Josamycin

DB01321

small molecule investigational

Deskripsi

A macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens.

Struktur Molekul 2D

Berat 827.995
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

173 Data
Alfentanil The serum concentration of Alfentanil can be increased when it is combined with Josamycin.
Alprazolam The serum concentration of Alprazolam can be increased when it is combined with Josamycin.
Buspirone The metabolism of Buspirone can be decreased when combined with Josamycin.
Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Josamycin.
Cisapride The serum concentration of Cisapride can be increased when it is combined with Josamycin.
Disopyramide Josamycin may increase the QTc-prolonging activities of Disopyramide.
Estazolam The serum concentration of Estazolam can be increased when it is combined with Josamycin.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Josamycin.
Quinine The serum concentration of Quinine can be increased when it is combined with Josamycin.
Quinidine The serum concentration of Quinidine can be increased when it is combined with Josamycin.
Repaglinide The serum concentration of Repaglinide can be increased when it is combined with Josamycin.
Sirolimus The metabolism of Sirolimus can be decreased when combined with Josamycin.
Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Josamycin.
Terfenadine The serum concentration of Terfenadine can be increased when it is combined with Josamycin.
Triazolam The serum concentration of Triazolam can be increased when it is combined with Josamycin.
Telaprevir The serum concentration of Telaprevir can be increased when it is combined with Josamycin.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Josamycin.
Vindesine The serum concentration of Vindesine can be increased when it is combined with Josamycin.
Vinorelbine The serum concentration of Vinorelbine can be increased when it is combined with Josamycin.
Vincristine The serum concentration of Vincristine can be increased when it is combined with Josamycin.
Vinblastine The serum concentration of Vinblastine can be increased when it is combined with Josamycin.
Vintafolide The serum concentration of Vintafolide can be increased when it is combined with Josamycin.
Vinflunine The serum concentration of Vinflunine can be increased when it is combined with Josamycin.
Vincamine The serum concentration of Vincamine can be increased when it is combined with Josamycin.
Acetyldigitoxin The serum concentration of Acetyldigitoxin can be increased when it is combined with Josamycin.
Deslanoside The serum concentration of Deslanoside can be increased when it is combined with Josamycin.
Ouabain The serum concentration of Ouabain can be increased when it is combined with Josamycin.
Oleandrin The serum concentration of Oleandrin can be increased when it is combined with Josamycin.
Cymarin The serum concentration of Cymarin can be increased when it is combined with Josamycin.
Proscillaridin The serum concentration of Proscillaridin can be increased when it is combined with Josamycin.
Metildigoxin The serum concentration of Metildigoxin can be increased when it is combined with Josamycin.
Lanatoside C The serum concentration of Lanatoside C can be increased when it is combined with Josamycin.
Gitoformate The serum concentration of Gitoformate can be increased when it is combined with Josamycin.
Acetyldigoxin The serum concentration of Acetyldigoxin can be increased when it is combined with Josamycin.
Peruvoside The serum concentration of Peruvoside can be increased when it is combined with Josamycin.
Digitoxin The serum concentration of Digitoxin can be increased when it is combined with Josamycin.
Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Josamycin.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Josamycin.
Dicoumarol The serum concentration of Dicoumarol can be increased when it is combined with Josamycin.
Phenindione The serum concentration of Phenindione can be increased when it is combined with Josamycin.
Coumarin The serum concentration of Coumarin can be increased when it is combined with Josamycin.
Tioclomarol The serum concentration of Tioclomarol can be increased when it is combined with Josamycin.
Warfarin The serum concentration of Warfarin can be increased when it is combined with Josamycin.
Phenprocoumon The serum concentration of Phenprocoumon can be increased when it is combined with Josamycin.
Acenocoumarol The serum concentration of Acenocoumarol can be increased when it is combined with Josamycin.
4-hydroxycoumarin The serum concentration of 4-hydroxycoumarin can be increased when it is combined with Josamycin.
(R)-warfarin The serum concentration of (R)-warfarin can be increased when it is combined with Josamycin.
Ethyl biscoumacetate The serum concentration of Ethyl biscoumacetate can be increased when it is combined with Josamycin.
Fluindione The serum concentration of Fluindione can be increased when it is combined with Josamycin.
Clorindione The serum concentration of Clorindione can be increased when it is combined with Josamycin.
Diphenadione The serum concentration of Diphenadione can be increased when it is combined with Josamycin.
(S)-Warfarin The serum concentration of (S)-Warfarin can be increased when it is combined with Josamycin.
Oxtriphylline The metabolism of Oxtriphylline can be decreased when combined with Josamycin.
