Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid.A216008 Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to coat the tips of hunting arrows and darts, which were typically derived from plants of the genera Chondrodendron and Strychnos.A216008 Tubocurarine is a benzylisoquinoline derivative and shares this structural backbone with a number of plant-derived alkaloids, including morphine and papaverine.A216028 It was first isolated by Harold King in 1935 and was used clinically to induce neuromuscular blockade during surgeries, particularly those involving the abdomen.A216038 Tubocurarine's clinical use was limited by its relatively long duration of action (30-60 minutes)A216038 and a number of significant side effects.A216048 Safer and more pharmacokinetically favorable non-depolarizing neuromuscular blockers, such as rocuronium, have largely replaced the use of tubocurarine in the clinical setting.A216048
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Buprenorphine | Tubocurarine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Tubocurarine. |
| Dronabinol | Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Tubocurarine. |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Tubocurarine. |
| Hydrocodone | Tubocurarine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. |
| Hydroxyzine | Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tubocurarine. |
| Magnesium sulfate | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium sulfate. |
| Methotrimeprazine | Tubocurarine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. |
| Metyrosine | Tubocurarine may increase the sedative activities of Metyrosine. |
| Minocycline | Minocycline may increase the central nervous system depressant (CNS depressant) activities of Tubocurarine. |
| Mirtazapine | Tubocurarine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. |
| Nabilone | Nabilone may increase the central nervous system depressant (CNS depressant) activities of Tubocurarine. |
| Orphenadrine | Tubocurarine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Paraldehyde | Tubocurarine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. |
| Perampanel | Perampanel may increase the central nervous system depressant (CNS depressant) activities of Tubocurarine. |
| Pramipexole | Tubocurarine may increase the sedative activities of Pramipexole. |
| Ropinirole | Tubocurarine may increase the sedative activities of Ropinirole. |
| Rotigotine | Tubocurarine may increase the sedative activities of Rotigotine. |
| Rufinamide | The risk or severity of adverse effects can be increased when Rufinamide is combined with Tubocurarine. |
| Sodium oxybate | The risk or severity of CNS depression can be increased when Tubocurarine is combined with Sodium oxybate. |
| Suvorexant | Tubocurarine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Tapentadol | Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Tubocurarine. |
| Thalidomide | Tubocurarine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. |
| Zolpidem | Tubocurarine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. |
| Capreomycin | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Capreomycin. |
| Quinidine | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Quinidine. |
| Cyclosporine | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Cyclosporine. |
| Doxycycline | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Doxycycline. |
| Lymecycline | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Lymecycline. |
| Piperacillin | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Piperacillin. |
| Framycetin | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Framycetin. |
| Clomocycline | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Clomocycline. |
| Quinine | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Quinine. |
| Vancomycin | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Vancomycin. |
| Tigecycline | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Tigecycline. |
| Oxytetracycline | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Oxytetracycline. |
| Chloroquine | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Chloroquine. |
| Demeclocycline | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Demeclocycline. |
| Mecamylamine | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Mecamylamine. |
| Tobramycin | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Tobramycin. |
| Tetracycline | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Tetracycline. |
| Gentamicin | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Gentamicin. |
| Etacrynic acid | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Etacrynic acid. |
| Metacycline | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Metacycline. |
| Netilmicin | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Netilmicin. |
| Neomycin | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Neomycin. |
| Procainamide | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Procainamide. |
| Streptomycin | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Streptomycin. |
| Colistimethate | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Colistimethate. |
| Kanamycin | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Kanamycin. |
| Dantrolene | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Dantrolene. |
| Rolitetracycline | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Rolitetracycline. |
| Magnesium oxide | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium oxide. |
| Magnesium cation | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium cation. |
| Paromomycin | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Paromomycin. |
| Lincomycin | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Lincomycin. |
| Ribostamycin | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Ribostamycin. |
| Geneticin | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Geneticin. |
| Apramycin | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Apramycin. |
| Gentamicin C1a | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Gentamicin C1a. |
| Neamine | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Neamine. |
| Arbekacin | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Arbekacin. |
| Viomycin | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Viomycin. |
| Puromycin | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Puromycin. |
| Magnesium hydroxide | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium hydroxide. |
| Magnesium trisilicate | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium trisilicate. |
| Magnesium chloride | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium chloride. |
| Magnesium acetate tetrahydrate | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium acetate tetrahydrate. |
| Magnesium carbonate | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium carbonate. |
| Magnesium citrate | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium citrate. |
| Magnesium glycinate | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium glycinate. |
| Magnesium Aluminum Silicate | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium Aluminum Silicate. |
| Dihydrostreptomycin | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Dihydrostreptomycin. |
| Hygromycin B | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Hygromycin B. |
| Sisomicin | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Sisomicin. |
| Plazomicin | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Plazomicin. |
| Magnesium silicate | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium silicate. |
| Penimepicycline | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Penimepicycline. |
| Magnesium aspartate | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium aspartate. |
| Isepamicin | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Isepamicin. |
| Magnesium gluconate | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium gluconate. |
| Magnesium orotate | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium orotate. |
| Magnesium phosphate | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium phosphate. |
| Magnesium acetate | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium acetate. |
| Magnesium stearate | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium stearate. |
| Colistin | The therapeutic efficacy of Tubocurarine can be increased when used in combination with Colistin. |
| Secretin porcine | The therapeutic efficacy of Secretin porcine can be decreased when used in combination with Tubocurarine. |
| Methadone | The risk or severity of adverse effects can be increased when Methadone is combined with Tubocurarine. |
| Dipyridamole | The therapeutic efficacy of Tubocurarine can be decreased when used in combination with Dipyridamole. |
| Ephedrine | Tubocurarine may increase the neuromuscular blocking activities of Ephedrine. |
| Sar9, Met (O2)11-Substance P | Tubocurarine may increase the neuromuscular blocking activities of Sar9, Met (O2)11-Substance P. |
| Mirabegron | Tubocurarine may increase the neuromuscular blocking activities of Mirabegron. |
| Moxisylyte | Tubocurarine may increase the neuromuscular blocking activities of Moxisylyte. |
| Propacetamol | Tubocurarine may increase the neuromuscular blocking activities of Propacetamol. |
| Pegvisomant | Pegvisomant may increase the neuromuscular blocking activities of Tubocurarine. |
| Mefloquine | Mefloquine may increase the neuromuscular blocking activities of Tubocurarine. |
| Tacrine | Tacrine may increase the neuromuscular blocking activities of Tubocurarine. |
| Sulpiride | Sulpiride may increase the neuromuscular blocking activities of Tubocurarine. |
| Profenamine | Profenamine may increase the neuromuscular blocking activities of Tubocurarine. |
| Chlorpromazine | Chlorpromazine may increase the neuromuscular blocking activities of Tubocurarine. |