Peringatan Keamanan

Side effects incldue coughing noisy, rattling, troubled breathing, loss of appetite, aches and pain in joints, indigestion,and skin itching or rash.

Halofantrine

DB01218

small molecule approved

Deskripsi

Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferentially block open and inactivated HERG channels leading to some degree of cardiotoxicity.

Struktur Molekul 2D

Berat 500.424
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 6-10 days
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Hepatic

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take on an empty stomach. Food increases the bioavailability 6-fold, which may increase the risk of cardiotoxicity.

Interaksi Obat

978 Data
Artemether The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Artemether.
Mifepristone The serum concentration of Halofantrine can be increased when it is combined with Mifepristone.
Quinine The risk or severity of QTc prolongation, ventricular arrhythmias, torsade de pointes, and convulsion can be increased when Quinine is combined with Halofantrine.
Quinidine The risk or severity of QTc prolongation, ventricular arrhythmias, torsade de pointes, and convulsion can be increased when Quinidine is combined with Halofantrine.
Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Halofantrine.
Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Halofantrine.
Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Halofantrine.
Eliglustat The metabolism of Eliglustat can be decreased when combined with Halofantrine.
Iloperidone The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Iloperidone.
Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Halofantrine.
Sucralfate Sucralfate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Bentoquatam Bentoquatam can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium sulfate Magnesium sulfate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium oxide Magnesium oxide can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium salicylate Magnesium salicylate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Kaolin Kaolin can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Zinc Zinc can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Zinc trihydroxide Zinc trihydroxide can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Zinc Substituted Heme C Zinc Substituted Heme C can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminum hydroxide Aluminum hydroxide can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lanthanum carbonate Lanthanum carbonate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magaldrate Magaldrate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Potassium alum Potassium alum can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium hydroxide Magnesium hydroxide can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Polaprezinc Polaprezinc can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium trisilicate Magnesium trisilicate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Zinc oxide Zinc oxide can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Zinc sulfate Zinc sulfate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium chloride Magnesium chloride can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium carbonate Magnesium carbonate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminum chloride Aluminum chloride can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium citrate Magnesium citrate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Zinc citrate Zinc citrate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Zinc picolinate Zinc picolinate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminum sulfate Aluminum sulfate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Zinc gluconate Zinc gluconate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Bentonite Bentonite can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium silicate Magnesium silicate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminium acetoacetate Aluminium acetoacetate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Hydrotalcite Hydrotalcite can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium aspartate Magnesium aspartate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium peroxide Magnesium peroxide can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminium glycinate Aluminium glycinate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aloglutamol Aloglutamol can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Montmorillonite Montmorillonite can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium gluconate Magnesium gluconate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium orotate Magnesium orotate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acetylcysteine zinc Acetylcysteine zinc can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Zinc ascorbate Zinc ascorbate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Zinc acetate Zinc acetate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Zinc glycinate Zinc glycinate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium Magnesium can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium levulinate Magnesium levulinate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium lactate Magnesium lactate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminium phosphate Aluminium phosphate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Zinc chloride Zinc chloride can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Zinc sulfate, unspecified form Zinc sulfate, unspecified form can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lanthanum III cation Lanthanum III cation can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Zinc cation Zinc cation can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminum chlorohydrate Aluminum chlorohydrate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dihydroxyaluminum sodium carbonate Dihydroxyaluminum sodium carbonate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lumefantrine Lumefantrine may increase the QTc-prolonging activities of Halofantrine.
Thiethylperazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Thiethylperazine.
Promazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Promazine.
Prochlorperazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Prochlorperazine.
Chlorpromazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Chlorpromazine.
Triflupromazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Triflupromazine.
Fluphenazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Fluphenazine.
Thioridazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Thioridazine.
Moricizine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Moricizine.
Trifluoperazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Trifluoperazine.
Perphenazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Perphenazine.
Mesoridazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Mesoridazine.
Acetophenazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Acetophenazine.
Promethazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Promethazine.
Alimemazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Alimemazine.
Methotrimeprazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Methotrimeprazine.
Periciazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Periciazine.
Acepromazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Acepromazine.
Aceprometazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Aceprometazine.
Pipotiazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Pipotiazine.
Thioproperazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Thioproperazine.
BL-1020 The risk or severity of QTc prolongation can be increased when Halofantrine is combined with BL-1020.
Cyamemazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Cyamemazine.
Methylene blue The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Methylene blue.
Propiopromazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Propiopromazine.
Perazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Perazine.
Butaperazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Butaperazine.
Chlorproethazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Chlorproethazine.
Thiazinam The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Thiazinam.
Dixyrazine The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Dixyrazine.
Perphenazine enanthate The risk or severity of QTc prolongation can be increased when Halofantrine is combined with Perphenazine enanthate.
Dapsone The risk or severity of adverse effects can be increased when Halofantrine is combined with Dapsone.
Leuprolide The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Halofantrine.
Goserelin The risk or severity of QTc prolongation can be increased when Goserelin is combined with Halofantrine.
Erythromycin The serum concentration of Halofantrine can be increased when it is combined with Erythromycin.
Azithromycin The risk or severity of QTc prolongation can be increased when Azithromycin is combined with Halofantrine.
Moxifloxacin The risk or severity of QTc prolongation can be increased when Moxifloxacin is combined with Halofantrine.
Ranolazine The risk or severity of QTc prolongation can be increased when Ranolazine is combined with Halofantrine.
Sulfisoxazole The risk or severity of QTc prolongation can be increased when Sulfisoxazole is combined with Halofantrine.

Target Protein

Fe(II)-protoporphyrin IX
Calmodulin-1 CALM1
Calmodulin-3 CALM3
Calmodulin-2 CALM2
Voltage-gated inwardly rectifying potassium channel KCNH2 KCNH2
Plasmepsin-2

Referensi & Sumber

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Contoh Produk & Brand

Produk: 2 • International brands: 0
Produk
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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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