Peringatan Keamanan

Symptoms of overdose include cold and clammy skin, confusion, nervousness, or severe restlessness, convulsions (seizures), severe dizziness, severe drowsiness, low blood pressure, pinpoint pupils of eyes, slow heartbeat, slow or troubled breathing and severe weakness.

Dezocine

DB01209

small molecule approved investigational

Deskripsi

Dezocine is a partial opiate drug and is used for pain management. Dezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea.

Struktur Molekul 2D

Berat 245.3599
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Elimination half-life following intramuscular administration averages 2.2 hours. Elimination half-life following a 5mg intravenous dose averages 1.7 to 2.6 hours (range 0.6 to 4.4 hours) while a 10mg dose averages 2.4 to 2.6 hours (range 1.2 to 7.4 hours). In patients with hepatic cirrhosis, the half-life is increased by 30 to 50%.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapid and complete following intramuscular administration.

Metabolisme

Hepatic, via conjugation (glucuronidation).

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

915 Data
Buprenorphine Dezocine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Dezocine.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Dezocine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Dezocine.
Hydrocodone Dezocine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dezocine.
Magnesium sulfate The therapeutic efficacy of Dezocine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Dezocine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Dezocine may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Dezocine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Dezocine.
Orphenadrine Dezocine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Dezocine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Dezocine.
Pramipexole Dezocine may increase the sedative activities of Pramipexole.
Ropinirole Dezocine may increase the sedative activities of Ropinirole.
Rotigotine Dezocine may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Dezocine.
Sodium oxybate Dezocine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Dezocine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Dezocine.
Thalidomide Dezocine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Dezocine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Alvimopan The risk or severity of adverse effects can be increased when Dezocine is combined with Alvimopan.
Desmopressin The risk or severity of hyponatremia can be increased when Dezocine is combined with Desmopressin.
Morphine The risk or severity of adverse effects can be increased when Morphine is combined with Dezocine.
Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Dezocine.
Hydromorphone The risk or severity of adverse effects can be increased when Hydromorphone is combined with Dezocine.
Meperidine The risk or severity of adverse effects can be increased when Meperidine is combined with Dezocine.
Oxycodone The therapeutic efficacy of Oxycodone can be decreased when used in combination with Dezocine.
Dextropropoxyphene The risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Dezocine.
Naltrexone The therapeutic efficacy of Dezocine can be decreased when used in combination with Naltrexone.
Sufentanil The risk or severity of adverse effects can be increased when Sufentanil is combined with Dezocine.
Alfentanil The risk or severity of adverse effects can be increased when Alfentanil is combined with Dezocine.
Fentanyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Dezocine.
Levorphanol The risk or severity of adverse effects can be increased when Levorphanol is combined with Dezocine.
Remifentanil The risk or severity of adverse effects can be increased when Remifentanil is combined with Dezocine.
Diphenoxylate The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Dezocine.
Oxymorphone The risk or severity of adverse effects can be increased when Oxymorphone is combined with Dezocine.
Methadyl acetate The risk or severity of adverse effects can be increased when Dezocine is combined with Methadyl acetate.
Dihydroetorphine The risk or severity of adverse effects can be increased when Dezocine is combined with Dihydroetorphine.
Diamorphine The risk or severity of adverse effects can be increased when Dezocine is combined with Diamorphine.
Bezitramide The risk or severity of adverse effects can be increased when Dezocine is combined with Bezitramide.
Ethylmorphine The risk or severity of adverse effects can be increased when Dezocine is combined with Ethylmorphine.
Etorphine The risk or severity of adverse effects can be increased when Dezocine is combined with Etorphine.
Dextromoramide The risk or severity of adverse effects can be increased when Dezocine is combined with Dextromoramide.
Desomorphine The risk or severity of adverse effects can be increased when Dezocine is combined with Desomorphine.
Carfentanil The risk or severity of adverse effects can be increased when Dezocine is combined with Carfentanil.
Dihydrocodeine The risk or severity of adverse effects can be increased when Dezocine is combined with Dihydrocodeine.
Alphacetylmethadol The risk or severity of adverse effects can be increased when Dezocine is combined with Alphacetylmethadol.
