Peringatan Keamanan

Symptoms of overdose include drowsiness (severe); shortness of breath or troubled breathing; unusual tiredness or weakness (severe).

Diphenidol

DB01231

small molecule approved investigational withdrawn

Deskripsi

Diphenidol is an antiemetic agent used in the treatment of vomiting and vertigo. Diphenidol overdose may result in serious toxicity in children.

Struktur Molekul 2D

Berat 309.4452
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 4 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Well absorbed from gastrointestinal tract following oral administration.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

516 Data
Aclidinium The risk or severity of adverse effects can be increased when Diphenidol is combined with Aclidinium.
Mianserin Mianserin may increase the anticholinergic activities of Diphenidol.
Mirabegron The risk or severity of urinary retention can be increased when Diphenidol is combined with Mirabegron.
Potassium chloride The risk or severity of gastrointestinal ulceration can be increased when Diphenidol is combined with Potassium chloride.
Pramlintide The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Diphenidol.
Secretin porcine The therapeutic efficacy of Secretin porcine can be decreased when used in combination with Diphenidol.
Tiotropium The risk or severity of adverse effects can be increased when Diphenidol is combined with Tiotropium.
Topiramate The risk or severity of hyperthermia and oligohydrosis can be increased when Diphenidol is combined with Topiramate.
Umeclidinium The risk or severity of adverse effects can be increased when Diphenidol is combined with Umeclidinium.
Glycopyrronium The risk or severity of adverse effects can be increased when Diphenidol is combined with Glycopyrronium.
Botulinum toxin type A The risk or severity of adverse effects can be increased when Diphenidol is combined with Botulinum toxin type A.
Glucagon Diphenidol may increase the gastrointestinal motility reducing activities of Glucagon.
Sulpiride Diphenidol may increase the anticholinergic activities of Sulpiride.
Botulinum toxin type B The risk or severity of adverse effects can be increased when Diphenidol is combined with Botulinum toxin type B.
Eluxadoline The risk or severity of constipation can be increased when Diphenidol is combined with Eluxadoline.
Ramosetron The risk or severity of constipation can be increased when Diphenidol is combined with Ramosetron.
Naltrexone The risk or severity of adverse effects can be increased when Diphenidol is combined with Naltrexone.
Bezitramide The risk or severity of adverse effects can be increased when Diphenidol is combined with Bezitramide.
Tramadol The risk or severity of adverse effects can be increased when Diphenidol is combined with Tramadol.
Morphine The risk or severity of adverse effects can be increased when Diphenidol is combined with Morphine.
Codeine The risk or severity of adverse effects can be increased when Diphenidol is combined with Codeine.
Hydromorphone The risk or severity of adverse effects can be increased when Diphenidol is combined with Hydromorphone.
Methadone The risk or severity of adverse effects can be increased when Diphenidol is combined with Methadone.
Meperidine The risk or severity of adverse effects can be increased when Diphenidol is combined with Meperidine.
Oxycodone The risk or severity of adverse effects can be increased when Diphenidol is combined with Oxycodone.
Butorphanol The risk or severity of adverse effects can be increased when Diphenidol is combined with Butorphanol.
Dextropropoxyphene The risk or severity of adverse effects can be increased when Diphenidol is combined with Dextropropoxyphene.
Pentazocine The risk or severity of adverse effects can be increased when Diphenidol is combined with Pentazocine.
Sufentanil The risk or severity of adverse effects can be increased when Diphenidol is combined with Sufentanil.
Alfentanil The risk or severity of adverse effects can be increased when Diphenidol is combined with Alfentanil.
Fentanyl The risk or severity of adverse effects can be increased when Diphenidol is combined with Fentanyl.
Nalbuphine The risk or severity of adverse effects can be increased when Diphenidol is combined with Nalbuphine.
