Peringatan Keamanan

Signs of overdose include apnea, circulatory collapse, pulmonary edema, cardiac arrest, and death.

Levacetylmethadol

DB01227

small molecule approved investigational withdrawn

Deskripsi

Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence.

Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well.L44052,T862

Struktur Molekul 2D

Berat 353.4977
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 2.6 days
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Levomethadyl acetate is rapidly absorbed from an oral solution.

Metabolisme

Levomethadyl acetate is demethylated to nor-levomethadyl acetate which is again demethylated to dinor-levomethadyl acetate. This extensive first pass metabolism produces 2 metabolites that are more active than the parent drug.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1538 Data
Ivabradine Ivabradine may increase the QTc-prolonging activities of Levacetylmethadol.
Modafinil The metabolism of Levacetylmethadol can be increased when combined with Modafinil.
Armodafinil The metabolism of Levacetylmethadol can be increased when combined with Armodafinil.
Buprenorphine Levacetylmethadol may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Levacetylmethadol.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Levacetylmethadol.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Levacetylmethadol.
Hydrocodone Levacetylmethadol may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Magnesium sulfate The therapeutic efficacy of Levacetylmethadol can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Levacetylmethadol may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Levacetylmethadol may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Levacetylmethadol.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Levacetylmethadol.
Orphenadrine Levacetylmethadol may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Levacetylmethadol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Levacetylmethadol.
Pramipexole Levacetylmethadol may increase the sedative activities of Pramipexole.
Ropinirole Levacetylmethadol may increase the sedative activities of Ropinirole.
Rotigotine Levacetylmethadol may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Levacetylmethadol.
Sodium oxybate Levacetylmethadol may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Levacetylmethadol may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Levacetylmethadol.
Thalidomide Levacetylmethadol may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Levacetylmethadol may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Alvimopan The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with Alvimopan.
Desmopressin The risk or severity of hyponatremia can be increased when Levacetylmethadol is combined with Desmopressin.
Naloxegol The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with Naloxegol.
Pegvisomant The therapeutic efficacy of Pegvisomant can be decreased when used in combination with Levacetylmethadol.
Succinylcholine The risk or severity of bradycardia can be increased when Succinylcholine is combined with Levacetylmethadol.
Secretin porcine The therapeutic efficacy of Secretin porcine can be decreased when used in combination with Levacetylmethadol.
Metreleptin The metabolism of Levacetylmethadol can be increased when combined with Metreleptin.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Levacetylmethadol.
Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Levacetylmethadol.
Crizotinib The metabolism of Levacetylmethadol can be decreased when combined with Crizotinib.
Botulinum toxin type A The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with Botulinum toxin type A.
Botulinum toxin type B The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with Botulinum toxin type B.
Mirtazapine Levacetylmethadol may increase the serotonergic activities of Mirtazapine.
Seproxetine The risk or severity of serotonin syndrome can be increased when Levacetylmethadol is combined with Seproxetine.
Ritanserin The risk or severity of serotonin syndrome can be increased when Levacetylmethadol is combined with Ritanserin.
Alaproclate The risk or severity of serotonin syndrome can be increased when Levacetylmethadol is combined with Alaproclate.
Fluvoxamine The risk or severity of serotonin syndrome can be increased when Levacetylmethadol is combined with Fluvoxamine.
Zimelidine The risk or severity of serotonin syndrome can be increased when Levacetylmethadol is combined with Zimelidine.
Citalopram The risk or severity of QTc prolongation can be increased when Levacetylmethadol is combined with Citalopram.
Duloxetine The risk or severity of serotonin syndrome can be increased when Levacetylmethadol is combined with Duloxetine.
Paroxetine The risk or severity of serotonin syndrome can be increased when Levacetylmethadol is combined with Paroxetine.
Sertraline The risk or severity of serotonin syndrome can be increased when Levacetylmethadol is combined with Sertraline.
Sibutramine The risk or severity of serotonin syndrome can be increased when Levacetylmethadol is combined with Sibutramine.
Dapoxetine The risk or severity of serotonin syndrome can be increased when Levacetylmethadol is combined with Dapoxetine.
