Peringatan Keamanan

Symptoms of toxicity include abdominal pain (continuing or severe), confusion or change in behavior, convulsions (seizures), dark or bloody vomit, diarrhea, dizziness or lightheadedness, fast and/or irregular heartbeat, nervousness or restlessness (continuing), and trembling (continuing).

Oxtriphylline

DB01303

small molecule approved

Deskripsi

Oxtriphylline is the choline salt form of theophylline. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Its main physiological reponse is to dilate the bronchioles. As such, oxytriphylline is indicated mainly for asthma, bronchospasm, and COPD (i.e. all the same indications as the other theophyllines). It is marketed under the name Choledyl SA, and several forms of oxytriphylline have been discontinued. In the US, oxtriphylline is no longer available.

Struktur Molekul 2D

Berat 283.3268
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The serum half life varies greatly between patients and in age. The half life range for a healthy, nonsmoking adult is 3-12.8 hours, for children is 1.5–9.5 hours, and for for premature infants is 15–58 hours.
Volume Distribusi Theophylline has an apparent volume of distribution of 0.3–0.7 L/kg in children and adults, and the Vd is about twice that of an adult in premature infants.
Klirens (Clearance) Theophylline has an average clearance in children (over 6 months) of 1.45 mL/kg per minute, and in healthy, nonsmoking adults of 0.65 mL/kg per hour.

Absorpsi

After ingestion, theophylline is released from oxytriphylline in the acidic environment of the stomach.

Metabolisme

Theophylline undergoes hepatic metabolism to 1,3-dimethyluric acid, 1-methyluric acid, and 3-methylxanthine.

Rute Eliminasi

The kidneys are the main route of elimination for both theophylline and its metabolites, but some unchanged theophylline is eliminated in the feces.

