Glisoxepide is one of the sulphonamide-derived oral antidiabetic drugs. It inhibits the uptake of bile acids into isolated rat hepatocytes. However it inhibits taurocholate uptake only in the absence of sodium ions. Glisoxepide uptake could be further inhibited by blockers of the hepatocellular monocarboxylate transporter, by the loop diuretic bumetanide, by 4,4'-diisothiocyano-2,2'-stilbenedisulfonate (DIDS) and by sulphate. These results are consistent with the transport of glisoxepide via the transport system for the unconjugated bile acid cholate. A31819,A31820
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Pegvisomant | The risk or severity of hypoglycemia can be increased when Pegvisomant is combined with Glisoxepide. |
| Carbocisteine | The risk or severity of adverse effects can be increased when Glisoxepide is combined with Carbocisteine. |
| Chloramphenicol | The metabolism of Glisoxepide can be decreased when combined with Chloramphenicol. |
| Cimetidine | The serum concentration of Glisoxepide can be increased when it is combined with Cimetidine. |
| Fluconazole | The serum concentration of Glisoxepide can be increased when it is combined with Fluconazole. |
| Metreleptin | Metreleptin may increase the hypoglycemic activities of Glisoxepide. |
| Probenecid | The protein binding of Glisoxepide can be decreased when combined with Probenecid. |
| Ranitidine | The serum concentration of Glisoxepide can be increased when it is combined with Ranitidine. |
| Voriconazole | The serum concentration of Glisoxepide can be increased when it is combined with Voriconazole. |
| Clarithromycin | The serum concentration of Glisoxepide can be increased when it is combined with Clarithromycin. |
| Lipoic acid | The risk or severity of hypoglycemia can be increased when Lipoic acid is combined with Glisoxepide. |
| Rifampin | The serum concentration of Glisoxepide can be decreased when it is combined with Rifampicin. |
| Moxifloxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Moxifloxacin. |
| Grepafloxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Grepafloxacin. |
| Enoxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Enoxacin. |
| Pefloxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Pefloxacin. |
| Ciprofloxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Ciprofloxacin. |
| Trovafloxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Trovafloxacin. |
| Nalidixic acid | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Nalidixic acid. |
| Rosoxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Rosoxacin. |
| Cinoxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Cinoxacin. |
| Lomefloxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Lomefloxacin. |
| Gatifloxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Gatifloxacin. |
| Norfloxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Norfloxacin. |
| Levofloxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Levofloxacin. |
| Gemifloxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Gemifloxacin. |
| Ofloxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Ofloxacin. |
| Sparfloxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Sparfloxacin. |
| Temafloxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Temafloxacin. |
| Fleroxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Fleroxacin. |
| Technetium Tc-99m ciprofloxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Technetium Tc-99m ciprofloxacin. |
| Garenoxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Garenoxacin. |
| Nemonoxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Nemonoxacin. |
| Flumequine | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Flumequine. |
| Enrofloxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Enrofloxacin. |
| Orbifloxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Orbifloxacin. |
| Sarafloxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Sarafloxacin. |
| Difloxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Difloxacin. |
| Pazufloxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Pazufloxacin. |
| Prulifloxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Prulifloxacin. |
| Delafloxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Delafloxacin. |
| Sitafloxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Sitafloxacin. |
| Oxolinic acid | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Oxolinic acid. |
| Rufloxacin | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Rufloxacin. |
| Pipemidic acid | The therapeutic efficacy of Glisoxepide can be increased when used in combination with Pipemidic acid. |
| Methyclothiazide | The therapeutic efficacy of Glisoxepide can be decreased when used in combination with Methyclothiazide. |
| Chlorthalidone | The therapeutic efficacy of Glisoxepide can be decreased when used in combination with Chlorthalidone. |
| Bendroflumethiazide | The therapeutic efficacy of Glisoxepide can be decreased when used in combination with Bendroflumethiazide. |
| Metolazone | The therapeutic efficacy of Glisoxepide can be decreased when used in combination with Metolazone. |