Dihydromorphine The risk or severity of adverse effects can be increased when Dezocine is combined with Dihydromorphine.
Ketobemidone The risk or severity of adverse effects can be increased when Dezocine is combined with Ketobemidone.
DPDPE The risk or severity of adverse effects can be increased when Dezocine is combined with DPDPE.
Lofentanil The risk or severity of adverse effects can be increased when Dezocine is combined with Lofentanil.
Opium The risk or severity of adverse effects can be increased when Dezocine is combined with Opium.
Normethadone The risk or severity of adverse effects can be increased when Dezocine is combined with Normethadone.
Piritramide The risk or severity of adverse effects can be increased when Dezocine is combined with Piritramide.
Alphaprodine The risk or severity of adverse effects can be increased when Dezocine is combined with Alphaprodine.
Nicomorphine The risk or severity of adverse effects can be increased when Dezocine is combined with Nicomorphine.
Meptazinol The therapeutic efficacy of Dezocine can be decreased when used in combination with Meptazinol.
Phenoperidine The risk or severity of adverse effects can be increased when Dezocine is combined with Phenoperidine.
Phenazocine The risk or severity of adverse effects can be increased when Dezocine is combined with Phenazocine.
Tilidine The risk or severity of adverse effects can be increased when Dezocine is combined with Tilidine.
Carfentanil, C-11 The risk or severity of adverse effects can be increased when Dezocine is combined with Carfentanil, C-11.
Benzhydrocodone The risk or severity of adverse effects can be increased when Dezocine is combined with Benzhydrocodone.
Pegvisomant The therapeutic efficacy of Pegvisomant can be decreased when used in combination with Dezocine.
Succinylcholine The risk or severity of bradycardia can be increased when Succinylcholine is combined with Dezocine.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Dezocine.
Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Dezocine.
Methylnaltrexone Dezocine may increase the opioid antagonism activities of Methylnaltrexone.
Naloxegol Dezocine may increase the opioid antagonism activities of Naloxegol.
Mirtazapine Dezocine may increase the serotonergic activities of Mirtazapine.
Fluvoxamine The risk or severity of serotonin syndrome can be increased when Dezocine is combined with Fluvoxamine.
Citalopram The risk or severity of serotonin syndrome can be increased when Dezocine is combined with Citalopram.
Duloxetine The risk or severity of serotonin syndrome can be increased when Dezocine is combined with Duloxetine.
Paroxetine The risk or severity of serotonin syndrome can be increased when Dezocine is combined with Paroxetine.
Sertraline The risk or severity of serotonin syndrome can be increased when Dezocine is combined with Sertraline.
Sibutramine The risk or severity of serotonin syndrome can be increased when Dezocine is combined with Sibutramine.
Nefazodone The risk or severity of serotonin syndrome can be increased when Dezocine is combined with Nefazodone.
Zimelidine The risk or severity of serotonin syndrome can be increased when Dezocine is combined with Zimelidine.
Dapoxetine The risk or severity of serotonin syndrome can be increased when Dezocine is combined with Dapoxetine.
Milnacipran The risk or severity of serotonin syndrome can be increased when Dezocine is combined with Milnacipran.
Desvenlafaxine The risk or severity of serotonin syndrome can be increased when Desvenlafaxine is combined with Dezocine.
Seproxetine The risk or severity of serotonin syndrome can be increased when Dezocine is combined with Seproxetine.
Levomilnacipran The risk or severity of serotonin syndrome can be increased when Dezocine is combined with Levomilnacipran.
Indalpine The risk or severity of serotonin syndrome can be increased when Dezocine is combined with Indalpine.
Ritanserin The risk or severity of serotonin syndrome can be increased when Dezocine is combined with Ritanserin.
Alaproclate The risk or severity of serotonin syndrome can be increased when Dezocine is combined with Alaproclate.
Ethanol Dezocine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Dezocine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Dezocine.
Phentermine Phentermine may increase the analgesic activities of Dezocine.
Pseudoephedrine Pseudoephedrine may increase the analgesic activities of Dezocine.
Benzphetamine Benzphetamine may increase the analgesic activities of Dezocine.
Diethylpropion Diethylpropion may increase the analgesic activities of Dezocine.
Lisdexamfetamine The risk or severity of serotonin syndrome can be increased when Dezocine is combined with Lisdexamfetamine.
Mephentermine Mephentermine may increase the analgesic activities of Dezocine.
MMDA MMDA may increase the analgesic activities of Dezocine.
Midomafetamine Midomafetamine may increase the analgesic activities of Dezocine.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may increase the analgesic activities of Dezocine.

Target Protein

Mu-type opioid receptor OPRM1
Kappa-type opioid receptor OPRK1

Referensi & Sumber

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