Levorphanol The risk or severity of adverse effects can be increased when Diphenidol is combined with Levorphanol.
Remifentanil The risk or severity of adverse effects can be increased when Diphenidol is combined with Remifentanil.
Buprenorphine The risk or severity of adverse effects can be increased when Diphenidol is combined with Buprenorphine.
Hydrocodone The risk or severity of adverse effects can be increased when Diphenidol is combined with Hydrocodone.
Diphenoxylate The risk or severity of adverse effects can be increased when Diphenidol is combined with Diphenoxylate.
Oxymorphone The risk or severity of adverse effects can be increased when Diphenidol is combined with Oxymorphone.
Dezocine The risk or severity of adverse effects can be increased when Diphenidol is combined with Dezocine.
Levacetylmethadol The risk or severity of adverse effects can be increased when Diphenidol is combined with Levacetylmethadol.
Methadyl acetate The risk or severity of adverse effects can be increased when Diphenidol is combined with Methadyl acetate.
Dihydroetorphine The risk or severity of adverse effects can be increased when Diphenidol is combined with Dihydroetorphine.
Diamorphine The risk or severity of adverse effects can be increased when Diphenidol is combined with Diamorphine.
Ethylmorphine The risk or severity of adverse effects can be increased when Diphenidol is combined with Ethylmorphine.
Etorphine The risk or severity of adverse effects can be increased when Diphenidol is combined with Etorphine.
Dextromoramide The risk or severity of adverse effects can be increased when Diphenidol is combined with Dextromoramide.
Desomorphine The risk or severity of adverse effects can be increased when Diphenidol is combined with Desomorphine.
Carfentanil The risk or severity of adverse effects can be increased when Diphenidol is combined with Carfentanil.
Dihydrocodeine The risk or severity of adverse effects can be increased when Diphenidol is combined with Dihydrocodeine.
Alphacetylmethadol The risk or severity of adverse effects can be increased when Diphenidol is combined with Alphacetylmethadol.
Dihydromorphine The risk or severity of adverse effects can be increased when Diphenidol is combined with Dihydromorphine.
Tapentadol The risk or severity of urinary retention and constipation can be increased when Diphenidol is combined with Tapentadol.
Ketobemidone The risk or severity of adverse effects can be increased when Diphenidol is combined with Ketobemidone.
DPDPE The risk or severity of adverse effects can be increased when Diphenidol is combined with DPDPE.
Lofentanil The risk or severity of adverse effects can be increased when Diphenidol is combined with Lofentanil.
Opium The risk or severity of adverse effects can be increased when Diphenidol is combined with Opium.
Normethadone The risk or severity of adverse effects can be increased when Diphenidol is combined with Normethadone.
Piritramide The risk or severity of adverse effects can be increased when Diphenidol is combined with Piritramide.
Alphaprodine The risk or severity of adverse effects can be increased when Diphenidol is combined with Alphaprodine.
Nicomorphine The risk or severity of adverse effects can be increased when Diphenidol is combined with Nicomorphine.
Meptazinol The risk or severity of adverse effects can be increased when Diphenidol is combined with Meptazinol.
Phenoperidine The risk or severity of adverse effects can be increased when Diphenidol is combined with Phenoperidine.
Phenazocine The risk or severity of adverse effects can be increased when Diphenidol is combined with Phenazocine.
Tilidine The risk or severity of adverse effects can be increased when Diphenidol is combined with Tilidine.
Carfentanil, C-11 The risk or severity of adverse effects can be increased when Diphenidol is combined with Carfentanil, C-11.
Benzhydrocodone The risk or severity of adverse effects can be increased when Diphenidol is combined with Benzhydrocodone.
Naloxegol The risk or severity of adverse effects can be increased when Diphenidol is combined with Naloxegol.
Trospium The risk or severity of adverse effects can be increased when Trospium is combined with Diphenidol.
Oxyphenonium The risk or severity of adverse effects can be increased when Oxyphenonium is combined with Diphenidol.
