As with all sympathomimetic aerosol medication, cardiac arrest and even death may be associated with abuse of pirbuterol.
Pirbuterol is a beta-2 adrenergic bronchodilator. In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential effect on beta-2 Adrenergic receptors compared with isoproterenol. While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is a population of beta-2 receptors in the human heart, existing in a concentration between 10-50%. The precise function of these receptors has not been established.
The pharmacologic effects of beta adrenergic agonist drugs, including pirbuterol, are at least in proof attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (AlP) to cyclic-3† ,5†-adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Loxapine | The therapeutic efficacy of Pirbuterol can be decreased when used in combination with Loxapine. |
| Valsartan | Pirbuterol may decrease the antihypertensive activities of Valsartan. |
| Ramipril | Pirbuterol may decrease the antihypertensive activities of Ramipril. |
| Reserpine | Pirbuterol may decrease the antihypertensive activities of Reserpine. |
| Remikiren | Pirbuterol may decrease the antihypertensive activities of Remikiren. |
| Isradipine | Pirbuterol may decrease the antihypertensive activities of Isradipine. |
| Olmesartan | Pirbuterol may decrease the antihypertensive activities of Olmesartan. |
| Nitroprusside | Pirbuterol may decrease the antihypertensive activities of Nitroprusside. |
| Diltiazem | Pirbuterol may decrease the antihypertensive activities of Diltiazem. |
| Minoxidil | Pirbuterol may decrease the antihypertensive activities of Minoxidil. |
| Treprostinil | Pirbuterol may decrease the antihypertensive activities of Treprostinil. |
| Amlodipine | Pirbuterol may decrease the antihypertensive activities of Amlodipine. |
| Nimodipine | Pirbuterol may decrease the antihypertensive activities of Nimodipine. |
| Nisoldipine | Pirbuterol may decrease the antihypertensive activities of Nisoldipine. |
| Fosinopril | Pirbuterol may decrease the antihypertensive activities of Fosinopril. |
| Trandolapril | Pirbuterol may decrease the antihypertensive activities of Trandolapril. |
| Lercanidipine | Pirbuterol may decrease the antihypertensive activities of Lercanidipine. |
| Benazepril | Pirbuterol may decrease the antihypertensive activities of Benazepril. |
| Bosentan | Pirbuterol may decrease the antihypertensive activities of Bosentan. |
| Enalapril | Pirbuterol may decrease the antihypertensive activities of Enalapril. |
| Candoxatril | Pirbuterol may decrease the antihypertensive activities of Candoxatril. |
| Mecamylamine | Pirbuterol may decrease the antihypertensive activities of Mecamylamine. |
| Losartan | Pirbuterol may decrease the antihypertensive activities of Losartan. |
| Moexipril | Pirbuterol may decrease the antihypertensive activities of Moexipril. |
| Eplerenone | Pirbuterol may decrease the antihypertensive activities of Eplerenone. |
| Lisinopril | Pirbuterol may decrease the antihypertensive activities of Lisinopril. |
| Nitroglycerin | Pirbuterol may decrease the antihypertensive activities of Nitroglycerin. |
| Metyrosine | Pirbuterol may decrease the antihypertensive activities of Metyrosine. |
| Cryptenamine | Pirbuterol may decrease the antihypertensive activities of Cryptenamine. |
| Perindopril | Pirbuterol may decrease the antihypertensive activities of Perindopril. |
| Candesartan cilexetil | Pirbuterol may decrease the antihypertensive activities of Candesartan cilexetil. |
| Fenoldopam | Pirbuterol may decrease the antihypertensive activities of Fenoldopam. |
| Tadalafil | Pirbuterol may decrease the antihypertensive activities of Tadalafil. |
| Eprosartan | Pirbuterol may decrease the antihypertensive activities of Eprosartan. |
| Quinapril | Pirbuterol may decrease the antihypertensive activities of Quinapril. |
| Telmisartan | Pirbuterol may decrease the antihypertensive activities of Telmisartan. |
| Methyldopa | Pirbuterol may decrease the antihypertensive activities of Methyldopa. |
| Irbesartan | Pirbuterol may decrease the antihypertensive activities of Irbesartan. |
| Nitrendipine | Pirbuterol may decrease the antihypertensive activities of Nitrendipine. |
| Deserpidine | Pirbuterol may decrease the antihypertensive activities of Deserpidine. |
| Pentolinium | Pirbuterol may decrease the antihypertensive activities of Pentolinium. |
| Trimethaphan | Pirbuterol may decrease the antihypertensive activities of Trimethaphan. |
| Diazoxide | Pirbuterol may decrease the antihypertensive activities of Diazoxide. |
| Captopril | Pirbuterol may decrease the antihypertensive activities of Captopril. |
| Epoprostenol | Pirbuterol may decrease the antihypertensive activities of Epoprostenol. |
| Bepridil | Pirbuterol may decrease the antihypertensive activities of Bepridil. |
