Peringatan Keamanan

Symptoms of overdose include emesis and decreased blood pressure. Side effects include dose-dependent rash (usually maculopapular), taste alterations, hypotension, gastric irritation, cough, and angioedema.

Captopril

DB01197

small molecule approved

Deskripsi

Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment of hypertension.

Struktur Molekul 2D

Berat 217.285
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 2 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

60-75% in fasting individuals; food decreases absorption by 25-40% (some evidence indicates that this is not clinically significant)

Metabolisme

Hepatic. Major metabolites are captopril-cysteine disulfide and the disulfide dimer of captopril. Metabolites may undergo reversible interconversion.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

4 Data
  • 1. Avoid hypertensive herbs (e.g. bayberry, blue cohosh, cayenne, ephedra, and licorice).
  • 2. Avoid potassium-containing products. Potassium products increase the risk of hyperkalemia.
  • 3. Limit salt intake. Salt may attenuate the antihypertensive effect.
  • 4. Take separate from meals. The presence of food decreases absorption. Take one hour prior to meals.

Interaksi Obat

1061 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Captopril is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Captopril is combined with Levodopa.
Risperidone Captopril may increase the hypotensive activities of Risperidone.
Alfuzosin Alfuzosin may increase the hypotensive activities of Captopril.
Amifostine Captopril may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Captopril.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Captopril.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Captopril.
Obinutuzumab Captopril may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Captopril.
Rituximab Captopril may increase the hypotensive activities of Rituximab.
Desmopressin Desmopressin may decrease the antihypertensive activities of Captopril.
Phentermine Phentermine may decrease the antihypertensive activities of Captopril.
Isoetharine Isoetharine may decrease the antihypertensive activities of Captopril.
Methysergide Methysergide may decrease the antihypertensive activities of Captopril.
Etomidate Etomidate may decrease the antihypertensive activities of Captopril.
Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Captopril.
Dihydroergotamine Dihydroergotamine may decrease the antihypertensive activities of Captopril.
Methylergometrine Methylergometrine may decrease the antihypertensive activities of Captopril.
Norepinephrine Norepinephrine may decrease the antihypertensive activities of Captopril.
Phenylephrine Phenylephrine may decrease the antihypertensive activities of Captopril.
Phenylpropanolamine Phenylpropanolamine may decrease the antihypertensive activities of Captopril.
Droperidol Droperidol may decrease the antihypertensive activities of Captopril.
Doxapram Doxapram may decrease the antihypertensive activities of Captopril.
Atropine Atropine may decrease the antihypertensive activities of Captopril.
Metaraminol Metaraminol may decrease the antihypertensive activities of Captopril.
Epinephrine Epinephrine may decrease the antihypertensive activities of Captopril.
Ergotamine Ergotamine may decrease the antihypertensive activities of Captopril.
Methoxamine Methoxamine may decrease the antihypertensive activities of Captopril.
Propiomazine Propiomazine may decrease the antihypertensive activities of Captopril.
Alfentanil Alfentanil may decrease the antihypertensive activities of Captopril.
Fentanyl Fentanyl may decrease the antihypertensive activities of Captopril.
Orciprenaline Orciprenaline may decrease the antihypertensive activities of Captopril.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Captopril.
Dobutamine Dobutamine may decrease the antihypertensive activities of Captopril.
Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Captopril.
Benzphetamine Benzphetamine may decrease the antihypertensive activities of Captopril.
Ritodrine Ritodrine may decrease the antihypertensive activities of Captopril.
Terbutaline Terbutaline may decrease the antihypertensive activities of Captopril.
Bitolterol Bitolterol may decrease the antihypertensive activities of Captopril.
Diethylpropion Diethylpropion may decrease the antihypertensive activities of Captopril.
Naratriptan Naratriptan may decrease the antihypertensive activities of Captopril.
Rizatriptan Rizatriptan may decrease the antihypertensive activities of Captopril.
Dopamine Dopamine may decrease the antihypertensive activities of Captopril.
Frovatriptan Frovatriptan may decrease the antihypertensive activities of Captopril.
Albuterol Salbutamol may decrease the antihypertensive activities of Captopril.
Ergoloid mesylate Ergoloid mesylate may decrease the antihypertensive activities of Captopril.
Isoprenaline Isoprenaline may decrease the antihypertensive activities of Captopril.
Arbutamine Arbutamine may decrease the antihypertensive activities of Captopril.
Dutasteride Dutasteride may decrease the antihypertensive activities of Captopril.
Finasteride Finasteride may decrease the antihypertensive activities of Captopril.
Ergometrine Ergometrine may decrease the antihypertensive activities of Captopril.
Fenoterol Fenoterol may decrease the antihypertensive activities of Captopril.
Pirbuterol Pirbuterol may decrease the antihypertensive activities of Captopril.
Ephedra sinica root Ephedra sinica root may decrease the antihypertensive activities of Captopril.
Ephedrine Ephedrine may decrease the antihypertensive activities of Captopril.
Mephentermine Mephentermine may decrease the antihypertensive activities of Captopril.
Procaterol Procaterol may decrease the antihypertensive activities of Captopril.
Yohimbine Yohimbine may decrease the antihypertensive activities of Captopril.
Clenbuterol Clenbuterol may decrease the antihypertensive activities of Captopril.
Bambuterol Bambuterol may decrease the antihypertensive activities of Captopril.
MMDA MMDA may decrease the antihypertensive activities of Captopril.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Captopril.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Captopril.
Tenamfetamine Tenamfetamine may decrease the antihypertensive activities of Captopril.
Chlorphentermine Chlorphentermine may decrease the antihypertensive activities of Captopril.
Dextroamphetamine Dextroamphetamine may decrease the antihypertensive activities of Captopril.
Phendimetrazine Phendimetrazine may decrease the antihypertensive activities of Captopril.
Solifenacin Solifenacin may decrease the antihypertensive activities of Captopril.
Periciazine Periciazine may decrease the antihypertensive activities of Captopril.
Acepromazine Acepromazine may decrease the antihypertensive activities of Captopril.
Thioproperazine Thioproperazine may decrease the antihypertensive activities of Captopril.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Captopril.
1-benzylimidazole 1-benzylimidazole may decrease the antihypertensive activities of Captopril.
Amineptine Amineptine may decrease the antihypertensive activities of Captopril.
Flibanserin Flibanserin may decrease the antihypertensive activities of Captopril.
Amibegron Amibegron may decrease the antihypertensive activities of Captopril.
Naluzotan Naluzotan may decrease the antihypertensive activities of Captopril.
Pizotifen Pizotifen may decrease the antihypertensive activities of Captopril.
Solabegron Solabegron may decrease the antihypertensive activities of Captopril.
Droxidopa Droxidopa may decrease the antihypertensive activities of Captopril.
Nitrous oxide Nitrous oxide may decrease the antihypertensive activities of Captopril.
Xylometazoline Xylometazoline may decrease the antihypertensive activities of Captopril.
Isometheptene Isometheptene may decrease the antihypertensive activities of Captopril.
Levonordefrin Levonordefrin may decrease the antihypertensive activities of Captopril.
Naphazoline Naphazoline may decrease the antihypertensive activities of Captopril.
Tetryzoline Tetryzoline may decrease the antihypertensive activities of Captopril.
Cinitapride Cinitapride may decrease the antihypertensive activities of Captopril.
Lurasidone Lurasidone may decrease the antihypertensive activities of Captopril.
Tyramine Tyramine may decrease the antihypertensive activities of Captopril.
Adrafinil Adrafinil may decrease the antihypertensive activities of Captopril.
Ifenprodil Ifenprodil may decrease the antihypertensive activities of Captopril.
Hexoprenaline Hexoprenaline may decrease the antihypertensive activities of Captopril.
Etilefrine Etilefrine may decrease the antihypertensive activities of Captopril.
Dimetacrine Dimetacrine may decrease the antihypertensive activities of Captopril.
Butriptyline Butriptyline may decrease the antihypertensive activities of Captopril.
Cannabidiol Cannabidiol may decrease the antihypertensive activities of Captopril.
Olodaterol Olodaterol may decrease the antihypertensive activities of Captopril.
Vilanterol Vilanterol may decrease the antihypertensive activities of Captopril.
Cirazoline Cirazoline may decrease the antihypertensive activities of Captopril.

