Peringatan Keamanan

The oral LD50 in mice is 4500mg/kg.L7934

Patients experiencing an overdose may present with bradycardia, cardiac failure, hypotension, and bronchospasm.L7922,L7925 An overdose may be treated with atropine for bradycardia, digitalis and diuretics for cardiac failure, vasopressors for hypotension, and beta-2 stimulants for bronchospasms, as well as gastric lavage and hemodialysis.L7922,L7925

Nadolol

DB01203

small molecule approved

Deskripsi

Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.L7922,L7925 Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adverse effects.A34177

Nadolol was granted FDA approval on 10 December 1979.L7922

Struktur Molekul 2D

Berat 309.4006
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The half life of nadolol is 20 to 24 hours.[L7922,L7925]
Volume Distribusi In healthy subjects, the volume of distribution of nadolol is 147-157L.[A182423]
Klirens (Clearance) In healthy subjects, the total body clearance of nadolol is 219-250mL/min and the renal clearance is 131-150mL/min.[A182423]

Absorpsi

Oral doses of nadolol are approximately 30% absorbed.L7922,L7925 In healthy subjects, nadolol has a Tmax of 2.7h with a Cmax or 69±15ng/mL following a 60mg oral dose and 132±27ng/mL after a 120mg oral dose.A182417 The AUC following a 60mg oral dose was 1021ng\*h/mL and following a 120mg oral dose was 1913±382ng\*h/mL.A182417

Metabolisme

Nadolol is not metabolized by the liver in humans.A182423,L7922,L7925

Rute Eliminasi

Nadolol is not metabolized in the liver and excreted mainly in the urine.L7922,L7925 In healthy subjects, following intravenous dosing, 60% of a dose is eliminated in the urine and 15% in the feces after 72 hours.A182423 The remainder of the dose is expected to be eliminated in the feces afterwards.A182423

