There is no readily available data for the use of levodopa in pregnancyLabel. Rabbits treated with levodopa and carbidopa produced smaller litters and their offspring developed visceral and skeletal deformitiesLabel. Levodopa may lower prolactin and interfere with lactation but there is limited human data to demonstrate this effectLabel. Levodopa is present in human breast milk and so the potential effects of nursing while taking levodopa should be considered before prescribing levodopa to nursing mothersLabel. There is currently a lack of data on the safety and effectiveness of using levodopa in pediatric patientsLabel. Patients over 65 years of age are more likely to experience adverse effects associated with taking levodopa, however this generally is not sufficient to exclude this patient group from treatmentLabel.
Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrierLabel. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prevent metabolism until after it has crossed the blood-brain barrierLabel,A177781. Once past the blood-brain barrier, levodopa is metabolized to dopamine and supplements the low endogenous levels of dopamine to treat symptoms of Parkinson'sLabel. The first developed drug product that was approved by the FDA was a levodopa and carbidopa combined product called Sinemet that was approved on May 2, 1975A177781,L6133.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Duloxetine | The risk or severity of orthostatic hypotension and syncope can be increased when Levodopa is combined with Duloxetine. |
| Aldesleukin | The risk or severity of hypotension and orthostatic hypotension can be increased when Aldesleukin is combined with Levodopa. |
| Streptokinase | The risk or severity of hypotension and orthostatic hypotension can be increased when Streptokinase is combined with Levodopa. |
| Valsartan | The risk or severity of hypotension and orthostatic hypotension can be increased when Valsartan is combined with Levodopa. |
| Ramipril | The risk or severity of hypotension and orthostatic hypotension can be increased when Ramipril is combined with Levodopa. |
| Esmolol | The risk or severity of hypotension and orthostatic hypotension can be increased when Esmolol is combined with Levodopa. |
| Betaxolol | The risk or severity of hypotension and orthostatic hypotension can be increased when Betaxolol is combined with Levodopa. |
| Reserpine | The risk or severity of hypotension and orthostatic hypotension can be increased when Reserpine is combined with Levodopa. |
| Torasemide | The risk or severity of hypotension and orthostatic hypotension can be increased when Torasemide is combined with Levodopa. |
| Methyclothiazide | The risk or severity of hypotension and orthostatic hypotension can be increased when Methyclothiazide is combined with Levodopa. |
| Metoprolol | The risk or severity of hypotension and orthostatic hypotension can be increased when Metoprolol is combined with Levodopa. |
| Ropinirole | The risk or severity of hypotension and orthostatic hypotension can be increased when Ropinirole is combined with Levodopa. |
| Isradipine | The risk or severity of hypotension and orthostatic hypotension can be increased when Isradipine is combined with Levodopa. |
| Olmesartan | The risk or severity of hypotension and orthostatic hypotension can be increased when Olmesartan is combined with Levodopa. |
| Morphine | The risk or severity of hypotension and orthostatic hypotension can be increased when Morphine is combined with Levodopa. |
| Ropivacaine | The risk or severity of hypotension and orthostatic hypotension can be increased when Ropivacaine is combined with Levodopa. |
| Bupivacaine | The risk or severity of hypotension and orthostatic hypotension can be increased when Bupivacaine is combined with Levodopa. |
| Chlorthalidone | The risk or severity of hypotension and orthostatic hypotension can be increased when Chlorthalidone is combined with Levodopa. |
| Tolcapone | The risk or severity of hypotension and orthostatic hypotension can be increased when Tolcapone is combined with Levodopa. |
| Nitroprusside | The risk or severity of hypotension and orthostatic hypotension can be increased when Nitroprusside is combined with Levodopa. |
| Atenolol | The risk or severity of hypotension and orthostatic hypotension can be increased when Atenolol is combined with Levodopa. |
| Diltiazem | The risk or severity of hypotension and orthostatic hypotension can be increased when Diltiazem is combined with Levodopa. |
| Minoxidil | The risk or severity of hypotension and orthostatic hypotension can be increased when Minoxidil is combined with Levodopa. |
| Timolol | The risk or severity of hypotension and orthostatic hypotension can be increased when Timolol is combined with Levodopa. |
| Amlodipine | The risk or severity of hypotension and orthostatic hypotension can be increased when Amlodipine is combined with Levodopa. |
| Triamterene | The risk or severity of hypotension and orthostatic hypotension can be increased when Triamterene is combined with Levodopa. |
| Nimodipine | The risk or severity of hypotension and orthostatic hypotension can be increased when Nimodipine is combined with Levodopa. |
