Peringatan Keamanan

Symptoms of overdose include difficulty in breathing (severe), dizziness (severe), drowsiness (severe), muscle trembling, jerking, stiffness, or uncontrolled movements (severe), small pupils, unusual excitement, and unusual tiredness or weakness (severe).

Chlorprothixene

DB01239

small molecule approved experimental investigational withdrawn

Deskripsi

Chlorprothixene is a typical antipsychotic drug of the thioxanthene (tricyclic) class. Chlorprothixene exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.

Struktur Molekul 2D

Berat 315.86
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 8 to 12 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Incomplete bioavailability.

Metabolisme

Hepatic

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol.
  • 2. Take with food. Food reduces irritation.

Interaksi Obat

1276 Data
Buprenorphine Chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Chlorprothixene.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Chlorprothixene.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Chlorprothixene.
Hydrocodone Chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Magnesium sulfate The therapeutic efficacy of Chlorprothixene can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Chlorprothixene may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Chlorprothixene.
Mirtazapine Chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Chlorprothixene.
Orphenadrine Chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Chlorprothixene.
Rotigotine Chlorprothixene may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Chlorprothixene.
Sodium oxybate Chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Chlorprothixene.
Thalidomide Chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Aclidinium The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Aclidinium.
Mianserin Mianserin may increase the anticholinergic activities of Chlorprothixene.
Mirabegron The risk or severity of urinary retention can be increased when Chlorprothixene is combined with Mirabegron.
Potassium chloride The risk or severity of gastrointestinal ulceration can be increased when Chlorprothixene is combined with Potassium chloride.
Pramlintide The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Chlorprothixene.
Secretin porcine The therapeutic efficacy of Secretin porcine can be decreased when used in combination with Chlorprothixene.
Tiotropium The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Tiotropium.
Topiramate The risk or severity of hyperthermia and oligohydrosis can be increased when Chlorprothixene is combined with Topiramate.
Umeclidinium The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Umeclidinium.
Amisulpride Chlorprothixene may increase the antipsychotic activities of Amisulpride.
Methylphenidate The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Methylphenidate.
Dexmethylphenidate The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Dexmethylphenidate.
Metoclopramide The risk or severity of adverse effects can be increased when Metoclopramide is combined with Chlorprothixene.
Quinagolide The therapeutic efficacy of Quinagolide can be decreased when used in combination with Chlorprothixene.
Sulpiride Chlorprothixene may increase the antipsychotic activities of Sulpiride.
Benzylpenicilloyl polylysine Chlorprothixene may decrease effectiveness of Benzylpenicilloyl polylysine as a diagnostic agent.
Betahistine The therapeutic efficacy of Betahistine can be decreased when used in combination with Chlorprothixene.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Chlorprothixene.
Lithium citrate Lithium citrate may increase the neurotoxic activities of Chlorprothixene.
Lithium hydroxide Lithium hydroxide may increase the neurotoxic activities of Chlorprothixene.
Mequitazine Chlorprothixene may increase the arrhythmogenic activities of Mequitazine.
Glycopyrronium The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Glycopyrronium.
Dicoumarol The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Dicoumarol.
Phenindione The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Phenindione.
Warfarin The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Warfarin.
Phenprocoumon The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Phenprocoumon.
Acenocoumarol The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Acenocoumarol.
4-hydroxycoumarin The risk or severity of adverse effects can be increased when Chlorprothixene is combined with 4-hydroxycoumarin.
Coumarin The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Coumarin.
(R)-warfarin The risk or severity of adverse effects can be increased when Chlorprothixene is combined with (R)-warfarin.
Ethyl biscoumacetate The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Ethyl biscoumacetate.
Fluindione The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Fluindione.
Clorindione The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Clorindione.
Diphenadione The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Diphenadione.
Tioclomarol The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Tioclomarol.
(S)-Warfarin The risk or severity of adverse effects can be increased when Chlorprothixene is combined with (S)-Warfarin.
Botulinum toxin type A The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Botulinum toxin type A.
Glucagon Chlorprothixene may increase the gastrointestinal motility reducing activities of Glucagon.
Botulinum toxin type B The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Botulinum toxin type B.
Eluxadoline The risk or severity of constipation can be increased when Chlorprothixene is combined with Eluxadoline.
Ramosetron The risk or severity of constipation can be increased when Chlorprothixene is combined with Ramosetron.
Ethanol Chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Chlorprothixene may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Chlorprothixene.
Zimelidine The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Dapoxetine.
Seproxetine The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Seproxetine.
Fluvoxamine The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Fluvoxamine.
Citalopram The risk or severity of QTc prolongation can be increased when Chlorprothixene is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Duloxetine.
Paroxetine The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Nefazodone.
Escitalopram The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Escitalopram.
Milnacipran The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Desvenlafaxine.
Levomilnacipran The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Chlorprothixene.
Indalpine The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Alaproclate.
Amphetamine Amphetamine may decrease the sedative activities of Chlorprothixene.
Phentermine Phentermine may decrease the sedative activities of Chlorprothixene.
Pseudoephedrine Pseudoephedrine may decrease the sedative activities of Chlorprothixene.
Benzphetamine Benzphetamine may decrease the sedative activities of Chlorprothixene.
Diethylpropion Diethylpropion may decrease the sedative activities of Chlorprothixene.
Lisdexamfetamine Lisdexamfetamine may decrease the sedative activities of Chlorprothixene.
Mephentermine Mephentermine may decrease the sedative activities of Chlorprothixene.
MMDA MMDA may decrease the sedative activities of Chlorprothixene.
Midomafetamine Midomafetamine may decrease the sedative activities of Chlorprothixene.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Chlorprothixene.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Chlorprothixene.
Tenamfetamine Tenamfetamine may decrease the sedative activities of Chlorprothixene.
Chlorphentermine Chlorphentermine may decrease the sedative activities of Chlorprothixene.
Methylenedioxyethamphetamine Methylenedioxyethamphetamine may decrease the sedative activities of Chlorprothixene.
Dextroamphetamine Dextroamphetamine may decrease the sedative activities of Chlorprothixene.
Metamfetamine Metamfetamine may decrease the sedative activities of Chlorprothixene.
Iofetamine I-123 Iofetamine I-123 may decrease the sedative activities of Chlorprothixene.
Ritobegron Ritobegron may decrease the sedative activities of Chlorprothixene.

Target Protein

D(2) dopamine receptor DRD2
D(1A) dopamine receptor DRD1
D(3) dopamine receptor DRD3
5-hydroxytryptamine receptor 2A HTR2A
Histamine H1 receptor HRH1
Serotonin Receptors HTR1A
Muscarinic acetylcholine receptor M1 CHRM1
Muscarinic acetylcholine receptor M2 CHRM2
Muscarinic acetylcholine receptor M3 CHRM3
Muscarinic acetylcholine receptor M4 CHRM4
Muscarinic acetylcholine receptor M5 CHRM5

Referensi & Sumber

Synthesis reference: Sprague, J.M. and Engelhardt, E.L.; US. Patent 2,951,082; August 30, 1960; assigned to Merck & Co., Inc. Schlapfer, R. and Spiegelberg, H.; US. Patent 3,115,502; December 24,1963; assigned to Hoffmann-LaRoche Inc.

Contoh Produk & Brand

Produk: 0 • International brands: 3
International Brands
  • Clothixen — Yoshitomi
  • Cloxan — Orion
  • Taractan — Roche

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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