Interaksi Makanan

3 Data
  • 1. Avoid alcohol.
  • 2. Avoid natural licorice.
  • 3. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

1693 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Nadolol is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Nadolol is combined with Levodopa.
Risperidone Nadolol may increase the hypotensive activities of Risperidone.
Ceritinib Nadolol may increase the bradycardic activities of Ceritinib.
Ivabradine Nadolol may increase the bradycardic activities of Ivabradine.
Ruxolitinib Ruxolitinib may increase the bradycardic activities of Nadolol.
Alfuzosin Alfuzosin may increase the hypotensive activities of Nadolol.
Amifostine Nadolol may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Nadolol.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Nadolol.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Nadolol.
Obinutuzumab Nadolol may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Nadolol.
Rituximab Nadolol may increase the hypotensive activities of Rituximab.
Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Nadolol.
Doxapram Doxapram may decrease the antihypertensive activities of Nadolol.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Nadolol.
Naratriptan Naratriptan may decrease the antihypertensive activities of Nadolol.
Frovatriptan Frovatriptan may decrease the antihypertensive activities of Nadolol.
Dutasteride Dutasteride may decrease the antihypertensive activities of Nadolol.
Finasteride Finasteride may decrease the antihypertensive activities of Nadolol.
Solifenacin Solifenacin may decrease the antihypertensive activities of Nadolol.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Nadolol.
1-benzylimidazole 1-benzylimidazole may decrease the antihypertensive activities of Nadolol.
Amineptine Amineptine may decrease the antihypertensive activities of Nadolol.
Naluzotan Naluzotan may decrease the antihypertensive activities of Nadolol.
Nitrous oxide Nitrous oxide may decrease the antihypertensive activities of Nadolol.
Cinitapride Cinitapride may decrease the antihypertensive activities of Nadolol.
Lurasidone Lurasidone may decrease the antihypertensive activities of Nadolol.
Tyramine Tyramine may decrease the antihypertensive activities of Nadolol.
Ifenprodil Ifenprodil may decrease the antihypertensive activities of Nadolol.
Butriptyline Butriptyline may decrease the antihypertensive activities of Nadolol.
Tianeptine Tianeptine may decrease the antihypertensive activities of Nadolol.
Oxaprotiline Oxaprotiline may decrease the antihypertensive activities of Nadolol.
Atipamezole Atipamezole may decrease the antihypertensive activities of Nadolol.
Tetrahydrocannabivarin Tetrahydrocannabivarin may decrease the antihypertensive activities of Nadolol.
Piclozotan Piclozotan may decrease the antihypertensive activities of Nadolol.
Siponimod Siponimod may decrease the antihypertensive activities of Nadolol.
Idazoxan Idazoxan may decrease the antihypertensive activities of Nadolol.
Tramazoline Tramazoline may decrease the antihypertensive activities of Nadolol.
Amitriptylinoxide Amitriptylinoxide may decrease the antihypertensive activities of Nadolol.
Dibenzepin Dibenzepin may decrease the antihypertensive activities of Nadolol.
Quinupramine Quinupramine may decrease the antihypertensive activities of Nadolol.
Trichloroethylene Trichloroethylene may decrease the antihypertensive activities of Nadolol.
Fenozolone Fenozolone may decrease the antihypertensive activities of Nadolol.
Melitracen Melitracen may decrease the antihypertensive activities of Nadolol.
Lofepramine Lofepramine may decrease the antihypertensive activities of Nadolol.
Xenon Xenon may decrease the antihypertensive activities of Nadolol.
Iprindole Iprindole may decrease the antihypertensive activities of Nadolol.
Buflomedil Buflomedil may decrease the antihypertensive activities of Nadolol.
Imipramine oxide Imipramine oxide may decrease the antihypertensive activities of Nadolol.
Mefenorex Mefenorex may decrease the antihypertensive activities of Nadolol.
5-methoxy-N,N-dimethyltryptamine 5-methoxy-N,N-dimethyltryptamine may decrease the antihypertensive activities of Nadolol.
Quinoline Yellow WS Quinoline Yellow WS may decrease the antihypertensive activities of Nadolol.
Sufentanil Sufentanil may decrease the antihypertensive activities of Nadolol.
Isoflurane Isoflurane may decrease the antihypertensive activities of Nadolol.
Remifentanil Remifentanil may decrease the antihypertensive activities of Nadolol.
Halothane Halothane may decrease the antihypertensive activities of Nadolol.
Desflurane Desflurane may decrease the antihypertensive activities of Nadolol.
Sevoflurane Sevoflurane may decrease the antihypertensive activities of Nadolol.
Alfentanil Alfentanil may decrease the antihypertensive activities of Nadolol.
Propofol Propofol may decrease the antihypertensive activities of Nadolol.
Flibanserin Flibanserin may decrease the antihypertensive activities of Nadolol.
Diethyl ether Diethyl ether may decrease the antihypertensive activities of Nadolol.
Protriptyline Protriptyline may decrease the antihypertensive activities of Nadolol.
Fentanyl Fentanyl may decrease the antihypertensive activities of Nadolol.
Dimetacrine Dimetacrine may decrease the antihypertensive activities of Nadolol.
Opipramol Opipramol may decrease the antihypertensive activities of Nadolol.
Naxitamab Naxitamab may decrease the antihypertensive activities of Nadolol.
Cannabidiol The metabolism of Nadolol can be decreased when combined with Cannabidiol.
Amiodarone The therapeutic efficacy of Nadolol can be increased when used in combination with Amiodarone.
Bupivacaine The serum concentration of Bupivacaine can be increased when it is combined with Nadolol.
Dipyridamole Dipyridamole may increase the bradycardic activities of Nadolol.
Disopyramide Disopyramide may increase the bradycardic activities of Nadolol.
Dronedarone Dronedarone may increase the bradycardic activities of Nadolol.
Fingolimod Nadolol may increase the bradycardic activities of Fingolimod.
Floctafenine The risk or severity of adverse effects can be increased when Nadolol is combined with Floctafenine.
Mepivacaine The serum concentration of Mepivacaine can be increased when it is combined with Nadolol.
Methacholine Nadolol may increase the bronchoconstrictory activities of Methacholine.
Midodrine The therapeutic efficacy of Midodrine can be decreased when used in combination with Nadolol.
Nifedipine The risk or severity of congestive heart failure and hypotension can be increased when Nifedipine is combined with Nadolol.
Propafenone The risk or severity of adverse effects can be increased when Propafenone is combined with Nadolol.
Regorafenib Regorafenib may increase the bradycardic activities of Nadolol.
Deserpidine Deserpidine may increase the hypotensive activities of Nadolol.
Guanethidine Guanethidine may increase the hypotensive activities of Nadolol.
Rivastigmine Nadolol may increase the bradycardic activities of Rivastigmine.
Mirabegron The serum concentration of Nadolol can be increased when it is combined with Mirabegron.
Nicorandil Nicorandil may increase the hypotensive activities of Nadolol.
Molsidomine Molsidomine may increase the hypotensive activities of Nadolol.
Insulin argine Nadolol may increase the hypoglycemic activities of Insulin argine.
Dorzolamide Dorzolamide may increase the hypotensive activities of Nadolol.
Bimatoprost Bimatoprost may increase the hypotensive activities of Nadolol.
Unoprostone Nadolol may increase the hypotensive activities of Unoprostone.
Minoxidil Minoxidil may increase the hypotensive activities of Nadolol.
Nitroglycerin Nitroglycerin may increase the hypotensive activities of Nadolol.
Remikiren Remikiren may increase the hypotensive activities of Nadolol.
Guanadrel Guanadrel may increase the hypotensive activities of Nadolol.
Bosentan Bosentan may increase the hypotensive activities of Nadolol.
Candoxatril Candoxatril may increase the hypotensive activities of Nadolol.
Metyrosine Metyrosine may increase the hypotensive activities of Nadolol.

