Tetracosactide

DB01284

small molecule approved

Deskripsi

Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticosteroids in the adrenal cortex. Tetracosactide exhibits the same activity as natural ACTH with regard to all its biological activities. The complex results in a product whose absorption in man is effected over a longer period of time as compared to corticotropin. Therefore, therapy may be maintained with less frequent administration.

Struktur Molekul 2D

Berat 2933.49
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) About 15 minutes following intravenous administration.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapidly absorbed following intramuscular administration.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

87 Data
Valproic acid Tetracosactide may increase the hepatotoxic activities of Valproic acid.
Lorazepam The risk or severity of liver damage can be increased when Tetracosactide is combined with Lorazepam.
Pregabalin The risk or severity of liver damage can be increased when Tetracosactide is combined with Pregabalin.
Butalbital The risk or severity of liver damage can be increased when Tetracosactide is combined with Butalbital.
Phenytoin Tetracosactide may increase the hepatotoxic activities of Phenytoin.
Topiramate The risk or severity of liver damage can be increased when Tetracosactide is combined with Topiramate.
Pentobarbital The risk or severity of liver damage can be increased when Tetracosactide is combined with Pentobarbital.
Trimethadione The risk or severity of liver damage can be increased when Tetracosactide is combined with Trimethadione.
Clobazam The risk or severity of liver damage can be increased when Tetracosactide is combined with Clobazam.
Secobarbital The risk or severity of liver damage can be increased when Tetracosactide is combined with Secobarbital.
Metharbital The risk or severity of liver damage can be increased when Tetracosactide is combined with Metharbital.
Methohexital The risk or severity of liver damage can be increased when Tetracosactide is combined with Methohexital.
Mephenytoin The risk or severity of liver damage can be increased when Tetracosactide is combined with Mephenytoin.
Lamotrigine The risk or severity of liver damage can be increased when Tetracosactide is combined with Lamotrigine.
Carbamazepine The risk or severity of liver damage can be increased when Tetracosactide is combined with Carbamazepine.
Ethosuximide The risk or severity of liver damage can be increased when Tetracosactide is combined with Ethosuximide.
Thiopental The risk or severity of liver damage can be increased when Tetracosactide is combined with Thiopental.
Paramethadione The risk or severity of liver damage can be increased when Tetracosactide is combined with Paramethadione.
Clorazepic acid The risk or severity of liver damage can be increased when Tetracosactide is combined with Clorazepic acid.
Magnesium sulfate The risk or severity of liver damage can be increased when Tetracosactide is combined with Magnesium sulfate.
Tizanidine The risk or severity of liver damage can be increased when Tetracosactide is combined with Tizanidine.
Riluzole The risk or severity of liver damage can be increased when Tetracosactide is combined with Riluzole.
Ethotoin The risk or severity of liver damage can be increased when Tetracosactide is combined with Ethotoin.
Oxcarbazepine The risk or severity of liver damage can be increased when Tetracosactide is combined with Oxcarbazepine.
Primidone The risk or severity of liver damage can be increased when Tetracosactide is combined with Primidone.
Acetazolamide The risk or severity of liver damage can be increased when Tetracosactide is combined with Acetazolamide.
Diazepam The risk or severity of liver damage can be increased when Tetracosactide is combined with Diazepam.
Phensuximide The risk or severity of liver damage can be increased when Tetracosactide is combined with Phensuximide.
Progabide The risk or severity of liver damage can be increased when Tetracosactide is combined with Progabide.
Methylphenobarbital The risk or severity of liver damage can be increased when Tetracosactide is combined with Methylphenobarbital.
Tiagabine The risk or severity of liver damage can be increased when Tetracosactide is combined with Tiagabine.
Zonisamide The risk or severity of liver damage can be increased when Tetracosactide is combined with Zonisamide.
Felbamate The risk or severity of liver damage can be increased when Tetracosactide is combined with Felbamate.
Zaleplon The risk or severity of liver damage can be increased when Tetracosactide is combined with Zaleplon.
Gabapentin The risk or severity of liver damage can be increased when Tetracosactide is combined with Gabapentin.
Vigabatrin The risk or severity of liver damage can be increased when Tetracosactide is combined with Vigabatrin.
Phenacemide The risk or severity of liver damage can be increased when Tetracosactide is combined with Phenacemide.
Thiamylal The risk or severity of liver damage can be increased when Tetracosactide is combined with Thiamylal.
Phenobarbital The risk or severity of liver damage can be increased when Tetracosactide is combined with Phenobarbital.
Levetiracetam The risk or severity of liver damage can be increased when Tetracosactide is combined with Levetiracetam.
Estazolam The risk or severity of liver damage can be increased when Tetracosactide is combined with Estazolam.
