Peringatan Keamanan

Symptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting.

Cefamandole

DB01326

small molecule approved experimental

Deskripsi

Cefamandole is also known as cephamandole. It is a parenterally administered broad-spectrum cephalosporin antibiotic. It is generally formulated as a formate ester, cefamandole nafate. It is no longer marketed in the United States.

Struktur Molekul 2D

Berat 462.503
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The half-life after an intravenous dose is 32 minutes; after intramuscular administration, the half-life is 60 minutes.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Avoid alcohol. Ingesting alcohol with cefamandole may precipitate a disulfiram like reaction due to elevated levels of acetaldehyde in the blood.

Interaksi Obat

835 Data
Probenecid The serum concentration of Cefamandole can be increased when it is combined with Probenecid.
Foscarnet The risk or severity of nephrotoxicity can be increased when Cefamandole is combined with Foscarnet.
Mannitol The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Cefamandole.
Tenofovir disoproxil Cefamandole may increase the nephrotoxic activities of Tenofovir disoproxil.
Tenofovir alafenamide Cefamandole may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir Cefamandole may increase the nephrotoxic activities of Tenofovir.
Succinic acid The excretion of Succinic acid can be decreased when combined with Cefamandole.
Citrulline The excretion of Citrulline can be decreased when combined with Cefamandole.
Pravastatin The excretion of Pravastatin can be decreased when combined with Cefamandole.
Aminohippuric acid The excretion of Aminohippuric acid can be decreased when combined with Cefamandole.
Zidovudine The excretion of Zidovudine can be decreased when combined with Cefamandole.
Cefdinir The excretion of Cefdinir can be decreased when combined with Cefamandole.
Leucovorin The excretion of Leucovorin can be decreased when combined with Cefamandole.
Fluorescein The excretion of Fluorescein can be decreased when combined with Cefamandole.
Hydrocortisone The excretion of Hydrocortisone can be decreased when combined with Cefamandole.
Quinapril The excretion of Quinapril can be decreased when combined with Cefamandole.
Dinoprostone The excretion of Dinoprostone can be decreased when combined with Cefamandole.
Famotidine The excretion of Famotidine can be decreased when combined with Cefamandole.
Fexofenadine The excretion of Fexofenadine can be decreased when combined with Cefamandole.
Benzylpenicillin The excretion of Benzylpenicillin can be decreased when combined with Cefamandole.
Rosuvastatin The excretion of Rosuvastatin can be decreased when combined with Cefamandole.
Captopril The excretion of Captopril can be decreased when combined with Cefamandole.
Tazobactam The excretion of Tazobactam can be decreased when combined with Cefamandole.
Cyclic adenosine monophosphate The excretion of Cyclic adenosine monophosphate can be decreased when combined with Cefamandole.
Cholic Acid The excretion of Cholic Acid can be decreased when combined with Cefamandole.
Glutaric Acid The excretion of Glutaric Acid can be decreased when combined with Cefamandole.
Oxalic Acid The excretion of Oxalic Acid can be decreased when combined with Cefamandole.
Taurocholic acid The excretion of Taurocholic acid can be decreased when combined with Cefamandole.
Ellagic acid The excretion of Ellagic acid can be decreased when combined with Cefamandole.
Avibactam The excretion of Avibactam can be decreased when combined with Cefamandole.
Eluxadoline The excretion of Eluxadoline can be decreased when combined with Cefamandole.
Silibinin The excretion of Silibinin can be decreased when combined with Cefamandole.
Relebactam The excretion of Relebactam can be decreased when combined with Cefamandole.
Oseltamivir The excretion of Oseltamivir can be decreased when combined with Cefamandole.
Conjugated estrogens The excretion of Conjugated estrogens can be decreased when combined with Cefamandole.
Piperacillin The excretion of Piperacillin can be decreased when combined with Cefamandole.
Trifluridine The excretion of Trifluridine can be decreased when combined with Cefamandole.
Allopurinol The excretion of Allopurinol can be decreased when combined with Cefamandole.
Cimetidine The excretion of Cimetidine can be decreased when combined with Cefamandole.
Methotrexate The excretion of Methotrexate can be decreased when combined with Cefamandole.
Cephalexin The excretion of Cephalexin can be decreased when combined with Cefamandole.
Valaciclovir The excretion of Valaciclovir can be decreased when combined with Cefamandole.
Levocarnitine The excretion of Levocarnitine can be decreased when combined with Cefamandole.
Tetracycline The excretion of Tetracycline can be decreased when combined with Cefamandole.
Estradiol The excretion of Estradiol can be decreased when combined with Cefamandole.
Acyclovir The excretion of Acyclovir can be decreased when combined with Cefamandole.
Cefaclor The excretion of Cefaclor can be decreased when combined with Cefamandole.
Ranitidine The excretion of Ranitidine can be decreased when combined with Cefamandole.
Bumetanide The excretion of Bumetanide can be decreased when combined with Cefamandole.
Sitagliptin The excretion of Sitagliptin can be decreased when combined with Cefamandole.
Ceftibuten The excretion of Ceftibuten can be decreased when combined with Cefamandole.
Doripenem The excretion of Doripenem can be decreased when combined with Cefamandole.
