Oral, rat: LD50 = 70 mg/kg. Pulmonary toxicity has been reported at cumulative doses usually greater than 1,100 mg/m2. There is one report of pulmonary toxicity at a cumulative dose of only 600 mg. The onset of toxicity has varied from 6 months after initiation of therapy, to as late as 15 years after.
An alkylating agent of value against both hematologic malignancies and solid tumors.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Denosumab | The risk or severity of adverse effects can be increased when Denosumab is combined with Lomustine. |
| Etanercept | The risk or severity of adverse effects can be increased when Etanercept is combined with Lomustine. |
| Peginterferon alfa-2a | The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Lomustine. |
| Interferon alfa-n1 | The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Lomustine. |
| Interferon alfa-n3 | The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Lomustine. |
| Peginterferon alfa-2b | The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Lomustine. |
| Anakinra | The risk or severity of adverse effects can be increased when Anakinra is combined with Lomustine. |
| Interferon gamma-1b | The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Lomustine. |
| Interferon alfa-2a | The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Lomustine. |
| Aldesleukin | The risk or severity of adverse effects can be increased when Aldesleukin is combined with Lomustine. |
| Adalimumab | The risk or severity of adverse effects can be increased when Adalimumab is combined with Lomustine. |
| Gemtuzumab ozogamicin | The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Lomustine. |
| Pegaspargase | The risk or severity of adverse effects can be increased when Pegaspargase is combined with Lomustine. |
| Infliximab | The risk or severity of adverse effects can be increased when Infliximab is combined with Lomustine. |
| Interferon beta-1b | The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Lomustine. |
| Interferon alfacon-1 | The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Lomustine. |
| Rituximab | The risk or severity of adverse effects can be increased when Rituximab is combined with Lomustine. |
| Basiliximab | The risk or severity of adverse effects can be increased when Basiliximab is combined with Lomustine. |
| Muromonab | The risk or severity of adverse effects can be increased when Muromonab is combined with Lomustine. |
| Ibritumomab tiuxetan | The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Lomustine. |
| Tositumomab | The risk or severity of adverse effects can be increased when Tositumomab is combined with Lomustine. |
| Alemtuzumab | The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Lomustine. |
| Alefacept | The risk or severity of adverse effects can be increased when Alefacept is combined with Lomustine. |
| Efalizumab | The risk or severity of adverse effects can be increased when Efalizumab is combined with Lomustine. |
| Antithymocyte immunoglobulin (rabbit) | The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Lomustine. |
| Interferon alfa-2b | The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Lomustine. |
| Daclizumab | The risk or severity of adverse effects can be increased when Daclizumab is combined with Lomustine. |
| Phenylalanine | The risk or severity of adverse effects can be increased when Phenylalanine is combined with Lomustine. |
| Flunisolide | The risk or severity of adverse effects can be increased when Flunisolide is combined with Lomustine. |
| Bortezomib | The risk or severity of adverse effects can be increased when Bortezomib is combined with Lomustine. |
| Cladribine | Lomustine may increase the immunosuppressive activities of Cladribine. |
| Carmustine | The risk or severity of adverse effects can be increased when Carmustine is combined with Lomustine. |
| Amsacrine | The risk or severity of adverse effects can be increased when Amsacrine is combined with Lomustine. |
| Bleomycin | The risk or severity of adverse effects can be increased when Bleomycin is combined with Lomustine. |
| Chlorambucil | The risk or severity of adverse effects can be increased when Chlorambucil is combined with Lomustine. |
| Raltitrexed | The risk or severity of adverse effects can be increased when Raltitrexed is combined with Lomustine. |
| Mitomycin | The risk or severity of adverse effects can be increased when Mitomycin is combined with Lomustine. |
| Bexarotene | The risk or severity of adverse effects can be increased when Bexarotene is combined with Lomustine. |
| Vindesine | The risk or severity of adverse effects can be increased when Vindesine is combined with Lomustine. |
| Floxuridine | The risk or severity of adverse effects can be increased when Floxuridine is combined with Lomustine. |
| Indomethacin | The risk or severity of adverse effects can be increased when Indomethacin is combined with Lomustine. |
| Tioguanine | The risk or severity of adverse effects can be increased when Tioguanine is combined with Lomustine. |
| Vinorelbine | The risk or severity of adverse effects can be increased when Vinorelbine is combined with Lomustine. |
| Dexrazoxane | The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Lomustine. |
| Beclomethasone dipropionate | The risk or severity of adverse effects can be increased when Beclomethasone dipropionate is combined with Lomustine. |
| Sorafenib | The risk or severity of adverse effects can be increased when Sorafenib is combined with Lomustine. |
| Streptozocin | The risk or severity of adverse effects can be increased when Streptozocin is combined with Lomustine. |
| Trifluridine | The risk or severity of adverse effects can be increased when Trifluridine is combined with Lomustine. |
| Gemcitabine | The risk or severity of adverse effects can be increased when Gemcitabine is combined with Lomustine. |
