Cefazolin

DB01327

small molecule approved

Deskripsi

A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.

Struktur Molekul 2D

Berat 454.507
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The serum half-life is approximately 1.8 hours following IV administration and approximately 2.0 hours following IM administration.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Not absorbed from GI tract. Must be administered parenterally. Peak serum concentrations attained 1-2 hours post intramuscular injection.

Metabolisme

Not metabolized.

Rute Eliminasi

Cefazolin is present in very low concentrations in the milk of nursing mothers. Cefazolin is excreted unchanged in the urine. In the first six hours approximately 60% of the drug is excreted in the urine and this increases to 70%-80% within 24 hours.

Interaksi Obat

885 Data
Phenytoin The protein binding of Phenytoin can be decreased when combined with Cefazolin.
Fosphenytoin The protein binding of Fosphenytoin can be decreased when combined with Cefazolin.
Probenecid The serum concentration of Cefazolin can be increased when it is combined with Probenecid.
Foscarnet The risk or severity of nephrotoxicity can be increased when Cefazolin is combined with Foscarnet.
Mannitol The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Cefazolin.
Tenofovir disoproxil Cefazolin may increase the nephrotoxic activities of Tenofovir disoproxil.
Tenofovir alafenamide Cefazolin may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir Cefazolin may increase the nephrotoxic activities of Tenofovir.
Aspartame The excretion of Cefazolin can be decreased when combined with Aspartame.
Pravastatin The excretion of Cefazolin can be decreased when combined with Pravastatin.
Aminohippuric acid The excretion of Cefazolin can be decreased when combined with Aminohippuric acid.
Lansoprazole The excretion of Cefazolin can be decreased when combined with Lansoprazole.
Zidovudine The excretion of Cefazolin can be decreased when combined with Zidovudine.
Guanidine The excretion of Cefazolin can be decreased when combined with Guanidine.
Enalapril The excretion of Cefazolin can be decreased when combined with Enalapril.
Oxytetracycline The excretion of Cefazolin can be decreased when combined with Oxytetracycline.
Leucovorin The excretion of Cefazolin can be decreased when combined with Leucovorin.
Esomeprazole The excretion of Cefazolin can be decreased when combined with Esomeprazole.
Dinoprostone The excretion of Cefazolin can be decreased when combined with Dinoprostone.
Famotidine The excretion of Cefazolin can be decreased when combined with Famotidine.
Minocycline The excretion of Cefazolin can be decreased when combined with Minocycline.
Novobiocin The excretion of Cefazolin can be decreased when combined with Novobiocin.
Benzylpenicillin The excretion of Cefazolin can be decreased when combined with Benzylpenicillin.
Melatonin The excretion of Cefazolin can be decreased when combined with Melatonin.
Ouabain The excretion of Cefazolin can be decreased when combined with Ouabain.
Rosuvastatin The excretion of Cefazolin can be decreased when combined with Rosuvastatin.
Succinic acid The excretion of Succinic acid can be decreased when combined with Cefazolin.
Citrulline The excretion of Citrulline can be decreased when combined with Cefazolin.
Cefdinir The excretion of Cefdinir can be decreased when combined with Cefazolin.
Fluorescein The excretion of Fluorescein can be decreased when combined with Cefazolin.
Hydrocortisone The excretion of Hydrocortisone can be decreased when combined with Cefazolin.
Quinapril The excretion of Quinapril can be decreased when combined with Cefazolin.
Fexofenadine The excretion of Fexofenadine can be decreased when combined with Cefazolin.
Captopril The excretion of Captopril can be decreased when combined with Cefazolin.
Tazobactam The excretion of Tazobactam can be decreased when combined with Cefazolin.
Cyclic adenosine monophosphate The excretion of Cyclic adenosine monophosphate can be decreased when combined with Cefazolin.
Cholic Acid The excretion of Cholic Acid can be decreased when combined with Cefazolin.
Glutaric Acid The excretion of Glutaric Acid can be decreased when combined with Cefazolin.
Oxalic Acid The excretion of Oxalic Acid can be decreased when combined with Cefazolin.
Taurocholic acid The excretion of Taurocholic acid can be decreased when combined with Cefazolin.
Ellagic acid The excretion of Ellagic acid can be decreased when combined with Cefazolin.
Avibactam The excretion of Avibactam can be decreased when combined with Cefazolin.
Eluxadoline The excretion of Eluxadoline can be decreased when combined with Cefazolin.
Silibinin The excretion of Silibinin can be decreased when combined with Cefazolin.
Relebactam The excretion of Relebactam can be decreased when combined with Cefazolin.
Liotrix The excretion of Cefazolin can be decreased when combined with Liotrix.
Cilastatin The excretion of Cefazolin can be decreased when combined with Cilastatin.
trans-2-hydroxycinnamic acid The excretion of Cefazolin can be decreased when combined with trans-2-hydroxycinnamic acid.
Benzoic acid The excretion of Cefazolin can be decreased when combined with Benzoic acid.
Caprylic acid The excretion of Cefazolin can be decreased when combined with Caprylic acid.
Ataluren The excretion of Cefazolin can be decreased when combined with Ataluren.
Teriflunomide The excretion of Cefazolin can be decreased when combined with Teriflunomide.
Dabrafenib The excretion of Cefazolin can be decreased when combined with Dabrafenib.
Dolutegravir The excretion of Cefazolin can be decreased when combined with Dolutegravir.
Lenvatinib The excretion of Cefazolin can be decreased when combined with Lenvatinib.
Cabotegravir The excretion of Cefazolin can be decreased when combined with Cabotegravir.
Pradigastat The excretion of Cefazolin can be decreased when combined with Pradigastat.
Enasidenib The excretion of Cefazolin can be decreased when combined with Enasidenib.
Oseltamivir The excretion of Oseltamivir can be decreased when combined with Cefazolin.
Pantoprazole The excretion of Cefazolin can be decreased when combined with Pantoprazole.
Liothyronine The excretion of Cefazolin can be decreased when combined with Liothyronine.
Conjugated estrogens The excretion of Cefazolin can be decreased when combined with Conjugated estrogens.
Piperacillin The excretion of Piperacillin can be decreased when combined with Cefazolin.
Trifluridine The excretion of Trifluridine can be decreased when combined with Cefazolin.
Allopurinol The excretion of Allopurinol can be decreased when combined with Cefazolin.
Cimetidine The excretion of Cefazolin can be decreased when combined with Cimetidine.
Piroxicam The excretion of Cefazolin can be decreased when combined with Piroxicam.
Methotrexate The excretion of Cefazolin can be decreased when combined with Methotrexate.
Cephalexin The excretion of Cefazolin can be decreased when combined with Cephalexin.
Valaciclovir The excretion of Valaciclovir can be decreased when combined with Cefazolin.
Levocarnitine The excretion of Levocarnitine can be decreased when combined with Cefazolin.
Tetracycline The excretion of Cefazolin can be decreased when combined with Tetracycline.
Estradiol The excretion of Estradiol can be decreased when combined with Cefazolin.
Acyclovir The excretion of Cefazolin can be decreased when combined with Acyclovir.
Cefaclor The excretion of Cefazolin can be decreased when combined with Cefaclor.
Ranitidine The excretion of Ranitidine can be decreased when combined with Cefazolin.
Bumetanide The excretion of Cefazolin can be decreased when combined with Bumetanide.
Ganciclovir The excretion of Cefazolin can be decreased when combined with Ganciclovir.
Ketoprofen The excretion of Cefazolin can be decreased when combined with Ketoprofen.
Ibuprofen The excretion of Cefazolin can be decreased when combined with Ibuprofen.
Cefadroxil The excretion of Cefazolin can be decreased when combined with Cefadroxil.
Ceftriaxone The excretion of Cefazolin can be decreased when combined with Ceftriaxone.
Gemfibrozil The excretion of Cefazolin can be decreased when combined with Gemfibrozil.
Sitagliptin The excretion of Sitagliptin can be decreased when combined with Cefazolin.
Ceftibuten The excretion of Ceftibuten can be decreased when combined with Cefazolin.
Topiroxostat The excretion of Cefazolin can be decreased when combined with Topiroxostat.
Doripenem The excretion of Doripenem can be decreased when combined with Cefazolin.
Saxagliptin The excretion of Saxagliptin can be decreased when combined with Cefazolin.
Baricitinib The serum concentration of Baricitinib can be increased when it is combined with Cefazolin.
Apalutamide The excretion of Cefazolin can be decreased when combined with Apalutamide.
Dronedarone The excretion of Cefazolin can be decreased when combined with Dronedarone.
Dexamethasone The excretion of Dexamethasone can be decreased when combined with Cefazolin.
Favipiravir The excretion of Cefazolin can be decreased when combined with Favipiravir.
Polythiazide The excretion of Polythiazide can be decreased when combined with Cefazolin.
Prednisolone phosphate The excretion of Prednisolone phosphate can be decreased when combined with Cefazolin.
Tafamidis The excretion of Cefazolin can be decreased when combined with Tafamidis.
Dexamethasone acetate The excretion of Dexamethasone acetate can be decreased when combined with Cefazolin.
Linezolid The excretion of Cefazolin can be decreased when combined with Linezolid.
Acamprosate The excretion of Acamprosate can be decreased when combined with Cefazolin.
Cyclosporine The risk or severity of nephrotoxicity can be increased when Cyclosporine is combined with Cefazolin.