Benzatropine The risk or severity of adverse effects can be increased when Benzatropine is combined with Diphenidol.
Disopyramide The risk or severity of adverse effects can be increased when Disopyramide is combined with Diphenidol.
Metixene The risk or severity of adverse effects can be increased when Metixene is combined with Diphenidol.
Terfenadine The risk or severity of adverse effects can be increased when Terfenadine is combined with Diphenidol.
Buclizine The risk or severity of adverse effects can be increased when Buclizine is combined with Diphenidol.
Trihexyphenidyl The risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Diphenidol.
Oxyphencyclimine The risk or severity of adverse effects can be increased when Oxyphencyclimine is combined with Diphenidol.
Procyclidine The risk or severity of adverse effects can be increased when Procyclidine is combined with Diphenidol.
Hyoscyamine The risk or severity of adverse effects can be increased when Hyoscyamine is combined with Diphenidol.
Methscopolamine bromide The risk or severity of adverse effects can be increased when Methscopolamine bromide is combined with Diphenidol.
Darifenacin The risk or severity of adverse effects can be increased when Darifenacin is combined with Diphenidol.
Tridihexethyl The risk or severity of adverse effects can be increased when Tridihexethyl is combined with Diphenidol.
Anisotropine methylbromide The risk or severity of adverse effects can be increased when Anisotropine methylbromide is combined with Diphenidol.
Atropine The risk or severity of adverse effects can be increased when Atropine is combined with Diphenidol.
Nicardipine The risk or severity of adverse effects can be increased when Nicardipine is combined with Diphenidol.
Mecamylamine The risk or severity of adverse effects can be increased when Mecamylamine is combined with Diphenidol.
Pirenzepine The risk or severity of adverse effects can be increased when Pirenzepine is combined with Diphenidol.
Homatropine methylbromide The risk or severity of adverse effects can be increased when Homatropine methylbromide is combined with Diphenidol.
Benzquinamide The risk or severity of adverse effects can be increased when Benzquinamide is combined with Diphenidol.
Propantheline The risk or severity of adverse effects can be increased when Propantheline is combined with Diphenidol.
Dicyclomine The risk or severity of adverse effects can be increased when Dicyclomine is combined with Diphenidol.
Tropicamide The risk or severity of adverse effects can be increased when Tropicamide is combined with Diphenidol.
Cocaine The risk or severity of adverse effects can be increased when Cocaine is combined with Diphenidol.
Quinidine The risk or severity of adverse effects can be increased when Quinidine is combined with Diphenidol.
Amantadine The risk or severity of adverse effects can be increased when Amantadine is combined with Diphenidol.
Methantheline The risk or severity of adverse effects can be increased when Methantheline is combined with Diphenidol.
Cycrimine The risk or severity of adverse effects can be increased when Cycrimine is combined with Diphenidol.
Cyclopentolate The risk or severity of adverse effects can be increased when Cyclopentolate is combined with Diphenidol.
Tolterodine The risk or severity of adverse effects can be increased when Tolterodine is combined with Diphenidol.
Oxybutynin The risk or severity of adverse effects can be increased when Oxybutynin is combined with Diphenidol.
Pentolinium The risk or severity of adverse effects can be increased when Pentolinium is combined with Diphenidol.

Target Protein

Muscarinic acetylcholine receptor M4 CHRM4
Muscarinic acetylcholine receptor M2 CHRM2
Muscarinic acetylcholine receptor M1 CHRM1
Muscarinic acetylcholine receptor M3 CHRM3

Referensi & Sumber

Synthesis reference: Miescher, K. and Marxer, A.; U.S. Patent 2,411,664; November 26, 1946; assigned to Ciba Pharmaceutical Products, Inc.
Link

Contoh Produk & Brand

Produk: 1 • International brands: 3
Produk
  • Vontrol
    Tablet • 25 mg/1 • Oral • US • Approved
International Brands
  • Satanolon — Tatsumi Kagaku
  • Verterge
  • Yesdol

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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