Doxofylline The metabolism of Doxofylline can be decreased when combined with Josamycin.
Bamifylline The metabolism of Bamifylline can be decreased when combined with Josamycin.
Acefylline The metabolism of Acefylline can be decreased when combined with Josamycin.
Bufylline The metabolism of Bufylline can be decreased when combined with Josamycin.
Fenethylline The metabolism of Fenethylline can be decreased when combined with Josamycin.
Proxyphylline The metabolism of Proxyphylline can be decreased when combined with Josamycin.
Bromotheophylline The metabolism of Bromotheophylline can be decreased when combined with Josamycin.
Pentoxifylline The metabolism of Pentoxifylline can be decreased when combined with Josamycin.
8-azaguanine The metabolism of 8-azaguanine can be decreased when combined with Josamycin.
7,9-Dimethylguanine The metabolism of 7,9-Dimethylguanine can be decreased when combined with Josamycin.
Xanthine The metabolism of Xanthine can be decreased when combined with Josamycin.
7-Deazaguanine The metabolism of 7-Deazaguanine can be decreased when combined with Josamycin.
Guanine The metabolism of Guanine can be decreased when combined with Josamycin.
9-Methylguanine The metabolism of 9-Methylguanine can be decreased when combined with Josamycin.
Peldesine The metabolism of Peldesine can be decreased when combined with Josamycin.
Hypoxanthine The metabolism of Hypoxanthine can be decreased when combined with Josamycin.
9-Deazaguanine The metabolism of 9-Deazaguanine can be decreased when combined with Josamycin.
Valomaciclovir The metabolism of Valomaciclovir can be decreased when combined with Josamycin.
3-isobutyl-1-methyl-7H-xanthine The metabolism of 3-isobutyl-1-methyl-7H-xanthine can be decreased when combined with Josamycin.
Uric acid The metabolism of Uric acid can be decreased when combined with Josamycin.
6-O-benzylguanine The metabolism of 6-O-benzylguanine can be decreased when combined with Josamycin.
Lisofylline The metabolism of Lisofylline can be decreased when combined with Josamycin.
Lobucavir The metabolism of Lobucavir can be decreased when combined with Josamycin.
Cafedrine The metabolism of Cafedrine can be decreased when combined with Josamycin.
Theodrenaline The metabolism of Theodrenaline can be decreased when combined with Josamycin.
Etamiphylline The metabolism of Etamiphylline can be decreased when combined with Josamycin.
Pentifylline The metabolism of Pentifylline can be decreased when combined with Josamycin.
Furafylline The metabolism of Furafylline can be decreased when combined with Josamycin.
Theobromine The metabolism of Theobromine can be decreased when combined with Josamycin.
Propentofylline The metabolism of Propentofylline can be decreased when combined with Josamycin.
Caffeine The metabolism of Caffeine can be decreased when combined with Josamycin.
8-chlorotheophylline The metabolism of 8-chlorotheophylline can be decreased when combined with Josamycin.
Mercaptopurine The metabolism of Mercaptopurine can be decreased when combined with Josamycin.
PCS-499 The metabolism of PCS-499 can be decreased when combined with Josamycin.
Theophylline The metabolism of Theophylline can be decreased when combined with Josamycin.
Aminophylline The metabolism of Aminophylline can be decreased when combined with Josamycin.
Cabergoline The serum concentration of Cabergoline can be increased when it is combined with Josamycin.
Methylergometrine The serum concentration of Methylergometrine can be increased when it is combined with Josamycin.
Lisuride The serum concentration of Lisuride can be increased when it is combined with Josamycin.
Nicergoline The serum concentration of Nicergoline can be increased when it is combined with Josamycin.
Ergoloid mesylate The serum concentration of Ergoloid mesylate can be increased when it is combined with Josamycin.
Pergolide The serum concentration of Pergolide can be increased when it is combined with Josamycin.
Ergometrine The serum concentration of Ergometrine can be increased when it is combined with Josamycin.
Lysergic acid diethylamide The serum concentration of Lysergic acid diethylamide can be increased when it is combined with Josamycin.
Dihydroergocornine The serum concentration of Dihydroergocornine can be increased when it is combined with Josamycin.
Dihydroergocristine The serum concentration of Dihydroergocristine can be increased when it is combined with Josamycin.
Dihydroergocryptine The serum concentration of Dihydroergocryptine can be increased when it is combined with Josamycin.

Target Protein

50S ribosomal protein L4 rplD

Referensi & Sumber

Synthesis reference: Takashi Osono, Kiruko Moriyama, Keisuke Murakami, Hamao Umezawa, "Process for the production of monopropionyl-josamycin-2." U.S. Patent US4001399, issued January, 1972.
Artikel (PubMed)
  • PMID: 20186698
    Przybylski P, Pyta K, Stefanska J, Brzezinski B, Bartl F: Structure elucidation, complete NMR assignment and PM5 theoretical studies of new hydroxy-aminoalkyl-alpha,beta-unsaturated derivatives of the macrolide antibiotic josamycin. Magn Reson Chem. 2010 Apr;48(4):286-96. doi: 10.1002/mrc.2574.

Contoh Produk & Brand

Produk: 0 • International brands: 3
International Brands
  • Josacine
  • Josalid
  • Josamy

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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