| Nisoldipine | The risk or severity of hypotension and orthostatic hypotension can be increased when Nisoldipine is combined with Levodopa. |
| Pramipexole | The risk or severity of hypotension and orthostatic hypotension can be increased when Pramipexole is combined with Levodopa. |
| Spironolactone | The risk or severity of hypotension and orthostatic hypotension can be increased when Spironolactone is combined with Levodopa. |
| Nitric Oxide | The risk or severity of hypotension and orthostatic hypotension can be increased when Nitric Oxide is combined with Levodopa. |
| Bendroflumethiazide | The risk or severity of hypotension and orthostatic hypotension can be increased when Bendroflumethiazide is combined with Levodopa. |
| Prazosin | The risk or severity of hypotension and orthostatic hypotension can be increased when Prazosin is combined with Levodopa. |
| Nabilone | The risk or severity of hypotension and orthostatic hypotension can be increased when Nabilone is combined with Levodopa. |
| Sotalol | The risk or severity of hypotension and orthostatic hypotension can be increased when Sotalol is combined with Levodopa. |
| Fosinopril | The risk or severity of hypotension and orthostatic hypotension can be increased when Fosinopril is combined with Levodopa. |
| Trandolapril | The risk or severity of hypotension and orthostatic hypotension can be increased when Trandolapril is combined with Levodopa. |
| Metolazone | The risk or severity of hypotension and orthostatic hypotension can be increased when Metolazone is combined with Levodopa. |
| Lercanidipine | The risk or severity of hypotension and orthostatic hypotension can be increased when Lercanidipine is combined with Levodopa. |
| Benazepril | The risk or severity of hypotension and orthostatic hypotension can be increased when Benazepril is combined with Levodopa. |
| Propranolol | The risk or severity of hypotension and orthostatic hypotension can be increased when Propranolol is combined with Levodopa. |
| Enalapril | The risk or severity of hypotension and orthostatic hypotension can be increased when Enalapril is combined with Levodopa. |
| Doxazosin | The risk or severity of hypotension and orthostatic hypotension can be increased when Doxazosin is combined with Levodopa. |
| Amiloride | The risk or severity of hypotension and orthostatic hypotension can be increased when Amiloride is combined with Levodopa. |
| Labetalol | The risk or severity of hypotension and orthostatic hypotension can be increased when Labetalol is combined with Levodopa. |
| Thiopental | The risk or severity of hypotension and orthostatic hypotension can be increased when Thiopental is combined with Levodopa. |
| Bisoprolol | The risk or severity of hypotension and orthostatic hypotension can be increased when Bisoprolol is combined with Levodopa. |
| Clofarabine | The risk or severity of hypotension and orthostatic hypotension can be increased when Clofarabine is combined with Levodopa. |
| Dexmedetomidine | The risk or severity of hypotension and orthostatic hypotension can be increased when Dexmedetomidine is combined with Levodopa. |
| Mecamylamine | The risk or severity of hypotension and orthostatic hypotension can be increased when Mecamylamine is combined with Levodopa. |
| Verapamil | The risk or severity of hypotension and orthostatic hypotension can be increased when Verapamil is combined with Levodopa. |
| Losartan | The risk or severity of hypotension and orthostatic hypotension can be increased when Losartan is combined with Levodopa. |
| Thioridazine | The risk or severity of hypotension and orthostatic hypotension can be increased when Thioridazine is combined with Levodopa. |
| Amphotericin B | The risk or severity of hypotension and orthostatic hypotension can be increased when Amphotericin B is combined with Levodopa. |
| Moexipril | The risk or severity of hypotension and orthostatic hypotension can be increased when Moexipril is combined with Levodopa. |
| Phentolamine | The risk or severity of hypotension and orthostatic hypotension can be increased when Phentolamine is combined with Levodopa. |
| Furosemide | The risk or severity of hypotension and orthostatic hypotension can be increased when Furosemide is combined with Levodopa. |
| Tizanidine | The risk or severity of hypotension and orthostatic hypotension can be increased when Tizanidine is combined with Levodopa. |
| Eplerenone | The risk or severity of hypotension and orthostatic hypotension can be increased when Eplerenone is combined with Levodopa. |
| Methazolamide | The risk or severity of hypotension and orthostatic hypotension can be increased when Methazolamide is combined with Levodopa. |
| Tamsulosin | The risk or severity of hypotension and orthostatic hypotension can be increased when Tamsulosin is combined with Levodopa. |
| Sufentanil | The risk or severity of hypotension and orthostatic hypotension can be increased when Sufentanil is combined with Levodopa. |
| Apomorphine | The risk or severity of hypotension and orthostatic hypotension can be increased when Apomorphine is combined with Levodopa. |
| Lisinopril | The risk or severity of hypotension and orthostatic hypotension can be increased when Lisinopril is combined with Levodopa. |
