Peringatan Keamanan

LD50=190 mg/kg (orally in mice). Prolonged apnoea, neuromuscular paralysis and cardiac arrest may occur.

Decamethonium

DB01245

small molecule approved

Deskripsi

Decamethonium is used in anesthesia to cause paralysis. It is a short acting depolarizing muscle relaxant. It is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor.

Struktur Molekul 2D

Berat 258.4863
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapidly absorbed.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

976 Data
Buprenorphine Decamethonium may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Decamethonium.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Decamethonium.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Decamethonium.
Hydrocodone Decamethonium may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Decamethonium.
Magnesium sulfate The therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Decamethonium may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Decamethonium may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Decamethonium.
Mirtazapine Decamethonium may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Decamethonium.
Orphenadrine Decamethonium may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Decamethonium may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Decamethonium.
Pramipexole Decamethonium may increase the sedative activities of Pramipexole.
Ropinirole Decamethonium may increase the sedative activities of Ropinirole.
Rotigotine Decamethonium may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Decamethonium.
Sodium oxybate Decamethonium may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Decamethonium may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Decamethonium.
Thalidomide Decamethonium may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Decamethonium may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Capreomycin The therapeutic efficacy of Decamethonium can be increased when used in combination with Capreomycin.
Botulinum toxin type B The therapeutic efficacy of Decamethonium can be increased when used in combination with Botulinum toxin type B.
Botulinum toxin type A The therapeutic efficacy of Decamethonium can be increased when used in combination with Botulinum toxin type A.
Cyclosporine The therapeutic efficacy of Decamethonium can be increased when used in combination with Cyclosporine.
Doxycycline The therapeutic efficacy of Decamethonium can be increased when used in combination with Doxycycline.
Lymecycline The therapeutic efficacy of Decamethonium can be increased when used in combination with Lymecycline.
Piperacillin The therapeutic efficacy of Decamethonium can be increased when used in combination with Piperacillin.
Framycetin The therapeutic efficacy of Decamethonium can be increased when used in combination with Framycetin.
Clomocycline The therapeutic efficacy of Decamethonium can be increased when used in combination with Clomocycline.
Quinine The therapeutic efficacy of Decamethonium can be increased when used in combination with Quinine.
Vancomycin The therapeutic efficacy of Decamethonium can be increased when used in combination with Vancomycin.
Tigecycline The therapeutic efficacy of Decamethonium can be increased when used in combination with Tigecycline.
Oxytetracycline The therapeutic efficacy of Decamethonium can be increased when used in combination with Oxytetracycline.
Chloroquine The therapeutic efficacy of Decamethonium can be increased when used in combination with Chloroquine.
Demeclocycline The therapeutic efficacy of Decamethonium can be increased when used in combination with Demeclocycline.
Tobramycin The therapeutic efficacy of Decamethonium can be increased when used in combination with Tobramycin.
Tetracycline The therapeutic efficacy of Decamethonium can be increased when used in combination with Tetracycline.
Gentamicin The therapeutic efficacy of Decamethonium can be increased when used in combination with Gentamicin.
Etacrynic acid The therapeutic efficacy of Decamethonium can be increased when used in combination with Etacrynic acid.
Metacycline The therapeutic efficacy of Decamethonium can be increased when used in combination with Metacycline.
Netilmicin The therapeutic efficacy of Decamethonium can be increased when used in combination with Netilmicin.
Neomycin The therapeutic efficacy of Decamethonium can be increased when used in combination with Neomycin.
Procainamide The therapeutic efficacy of Decamethonium can be increased when used in combination with Procainamide.
Streptomycin The therapeutic efficacy of Decamethonium can be increased when used in combination with Streptomycin.
Colistimethate The therapeutic efficacy of Decamethonium can be increased when used in combination with Colistimethate.
Kanamycin The therapeutic efficacy of Decamethonium can be increased when used in combination with Kanamycin.
Rolitetracycline The therapeutic efficacy of Decamethonium can be increased when used in combination with Rolitetracycline.
Magnesium oxide The therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium oxide.
Magnesium cation The therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium cation.
Paromomycin The therapeutic efficacy of Decamethonium can be increased when used in combination with Paromomycin.
