Peringatan Keamanan

There has been one experience with overdosage in which a patient inadvertently took a single dose of 1600 mg of bepridil. The patient was observed for 72 hours in intensive care, but no significant adverse experiences were noted.

Bepridil

DB01244

small molecule approved withdrawn

Deskripsi

A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United States, as it has been implicated in causing ventricular arrhythmias (ie. Torsade de pointes).

Struktur Molekul 2D

Berat 366.5396
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 24-50 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapidly and completely absorbed after oral administration.

Metabolisme

Hepatic.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol. Alcohol can potentiate hypotension and dizziness when taken with this drug.
  • 2. Take with food. Food reduces nausea.

Interaksi Obat

1433 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Bepridil is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Bepridil is combined with Levodopa.
Risperidone Bepridil may increase the hypotensive activities of Risperidone.
Ceritinib Bepridil may increase the bradycardic activities of Ceritinib.
Ivabradine Bepridil may increase the bradycardic activities of Ivabradine.
Ruxolitinib Ruxolitinib may increase the bradycardic activities of Bepridil.
Alfuzosin Alfuzosin may increase the hypotensive activities of Bepridil.
Amifostine Bepridil may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Bepridil.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Bepridil.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Bepridil.
Obinutuzumab Bepridil may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Bepridil.
Rituximab Bepridil may increase the hypotensive activities of Rituximab.
Desmopressin Desmopressin may decrease the antihypertensive activities of Bepridil.
Isoetharine Isoetharine may decrease the antihypertensive activities of Bepridil.
Etomidate Etomidate may decrease the antihypertensive activities of Bepridil.
Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Bepridil.
Norepinephrine Norepinephrine may decrease the antihypertensive activities of Bepridil.
Phenylpropanolamine Phenylpropanolamine may decrease the antihypertensive activities of Bepridil.
Doxapram Doxapram may decrease the antihypertensive activities of Bepridil.
Metaraminol Metaraminol may decrease the antihypertensive activities of Bepridil.
Methoxamine Methoxamine may decrease the antihypertensive activities of Bepridil.
Orciprenaline Orciprenaline may decrease the antihypertensive activities of Bepridil.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Bepridil.
Dobutamine Dobutamine may decrease the antihypertensive activities of Bepridil.
Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Bepridil.
Ritodrine Ritodrine may decrease the antihypertensive activities of Bepridil.
Bitolterol Bitolterol may decrease the antihypertensive activities of Bepridil.
Diethylpropion Diethylpropion may decrease the antihypertensive activities of Bepridil.
Naratriptan Naratriptan may decrease the antihypertensive activities of Bepridil.
Rizatriptan Rizatriptan may decrease the antihypertensive activities of Bepridil.
Dopamine Dopamine may decrease the antihypertensive activities of Bepridil.
Frovatriptan Frovatriptan may decrease the antihypertensive activities of Bepridil.
Isoprenaline Isoprenaline may decrease the antihypertensive activities of Bepridil.
Arbutamine Arbutamine may decrease the antihypertensive activities of Bepridil.
Fenoterol Fenoterol may decrease the antihypertensive activities of Bepridil.
Pirbuterol Pirbuterol may decrease the antihypertensive activities of Bepridil.
Ephedra sinica root Ephedra sinica root may decrease the antihypertensive activities of Bepridil.
Ephedrine Ephedrine may decrease the antihypertensive activities of Bepridil.
Mephentermine Mephentermine may decrease the antihypertensive activities of Bepridil.
Procaterol Procaterol may decrease the antihypertensive activities of Bepridil.
Clenbuterol Clenbuterol may decrease the antihypertensive activities of Bepridil.
Bambuterol Bambuterol may decrease the antihypertensive activities of Bepridil.
MMDA MMDA may decrease the antihypertensive activities of Bepridil.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Bepridil.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Bepridil.
Tenamfetamine Tenamfetamine may decrease the antihypertensive activities of Bepridil.
Chlorphentermine Chlorphentermine may decrease the antihypertensive activities of Bepridil.
Phendimetrazine Phendimetrazine may decrease the antihypertensive activities of Bepridil.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Bepridil.
1-benzylimidazole 1-benzylimidazole may decrease the antihypertensive activities of Bepridil.