| Hydralazine | Pirbuterol may decrease the antihypertensive activities of Hydralazine. |
| Cilazapril | Pirbuterol may decrease the antihypertensive activities of Cilazapril. |
| Saprisartan | Pirbuterol may decrease the antihypertensive activities of Saprisartan. |
| Spirapril | Pirbuterol may decrease the antihypertensive activities of Spirapril. |
| Mibefradil | Pirbuterol may decrease the antihypertensive activities of Mibefradil. |
| Tienilic acid | Pirbuterol may decrease the antihypertensive activities of Tienilic acid. |
| Debrisoquine | Pirbuterol may decrease the antihypertensive activities of Debrisoquine. |
| Sitaxentan | Pirbuterol may decrease the antihypertensive activities of Sitaxentan. |
| Ambrisentan | Pirbuterol may decrease the antihypertensive activities of Ambrisentan. |
| Diethylnorspermine | Pirbuterol may decrease the antihypertensive activities of Diethylnorspermine. |
| Nilvadipine | Pirbuterol may decrease the antihypertensive activities of Nilvadipine. |
| Pinacidil | Pirbuterol may decrease the antihypertensive activities of Pinacidil. |
| Temocapril | Pirbuterol may decrease the antihypertensive activities of Temocapril. |
| Riociguat | Pirbuterol may decrease the antihypertensive activities of Riociguat. |
| Macitentan | Pirbuterol may decrease the antihypertensive activities of Macitentan. |
| Hexamethonium | Pirbuterol may decrease the antihypertensive activities of Hexamethonium. |
| Aliskiren | Pirbuterol may decrease the antihypertensive activities of Aliskiren. |
| Nicorandil | Pirbuterol may decrease the antihypertensive activities of Nicorandil. |
| Efonidipine | Pirbuterol may decrease the antihypertensive activities of Efonidipine. |
| Lacidipine | Pirbuterol may decrease the antihypertensive activities of Lacidipine. |
| Manidipine | Pirbuterol may decrease the antihypertensive activities of Manidipine. |
| Rauwolfia serpentina root | Pirbuterol may decrease the antihypertensive activities of Rauwolfia serpentina root. |
| Enalaprilat | Pirbuterol may decrease the antihypertensive activities of Enalaprilat. |
| Selexipag | Pirbuterol may decrease the antihypertensive activities of Selexipag. |
| Angiotensin 1-7 | Pirbuterol may decrease the antihypertensive activities of Angiotensin 1-7. |
| Imidapril | Pirbuterol may decrease the antihypertensive activities of Imidapril. |
| BQ-123 | Pirbuterol may decrease the antihypertensive activities of BQ-123. |
| Tetrahydropalmatine | Pirbuterol may decrease the antihypertensive activities of Tetrahydropalmatine. |
| Cicletanine | Pirbuterol may decrease the antihypertensive activities of Cicletanine. |
| Dihydralazine | Pirbuterol may decrease the antihypertensive activities of Dihydralazine. |
| Zofenopril | Pirbuterol may decrease the antihypertensive activities of Zofenopril. |
| Guanoxan | Pirbuterol may decrease the antihypertensive activities of Guanoxan. |
| Delapril | Pirbuterol may decrease the antihypertensive activities of Delapril. |
| Vincamine | Pirbuterol may decrease the antihypertensive activities of Vincamine. |
| Linsidomine | Pirbuterol may decrease the antihypertensive activities of Linsidomine. |
| Guanoxabenz | Pirbuterol may decrease the antihypertensive activities of Guanoxabenz. |
| Tolonidine | Pirbuterol may decrease the antihypertensive activities of Tolonidine. |
| Endralazine | Pirbuterol may decrease the antihypertensive activities of Endralazine. |
| Cadralazine | Pirbuterol may decrease the antihypertensive activities of Cadralazine. |
| Bietaserpine | Pirbuterol may decrease the antihypertensive activities of Bietaserpine. |
| Guanazodine | Pirbuterol may decrease the antihypertensive activities of Guanazodine. |
| Methoserpidine | Pirbuterol may decrease the antihypertensive activities of Methoserpidine. |
| Guanoclor | Pirbuterol may decrease the antihypertensive activities of Guanoclor. |
| Muzolimine | Pirbuterol may decrease the antihypertensive activities of Muzolimine. |
| Xipamide | Pirbuterol may decrease the antihypertensive activities of Xipamide. |
| Candesartan | Pirbuterol may decrease the antihypertensive activities of Candesartan. |
| Dexniguldipine | Pirbuterol may decrease the antihypertensive activities of Dexniguldipine. |
| Tocopherylquinone | Pirbuterol may decrease the antihypertensive activities of Tocopherylquinone. |
| Benazeprilat | Pirbuterol may decrease the antihypertensive activities of Benazeprilat. |
| Fosinoprilat | Pirbuterol may decrease the antihypertensive activities of Fosinoprilat. |
| Ramiprilat | Pirbuterol may decrease the antihypertensive activities of Ramiprilat. |
| Perindoprilat | Pirbuterol may decrease the antihypertensive activities of Perindoprilat. |
| Quinaprilat | Pirbuterol may decrease the antihypertensive activities of Quinaprilat. |
| Felodipine | Pirbuterol may decrease the antihypertensive activities of Felodipine. |