Lincomycin The therapeutic efficacy of Decamethonium can be increased when used in combination with Lincomycin.
Ribostamycin The therapeutic efficacy of Decamethonium can be increased when used in combination with Ribostamycin.
Geneticin The therapeutic efficacy of Decamethonium can be increased when used in combination with Geneticin.
Apramycin The therapeutic efficacy of Decamethonium can be increased when used in combination with Apramycin.
Gentamicin C1a The therapeutic efficacy of Decamethonium can be increased when used in combination with Gentamicin C1a.
Neamine The therapeutic efficacy of Decamethonium can be increased when used in combination with Neamine.
Arbekacin The therapeutic efficacy of Decamethonium can be increased when used in combination with Arbekacin.
Viomycin The therapeutic efficacy of Decamethonium can be increased when used in combination with Viomycin.
Puromycin The therapeutic efficacy of Decamethonium can be increased when used in combination with Puromycin.
Magnesium hydroxide The therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium hydroxide.
Magnesium trisilicate The therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium trisilicate.
Magnesium chloride The therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium chloride.
Magnesium acetate tetrahydrate The therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium acetate tetrahydrate.
Magnesium carbonate The therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium carbonate.
Magnesium citrate The therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium citrate.
Magnesium glycinate The therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium glycinate.
Magnesium Aluminum Silicate The therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium Aluminum Silicate.
Dihydrostreptomycin The therapeutic efficacy of Decamethonium can be increased when used in combination with Dihydrostreptomycin.
Hygromycin B The therapeutic efficacy of Decamethonium can be increased when used in combination with Hygromycin B.
Sisomicin The therapeutic efficacy of Decamethonium can be increased when used in combination with Sisomicin.
Plazomicin The therapeutic efficacy of Decamethonium can be increased when used in combination with Plazomicin.
Magnesium silicate The therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium silicate.
Penimepicycline The therapeutic efficacy of Decamethonium can be increased when used in combination with Penimepicycline.
Magnesium aspartate The therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium aspartate.
Isepamicin The therapeutic efficacy of Decamethonium can be increased when used in combination with Isepamicin.
Magnesium gluconate The therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium gluconate.
Magnesium orotate The therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium orotate.
Magnesium phosphate The therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium phosphate.
Magnesium acetate The therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium acetate.
Mecamylamine The therapeutic efficacy of Decamethonium can be increased when used in combination with Mecamylamine.
Quinidine The therapeutic efficacy of Decamethonium can be increased when used in combination with Quinidine.
Dantrolene The therapeutic efficacy of Decamethonium can be increased when used in combination with Dantrolene.
Magnesium stearate The therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium stearate.
Colistin The therapeutic efficacy of Decamethonium can be increased when used in combination with Colistin.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Decamethonium.
Dipyridamole The therapeutic efficacy of Decamethonium can be decreased when used in combination with Dipyridamole.
Ephedrine Decamethonium may increase the neuromuscular blocking activities of Ephedrine.
Bambuterol Decamethonium may increase the neuromuscular blocking activities of Bambuterol.
Clevidipine Decamethonium may increase the neuromuscular blocking activities of Clevidipine.
Sar9, Met (O2)11-Substance P Decamethonium may increase the neuromuscular blocking activities of Sar9, Met (O2)11-Substance P.
Mirabegron Decamethonium may increase the neuromuscular blocking activities of Mirabegron.
Moxisylyte Decamethonium may increase the neuromuscular blocking activities of Moxisylyte.
Propacetamol Decamethonium may increase the neuromuscular blocking activities of Propacetamol.
Procaine Decamethonium may increase the neuromuscular blocking activities of Procaine.
Cocaine Decamethonium may increase the neuromuscular blocking activities of Cocaine.
Trimethaphan Decamethonium may increase the neuromuscular blocking activities of Trimethaphan.

Target Protein

Neuronal acetylcholine receptor subunit alpha-2 CHRNA2
Acetylcholine receptor subunit alpha CHRNA1
Neuronal acetylcholine receptor subunit alpha-4 CHRNA4
Neuronal acetylcholine receptor subunit beta-2 CHRNB2
Acetylcholinesterase ACHE

Referensi & Sumber

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Contoh Produk & Brand

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International Brands
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Sekuens Gen/Protein (FASTA)

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