Amineptine Amineptine may decrease the antihypertensive activities of Bepridil.
Amibegron Amibegron may decrease the antihypertensive activities of Bepridil.
Naluzotan Naluzotan may decrease the antihypertensive activities of Bepridil.
Solabegron Solabegron may decrease the antihypertensive activities of Bepridil.
Droxidopa Droxidopa may decrease the antihypertensive activities of Bepridil.
Nitrous oxide Nitrous oxide may decrease the antihypertensive activities of Bepridil.
Isometheptene Isometheptene may decrease the antihypertensive activities of Bepridil.
Levonordefrin Levonordefrin may decrease the antihypertensive activities of Bepridil.
Naphazoline Naphazoline may decrease the antihypertensive activities of Bepridil.
Tetryzoline Tetryzoline may decrease the antihypertensive activities of Bepridil.
Cinitapride Cinitapride may decrease the antihypertensive activities of Bepridil.
Tyramine Tyramine may decrease the antihypertensive activities of Bepridil.
Adrafinil Adrafinil may decrease the antihypertensive activities of Bepridil.
Ifenprodil Ifenprodil may decrease the antihypertensive activities of Bepridil.
Hexoprenaline Hexoprenaline may decrease the antihypertensive activities of Bepridil.
Etilefrine Etilefrine may decrease the antihypertensive activities of Bepridil.
Dimetacrine Dimetacrine may decrease the antihypertensive activities of Bepridil.
Cirazoline Cirazoline may decrease the antihypertensive activities of Bepridil.
Synephrine Synephrine may decrease the antihypertensive activities of Bepridil.
Moxisylyte Moxisylyte may decrease the antihypertensive activities of Bepridil.
Oxaprotiline Oxaprotiline may decrease the antihypertensive activities of Bepridil.
Iofetamine I-123 Iofetamine I-123 may decrease the antihypertensive activities of Bepridil.
Racepinephrine Racepinephrine may decrease the antihypertensive activities of Bepridil.
DL-Methylephedrine DL-Methylephedrine may decrease the antihypertensive activities of Bepridil.
Amitraz Amitraz may decrease the antihypertensive activities of Bepridil.
Medetomidine Medetomidine may decrease the antihypertensive activities of Bepridil.
Xylazine Xylazine may decrease the antihypertensive activities of Bepridil.
Atipamezole Atipamezole may decrease the antihypertensive activities of Bepridil.
Ractopamine Ractopamine may decrease the antihypertensive activities of Bepridil.
Romifidine Romifidine may decrease the antihypertensive activities of Bepridil.
Detomidine Detomidine may decrease the antihypertensive activities of Bepridil.
Etafedrine Etafedrine may decrease the antihypertensive activities of Bepridil.
Tetrahydrocannabivarin Tetrahydrocannabivarin may decrease the antihypertensive activities of Bepridil.
PF-00610355 PF-00610355 may decrease the antihypertensive activities of Bepridil.
Ritobegron Ritobegron may decrease the antihypertensive activities of Bepridil.
Abediterol Abediterol may decrease the antihypertensive activities of Bepridil.
Tulobuterol Tulobuterol may decrease the antihypertensive activities of Bepridil.
Dopexamine Dopexamine may decrease the antihypertensive activities of Bepridil.
Piclozotan Piclozotan may decrease the antihypertensive activities of Bepridil.
Idazoxan Idazoxan may decrease the antihypertensive activities of Bepridil.
Higenamine Higenamine may decrease the antihypertensive activities of Bepridil.
Reproterol Reproterol may decrease the antihypertensive activities of Bepridil.
Theodrenaline Theodrenaline may decrease the antihypertensive activities of Bepridil.
Tramazoline Tramazoline may decrease the antihypertensive activities of Bepridil.
Mephedrone Mephedrone may decrease the antihypertensive activities of Bepridil.
Amitriptylinoxide Amitriptylinoxide may decrease the antihypertensive activities of Bepridil.
Dibenzepin Dibenzepin may decrease the antihypertensive activities of Bepridil.
Quinupramine Quinupramine may decrease the antihypertensive activities of Bepridil.

Target Protein

Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A
Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H
Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2
Sodium/potassium-transporting ATPase subunit alpha-1 ATP1A1
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1
Troponin C, slow skeletal and cardiac muscles TNNC1
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A
Voltage-gated inwardly rectifying potassium channel KCNH2 KCNH2
Calmodulin CALM1

Referensi & Sumber

Synthesis reference: Mauvernay, R.Y., Busch, N., Moleyre, J., Monteil, A. and Simond, J.; U.S. Patent 3,962,238; June 8,1976; assigned to Centre Europeen de Recherches Mauvernay "CERM".

Contoh Produk & Brand

Produk: 0 • International brands: 3
International Brands
  • Angopril
  • Cordium
  • Vascor

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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