Milnacipran The risk or severity of serotonin syndrome can be increased when Levacetylmethadol is combined with Milnacipran.
Desvenlafaxine The risk or severity of serotonin syndrome can be increased when Desvenlafaxine is combined with Levacetylmethadol.
Levomilnacipran The risk or severity of serotonin syndrome can be increased when Levacetylmethadol is combined with Levomilnacipran.
Indalpine The risk or severity of serotonin syndrome can be increased when Levacetylmethadol is combined with Indalpine.
Ethanol Levacetylmethadol may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Levacetylmethadol may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Levacetylmethadol.
Pseudoephedrine Pseudoephedrine may increase the analgesic activities of Levacetylmethadol.
Diethylpropion Diethylpropion may increase the analgesic activities of Levacetylmethadol.
Lisdexamfetamine The risk or severity of serotonin syndrome can be increased when Levacetylmethadol is combined with Lisdexamfetamine.
Mephentermine Mephentermine may increase the analgesic activities of Levacetylmethadol.
MMDA MMDA may increase the analgesic activities of Levacetylmethadol.
Midomafetamine Midomafetamine may increase the analgesic activities of Levacetylmethadol.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may increase the analgesic activities of Levacetylmethadol.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may increase the analgesic activities of Levacetylmethadol.
Tenamfetamine Tenamfetamine may increase the analgesic activities of Levacetylmethadol.
Chlorphentermine Chlorphentermine may increase the analgesic activities of Levacetylmethadol.
Methylenedioxyethamphetamine Methylenedioxyethamphetamine may increase the analgesic activities of Levacetylmethadol.
Dextroamphetamine Dextroamphetamine may increase the analgesic activities of Levacetylmethadol.
Metamfetamine Metamfetamine may increase the analgesic activities of Levacetylmethadol.
Iofetamine I-123 Iofetamine I-123 may increase the analgesic activities of Levacetylmethadol.
Ritobegron Ritobegron may increase the analgesic activities of Levacetylmethadol.
Mephedrone Mephedrone may increase the analgesic activities of Levacetylmethadol.
Methoxyphenamine Methoxyphenamine may increase the analgesic activities of Levacetylmethadol.
Gepefrine Gepefrine may increase the analgesic activities of Levacetylmethadol.
2,5-Dimethoxy-4-ethylthioamphetamine 2,5-Dimethoxy-4-ethylthioamphetamine may increase the analgesic activities of Levacetylmethadol.
Amphetamine Amphetamine may increase the analgesic activities of Levacetylmethadol.
Phentermine Phentermine may increase the analgesic activities of Levacetylmethadol.
Phendimetrazine Phendimetrazine may increase the analgesic activities of Levacetylmethadol.
Naltrexone The therapeutic efficacy of Levacetylmethadol can be decreased when used in combination with Naltrexone.
Levorphanol The risk or severity of adverse effects can be increased when Levorphanol is combined with Levacetylmethadol.
Remifentanil The risk or severity of adverse effects can be increased when Remifentanil is combined with Levacetylmethadol.
Diphenoxylate The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Levacetylmethadol.
Dezocine The risk or severity of adverse effects can be increased when Dezocine is combined with Levacetylmethadol.
Methadyl acetate The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with Methadyl acetate.
Dihydroetorphine The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with Dihydroetorphine.
Diamorphine The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with Diamorphine.
Bezitramide The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with Bezitramide.
Etorphine The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with Etorphine.
Dextromoramide The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with Dextromoramide.
Desomorphine The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with Desomorphine.
Carfentanil The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with Carfentanil.
Alphacetylmethadol The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with Alphacetylmethadol.
Dihydromorphine The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with Dihydromorphine.
DPDPE The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with DPDPE.
Lofentanil The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with Lofentanil.
Normethadone The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with Normethadone.
Piritramide The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with Piritramide.
Alphaprodine The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with Alphaprodine.
Nicomorphine The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with Nicomorphine.
Meptazinol The therapeutic efficacy of Levacetylmethadol can be decreased when used in combination with Meptazinol.

Target Protein

Mu-type opioid receptor OPRM1
Neuronal acetylcholine receptor subunit beta-4 CHRNB4
Neuronal acetylcholine receptor subunit alpha-3 CHRNA3

Referensi & Sumber

Textbook
  • ISBN: 0080931510,9780080931517
    Ghodse, AH; Galea, S. (2008). Chapter 8: Opioid analgesics and narcotic antagonists. In Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data and Trends in Adverse Drug Reactions (pp. 111). Elsevier.

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