Aminophylline

DB01223

small molecule approved

Deskripsi

Aminophylline is a drug combination that contains theophylline and ethylenediamine in a 2:1 ratio. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Similar to other theophyllines, aminophylline is indicated for the treatment of lung diseases such as asthma, chronic bronchitis, and COPD. The majority of aminophylline medications are discontinued and the remaining medications on the market are in short supply.

Struktur Molekul 2D

Berat 420.4264
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 7-9 hours
Volume Distribusi * 0.3 to 0.7 L/kg
Klirens (Clearance) * 0.29 mL/kg/min [postnatal age 3-15 days] * 0.64 mL/kg/min [postnatal age 25-57 days] * 1.7 mL/kg/min [ 1-4 years] * 1.6 mL/kg/min [4-12 years] * 0.9 mL/kg/min [13-15 years] * 1.4 mL/kg/min [16-17 years] * 0.65 mL/kg/min [Adults (16-60 years), non-smoking asthmatics] * 0.41 mL/kg/min [Elderly (>60 years). liver, and renal function] * 0.33 mL/kg/min [Acute pulmonary edema] * 0.54 mL/kg/min [COPD->60 years, stable non-smoker >1 year] * 0.48 mL/kg/min [COPD with cor pulmonale] * 1.25 mL/kg/min [Cystic fibrosis (14-28 years)] * 0.31 mL/kg/min [Liver disease -cholestasis] * 0.35 mL/kg/min [cirrhosis] * 0.65 mL/kg/min [acute hepatitis] * 0.47 mL/kg/min [Sepsis with multi-organ failure] * 0.38 mL/kg/min [hypothyroid] * 0.8 mL/kg/min [hyperthyroid]

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

6 Data
  • 1. Administer vitamin supplements. Aminophylline may reduce Vitamin B6 levels as an adverse effect. Consider supplementation.
  • 2. Avoid excessive or chronic alcohol consumption. Ingesting a large amount of alcohol may reduce aminophylline clearance, therefore increasing its serum concentration.
  • 3. Exercise caution with grapefruit products. Grapefruit inhibits CYP3A4 metabolism, which may increase the serum concentration of aminophylline.
  • 4. Exercise caution with St. John's Wort. This herb induces the CYP3A4 metabolism of aminophylline. Therefore it may reduce the serum concentration and effectiveness of aminophylline.
  • 5. Limit caffeine intake. Excessive caffeine intake with aminophylline may exacerbate caffiene-like side effects such as nausea, nervousness, irritability, insomnia and tremors.
  • 6. Take with food. This may reduce gastric irritation. Aminophylline absorption is slower when taken with food.