Target Protein

Angiotensin-converting enzyme ACE
72 kDa type IV collagenase MMP2
Matrix metalloproteinase-9 MMP9
Leukotriene A-4 hydrolase LTA4H
B1 bradykinin receptor BDKRB1

Referensi & Sumber

Synthesis reference: Charles M. Zepp, "Methods for preparing captopril and its analogues." U.S. Patent US5166361, issued July, 1981.
Artikel (PubMed)
  • PMID: 90928
    Atkinson AB, Robertson JI: Captopril in the treatment of clinical hypertension and cardiac failure. Lancet. 1979 Oct 20;2(8147):836-9.
  • PMID: 6253826
    Patchett AA, Harris E, Tristram EW, Wyvratt MJ, Wu MT, Taub D, Peterson ER, Ikeler TJ, ten Broeke J, Payne LG, Ondeyka DL, Thorsett ED, Greenlee WJ, Lohr NS, Hoffsommer RD, Joshua H, Ruyle WV, Rothrock JW, Aster SD, Maycock AL, Robinson FM, Hirschmann R, Sweet CS, Ulm EH, Gross DM, Vassil TC, Stone CA: A new class of angiotensin-converting enzyme inhibitors. Nature. 1980 Nov 20;288(5788):280-3.
  • PMID: 12724335
    Smith CG, Vane JR: The discovery of captopril. FASEB J. 2003 May;17(8):788-9.

Contoh Produk & Brand

Produk: 275 • International brands: 15
Produk
  • Apo-capto Tab 100mg
    Tablet • 100 mg • Oral • Canada • Generic • Approved
  • Apo-capto Tab 12.5mg
    Tablet • 12.5 mg • Oral • Canada • Generic • Approved
  • Apo-capto Tab 25mg
    Tablet • 25 mg • Oral • Canada • Generic • Approved
  • Apo-capto Tab 50mg
    Tablet • 50 mg • Oral • Canada • Generic • Approved
  • Apo-capto Tab 6.25mg
    Tablet • 6.25 mg • Oral • Canada • Generic • Approved
  • Bci Captopril Tablets
    Tablet • 12.5 mg • Oral • Canada • Approved
  • Bci Captopril Tablets
    Tablet • 25 mg • Oral • Canada • Approved
  • Bci Captopril Tablets
    Tablet • 50 mg • Oral • Canada • Approved
Menampilkan 8 dari 275 produk.
International Brands
  • Acepress — Bernofarm (Indonesia), BMS (Italy)
  • Acepril — BMS (United Kingdom)
  • Alopresin
  • Apopril
  • Captolane — Sanofi-Aventis (France)
  • Captoril — Novopharm (Canada)
  • Cesplon — Esteve (Spain)
  • Dilabar — Qualigen (Spain)
  • Garranil — Aristegui (Spain)
  • Hipertil — Normal (Portugal)

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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