Retapamulin

DB01256

small molecule approved

Deskripsi

Retapamulin, marketed by GlaxoSmithKline as the ointment Altabax, is an antibiotic for skin infections like impetigo. It was approved by the FDA in April 2007.

Struktur Molekul 2D

Berat 517.763
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

In vitro studies with human liver microsomes demonstrated that retapamulin is extensively metabolized to numerous metabolites, of which the predominant routes of metabolism were mono-oxygenation and N-demethylation. The major enzyme responsible for metabolism of retapamulin in human liver microsomes was cytochrome P450 3A4 (CYP3A4).

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

380 Data
Aldesleukin The metabolism of Retapamulin can be decreased when combined with Aldesleukin.
Octreotide The metabolism of Retapamulin can be decreased when combined with Octreotide.
Fluvoxamine The metabolism of Retapamulin can be decreased when combined with Fluvoxamine.
Fluconazole The metabolism of Retapamulin can be decreased when combined with Fluconazole.
Erythromycin The metabolism of Retapamulin can be decreased when combined with Erythromycin.
Citalopram The metabolism of Retapamulin can be decreased when combined with Citalopram.
Nelfinavir The metabolism of Retapamulin can be decreased when combined with Nelfinavir.
Indinavir The metabolism of Retapamulin can be decreased when combined with Indinavir.
Ziprasidone The metabolism of Retapamulin can be decreased when combined with Ziprasidone.
Cabergoline The metabolism of Retapamulin can be decreased when combined with Cabergoline.
Diethylstilbestrol The metabolism of Retapamulin can be decreased when combined with Diethylstilbestrol.
Isradipine The metabolism of Retapamulin can be decreased when combined with Isradipine.
Valproic acid The metabolism of Retapamulin can be decreased when combined with Valproic acid.
Dihydroergotamine The metabolism of Retapamulin can be decreased when combined with Dihydroergotamine.
Diltiazem The metabolism of Retapamulin can be decreased when combined with Diltiazem.
Methylergometrine The metabolism of Retapamulin can be decreased when combined with Methylergometrine.
Mefloquine The metabolism of Retapamulin can be decreased when combined with Mefloquine.
Mirtazapine The metabolism of Retapamulin can be decreased when combined with Mirtazapine.
Sorafenib The metabolism of Retapamulin can be decreased when combined with Sorafenib.
Nitric Oxide The metabolism of Retapamulin can be decreased when combined with Nitric Oxide.
Teniposide The metabolism of Retapamulin can be decreased when combined with Teniposide.
Chloramphenicol The metabolism of Retapamulin can be decreased when combined with Chloramphenicol.
Raloxifene The metabolism of Retapamulin can be decreased when combined with Raloxifene.
Cimetidine The metabolism of Retapamulin can be decreased when combined with Cimetidine.
Haloperidol The metabolism of Retapamulin can be decreased when combined with Haloperidol.
Erlotinib The metabolism of Retapamulin can be decreased when combined with Erlotinib.
Ciprofloxacin The metabolism of Retapamulin can be decreased when combined with Ciprofloxacin.
Zafirlukast The metabolism of Retapamulin can be decreased when combined with Zafirlukast.
Fluticasone propionate The metabolism of Retapamulin can be decreased when combined with Fluticasone propionate.
Imatinib The metabolism of Retapamulin can be decreased when combined with Imatinib.
Nicardipine The metabolism of Retapamulin can be decreased when combined with Nicardipine.
Astemizole The metabolism of Retapamulin can be decreased when combined with Astemizole.
Dextropropoxyphene The metabolism of Retapamulin can be decreased when combined with Dextropropoxyphene.
Verapamil The metabolism of Retapamulin can be decreased when combined with Verapamil.
Epinephrine The metabolism of Retapamulin can be decreased when combined with Epinephrine.
Aprepitant The metabolism of Retapamulin can be decreased when combined with Aprepitant.
Midazolam The metabolism of Retapamulin can be decreased when combined with Midazolam.
Daunorubicin The metabolism of Retapamulin can be decreased when combined with Daunorubicin.
Ergotamine The metabolism of Retapamulin can be decreased when combined with Ergotamine.
Amprenavir The metabolism of Retapamulin can be decreased when combined with Amprenavir.
Delavirdine The metabolism of Retapamulin can be decreased when combined with Delavirdine.
Paroxetine The metabolism of Retapamulin can be decreased when combined with Paroxetine.
Tranylcypromine The metabolism of Retapamulin can be decreased when combined with Tranylcypromine.
Tetracycline The metabolism of Retapamulin can be decreased when combined with Tetracycline.
Methimazole The metabolism of Retapamulin can be decreased when combined with Methimazole.
Roxithromycin The metabolism of Retapamulin can be decreased when combined with Roxithromycin.