Interaksi Obat

915 Data
Modafinil The metabolism of Aminophylline can be increased when combined with Modafinil.
Armodafinil The metabolism of Aminophylline can be increased when combined with Armodafinil.
Deferasirox The serum concentration of Aminophylline can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Aminophylline can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Aminophylline can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Aminophylline can be decreased when it is combined with Teriflunomide.
Regadenoson Aminophylline may decrease effectiveness of Regadenoson as a diagnostic agent.
Adalimumab The serum concentration of Aminophylline can be decreased when it is combined with Adalimumab.
Adenosine The therapeutic efficacy of Adenosine can be decreased when used in combination with Aminophylline.
Allopurinol The serum concentration of Aminophylline can be increased when it is combined with Allopurinol.
Carbamazepine The serum concentration of Aminophylline can be decreased when it is combined with Carbamazepine.
Cimetidine The metabolism of Aminophylline can be decreased when combined with Cimetidine.
Disulfiram The serum concentration of Aminophylline can be increased when it is combined with Disulfiram.
Febuxostat The serum concentration of the active metabolites of Aminophylline can be increased when Aminophylline is used in combination with Febuxostat.
Fluvoxamine The metabolism of Aminophylline can be decreased when combined with Fluvoxamine.
Formoterol The risk or severity of hypokalemia can be increased when Aminophylline is combined with Formoterol.
Indacaterol The risk or severity of adverse effects can be increased when Aminophylline is combined with Indacaterol.
Isoniazid The serum concentration of Aminophylline can be increased when it is combined with Isoniazid.
Lithium citrate The serum concentration of Lithium citrate can be decreased when it is combined with Aminophylline.
Lithium carbonate The serum concentration of Lithium carbonate can be decreased when it is combined with Aminophylline.
Lithium hydroxide The serum concentration of Lithium hydroxide can be decreased when it is combined with Aminophylline.
Mexiletine The metabolism of Aminophylline can be decreased when combined with Mexiletine.
Olodaterol Aminophylline may increase the hyperkalemic activities of Olodaterol.
Pancuronium The therapeutic efficacy of Pancuronium can be decreased when used in combination with Aminophylline.
Pentoxifylline The serum concentration of Aminophylline can be increased when it is combined with Pentoxifylline.
Propafenone The serum concentration of Aminophylline can be increased when it is combined with Propafenone.
Quinine The serum concentration of Aminophylline can be increased when it is combined with Quinine.
Quinidine The serum concentration of Aminophylline can be increased when it is combined with Quinidine.
Riociguat Aminophylline may increase the hypotensive activities of Riociguat.
Thiabendazole The metabolism of Aminophylline can be decreased when combined with Thiabendazole.
Ticlopidine The metabolism of Aminophylline can be decreased when combined with Ticlopidine.
Zafirlukast The serum concentration of Zafirlukast can be decreased when it is combined with Aminophylline.
Metreleptin The metabolism of Aminophylline can be increased when combined with Metreleptin.
Probenecid The serum concentration of Aminophylline can be increased when it is combined with Probenecid.
Crizotinib The metabolism of Aminophylline can be decreased when combined with Crizotinib.
Butalbital The therapeutic efficacy of Butalbital can be decreased when used in combination with Aminophylline.
Pentobarbital The therapeutic efficacy of Pentobarbital can be decreased when used in combination with Aminophylline.
Secobarbital The therapeutic efficacy of Secobarbital can be decreased when used in combination with Aminophylline.
Methohexital The therapeutic efficacy of Methohexital can be decreased when used in combination with Aminophylline.
Thiopental The therapeutic efficacy of Thiopental can be decreased when used in combination with Aminophylline.
Primidone The therapeutic efficacy of Primidone can be decreased when used in combination with Aminophylline.
Methylphenobarbital The therapeutic efficacy of Methylphenobarbital can be decreased when used in combination with Aminophylline.
Thiamylal The therapeutic efficacy of Thiamylal can be decreased when used in combination with Aminophylline.
Phenobarbital The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Aminophylline.
Amobarbital The therapeutic efficacy of Amobarbital can be decreased when used in combination with Aminophylline.
Hexobarbital The therapeutic efficacy of Hexobarbital can be decreased when used in combination with Aminophylline.
Barbital The therapeutic efficacy of Barbital can be decreased when used in combination with Aminophylline.
Barbexaclone The therapeutic efficacy of Barbexaclone can be decreased when used in combination with Aminophylline.
Butabarbital The therapeutic efficacy of Butabarbital can be decreased when used in combination with Aminophylline.
Abiraterone The serum concentration of Aminophylline can be increased when it is combined with Abiraterone.
Isoprenaline The serum concentration of Aminophylline can be decreased when it is combined with Isoprenaline.
Cyproterone acetate The metabolism of Aminophylline can be increased when combined with Cyproterone acetate.
Amphetamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Aminophylline.
Midodrine The risk or severity of adverse effects can be increased when Midodrine is combined with Aminophylline.
Norepinephrine The risk or severity of adverse effects can be increased when Norepinephrine is combined with Aminophylline.
Phenylpropanolamine The risk or severity of adverse effects can be increased when Phenylpropanolamine is combined with Aminophylline.
Labetalol The risk or severity of adverse effects can be increased when Labetalol is combined with Aminophylline.
Metaraminol The risk or severity of adverse effects can be increased when Metaraminol is combined with Aminophylline.
