Corticotropin

DB01285

biotech approved investigational vet_approved

Deskripsi

Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) About 15 minutes following intravenous administration.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Corticotropin is rapidly absorbed following intramuscular administration; the repository dosage form is slowly absorbed over approximately 8 to 16 hours.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1119 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Corticotropin.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Corticotropin.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Corticotropin.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Corticotropin.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Corticotropin.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Corticotropin.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Corticotropin.
Aldesleukin The risk or severity of adverse effects can be increased when Aldesleukin is combined with Corticotropin.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Corticotropin.
Pegaspargase The risk or severity of adverse effects can be increased when Pegaspargase is combined with Corticotropin.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Corticotropin.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Corticotropin.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Corticotropin.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Corticotropin.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Corticotropin.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Corticotropin.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Corticotropin.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Corticotropin.
Alefacept The risk or severity of adverse effects can be increased when Alefacept is combined with Corticotropin.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Corticotropin.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Corticotropin.
Interferon alfa-2b The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Corticotropin.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Corticotropin.
Phenylalanine The risk or severity of adverse effects can be increased when Phenylalanine is combined with Corticotropin.
Cladribine Corticotropin may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Corticotropin.
Amsacrine The risk or severity of adverse effects can be increased when Amsacrine is combined with Corticotropin.
Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Corticotropin.
Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Corticotropin.
Raltitrexed The risk or severity of adverse effects can be increased when Raltitrexed is combined with Corticotropin.
Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Corticotropin.
Bexarotene The risk or severity of adverse effects can be increased when Bexarotene is combined with Corticotropin.
Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Corticotropin.
Tioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Corticotropin.
Dexrazoxane The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Corticotropin.
Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Corticotropin.
Trifluridine The risk or severity of adverse effects can be increased when Trifluridine is combined with Corticotropin.
Gemcitabine The risk or severity of adverse effects can be increased when Gemcitabine is combined with Corticotropin.
Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Corticotropin.
Chloramphenicol The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Corticotropin.
Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Corticotropin.
Altretamine The risk or severity of adverse effects can be increased when Altretamine is combined with Corticotropin.
Zidovudine The risk or severity of adverse effects can be increased when Zidovudine is combined with Corticotropin.
Oxaliplatin The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Corticotropin.
Fluorouracil The risk or severity of adverse effects can be increased when Fluorouracil is combined with Corticotropin.
Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Corticotropin.
Pentostatin The risk or severity of adverse effects can be increased when Pentostatin is combined with Corticotropin.
Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Corticotropin.
Clofarabine The risk or severity of adverse effects can be increased when Clofarabine is combined with Corticotropin.
Pemetrexed The risk or severity of adverse effects can be increased when Pemetrexed is combined with Corticotropin.
Mycophenolate mofetil The risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with Corticotropin.
Dacarbazine The risk or severity of adverse effects can be increased when Dacarbazine is combined with Corticotropin.
Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Corticotropin.
Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Corticotropin.
Azacitidine The risk or severity of adverse effects can be increased when Azacitidine is combined with Corticotropin.
Carboplatin The risk or severity of adverse effects can be increased when Carboplatin is combined with Corticotropin.
Dactinomycin The risk or severity of adverse effects can be increased when Dactinomycin is combined with Corticotropin.
Azathioprine The risk or severity of adverse effects can be increased when Azathioprine is combined with Corticotropin.
Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Corticotropin.
Mycophenolic acid The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Corticotropin.
Topotecan The risk or severity of adverse effects can be increased when Topotecan is combined with Corticotropin.
Mercaptopurine The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Corticotropin.
Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Corticotropin.
Melphalan The risk or severity of adverse effects can be increased when Melphalan is combined with Corticotropin.
Fludarabine The risk or severity of adverse effects can be increased when Fludarabine is combined with Corticotropin.
Flucytosine The risk or severity of adverse effects can be increased when Flucytosine is combined with Corticotropin.
Capecitabine The risk or severity of adverse effects can be increased when Capecitabine is combined with Corticotropin.
Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Corticotropin.
Arsenic trioxide The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Corticotropin.
Idarubicin The risk or severity of adverse effects can be increased when Idarubicin is combined with Corticotropin.
Estramustine The risk or severity of adverse effects can be increased when Estramustine is combined with Corticotropin.
Mitoxantrone The risk or severity of adverse effects can be increased when Mitoxantrone is combined with Corticotropin.
Lomustine The risk or severity of adverse effects can be increased when Lomustine is combined with Corticotropin.
Eculizumab The risk or severity of adverse effects can be increased when Eculizumab is combined with Corticotropin.
Decitabine The risk or severity of adverse effects can be increased when Decitabine is combined with Corticotropin.
Nelarabine The risk or severity of adverse effects can be increased when Nelarabine is combined with Corticotropin.
Stepronin The risk or severity of adverse effects can be increased when Corticotropin is combined with Stepronin.
Hydroxychloroquine The risk or severity of adverse effects can be increased when Corticotropin is combined with Hydroxychloroquine.
Castanospermine The risk or severity of adverse effects can be increased when Corticotropin is combined with Castanospermine.
Vorinostat The risk or severity of adverse effects can be increased when Corticotropin is combined with Vorinostat.
2-Methoxyethanol The risk or severity of adverse effects can be increased when Corticotropin is combined with 2-Methoxyethanol.
Brequinar The risk or severity of adverse effects can be increased when Corticotropin is combined with Brequinar.
Pirfenidone The risk or severity of adverse effects can be increased when Corticotropin is combined with Pirfenidone.
Interferon alfa The risk or severity of adverse effects can be increased when Corticotropin is combined with Interferon alfa.
Glatiramer The risk or severity of adverse effects can be increased when Corticotropin is combined with Glatiramer.
Briakinumab The risk or severity of adverse effects can be increased when Corticotropin is combined with Briakinumab.
Human interferon omega-1 The risk or severity of adverse effects can be increased when Corticotropin is combined with Human interferon omega-1.
Mepolizumab The risk or severity of adverse effects can be increased when Corticotropin is combined with Mepolizumab.
Abetimus The risk or severity of adverse effects can be increased when Corticotropin is combined with Abetimus.
Belatacept The risk or severity of adverse effects can be increased when Corticotropin is combined with Belatacept.
Bendamustine The risk or severity of adverse effects can be increased when Corticotropin is combined with Bendamustine.
Pralatrexate The risk or severity of adverse effects can be increased when Corticotropin is combined with Pralatrexate.
Wortmannin The risk or severity of adverse effects can be increased when Corticotropin is combined with Wortmannin.
Eribulin The risk or severity of adverse effects can be increased when Corticotropin is combined with Eribulin.
Belimumab The risk or severity of adverse effects can be increased when Corticotropin is combined with Belimumab.
Teriflunomide The risk or severity of adverse effects can be increased when Corticotropin is combined with Teriflunomide.
Carfilzomib The risk or severity of adverse effects can be increased when Corticotropin is combined with Carfilzomib.
Dimethyl fumarate The risk or severity of adverse effects can be increased when Corticotropin is combined with Dimethyl fumarate.
Obinutuzumab The risk or severity of adverse effects can be increased when Corticotropin is combined with Obinutuzumab.
Vedolizumab The risk or severity of adverse effects can be increased when Corticotropin is combined with Vedolizumab.

