Sulfacytine is a short-acting sulfonamide. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections.
Sulfacytine is a competitive inhibitor of the enzyme dihydropteroate synthetase. It inhibits bacterial synthesis of of dihydrofolic acid by preventing the condensation of the pteridine with para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Nicotine | The risk or severity of adverse effects can be increased when Sulfacytine is combined with Nicotine. |
| Mecamylamine | The risk or severity of adverse effects can be increased when Sulfacytine is combined with Mecamylamine. |
| Pentolinium | The risk or severity of adverse effects can be increased when Sulfacytine is combined with Pentolinium. |
| Trimethaphan | The risk or severity of adverse effects can be increased when Sulfacytine is combined with Trimethaphan. |
| Hexamethonium | The risk or severity of adverse effects can be increased when Sulfacytine is combined with Hexamethonium. |
| Cyclopentamine | The risk or severity of adverse effects can be increased when Sulfacytine is combined with Cyclopentamine. |
| Methotrexate | The protein binding of Methotrexate can be increased when combined with Sulfacytine. |
| Ketoprofen | The risk or severity of adverse effects can be increased when Ketoprofen is combined with Sulfacytine. |
| Dexketoprofen | The risk or severity of adverse effects can be increased when Dexketoprofen is combined with Sulfacytine. |
| Cyclosporine | The risk or severity of renal failure can be increased when Sulfacytine is combined with Cyclosporine. |
| Insulin human | The risk or severity of hypoglycemia can be increased when Sulfacytine is combined with Insulin human. |
| Insulin lispro | The risk or severity of hypoglycemia can be increased when Sulfacytine is combined with Insulin lispro. |
| Insulin glargine | The risk or severity of hypoglycemia can be increased when Sulfacytine is combined with Insulin glargine. |
| Insulin pork | The risk or severity of hypoglycemia can be increased when Sulfacytine is combined with Insulin pork. |
| Troglitazone | The therapeutic efficacy of Troglitazone can be increased when used in combination with Sulfacytine. |
| Glimepiride | The therapeutic efficacy of Glimepiride can be increased when used in combination with Sulfacytine. |
| Sulfisoxazole | The therapeutic efficacy of Sulfisoxazole can be increased when used in combination with Sulfacytine. |
| Disopyramide | The therapeutic efficacy of Disopyramide can be increased when used in combination with Sulfacytine. |
| Acarbose | The therapeutic efficacy of Acarbose can be increased when used in combination with Sulfacytine. |
| Metformin | The therapeutic efficacy of Metformin can be increased when used in combination with Sulfacytine. |
| Sulfadiazine | The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Sulfacytine. |
| Rosiglitazone | The therapeutic efficacy of Rosiglitazone can be increased when used in combination with Sulfacytine. |
| Acetohexamide | The therapeutic efficacy of Acetohexamide can be increased when used in combination with Sulfacytine. |
| Quinine | The therapeutic efficacy of Quinine can be increased when used in combination with Sulfacytine. |
| Miglitol | The therapeutic efficacy of Miglitol can be increased when used in combination with Sulfacytine. |
| Chlorpropamide | The therapeutic efficacy of Chlorpropamide can be increased when used in combination with Sulfacytine. |
| Nateglinide | The therapeutic efficacy of Nateglinide can be increased when used in combination with Sulfacytine. |
| Pentamidine | The therapeutic efficacy of Pentamidine can be increased when used in combination with Sulfacytine. |
| Mifepristone | The therapeutic efficacy of Mifepristone can be increased when used in combination with Sulfacytine. |
| Tolazamide | The therapeutic efficacy of Tolazamide can be increased when used in combination with Sulfacytine. |
| Repaglinide | The therapeutic efficacy of Repaglinide can be increased when used in combination with Sulfacytine. |