| Nitroglycerin | The risk or severity of hypotension and orthostatic hypotension can be increased when Nitroglycerin is combined with Levodopa. |
| Mannitol | The risk or severity of hypotension and orthostatic hypotension can be increased when Mannitol is combined with Levodopa. |
| Isoflurane | The risk or severity of hypotension and orthostatic hypotension can be increased when Isoflurane is combined with Levodopa. |
| Hydroflumethiazide | The risk or severity of hypotension and orthostatic hypotension can be increased when Hydroflumethiazide is combined with Levodopa. |
| Perindopril | The risk or severity of hypotension and orthostatic hypotension can be increased when Perindopril is combined with Levodopa. |
| Candesartan cilexetil | The risk or severity of hypotension and orthostatic hypotension can be increased when Candesartan cilexetil is combined with Levodopa. |
| Tolazoline | The risk or severity of hypotension and orthostatic hypotension can be increased when Tolazoline is combined with Levodopa. |
| Fenoldopam | The risk or severity of hypotension and orthostatic hypotension can be increased when Fenoldopam is combined with Levodopa. |
| Indapamide | The risk or severity of hypotension and orthostatic hypotension can be increased when Indapamide is combined with Levodopa. |
| Propofol | The risk or severity of hypotension and orthostatic hypotension can be increased when Propofol is combined with Levodopa. |
| Conivaptan | The risk or severity of hypotension and orthostatic hypotension can be increased when Conivaptan is combined with Levodopa. |
| Eprosartan | The risk or severity of hypotension and orthostatic hypotension can be increased when Eprosartan is combined with Levodopa. |
| Chlorothiazide | The risk or severity of hypotension and orthostatic hypotension can be increased when Chlorothiazide is combined with Levodopa. |
| Quinapril | The risk or severity of hypotension and orthostatic hypotension can be increased when Quinapril is combined with Levodopa. |
| Isosorbide dinitrate | The risk or severity of hypotension and orthostatic hypotension can be increased when Isosorbide dinitrate is combined with Levodopa. |
| Bumetanide | The risk or severity of hypotension and orthostatic hypotension can be increased when Bumetanide is combined with Levodopa. |
| Remifentanil | The risk or severity of hypotension and orthostatic hypotension can be increased when Remifentanil is combined with Levodopa. |
| Etacrynic acid | The risk or severity of hypotension and orthostatic hypotension can be increased when Etacrynic acid is combined with Levodopa. |
| Levosimendan | The risk or severity of hypotension and orthostatic hypotension can be increased when Levosimendan is combined with Levodopa. |
| Phenoxybenzamine | The risk or severity of hypotension and orthostatic hypotension can be increased when Phenoxybenzamine is combined with Levodopa. |
| Pindolol | The risk or severity of hypotension and orthostatic hypotension can be increased when Pindolol is combined with Levodopa. |
| Telmisartan | The risk or severity of hypotension and orthostatic hypotension can be increased when Telmisartan is combined with Levodopa. |
| Methyldopa | The risk or severity of hypotension and orthostatic hypotension can be increased when Methyldopa is combined with Levodopa. |
| Dipyridamole | The risk or severity of hypotension and orthostatic hypotension can be increased when Dipyridamole is combined with Levodopa. |
| Hydrochlorothiazide | The risk or severity of hypotension and orthostatic hypotension can be increased when Hydrochlorothiazide is combined with Levodopa. |
| Levobupivacaine | The risk or severity of hypotension and orthostatic hypotension can be increased when Levobupivacaine is combined with Levodopa. |
| Guanfacine | The risk or severity of hypotension and orthostatic hypotension can be increased when Guanfacine is combined with Levodopa. |
| Isosorbide mononitrate | The risk or severity of hypotension and orthostatic hypotension can be increased when Isosorbide mononitrate is combined with Levodopa. |
| Felodipine | The risk or severity of hypotension and orthostatic hypotension can be increased when Felodipine is combined with Levodopa. |
| Irbesartan | The risk or severity of hypotension and orthostatic hypotension can be increased when Irbesartan is combined with Levodopa. |
| Nitrendipine | The risk or severity of hypotension and orthostatic hypotension can be increased when Nitrendipine is combined with Levodopa. |
| Iloprost | The risk or severity of hypotension and orthostatic hypotension can be increased when Iloprost is combined with Levodopa. |
| Nifedipine | The risk or severity of hypotension and orthostatic hypotension can be increased when Nifedipine is combined with Levodopa. |
| Amiodarone | The risk or severity of hypotension and orthostatic hypotension can be increased when Amiodarone is combined with Levodopa. |
| Diazoxide | The risk or severity of hypotension and orthostatic hypotension can be increased when Diazoxide is combined with Levodopa. |
| Carvedilol | The risk or severity of hypotension and orthostatic hypotension can be increased when Carvedilol is combined with Levodopa. |