Phenelzine The metabolism of Retapamulin can be decreased when combined with Phenelzine.
Propofol The metabolism of Retapamulin can be decreased when combined with Propofol.
Acetazolamide The metabolism of Retapamulin can be decreased when combined with Acetazolamide.
Diazepam The metabolism of Retapamulin can be decreased when combined with Diazepam.
Clofazimine The metabolism of Retapamulin can be decreased when combined with Clofazimine.
Tacrolimus The metabolism of Retapamulin can be decreased when combined with Tacrolimus.
Conivaptan The metabolism of Retapamulin can be decreased when combined with Conivaptan.
Metronidazole The metabolism of Retapamulin can be decreased when combined with Metronidazole.
Buprenorphine The metabolism of Retapamulin can be decreased when combined with Buprenorphine.
Tipranavir The metabolism of Retapamulin can be decreased when combined with Tipranavir.
Isoniazid The metabolism of Retapamulin can be decreased when combined with Isoniazid.
Dirithromycin The metabolism of Retapamulin can be decreased when combined with Dirithromycin.
Telithromycin The metabolism of Retapamulin can be decreased when combined with Telithromycin.
Doxorubicin The metabolism of Retapamulin can be decreased when combined with Doxorubicin.
Sulfamethoxazole The metabolism of Retapamulin can be decreased when combined with Sulfamethoxazole.
Glyburide The metabolism of Retapamulin can be decreased when combined with Glyburide.
Ketoconazole The metabolism of Retapamulin can be decreased when combined with Ketoconazole.
Irbesartan The metabolism of Retapamulin can be decreased when combined with Irbesartan.
Norfloxacin The metabolism of Retapamulin can be decreased when combined with Norfloxacin.
Oxybutynin The metabolism of Retapamulin can be decreased when combined with Oxybutynin.
Mequitazine The metabolism of Retapamulin can be decreased when combined with Mequitazine.
Atazanavir The metabolism of Retapamulin can be decreased when combined with Atazanavir.
Primaquine The metabolism of Retapamulin can be decreased when combined with Primaquine.
Dimethyl sulfoxide The metabolism of Retapamulin can be decreased when combined with Dimethyl sulfoxide.
Pimozide The metabolism of Retapamulin can be decreased when combined with Pimozide.
Miconazole The metabolism of Retapamulin can be decreased when combined with Miconazole.
Amiodarone The metabolism of Retapamulin can be decreased when combined with Amiodarone.
Bicalutamide The metabolism of Retapamulin can be decreased when combined with Bicalutamide.
Rabeprazole The metabolism of Retapamulin can be decreased when combined with Rabeprazole.
Nefazodone The metabolism of Retapamulin can be decreased when combined with Nefazodone.
Desipramine The metabolism of Retapamulin can be decreased when combined with Desipramine.
Candicidin The metabolism of Retapamulin can be decreased when combined with Candicidin.
Itraconazole The metabolism of Retapamulin can be decreased when combined with Itraconazole.
Orphenadrine The metabolism of Retapamulin can be decreased when combined with Orphenadrine.
Bromocriptine The metabolism of Retapamulin can be decreased when combined with Bromocriptine.
Saquinavir The metabolism of Retapamulin can be decreased when combined with Saquinavir.
Docetaxel The metabolism of Retapamulin can be decreased when combined with Docetaxel.
Dasatinib The metabolism of Retapamulin can be decreased when combined with Dasatinib.
Lapatinib The metabolism of Retapamulin can be decreased when combined with Lapatinib.
Posaconazole The metabolism of Retapamulin can be decreased when combined with Posaconazole.
Darunavir The metabolism of Retapamulin can be decreased when combined with Darunavir.
Sunitinib The metabolism of Retapamulin can be decreased when combined with Sunitinib.
Hydralazine The metabolism of Retapamulin can be decreased when combined with Hydralazine.
Quinupristin The metabolism of Retapamulin can be decreased when combined with Quinupristin.
Mibefradil The metabolism of Retapamulin can be decreased when combined with Mibefradil.
Danazol The metabolism of Retapamulin can be decreased when combined with Danazol.
Ketazolam The metabolism of Retapamulin can be decreased when combined with Ketazolam.
Lopinavir The metabolism of Retapamulin can be decreased when combined with Lopinavir.
Etoricoxib The metabolism of Retapamulin can be decreased when combined with Etoricoxib.
Topiroxostat The metabolism of Retapamulin can be decreased when combined with Topiroxostat.
Rutin The metabolism of Retapamulin can be decreased when combined with Rutin.
Dalfopristin The metabolism of Retapamulin can be decreased when combined with Dalfopristin.
Epothilone D The metabolism of Retapamulin can be decreased when combined with Epothilone D.
Ditiocarb The metabolism of Retapamulin can be decreased when combined with Ditiocarb.