| Betamethasone | The risk or severity of adverse effects can be increased when Betamethasone is combined with Lomustine. |
| Teniposide | The risk or severity of adverse effects can be increased when Teniposide is combined with Lomustine. |
| Epirubicin | The risk or severity of adverse effects can be increased when Epirubicin is combined with Lomustine. |
| Chloramphenicol | The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Lomustine. |
| Lenalidomide | The risk or severity of adverse effects can be increased when Lenalidomide is combined with Lomustine. |
| Altretamine | The risk or severity of adverse effects can be increased when Altretamine is combined with Lomustine. |
| Zidovudine | The risk or severity of adverse effects can be increased when Zidovudine is combined with Lomustine. |
| Cisplatin | The risk or severity of adverse effects can be increased when Cisplatin is combined with Lomustine. |
| Oxaliplatin | The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Lomustine. |
| Cyclophosphamide | The risk or severity of adverse effects can be increased when Cyclophosphamide is combined with Lomustine. |
| Vincristine | The risk or severity of adverse effects can be increased when Vincristine is combined with Lomustine. |
| Fluorouracil | The risk or severity of adverse effects can be increased when Fluorouracil is combined with Lomustine. |
| Propylthiouracil | The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Lomustine. |
| Pentostatin | The risk or severity of adverse effects can be increased when Pentostatin is combined with Lomustine. |
| Methotrexate | The risk or severity of adverse effects can be increased when Methotrexate is combined with Lomustine. |
| Vinblastine | The risk or severity of adverse effects can be increased when Vinblastine is combined with Lomustine. |
| Fluticasone propionate | The risk or severity of adverse effects can be increased when Fluticasone propionate is combined with Lomustine. |
| Fluocinolone acetonide | The risk or severity of adverse effects can be increased when Fluocinolone acetonide is combined with Lomustine. |
| Linezolid | The risk or severity of adverse effects can be increased when Linezolid is combined with Lomustine. |
| Imatinib | The risk or severity of adverse effects can be increased when Imatinib is combined with Lomustine. |
| Triamcinolone | The risk or severity of adverse effects can be increased when Triamcinolone is combined with Lomustine. |
| Clofarabine | The risk or severity of adverse effects can be increased when Clofarabine is combined with Lomustine. |
| Prednisone | The risk or severity of adverse effects can be increased when Prednisone is combined with Lomustine. |
| Pemetrexed | The risk or severity of adverse effects can be increased when Pemetrexed is combined with Lomustine. |
| Fludrocortisone | The risk or severity of adverse effects can be increased when Fludrocortisone is combined with Lomustine. |
| Mycophenolate mofetil | The risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with Lomustine. |
| Daunorubicin | The risk or severity of adverse effects can be increased when Daunorubicin is combined with Lomustine. |
| Irinotecan | The risk or severity of adverse effects can be increased when Irinotecan is combined with Lomustine. |
| Methimazole | The risk or severity of adverse effects can be increased when Methimazole is combined with Lomustine. |
| Etoposide | The risk or severity of adverse effects can be increased when Etoposide is combined with Lomustine. |
| Sulfasalazine | The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Lomustine. |
| Dacarbazine | The risk or severity of adverse effects can be increased when Dacarbazine is combined with Lomustine. |
| Temozolomide | The risk or severity of adverse effects can be increased when Temozolomide is combined with Lomustine. |
| Penicillamine | The risk or severity of adverse effects can be increased when Penicillamine is combined with Lomustine. |
| Prednisolone | The risk or severity of adverse effects can be increased when Prednisolone is combined with Lomustine. |
| Mechlorethamine | The risk or severity of adverse effects can be increased when Mechlorethamine is combined with Lomustine. |
| Azacitidine | The risk or severity of adverse effects can be increased when Azacitidine is combined with Lomustine. |
| Carboplatin | The risk or severity of adverse effects can be increased when Carboplatin is combined with Lomustine. |
| Methylprednisolone | The risk or severity of adverse effects can be increased when Methylprednisolone is combined with Lomustine. |
| Dactinomycin | The risk or severity of adverse effects can be increased when Dactinomycin is combined with Lomustine. |
| Cytarabine | The risk or severity of adverse effects can be increased when Cytarabine is combined with Lomustine. |
| Azathioprine | The risk or severity of adverse effects can be increased when Azathioprine is combined with Lomustine. |
| Doxorubicin | The risk or severity of adverse effects can be increased when Doxorubicin is combined with Lomustine. |
| Hydroxyurea | The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Lomustine. |
| Mycophenolic acid | The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Lomustine. |
| Topotecan | The risk or severity of adverse effects can be increased when Topotecan is combined with Lomustine. |
| Mercaptopurine | The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Lomustine. |
| Thalidomide | The risk or severity of adverse effects can be increased when Thalidomide is combined with Lomustine. |
| Melphalan | The risk or severity of adverse effects can be increased when Melphalan is combined with Lomustine. |
| Fludarabine | The risk or severity of adverse effects can be increased when Fludarabine is combined with Lomustine. |
| Flucytosine | The risk or severity of adverse effects can be increased when Flucytosine is combined with Lomustine. |