Bevantolol

DB01295

small molecule experimental

Deskripsi

Bevantolol is a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension. Mechanism of Action Animal experiments confirm both agonist and antagonist effects on alpha-receptors, in addition to antagonist activity at beta-1 receptors.

Struktur Molekul 2D

Berat 345.4327
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1276 Data
Ceritinib Bevantolol may increase the bradycardic activities of Ceritinib.
Ivabradine Bevantolol may increase the bradycardic activities of Ivabradine.
Ruxolitinib Ruxolitinib may increase the bradycardic activities of Bevantolol.
Amifostine Bevantolol may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Bevantolol.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Bevantolol.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Bevantolol.
Obinutuzumab Bevantolol may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Bevantolol.
Rituximab Bevantolol may increase the hypotensive activities of Rituximab.
Desmopressin Desmopressin may decrease the antihypertensive activities of Bevantolol.
Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Bevantolol.
Doxapram Doxapram may decrease the antihypertensive activities of Bevantolol.
Atropine Atropine may decrease the antihypertensive activities of Bevantolol.
Sumatriptan Sumatriptan may decrease the antihypertensive activities of Bevantolol.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Bevantolol.
Naratriptan Naratriptan may decrease the antihypertensive activities of Bevantolol.
Rizatriptan Rizatriptan may decrease the antihypertensive activities of Bevantolol.
Dopamine Dopamine may decrease the antihypertensive activities of Bevantolol.
Frovatriptan Frovatriptan may decrease the antihypertensive activities of Bevantolol.
Dutasteride Dutasteride may decrease the antihypertensive activities of Bevantolol.
Finasteride Finasteride may decrease the antihypertensive activities of Bevantolol.
Yohimbine Yohimbine may decrease the antihypertensive activities of Bevantolol.
Solifenacin Solifenacin may decrease the antihypertensive activities of Bevantolol.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Bevantolol.
1-benzylimidazole 1-benzylimidazole may decrease the antihypertensive activities of Bevantolol.
Amineptine Amineptine may decrease the antihypertensive activities of Bevantolol.
Flibanserin Flibanserin may decrease the antihypertensive activities of Bevantolol.
Naluzotan Naluzotan may decrease the antihypertensive activities of Bevantolol.
Nitrous oxide Nitrous oxide may decrease the antihypertensive activities of Bevantolol.
Cinitapride Cinitapride may decrease the antihypertensive activities of Bevantolol.
Tyramine Tyramine may decrease the antihypertensive activities of Bevantolol.
Ifenprodil Ifenprodil may decrease the antihypertensive activities of Bevantolol.
Dimetacrine Dimetacrine may decrease the antihypertensive activities of Bevantolol.
Butriptyline Butriptyline may decrease the antihypertensive activities of Bevantolol.
Moxisylyte Moxisylyte may decrease the antihypertensive activities of Bevantolol.
Tianeptine Tianeptine may decrease the antihypertensive activities of Bevantolol.
Oxaprotiline Oxaprotiline may decrease the antihypertensive activities of Bevantolol.
Atipamezole Atipamezole may decrease the antihypertensive activities of Bevantolol.
Tetrahydrocannabivarin Tetrahydrocannabivarin may decrease the antihypertensive activities of Bevantolol.
Piclozotan Piclozotan may decrease the antihypertensive activities of Bevantolol.
Siponimod Siponimod may decrease the antihypertensive activities of Bevantolol.
Idazoxan Idazoxan may decrease the antihypertensive activities of Bevantolol.
Tramazoline Tramazoline may decrease the antihypertensive activities of Bevantolol.
Amitriptylinoxide Amitriptylinoxide may decrease the antihypertensive activities of Bevantolol.
Dibenzepin Dibenzepin may decrease the antihypertensive activities of Bevantolol.
Quinupramine Quinupramine may decrease the antihypertensive activities of Bevantolol.
Trichloroethylene Trichloroethylene may decrease the antihypertensive activities of Bevantolol.
Fenozolone Fenozolone may decrease the antihypertensive activities of Bevantolol.
Melitracen Melitracen may decrease the antihypertensive activities of Bevantolol.
Lofepramine Lofepramine may decrease the antihypertensive activities of Bevantolol.
Xenon Xenon may decrease the antihypertensive activities of Bevantolol.
Iprindole Iprindole may decrease the antihypertensive activities of Bevantolol.
Buflomedil Buflomedil may decrease the antihypertensive activities of Bevantolol.