| Phenformin | The therapeutic efficacy of Phenformin can be increased when used in combination with Sulfacytine. |
| Sulfamethoxazole | The therapeutic efficacy of Sulfamethoxazole can be increased when used in combination with Sulfacytine. |
| Glyburide | The therapeutic efficacy of Glyburide can be increased when used in combination with Sulfacytine. |
| Glipizide | The therapeutic efficacy of Glipizide can be increased when used in combination with Sulfacytine. |
| Gliclazide | The therapeutic efficacy of Gliclazide can be increased when used in combination with Sulfacytine. |
| Tolbutamide | The therapeutic efficacy of Tolbutamide can be increased when used in combination with Sulfacytine. |
| Pioglitazone | The therapeutic efficacy of Pioglitazone can be increased when used in combination with Sulfacytine. |
| Bromocriptine | The therapeutic efficacy of Bromocriptine can be increased when used in combination with Sulfacytine. |
| Gliquidone | The therapeutic efficacy of Gliquidone can be increased when used in combination with Sulfacytine. |
| Mitiglinide | The therapeutic efficacy of Mitiglinide can be increased when used in combination with Sulfacytine. |
| Sitagliptin | The therapeutic efficacy of Sitagliptin can be increased when used in combination with Sulfacytine. |
| Sunitinib | The therapeutic efficacy of Sunitinib can be increased when used in combination with Sulfacytine. |
| Exenatide | The therapeutic efficacy of Exenatide can be increased when used in combination with Sulfacytine. |
| Mecasermin | The therapeutic efficacy of Mecasermin can be increased when used in combination with Sulfacytine. |
| Pramlintide | The therapeutic efficacy of Pramlintide can be increased when used in combination with Sulfacytine. |
| Glisoxepide | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Sulfacytine. |
| Insulin aspart | The risk or severity of hypoglycemia can be increased when Sulfacytine is combined with Insulin aspart. |
| Insulin detemir | The risk or severity of hypoglycemia can be increased when Sulfacytine is combined with Insulin detemir. |
| Insulin glulisine | The risk or severity of hypoglycemia can be increased when Sulfacytine is combined with Insulin glulisine. |
| Glymidine | The therapeutic efficacy of Glymidine can be increased when used in combination with Sulfacytine. |
| AICA ribonucleotide | The therapeutic efficacy of AICA ribonucleotide can be increased when used in combination with Sulfacytine. |
| Buformin | The therapeutic efficacy of Buformin can be increased when used in combination with Sulfacytine. |
| Vildagliptin | The therapeutic efficacy of Vildagliptin can be increased when used in combination with Sulfacytine. |
| Voglibose | The therapeutic efficacy of Voglibose can be increased when used in combination with Sulfacytine. |
| NN344 | The risk or severity of hypoglycemia can be increased when Sulfacytine is combined with NN344. |
| AMG-222 | The therapeutic efficacy of AMG-222 can be increased when used in combination with Sulfacytine. |
| Bisegliptin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Sulfacytine. |
| Alogliptin | The therapeutic efficacy of Alogliptin can be increased when used in combination with Sulfacytine. |
| Dapagliflozin | The therapeutic efficacy of Dapagliflozin can be increased when used in combination with Sulfacytine. |
| Saxagliptin | The therapeutic efficacy of Saxagliptin can be increased when used in combination with Sulfacytine. |
| Liraglutide | The therapeutic efficacy of Liraglutide can be increased when used in combination with Sulfacytine. |
| Gosogliptin | The therapeutic efficacy of Gosogliptin can be increased when used in combination with Sulfacytine. |
| Linagliptin | The therapeutic efficacy of Linagliptin can be increased when used in combination with Sulfacytine. |
| Canagliflozin | The therapeutic efficacy of Canagliflozin can be increased when used in combination with Sulfacytine. |
| Glibornuride | The therapeutic efficacy of Glibornuride can be increased when used in combination with Sulfacytine. |
