be decreased when combined with Cefoperazone.
Doripenem The excretion of Doripenem can be decreased when combined with Cefoperazone.
Saxagliptin The excretion of Saxagliptin can be decreased when combined with Cefoperazone.
Conjugated estrogens The excretion of Conjugated estrogens can be decreased when combined with Cefoperazone.
Indomethacin The excretion of Indomethacin can be decreased when combined with Cefoperazone.
Zidovudine The excretion of Zidovudine can be decreased when combined with Cefoperazone.
Cimetidine The excretion of Cimetidine can be decreased when combined with Cefoperazone.
Methotrexate The excretion of Methotrexate can be decreased when combined with Cefoperazone.
Hydrocortisone The excretion of Hydrocortisone can be decreased when combined with Cefoperazone.
Tetracycline The excretion of Tetracycline can be decreased when combined with Cefoperazone.
Estradiol The excretion of Estradiol can be decreased when combined with Cefoperazone.
Ranitidine The excretion of Ranitidine can be decreased when combined with Cefoperazone.
Dexamethasone The excretion of Dexamethasone can be decreased when combined with Cefoperazone.
Pravastatin The excretion of Pravastatin can be decreased when combined with Cefoperazone.
Fexofenadine The excretion of Fexofenadine can be decreased when combined with Cefoperazone.
Sitagliptin The excretion of Sitagliptin can be decreased when combined with Cefoperazone.
Taurocholic acid The excretion of Taurocholic acid can be decreased when combined with Cefoperazone.
Baricitinib The serum concentration of Baricitinib can be increased when it is combined with Cefoperazone.
Oxytetracycline The excretion of Oxytetracycline can be decreased when combined with Cefoperazone.
Polythiazide The excretion of Polythiazide can be decreased when combined with Cefoperazone.
Prednisolone phosphate The excretion of Prednisolone phosphate can be decreased when combined with Cefoperazone.
Dexamethasone acetate The excretion of Dexamethasone acetate can be decreased when combined with Cefoperazone.
Acamprosate The excretion of Acamprosate can be decreased when combined with Cefoperazone.
Icosapent The risk or severity of nephrotoxicity can be increased when Icosapent is combined with Cefoperazone.
Cefotiam The excretion of Cefotiam can be decreased when combined with Cefoperazone.
Mesalazine The risk or severity of nephrotoxicity can be increased when Mesalazine is combined with Cefoperazone.
Cefmenoxime The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefoperazone.
Cefmetazole The risk or severity of nephrotoxicity can be increased when Cefmetazole is combined with Cefoperazone.
Triamterene The risk or severity of nephrotoxicity can be increased when Triamterene is combined with Cefoperazone.
Cefpiramide The risk or severity of nephrotoxicity can be increased when Cefpiramide is combined with Cefoperazone.
Loracarbef The risk or severity of nephrotoxicity can be increased when Loracarbef is combined with Cefoperazone.
Cefalotin The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Cefoperazone.
Nabumetone The risk or severity of nephrotoxicity can be increased when Nabumetone is combined with Cefoperazone.
Ketorolac The risk or severity of nephrotoxicity can be increased when Ketorolac is combined with Cefoperazone.
Tenoxicam The risk or severity of nephrotoxicity can be increased when Tenoxicam is combined with Cefoperazone.
Celecoxib The risk or severity of nephrotoxicity can be increased when Celecoxib is combined with Cefoperazone.
Cefotaxime The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Cefoperazone.
Tolmetin The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Cefoperazone.
Rofecoxib The risk or severity of nephrotoxicity can be increased when Rofecoxib is combined with Cefoperazone.
Fenoprofen The risk or severity of nephrotoxicity can be increased when Fenoprofen is combined with Cefoperazone.
Valdecoxib The risk or severity of nephrotoxicity can be increased when Valdecoxib is combined with Cefoperazone.
Diclofenac The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Cefoperazone.
Sulindac The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Cefoperazone.
Bacitracin The risk or severity of nephrotoxicity can be increased when Bacitracin is combined with Cefoperazone.
Amphotericin B The risk or severity of nephrotoxicity can be increased when Amphotericin B is combined with Cefoperazone.
Cephaloglycin The risk or severity of nephrotoxicity can be increased when Cephaloglycin is combined with Cefoperazone.
Adefovir dipivoxil The risk or severity of nephrotoxicity can be increased when Adefovir dipivoxil is combined with Cefoperazone.
Pentamidine The risk or severity of nephrotoxicity can be increased when Pentamidine is combined with Cefoperazone.
Mefenamic acid The risk or severity of nephrotoxicity can be increased when Mefenamic acid is combined with Cefoperazone.
Naproxen The risk or severity of nephrotoxicity can be increased when Naproxen is combined with Cefoperazone.
Sulfasalazine The risk or severity of nephrotoxicity can be increased when Sulfasalazine is combined with Cefoperazone.
Phenylbutazone The risk or severity of nephrotoxicity can be increased when Phenylbutazone is combined with Cefoperazone.
Meloxicam The risk or severity of methemoglobinemia can be increased when Cefoperazone is combined with Meloxicam.
Carprofen The risk or severity of nephrotoxicity can be increased when Carprofen is combined with Cefoperazone.
Etacrynic acid The risk or severity of nephrotoxicity can be increased when Etacrynic acid is combined with Cefoperazone.
Ceforanide The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cefoperazone.
Salicylic acid The risk or severity of nephrotoxicity can be increased when Salicylic acid is combined with Cefoperazone.
Hydrochlorothiazide The excretion of Hydrochlorothiazide can be decreased when combined with Cefoperazone.
Balsalazide The risk or severity of nephrotoxicity can be increased when Balsalazide is combined with Cefoperazone.
Cefditoren The risk or severity of nephrotoxicity can be increased when Cefditoren is combined with Cefoperazone.
Colistimethate The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Cefoperazone.
Cefuroxime The risk or severity of nephrotoxicity can be increased when Cefuroxime is combined with Cefoperazone.

Target Protein

Peptidoglycan synthase FtsI ftsI
Penicillin-binding protein 1B mrcB
Penicillin-binding protein 2 mrdA
Penicillin-binding protein 1A mrcA
Penicillin-binding protein 1B ponB
D-alanyl-D-alanine carboxypeptidase DacC dacC
Penicillin-binding protein 1A mrcA
D-alanyl-D-alanine carboxypeptidase DacA dacA
D-alanyl-D-alanine carboxypeptidase DacB dacB

Referensi & Sumber

Synthesis reference: Walter Cabri, "Process for the preparation of highly crystalline sodium cefoperazone." U.S. Patent US20040030127, issued February 12, 2004.
Artikel (PubMed)
  • PMID: 6221381
    Jones RN, Barry AL: Cefoperazone: a review of its antimicrobial spectrum, beta-lactamase stability, enzyme inhibition, and other in vitro characteristics. Rev Infect Dis. 1983 Mar-Apr;5 Suppl 1:S108-26.

Contoh Produk & Brand

Produk: 3 • International brands: 3
Produk
  • Cefobid
    Powder, for solution • 1 g/1 • Intravenous • US • Approved
  • Cefobid
    Powder, for solution • 2 g/1 • Intravenous • US • Approved
  • Cefobid
    Powder, for solution • 10 g/1 • Intravenous • US • Approved
International Brands
  • Cefobine — Pfizer
  • Cefobis — Pfizer
  • Cefoperazin — Pfizer

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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