Target Protein

Beta-1 adrenergic receptor ADRB1
Beta-2 adrenergic receptor ADRB2

Referensi & Sumber

Artikel (PubMed)
  • PMID: 24890609
    Cernecka H, Sand C, Michel MC: The odd sibling: features of beta3-adrenoceptor pharmacology. Mol Pharmacol. 2014 Nov;86(5):479-84. doi: 10.1124/mol.114.092817. Epub 2014 Jun 2.
  • PMID: 6714285
    Schafer-Korting M, Bach N, Knauf H, Mutschler E: Pharmacokinetics of nadolol in healthy subjects. Eur J Clin Pharmacol. 1984;26(1):125-7.
  • PMID: 3366166
    Morrison RA, Singhvi SM, Creasey WA, Willard DA: Dose proportionality of nadolol pharmacokinetics after intravenous administration to healthy subjects. Eur J Clin Pharmacol. 1988;33(6):625-8.
  • PMID: 6146679
    Patel L, Johnson A, Turner P: Nadolol binding to human serum proteins. J Pharm Pharmacol. 1984 Jun;36(6):414-5. doi: 10.1111/j.2042-7158.1984.tb04413.x.
  • PMID: 11495502
    Israili ZH, Dayton PG: Human alpha-1-glycoprotein and its interactions with drugs. Drug Metab Rev. 2001 May;33(2):161-235. doi: 10.1081/DMR-100104402 .
  • PMID: 27667324
    Lee WG, Murphy R, McCall JL, Gane EJ, Soop M, Tura A, Plank LD: Nadolol reduces insulin sensitivity in liver cirrhosis: a randomized double-blind crossover trial. Diabetes Metab Res Rev. 2017 Mar;33(3). doi: 10.1002/dmrr.2859. Epub 2016 Nov 10.
  • PMID: 21125979
    Gorre F, Vandekerckhove H: Beta-blockers: focus on mechanism of action. Which beta-blocker, when and why? Acta Cardiol. 2010 Oct;65(5):565-70. doi: 10.2143/AC.65.5.2056244.

Contoh Produk & Brand

Produk: 148 • International brands: 2
Produk
  • Apo-nadolol
    Tablet • 80 mg • Oral • Canada • Generic • Approved
  • Apo-nadolol
    Tablet • 160 mg • Oral • Canada • Generic • Approved
  • Apo-nadolol
    Tablet • 40 mg • Oral • Canada • Generic • Approved
  • Corgard
    Tablet • 40 mg/1 • Oral • US • Approved
  • Corgard
    Tablet • 20 mg/1 • Oral • US • Approved
  • Corgard
    Tablet • 40 mg/1 • Oral • US • Approved
  • Corgard
    Tablet • 80 mg/1 • Oral • US • Approved
  • Corgard
    Tablet • 120 mg/1 • Oral • US • Approved
Menampilkan 8 dari 148 produk.
International Brands
  • Anabet
  • Solgol

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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