Methoxamine The risk or severity of adverse effects can be increased when Methoxamine is combined with Aminophylline.
Orciprenaline The risk or severity of adverse effects can be increased when Orciprenaline is combined with Aminophylline.
Phenmetrazine The risk or severity of adverse effects can be increased when Phenmetrazine is combined with Aminophylline.
Dobutamine The risk or severity of adverse effects can be increased when Dobutamine is combined with Aminophylline.
Pseudoephedrine The risk or severity of adverse effects can be increased when Pseudoephedrine is combined with Aminophylline.
Ritodrine The risk or severity of adverse effects can be increased when Ritodrine is combined with Aminophylline.
Terbutaline The risk or severity of adverse effects can be increased when Terbutaline is combined with Aminophylline.
Oxymetazoline The risk or severity of adverse effects can be increased when Oxymetazoline is combined with Aminophylline.
Diethylpropion The risk or severity of adverse effects can be increased when Diethylpropion is combined with Aminophylline.
Dopamine The risk or severity of adverse effects can be increased when Dopamine is combined with Aminophylline.
Acebutolol The risk or severity of adverse effects can be increased when Acebutolol is combined with Aminophylline.
Lisdexamfetamine The risk or severity of adverse effects can be increased when Lisdexamfetamine is combined with Aminophylline.
Fenoterol The risk or severity of adverse effects can be increased when Fenoterol is combined with Aminophylline.
Ephedrine The risk or severity of adverse effects can be increased when Ephedrine is combined with Aminophylline.
Mephentermine The risk or severity of adverse effects can be increased when Mephentermine is combined with Aminophylline.
Procaterol The risk or severity of adverse effects can be increased when Procaterol is combined with Aminophylline.
Clenbuterol The risk or severity of adverse effects can be increased when Clenbuterol is combined with Aminophylline.
MMDA The risk or severity of adverse effects can be increased when MMDA is combined with Aminophylline.
Midomafetamine The risk or severity of adverse effects can be increased when Midomafetamine is combined with Aminophylline.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of adverse effects can be increased when 2,5-Dimethoxy-4-ethylamphetamine is combined with Aminophylline.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of adverse effects can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Aminophylline.
Tenamfetamine The risk or severity of adverse effects can be increased when Tenamfetamine is combined with Aminophylline.
Chlorphentermine The risk or severity of adverse effects can be increased when Chlorphentermine is combined with Aminophylline.
Methylenedioxyethamphetamine The risk or severity of adverse effects can be increased when Methylenedioxyethamphetamine is combined with Aminophylline.
Dextroamphetamine The risk or severity of adverse effects can be increased when Dextroamphetamine is combined with Aminophylline.
Metamfetamine The risk or severity of adverse effects can be increased when Metamfetamine is combined with Aminophylline.
Celiprolol The risk or severity of adverse effects can be increased when Celiprolol is combined with Aminophylline.
Tetryzoline The risk or severity of adverse effects can be increased when Tetryzoline is combined with Aminophylline.
Tyramine The risk or severity of adverse effects can be increased when Tyramine is combined with Aminophylline.
Isoxsuprine The risk or severity of adverse effects can be increased when Isoxsuprine is combined with Aminophylline.
Etilefrine The risk or severity of adverse effects can be increased when Etilefrine is combined with Aminophylline.
Synephrine The risk or severity of adverse effects can be increased when Synephrine is combined with Aminophylline.
Hydroxyamphetamine The risk or severity of adverse effects can be increased when Hydroxyamphetamine is combined with Aminophylline.
Iofetamine I-123 The risk or severity of adverse effects can be increased when Iofetamine I-123 is combined with Aminophylline.
Racepinephrine The risk or severity of adverse effects can be increased when Racepinephrine is combined with Aminophylline.
Ritobegron The risk or severity of adverse effects can be increased when Ritobegron is combined with Aminophylline.
Bucindolol The risk or severity of adverse effects can be increased when Bucindolol is combined with Aminophylline.
Tramazoline The risk or severity of adverse effects can be increased when Tramazoline is combined with Aminophylline.
Mephedrone The risk or severity of adverse effects can be increased when Mephedrone is combined with Aminophylline.
Fenozolone The risk or severity of adverse effects can be increased when Fenozolone is combined with Aminophylline.
Methoxyphenamine The risk or severity of adverse effects can be increased when Methoxyphenamine is combined with Aminophylline.
Tretoquinol The risk or severity of adverse effects can be increased when Tretoquinol is combined with Aminophylline.

Target Protein

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A PDE3A
Adenosine receptor A1 ADORA1
Adenosine receptor A3 ADORA3
Histone deacetylase 2 HDAC2

Referensi & Sumber

Contoh Produk & Brand

Produk: 31 • International brands: 2
Produk
  • Aminophylline
    Injection, solution • 25 mg/1mL • Intravenous • US • Generic • Approved
  • Aminophylline
    Tablet • 100 mg/1 • Oral • US • Generic • Approved
  • Aminophylline
    Tablet • 200 mg/1 • Oral • US • Generic • Approved
  • Aminophylline
    Solution • 105 mg/5mL • Oral • US • Generic • Approved
  • Aminophylline
    Injection • 25 mg/1mL • Intravenous • US • Generic • Approved
  • Aminophylline
    Injection • 25 mg/1mL • Intravenous • US • Generic • Approved
  • Aminophylline
    Injection, solution • 25 mg/1mL • Intravenous • US • Approved
  • Aminophylline
    Injection, solution • 25 mg/1mL • Intravenous • US • Approved
Menampilkan 8 dari 31 produk.
International Brands
  • Minomal
  • Somophyllin

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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