Target Protein

Penicillin-binding protein 1A mrcA
Penicillin-binding protein 1B mrcB
Penicillin-binding protein 1C pbpC
Penicillin-binding protein 2 mrdA
Peptidoglycan synthase FtsI ftsI
Serum paraoxonase/arylesterase 1 PON1
Interleukin-15 IL15
Interleukin-2 IL2

Referensi & Sumber

Synthesis reference: Michael Bornstein, Sandra M. Carone, "Method of preparing sterile essentially amorphous cefazolin for reconstitution for parenteral administration." U.S. Patent US4002748, issued August, 1967.

Contoh Produk & Brand

Produk: 140 • International brands: 2
Produk
  • Ancef
    Injection • 1 g/1 • Intramuscular • US • Approved
  • Ancef
    Injection • 1 g/1 • Intramuscular • US • Approved
  • Ancef
    Injection • 10 g/1 • Intramuscular • US • Approved
  • Ancef Inj Pws 10gm/vial USP
    Powder, for solution • 10 g / vial • Intravenous • Canada • Approved
  • Ancef Inj Pws 1gm/vial USP
    Powder, for solution • 1 g / vial • Intramuscular; Intravenous • Canada • Approved
  • Ancef Inj Pws 500mg/vial USP
    Powder, for solution • 500 mg / vial • Intramuscular; Intravenous • Canada • Approved
  • Cefazolin
    Injection, powder, for solution • 10 g/1 • Intravenous • US • Approved
  • Cefazolin
    Injection, powder, for solution • 500 mg/1 • Intramuscular; Intravenous • US • Approved
Menampilkan 8 dari 140 produk.
International Brands
  • Elzogram — Lilly
  • Zolicef — Bristol-Myers Squibb

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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