| Benzthiazide | The therapeutic efficacy of Glisoxepide can be decreased when used in combination with Benzthiazide. |
| Hydroflumethiazide | The therapeutic efficacy of Glisoxepide can be decreased when used in combination with Hydroflumethiazide. |
| Indapamide | The therapeutic efficacy of Glisoxepide can be decreased when used in combination with Indapamide. |
| Chlorothiazide | The therapeutic efficacy of Glisoxepide can be decreased when used in combination with Chlorothiazide. |
| Hydrochlorothiazide | The therapeutic efficacy of Glisoxepide can be decreased when used in combination with Hydrochlorothiazide. |
| Trichlormethiazide | The therapeutic efficacy of Glisoxepide can be decreased when used in combination with Trichlormethiazide. |
| Polythiazide | The therapeutic efficacy of Glisoxepide can be decreased when used in combination with Polythiazide. |
| Quinethazone | The therapeutic efficacy of Glisoxepide can be decreased when used in combination with Quinethazone. |
| Cyclopenthiazide | The therapeutic efficacy of Glisoxepide can be decreased when used in combination with Cyclopenthiazide. |
| Epitizide | The therapeutic efficacy of Glisoxepide can be decreased when used in combination with Epitizide. |
| Esmolol | Esmolol may increase the hypoglycemic activities of Glisoxepide. |
| Landiolol | Landiolol may increase the hypoglycemic activities of Glisoxepide. |
| Ethanol | The risk or severity of adverse effects can be increased when Glisoxepide is combined with Ethanol. |
| Amitriptyline | Amitriptyline may decrease the hypoglycemic activities of Glisoxepide. |
| Protriptyline | Protriptyline may decrease the hypoglycemic activities of Glisoxepide. |
| Imipramine | Imipramine may decrease the hypoglycemic activities of Glisoxepide. |
| Nortriptyline | Nortriptyline may decrease the hypoglycemic activities of Glisoxepide. |
| Amoxapine | Amoxapine may decrease the hypoglycemic activities of Glisoxepide. |
| Desipramine | Desipramine may decrease the hypoglycemic activities of Glisoxepide. |
| Clomipramine | Clomipramine may decrease the hypoglycemic activities of Glisoxepide. |
| Amineptine | Amineptine may decrease the hypoglycemic activities of Glisoxepide. |
| Dimetacrine | Dimetacrine may decrease the hypoglycemic activities of Glisoxepide. |
| Butriptyline | Butriptyline may decrease the hypoglycemic activities of Glisoxepide. |
| Dosulepin | Dosulepin may decrease the hypoglycemic activities of Glisoxepide. |
| Tianeptine | Tianeptine may decrease the hypoglycemic activities of Glisoxepide. |
| Oxaprotiline | Oxaprotiline may decrease the hypoglycemic activities of Glisoxepide. |
| Opipramol | Opipramol may decrease the hypoglycemic activities of Glisoxepide. |
| Amitriptylinoxide | Amitriptylinoxide may decrease the hypoglycemic activities of Glisoxepide. |
| Dibenzepin | Dibenzepin may decrease the hypoglycemic activities of Glisoxepide. |
| Quinupramine | Quinupramine may decrease the hypoglycemic activities of Glisoxepide. |
| Melitracen | Melitracen may decrease the hypoglycemic activities of Glisoxepide. |
| Lofepramine | Lofepramine may decrease the hypoglycemic activities of Glisoxepide. |
| Iprindole | Iprindole may decrease the hypoglycemic activities of Glisoxepide. |
| Imipramine oxide | Imipramine oxide may decrease the hypoglycemic activities of Glisoxepide. |
| Doxepin | Doxepin may decrease the hypoglycemic activities of Glisoxepide. |
| Clofibrate | The risk or severity of hypoglycemia can be increased when Clofibrate is combined with Glisoxepide. |
| Fenofibrate | The risk or severity of hypoglycemia can be increased when Fenofibrate is combined with Glisoxepide. |
| Bezafibrate | The risk or severity of hypoglycemia can be increased when Bezafibrate is combined with Glisoxepide. |
| Etofibrate | The risk or severity of hypoglycemia can be increased when Etofibrate is combined with Glisoxepide. |
| Ciprofibrate | The risk or severity of hypoglycemia can be increased when Ciprofibrate is combined with Glisoxepide. |
| Simfibrate | The risk or severity of hypoglycemia can be increased when Simfibrate is combined with Glisoxepide. |
| Ronifibrate | The risk or severity of hypoglycemia can be increased when Ronifibrate is combined with Glisoxepide. |
| Aluminium clofibrate | The risk or severity of hypoglycemia can be increased when Aluminium clofibrate is combined with Glisoxepide. |
| Clofibride | The risk or severity of hypoglycemia can be increased when Clofibride is combined with Glisoxepide. |
| Fenofibric acid | The risk or severity of hypoglycemia can be increased when Fenofibric acid is combined with Glisoxepide. |
| Miconazole | The serum concentration of Glisoxepide can be increased when it is combined with Miconazole. |
| Phenindione | Glisoxepide may increase the anticoagulant activities of Phenindione. |
| Coumarin | Glisoxepide may increase the anticoagulant activities of Coumarin. |
| (R)-warfarin | Glisoxepide may increase the anticoagulant activities of (R)-warfarin. |
| Clorindione | Glisoxepide may increase the anticoagulant activities of Clorindione. |
| Diphenadione | Glisoxepide may increase the anticoagulant activities of Diphenadione. |