Fosphenytoin Tetracosactide may increase the hepatotoxic activities of Fosphenytoin.
Amobarbital The risk or severity of liver damage can be increased when Tetracosactide is combined with Amobarbital.
Hexobarbital The risk or severity of liver damage can be increased when Tetracosactide is combined with Hexobarbital.
Barbital The risk or severity of liver damage can be increased when Tetracosactide is combined with Barbital.
Delorazepam The risk or severity of liver damage can be increased when Tetracosactide is combined with Delorazepam.
7-Nitroindazole The risk or severity of liver damage can be increased when Tetracosactide is combined with 7-Nitroindazole.
Valpromide The risk or severity of liver damage can be increased when Tetracosactide is combined with Valpromide.
Flunarizine The risk or severity of liver damage can be increased when Tetracosactide is combined with Flunarizine.
Ezogabine The risk or severity of liver damage can be increased when Tetracosactide is combined with Ezogabine.
Methsuximide The risk or severity of liver damage can be increased when Tetracosactide is combined with Methsuximide.
Brivaracetam The risk or severity of liver damage can be increased when Tetracosactide is combined with Brivaracetam.
Rufinamide The risk or severity of liver damage can be increased when Tetracosactide is combined with Rufinamide.
Lacosamide The risk or severity of liver damage can be increased when Tetracosactide is combined with Lacosamide.
Remacemide The risk or severity of liver damage can be increased when Tetracosactide is combined with Remacemide.
Clomethiazole The risk or severity of liver damage can be increased when Tetracosactide is combined with Clomethiazole.
Deramciclane The risk or severity of liver damage can be increased when Tetracosactide is combined with Deramciclane.
Tramiprosate The risk or severity of liver damage can be increased when Tetracosactide is combined with Tramiprosate.
Gaboxadol The risk or severity of liver damage can be increased when Tetracosactide is combined with Gaboxadol.
Sulthiame The risk or severity of liver damage can be increased when Tetracosactide is combined with Sulthiame.
Perampanel The risk or severity of liver damage can be increased when Tetracosactide is combined with Perampanel.
Ifenprodil The risk or severity of liver damage can be increased when Tetracosactide is combined with Ifenprodil.
Barbexaclone The risk or severity of liver damage can be increased when Tetracosactide is combined with Barbexaclone.
Beclamide The risk or severity of liver damage can be increased when Tetracosactide is combined with Beclamide.
Cannabidiol The risk or severity of liver damage can be increased when Tetracosactide is combined with Cannabidiol.
Paraldehyde The risk or severity of liver damage can be increased when Tetracosactide is combined with Paraldehyde.
Stiripentol The risk or severity of liver damage can be increased when Tetracosactide is combined with Stiripentol.
Eslicarbazepine acetate The risk or severity of liver damage can be increased when Tetracosactide is combined with Eslicarbazepine acetate.
Doramectin The risk or severity of liver damage can be increased when Tetracosactide is combined with Doramectin.
Tiletamine The risk or severity of liver damage can be increased when Tetracosactide is combined with Tiletamine.
Brexanolone The risk or severity of liver damage can be increased when Tetracosactide is combined with Brexanolone.
Etiracetam The risk or severity of liver damage can be increased when Tetracosactide is combined with Etiracetam.
Vinpocetine The risk or severity of liver damage can be increased when Tetracosactide is combined with Vinpocetine.
Carisbamate The risk or severity of liver damage can be increased when Tetracosactide is combined with Carisbamate.
Pheneturide The risk or severity of liver damage can be increased when Tetracosactide is combined with Pheneturide.
Neocitrullamon The risk or severity of liver damage can be increased when Tetracosactide is combined with Neocitrullamon.
Medazepam The risk or severity of liver damage can be increased when Tetracosactide is combined with Medazepam.
Phenibut The risk or severity of liver damage can be increased when Tetracosactide is combined with Phenibut.
Ethadione The risk or severity of liver damage can be increased when Tetracosactide is combined with Ethadione.
Cannabidivarin The risk or severity of liver damage can be increased when Tetracosactide is combined with Cannabidivarin.
Eslicarbazepine The risk or severity of liver damage can be increased when Tetracosactide is combined with Eslicarbazepine.
JNJ-26489112 The risk or severity of liver damage can be increased when Tetracosactide is combined with JNJ-26489112.
Cenobamate The risk or severity of liver damage can be increased when Tetracosactide is combined with Cenobamate.
Clonazepam Tetracosactide may increase the hepatotoxic activities of Clonazepam.
Nitrazepam The serum concentration of Nitrazepam can be increased when it is combined with Tetracosactide.
Fenfluramine The risk or severity of liver damage can be increased when Tetracosactide is combined with Fenfluramine.
Ganaxolone The risk or severity of liver damage can be increased when Tetracosactide is combined with Ganaxolone.

Target Protein

Adrenocorticotropic hormone receptor MC2R

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

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