Interaksi Makanan

2 Data
  • 1. Limit caffeine intake.
  • 2. Take with food. Food reduces irritation.

Interaksi Obat

604 Data
Deferasirox The serum concentration of Oxtriphylline can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Oxtriphylline can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Oxtriphylline can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Oxtriphylline can be decreased when it is combined with Teriflunomide.
Regadenoson Oxtriphylline may decrease effectiveness of Regadenoson as a diagnostic agent.
Adalimumab The serum concentration of Oxtriphylline can be decreased when it is combined with Adalimumab.
Adenosine The therapeutic efficacy of Adenosine can be decreased when used in combination with Oxtriphylline.
Allopurinol The serum concentration of Oxtriphylline can be increased when it is combined with Allopurinol.
Carbamazepine The serum concentration of Oxtriphylline can be decreased when it is combined with Carbamazepine.
Cimetidine The metabolism of Oxtriphylline can be decreased when combined with Cimetidine.
Disulfiram The serum concentration of Oxtriphylline can be increased when it is combined with Disulfiram.
Febuxostat The serum concentration of the active metabolites of Oxtriphylline can be increased when Oxtriphylline is used in combination with Febuxostat.
Fluvoxamine The metabolism of Oxtriphylline can be decreased when combined with Fluvoxamine.
Formoterol The risk or severity of hypokalemia can be increased when Oxtriphylline is combined with Formoterol.
Indacaterol The risk or severity of adverse effects can be increased when Oxtriphylline is combined with Indacaterol.
Isoniazid The serum concentration of Oxtriphylline can be increased when it is combined with Isoniazid.
Lithium citrate The serum concentration of Lithium citrate can be decreased when it is combined with Oxtriphylline.
Lithium carbonate The serum concentration of Lithium carbonate can be decreased when it is combined with Oxtriphylline.
Lithium hydroxide The serum concentration of Lithium hydroxide can be decreased when it is combined with Oxtriphylline.
Mexiletine The metabolism of Oxtriphylline can be decreased when combined with Mexiletine.
Olodaterol Oxtriphylline may increase the hyperkalemic activities of Olodaterol.
Pancuronium The therapeutic efficacy of Pancuronium can be decreased when used in combination with Oxtriphylline.
Pentoxifylline The serum concentration of Oxtriphylline can be increased when it is combined with Pentoxifylline.
Phenytoin The serum concentration of Oxtriphylline can be decreased when it is combined with Phenytoin.
Fosphenytoin The serum concentration of Oxtriphylline can be decreased when it is combined with Fosphenytoin.
Propafenone The serum concentration of Oxtriphylline can be increased when it is combined with Propafenone.
Quinine The serum concentration of Oxtriphylline can be increased when it is combined with Quinine.
Quinidine The serum concentration of Oxtriphylline can be increased when it is combined with Quinidine.
Riociguat Oxtriphylline may increase the hypotensive activities of Riociguat.
Thiabendazole The metabolism of Oxtriphylline can be decreased when combined with Thiabendazole.
Ticlopidine The metabolism of Oxtriphylline can be decreased when combined with Ticlopidine.
Zafirlukast The serum concentration of Zafirlukast can be decreased when it is combined with Oxtriphylline.
Probenecid The serum concentration of Oxtriphylline can be increased when it is combined with Probenecid.
Abiraterone The serum concentration of Oxtriphylline can be increased when it is combined with Abiraterone.
Isoprenaline The serum concentration of Oxtriphylline can be decreased when it is combined with Isoprenaline.
Cyproterone acetate The metabolism of Oxtriphylline can be increased when combined with Cyproterone acetate.
Amphetamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Oxtriphylline.
Phentermine The risk or severity of adverse effects can be increased when Phentermine is combined with Oxtriphylline.
Midodrine The risk or severity of adverse effects can be increased when Midodrine is combined with Oxtriphylline.
Norepinephrine The risk or severity of adverse effects can be increased when Norepinephrine is combined with Oxtriphylline.
Phenylephrine The risk or severity of adverse effects can be increased when Phenylephrine is combined with Oxtriphylline.
Phenylpropanolamine The risk or severity of adverse effects can be increased when Phenylpropanolamine is combined with Oxtriphylline.
Labetalol The risk or severity of adverse effects can be increased when Labetalol is combined with Oxtriphylline.
Metaraminol The risk or severity of adverse effects can be increased when Metaraminol is combined with Oxtriphylline.
Epinephrine The risk or severity of adverse effects can be increased when Epinephrine is combined with Oxtriphylline.
Methoxamine The risk or severity of adverse effects can be increased when Methoxamine is combined with Oxtriphylline.
Orciprenaline The risk or severity of adverse effects can be increased when Orciprenaline is combined with Oxtriphylline.
Phenmetrazine The risk or severity of adverse effects can be increased when Phenmetrazine is combined with Oxtriphylline.
Dobutamine The risk or severity of adverse effects can be increased when Dobutamine is combined with Oxtriphylline.
Pseudoephedrine The risk or severity of adverse effects can be increased when Pseudoephedrine is combined with Oxtriphylline.
Benzphetamine The risk or severity of adverse effects can be increased when Benzphetamine is combined with Oxtriphylline.
Ritodrine The risk or severity of adverse effects can be increased when Ritodrine is combined with Oxtriphylline.
Terbutaline The risk or severity of adverse effects can be increased when Terbutaline is combined with Oxtriphylline.
Oxymetazoline The risk or severity of adverse effects can be increased when Oxymetazoline is combined with Oxtriphylline.
Diethylpropion The risk or severity of adverse effects can be increased when Diethylpropion is combined with Oxtriphylline.
Dopamine The risk or severity of adverse effects can be increased when Dopamine is combined with Oxtriphylline.
Acebutolol The risk or severity of adverse effects can be increased when Acebutolol is combined with Oxtriphylline.
Lisdexamfetamine The risk or severity of adverse effects can be increased when Lisdexamfetamine is combined with Oxtriphylline.
Fenoterol The risk or severity of adverse effects can be increased when Fenoterol is combined with Oxtriphylline.
Ephedrine The risk or severity of adverse effects can be increased when Ephedrine is combined with Oxtriphylline.
Mephentermine The risk or severity of adverse effects can be increased when Mephentermine is combined with Oxtriphylline.
Procaterol The risk or severity of adverse effects can be increased when Procaterol is combined with Oxtriphylline.
Clenbuterol The risk or severity of adverse effects can be increased when Clenbuterol is combined with Oxtriphylline.
MMDA The risk or severity of adverse effects can be increased when MMDA is combined with Oxtriphylline.
Midomafetamine The risk or severity of adverse effects can be increased when Midomafetamine is combined with Oxtriphylline.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of adverse effects can be increased when 2,5-Dimethoxy-4-ethylamphetamine is combined with Oxtriphylline.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of adverse effects can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Oxtriphylline.
Tenamfetamine The risk or severity of adverse effects can be increased when Tenamfetamine is combined with Oxtriphylline.
Chlorphentermine The risk or severity of adverse effects can be increased when Chlorphentermine is combined with Oxtriphylline.
Methylenedioxyethamphetamine The risk or severity of adverse effects can be increased when Methylenedioxyethamphetamine is combined with Oxtriphylline.
Dextroamphetamine The risk or severity of adverse effects can be increased when Dextroamphetamine is combined with Oxtriphylline.
Metamfetamine The risk or severity of adverse effects can be increased when Metamfetamine is combined with Oxtriphylline.
Celiprolol The risk or severity of adverse effects can be increased when Celiprolol is combined with Oxtriphylline.
Nylidrin The risk or severity of adverse effects can be increased when Nylidrin is combined with Oxtriphylline.
Tetryzoline The risk or severity of adverse effects can be increased when Tetryzoline is combined with Oxtriphylline.
Tyramine The risk or severity of adverse effects can be increased when Tyramine is combined with Oxtriphylline.
Isoxsuprine The risk or severity of adverse effects can be increased when Isoxsuprine is combined with Oxtriphylline.
Etilefrine The risk or severity of adverse effects can be increased when Etilefrine is combined with Oxtriphylline.
Synephrine The risk or severity of adverse effects can be increased when Synephrine is combined with Oxtriphylline.
Hydroxyamphetamine The risk or severity of adverse effects can be increased when Hydroxyamphetamine is combined with Oxtriphylline.
Iofetamine I-123 The risk or severity of adverse effects can be increased when Iofetamine I-123 is combined with Oxtriphylline.
Racepinephrine The risk or severity of adverse effects can be increased when Racepinephrine is combined with Oxtriphylline.
Ritobegron The risk or severity of adverse effects can be increased when Ritobegron is combined with Oxtriphylline.
Bucindolol The risk or severity of adverse effects can be increased when Bucindolol is combined with Oxtriphylline.
Tramazoline The risk or severity of adverse effects can be increased when Tramazoline is combined with Oxtriphylline.
Mephedrone The risk or severity of adverse effects can be increased when Mephedrone is combined with Oxtriphylline.
Fenozolone The risk or severity of adverse effects can be increased when Fenozolone is combined with Oxtriphylline.
Methoxyphenamine The risk or severity of adverse effects can be increased when Methoxyphenamine is combined with Oxtriphylline.
Tretoquinol The risk or severity of adverse effects can be increased when Tretoquinol is combined with Oxtriphylline.
Gepefrine The risk or severity of adverse effects can be increased when Gepefrine is combined with Oxtriphylline.
Epanolol The risk or severity of adverse effects can be increased when Epanolol is combined with Oxtriphylline.
Prenalterol The risk or severity of adverse effects can be increased when Prenalterol is combined with Oxtriphylline.
Mefenorex The risk or severity of adverse effects can be increased when Mefenorex is combined with Oxtriphylline.
2,5-Dimethoxy-4-ethylthioamphetamine The risk or severity of adverse effects can be increased when 2,5-Dimethoxy-4-ethylthioamphetamine is combined with Oxtriphylline.
Esmolol The risk or severity of adverse effects can be increased when Esmolol is combined with Oxtriphylline.
Betaxolol The risk or severity of adverse effects can be increased when Betaxolol is combined with Oxtriphylline.
Metoprolol The risk or severity of adverse effects can be increased when Metoprolol is combined with Oxtriphylline.
Atenolol The risk or severity of adverse effects can be increased when Atenolol is combined with Oxtriphylline.
Timolol The risk or severity of adverse effects can be increased when Timolol is combined with Oxtriphylline.
Sotalol The risk or severity of adverse effects can be increased when Sotalol is combined with Oxtriphylline.