| Benfluorex | The therapeutic efficacy of Benfluorex can be increased when used in combination with Sulfacytine. |
| Empagliflozin | The therapeutic efficacy of Empagliflozin can be increased when used in combination with Sulfacytine. |
| Albiglutide | The therapeutic efficacy of Albiglutide can be increased when used in combination with Sulfacytine. |
| Dulaglutide | The therapeutic efficacy of Dulaglutide can be increased when used in combination with Sulfacytine. |
| Lobeglitazone | The therapeutic efficacy of Lobeglitazone can be increased when used in combination with Sulfacytine. |
| Netoglitazone | The therapeutic efficacy of Netoglitazone can be increased when used in combination with Sulfacytine. |
| Rivoglitazone | The therapeutic efficacy of Rivoglitazone can be increased when used in combination with Sulfacytine. |
| Ciglitazone | The therapeutic efficacy of Ciglitazone can be increased when used in combination with Sulfacytine. |
| Lixisenatide | The therapeutic efficacy of Lixisenatide can be increased when used in combination with Sulfacytine. |
| Insulin beef | The risk or severity of hypoglycemia can be increased when Sulfacytine is combined with Insulin beef. |
| Insulin degludec | The risk or severity of hypoglycemia can be increased when Sulfacytine is combined with Insulin degludec. |
| Insulin peglispro | The risk or severity of hypoglycemia can be increased when Sulfacytine is combined with Insulin peglispro. |
| Insulin tregopil | The risk or severity of hypoglycemia can be increased when Sulfacytine is combined with Insulin tregopil. |
| Ipragliflozin | The therapeutic efficacy of Ipragliflozin can be increased when used in combination with Sulfacytine. |
| Dutogliptin | The therapeutic efficacy of Dutogliptin can be increased when used in combination with Sulfacytine. |
| Allicin | The therapeutic efficacy of Allicin can be increased when used in combination with Sulfacytine. |
| Tofogliflozin | The therapeutic efficacy of Tofogliflozin can be increased when used in combination with Sulfacytine. |
| Ertugliflozin | The therapeutic efficacy of Ertugliflozin can be increased when used in combination with Sulfacytine. |
| 2,4-thiazolidinedione | The therapeutic efficacy of 2,4-thiazolidinedione can be increased when used in combination with Sulfacytine. |
| Teneligliptin | The therapeutic efficacy of Teneligliptin can be increased when used in combination with Sulfacytine. |
| Omarigliptin | The therapeutic efficacy of Omarigliptin can be increased when used in combination with Sulfacytine. |
| Carmegliptin | The therapeutic efficacy of Carmegliptin can be increased when used in combination with Sulfacytine. |
| Gemigliptin | The therapeutic efficacy of Gemigliptin can be increased when used in combination with Sulfacytine. |
| Anagliptin | The therapeutic efficacy of Anagliptin can be increased when used in combination with Sulfacytine. |
| Evogliptin | The therapeutic efficacy of Evogliptin can be increased when used in combination with Sulfacytine. |
| Sotagliflozin | The therapeutic efficacy of Sotagliflozin can be increased when used in combination with Sulfacytine. |
| Balaglitazone | The therapeutic efficacy of Balaglitazone can be increased when used in combination with Sulfacytine. |
| Remogliflozin etabonate | The therapeutic efficacy of Remogliflozin etabonate can be increased when used in combination with Sulfacytine. |
| Carbutamide | The therapeutic efficacy of Carbutamide can be increased when used in combination with Sulfacytine. |
| Guar gum | The therapeutic efficacy of Guar gum can be increased when used in combination with Sulfacytine. |
| Metahexamide | The therapeutic efficacy of Metahexamide can be increased when used in combination with Sulfacytine. |
| Semaglutide | The therapeutic efficacy of Semaglutide can be increased when used in combination with Sulfacytine. |
| Taspoglutide | The therapeutic efficacy of Taspoglutide can be increased when used in combination with Sulfacytine. |
| Englitazone | The therapeutic efficacy of Englitazone can be increased when used in combination with Sulfacytine. |