Saxagliptin The excretion of Saxagliptin can be decreased when combined with Cefamandole.
Baricitinib The serum concentration of Baricitinib can be increased when it is combined with Cefamandole.
Dexamethasone The excretion of Dexamethasone can be decreased when combined with Cefamandole.
Oxytetracycline The excretion of Oxytetracycline can be decreased when combined with Cefamandole.
Polythiazide The excretion of Polythiazide can be decreased when combined with Cefamandole.
Prednisolone phosphate The excretion of Prednisolone phosphate can be decreased when combined with Cefamandole.
Dexamethasone acetate The excretion of Dexamethasone acetate can be decreased when combined with Cefamandole.
Acamprosate The excretion of Acamprosate can be decreased when combined with Cefamandole.
Cyclosporine The risk or severity of nephrotoxicity can be increased when Cyclosporine is combined with Cefamandole.
Icosapent The risk or severity of nephrotoxicity can be increased when Icosapent is combined with Cefamandole.
Cefotiam The excretion of Cefotiam can be decreased when combined with Cefamandole.
Mesalazine The risk or severity of nephrotoxicity can be increased when Mesalazine is combined with Cefamandole.
Cefmenoxime The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefamandole.
Cefmetazole The risk or severity of nephrotoxicity can be increased when Cefmetazole is combined with Cefamandole.
Indomethacin The excretion of Indomethacin can be decreased when combined with Cefamandole.
Triamterene The risk or severity of nephrotoxicity can be increased when Triamterene is combined with Cefamandole.
Cefpiramide The risk or severity of nephrotoxicity can be increased when Cefpiramide is combined with Cefamandole.
Loracarbef The risk or severity of nephrotoxicity can be increased when Loracarbef is combined with Cefamandole.
Cefalotin The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Cefamandole.
Nabumetone The risk or severity of nephrotoxicity can be increased when Nabumetone is combined with Cefamandole.
Ketorolac The risk or severity of nephrotoxicity can be increased when Ketorolac is combined with Cefamandole.
Tenoxicam The risk or severity of nephrotoxicity can be increased when Tenoxicam is combined with Cefamandole.
Celecoxib The risk or severity of nephrotoxicity can be increased when Celecoxib is combined with Cefamandole.
Cefotaxime The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Cefamandole.
Tolmetin The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Cefamandole.
Rofecoxib The risk or severity of nephrotoxicity can be increased when Rofecoxib is combined with Cefamandole.
Fenoprofen The risk or severity of nephrotoxicity can be increased when Fenoprofen is combined with Cefamandole.
Valdecoxib The risk or severity of nephrotoxicity can be increased when Valdecoxib is combined with Cefamandole.
Diclofenac The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Cefamandole.
Sulindac The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Cefamandole.
Bacitracin The risk or severity of nephrotoxicity can be increased when Bacitracin is combined with Cefamandole.
Amphotericin B The risk or severity of nephrotoxicity can be increased when Amphotericin B is combined with Cefamandole.
Cephaloglycin The risk or severity of nephrotoxicity can be increased when Cephaloglycin is combined with Cefamandole.
Adefovir dipivoxil The risk or severity of nephrotoxicity can be increased when Adefovir dipivoxil is combined with Cefamandole.
Pentamidine The risk or severity of nephrotoxicity can be increased when Pentamidine is combined with Cefamandole.
Mefenamic acid The risk or severity of nephrotoxicity can be increased when Mefenamic acid is combined with Cefamandole.
Naproxen The risk or severity of nephrotoxicity can be increased when Naproxen is combined with Cefamandole.
Sulfasalazine The risk or severity of nephrotoxicity can be increased when Sulfasalazine is combined with Cefamandole.
Phenylbutazone The risk or severity of nephrotoxicity can be increased when Phenylbutazone is combined with Cefamandole.
Meloxicam The risk or severity of methemoglobinemia can be increased when Cefamandole is combined with Meloxicam.
Carprofen The risk or severity of nephrotoxicity can be increased when Carprofen is combined with Cefamandole.
Tacrolimus The risk or severity of nephrotoxicity can be increased when Tacrolimus is combined with Cefamandole.
Etacrynic acid The risk or severity of nephrotoxicity can be increased when Etacrynic acid is combined with Cefamandole.
Ceforanide The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cefamandole.
Salicylic acid The risk or severity of nephrotoxicity can be increased when Salicylic acid is combined with Cefamandole.
Acetylsalicylic acid The risk or severity of nephrotoxicity can be increased when Acetylsalicylic acid is combined with Cefamandole.
Hydrochlorothiazide The excretion of Hydrochlorothiazide can be decreased when combined with Cefamandole.
Balsalazide The risk or severity of nephrotoxicity can be increased when Balsalazide is combined with Cefamandole.

Target Protein

Penicillin-binding protein 2 pbpA

Referensi & Sumber

Synthesis reference: Ta Sen Chou, Gary D. Zintgraff, "Process for preparing pure cefamandole from alkali metal and ammonium salts thereof." U.S. Patent US4115644, issued June, 1977.

Contoh Produk & Brand

Produk: 0 • International brands: 0
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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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