Target Protein

Adrenocorticotropic hormone receptor MC2R
Corticoliberin CRH

Referensi & Sumber

Synthesis reference: Wylie W. Vale, Jr., Mary P. Stenzel-Poore, "Corticotropin-releasing factor overproducing transgenic mice." U.S. Patent US6023011, issued June, 1993.

Contoh Produk & Brand

Produk: 9 • International brands: 2
Produk
  • Acthar
    Injection • 80 [USP'U]/1mL • Intramuscular; Subcutaneous • US • Approved
  • Acthar
    Injection • 40 [USP'U]/0.5mL • Subcutaneous • US • Approved
  • Acthar
    Injection • 80 [USP'U]/1mL • Subcutaneous • US • Approved
  • Acthar Gel Hp Inj 40unit/ml
    Gel • 40 unit / mL • Intramuscular; Subcutaneous • Canada • Approved
  • Acthar Powder Inj 40unit/vial
    Powder, for solution • 40 unit / vial • Intramuscular; Intravenous; Subcutaneous • Canada • Approved
  • H.P. Acthar
    Injection • 80 [iU]/1mL • Intravenous • US • Approved
  • H.P. Acthar
    Injection • 80 [USP'U]/1mL • Intramuscular; Subcutaneous • US • Approved
  • Purified Cortrophin Gel
    Injection • 80 [USP'U]/1mL • Intramuscular; Subcutaneous • US • Approved
Menampilkan 8 dari 9 produk.
International Brands
  • Acthar
  • Acthar Gel

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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