Diethyl ether Diethyl ether may decrease the antihypertensive activities of Bevantolol.
Imipramine oxide Imipramine oxide may decrease the antihypertensive activities of Bevantolol.
Mefenorex Mefenorex may decrease the antihypertensive activities of Bevantolol.
5-methoxy-N,N-dimethyltryptamine 5-methoxy-N,N-dimethyltryptamine may decrease the antihypertensive activities of Bevantolol.
Quinoline Yellow WS Quinoline Yellow WS may decrease the antihypertensive activities of Bevantolol.
Solriamfetol Solriamfetol may decrease the antihypertensive activities of Bevantolol.
Sufentanil Sufentanil may decrease the antihypertensive activities of Bevantolol.
Isoflurane Isoflurane may decrease the antihypertensive activities of Bevantolol.
Propofol Propofol may decrease the antihypertensive activities of Bevantolol.
Remifentanil Remifentanil may decrease the antihypertensive activities of Bevantolol.
Halothane Halothane may decrease the antihypertensive activities of Bevantolol.
Desflurane Desflurane may decrease the antihypertensive activities of Bevantolol.
Sevoflurane Sevoflurane may decrease the antihypertensive activities of Bevantolol.
Protriptyline Protriptyline may decrease the antihypertensive activities of Bevantolol.
Opipramol Opipramol may decrease the antihypertensive activities of Bevantolol.
Selpercatinib Selpercatinib may decrease the antihypertensive activities of Bevantolol.
Naxitamab Naxitamab may decrease the antihypertensive activities of Bevantolol.
Cannabidiol The metabolism of Bevantolol can be decreased when combined with Cannabidiol.
Amiodarone The therapeutic efficacy of Bevantolol can be increased when used in combination with Amiodarone.
Bupivacaine The serum concentration of Bupivacaine can be increased when it is combined with Bevantolol.
Dipyridamole Dipyridamole may increase the bradycardic activities of Bevantolol.
Disopyramide Disopyramide may increase the bradycardic activities of Bevantolol.
Dronedarone Dronedarone may increase the bradycardic activities of Bevantolol.
Fingolimod Bevantolol may increase the bradycardic activities of Fingolimod.
Floctafenine The risk or severity of adverse effects can be increased when Bevantolol is combined with Floctafenine.
Mepivacaine The serum concentration of Mepivacaine can be increased when it is combined with Bevantolol.
Methacholine Bevantolol may increase the bronchoconstrictory activities of Methacholine.
Midodrine The therapeutic efficacy of Midodrine can be decreased when used in combination with Bevantolol.
Nifedipine The risk or severity of congestive heart failure and hypotension can be increased when Nifedipine is combined with Bevantolol.
Propafenone The risk or severity of adverse effects can be increased when Propafenone is combined with Bevantolol.
Regorafenib Regorafenib may increase the bradycardic activities of Bevantolol.
Reserpine Reserpine may increase the hypotensive activities of Bevantolol.
Deserpidine Deserpidine may increase the hypotensive activities of Bevantolol.
Guanethidine Guanethidine may increase the hypotensive activities of Bevantolol.
Rivastigmine Bevantolol may increase the bradycardic activities of Rivastigmine.
Dapoxetine Dapoxetine may increase the orthostatic hypotensive activities of Bevantolol.
Lurasidone Bevantolol may increase the hypotensive activities of Lurasidone.
Mirabegron The serum concentration of Bevantolol can be increased when it is combined with Mirabegron.
Molsidomine Molsidomine may increase the hypotensive activities of Bevantolol.
Insulin argine Bevantolol may increase the hypoglycemic activities of Insulin argine.
Remikiren Remikiren may increase the hypotensive activities of Bevantolol.
Guanadrel Guanadrel may increase the hypotensive activities of Bevantolol.
Carteolol Carteolol may increase the hypotensive activities of Bevantolol.
Bosentan Bosentan may increase the hypotensive activities of Bevantolol.
Candoxatril Candoxatril may increase the hypotensive activities of Bevantolol.
Metyrosine Metyrosine may increase the hypotensive activities of Bevantolol.

Target Protein

D(2) dopamine receptor DRD2
Beta-1 adrenergic receptor ADRB1
Beta-2 adrenergic receptor ADRB2
Alpha-1A adrenergic receptor ADRA1A

Referensi & Sumber

Synthesis reference: Yutaka Nomura, "Process for preparation of bevantolol hydrochloride." U.S. Patent US5382689, issued December, 1974.
Artikel (PubMed)
  • PMID: 2888789
    Vaughan Williams EM: Bevantolol: a beta-1 adrenoceptor antagonist with unique additional actions. J Clin Pharmacol. 1987 Jul;27(7):450-60.

Contoh Produk & Brand

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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