Target Protein

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A PDE3A
3',5'-cyclic-AMP phosphodiesterase 4A PDE4A
Adenosine receptor A2a ADORA2A
Adenosine receptor A1 ADORA1
Histone deacetylase 2 HDAC2

Referensi & Sumber

Synthesis reference: Ladenburg, K., Duesel, B.F. and Fand,T.I.; U S . Patent 2,776,287; January 1,1957; assigned to Nepera Chemical Co., Inc.

Contoh Produk & Brand

Produk: 19 • International brands: 2
Produk
  • Apo Oxtriphylline Tab 100mg
    Tablet • 100 mg • Oral • Canada • Generic • Approved
  • Apo Oxtriphylline Tab 200mg
    Tablet • 200 mg • Oral • Canada • Generic • Approved
  • Apo Oxtriphylline Tab 300mg
    Tablet • 300 mg • Oral • Canada • Generic • Approved
  • Choledyl
    Solution • 100 mg / 5 mL • Oral • Canada • Approved
  • Choledyl Expectorant
    Solution • - • Oral • Canada • Approved
  • Choledyl Pediatric Syr 50mg/5ml
    Syrup • 50 mg / 5 mL • Oral • Canada • Approved
  • Choledyl Sa Tablets 400mg
    Tablet, extended release • 400 mg • Oral • Canada • Approved
  • Choledyl Sa Tablets 600mg
    Tablet, extended release • 600 mg • Oral • Canada • Approved
Menampilkan 8 dari 19 produk.
International Brands
  • Choledyl — Warner Chilcott
  • Theocolin — Sannova

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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