Target Protein

50S ribosomal protein L3 rplC

Referensi & Sumber

Synthesis reference: Eli Lancry, Lilach Hedvati, Greta Sterimbaum, Ariel Mittelman, Tali Katav, "Amorphous retapamulin and processes for preparation thereof." U.S. Patent US20090234125, issued September 17, 2009.
Artikel (PubMed)
  • PMID: 16801451
    Jones RN, Fritsche TR, Sader HS, Ross JE: Activity of retapamulin (SB-275833), a novel pleuromutilin, against selected resistant gram-positive cocci. Antimicrob Agents Chemother. 2006 Jul;50(7):2583-6.
  • PMID: 18416589
    Yang LP, Keam SJ: Retapamulin: a review of its use in the management of impetigo and other uncomplicated superficial skin infections. Drugs. 2008;68(6):855-73.
  • PMID: 20112168
    Novak R, Shlaes DM: The pleuromutilin antibiotics: a new class for human use. Curr Opin Investig Drugs. 2010 Feb;11(2):182-91.
  • PMID: 18041900
    Jacobs MR: Retapamulin: a semisynthetic pleuromutilin compound for topical treatment of skin infections in adults and children. Future Microbiol. 2007 Dec;2(6):591-600.
  • PMID: 18389088
    Parish LC, Parish JL: Retapamulin: a new topical antibiotic for the treatment of uncomplicated skin infections. Drugs Today (Barc). 2008 Feb;44(2):91-102. doi: 10.1358/dot.2008.44.2.1153446.
  • PMID: 18832258
    Authors unspecified: Retapamulin for impetigo and other infections. Drug Ther Bull. 2008 Oct;46(10):76-9. doi: 10.1136/dtb.2008.09.0023.
  • PMID: 20061745
    Nagabushan H: Retapamulin: a novel topical antibiotic. Indian J Dermatol Venereol Leprol. 2010 Jan-Feb;76(1):77-9. doi: 10.4103/0378-6323.58693.
  • PMID: 19436611
    Shawar R, Scangarella-Oman N, Dalessandro M, Breton J, Twynholm M, Li G, Garges H: Topical retapamulin in the management of infected traumatic skin lesions. Ther Clin Risk Manag. 2009 Feb;5(1):41-9. Epub 2009 Mar 26.

Contoh Produk & Brand

Produk: 9 • International brands: 2
Produk
  • Altabax
    Ointment • 10 mg/1g • Topical • US • Approved
  • Altabax
    Ointment • 10 mg/1g • Topical • US • Approved
  • Altabax
    Ointment • 10 mg/1g • Topical • US • Approved
  • Altabax
    Ointment • 10 mg/1g • Topical • US • Approved
  • Altargo
    Ointment • 1 % • Topical • Canada • Approved
  • Altargo
    Ointment • 1 % • Cutaneous • EU
  • Altargo
    Ointment • 1 % • Cutaneous • EU
  • Altargo
    Ointment • 1 % • Cutaneous • EU
Menampilkan 8 dari 9 produk.
International Brands
  • Aitabax
  • Altargo

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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