Peringatan Keamanan

Symptoms of overdose include extreme bradycardia, advanced atrioventricular block, intraventricular conduction defects, hypotension, severe congestive heart failure, seizures, and in susceptible patients, bronchospasm, and hypoglycemia.

Acebutolol

DB01193

small molecule approved investigational

Deskripsi

A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action.

Struktur Molekul 2D

Berat 336.4259
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The plasma elimination half-life is approximately 3 to 4 hours. The half-life of its metabolite, diacetolol, is 8 to 13 hours.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Well absorbed from the Gl tract with an absolute bioavailability of approximately 40% for the parent compound.

Metabolisme

Subject to extensive first-pass hepatic biotransformation (primarily to diacetolol).

Rute Eliminasi

Elimination via renal excretion is approximately 30% to 40% and by non-renal mechanisms 50% to 60%, which includes excretion into the bile and direct passage through the intestinal wall.

Interaksi Makanan

1 Data
  • 1. Take with or without food. Food decreases absorption rate and maximum concentration, but not to a clinically significant extent.

Interaksi Obat

1344 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Acebutolol is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Acebutolol is combined with Levodopa.
Risperidone Acebutolol may increase the hypotensive activities of Risperidone.
Ceritinib Acebutolol may increase the bradycardic activities of Ceritinib.
Ivabradine Acebutolol may increase the bradycardic activities of Ivabradine.
Ruxolitinib Ruxolitinib may increase the bradycardic activities of Acebutolol.
Alfuzosin Alfuzosin may increase the hypotensive activities of Acebutolol.
Amifostine Acebutolol may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Acebutolol.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Acebutolol.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Acebutolol.
Obinutuzumab Acebutolol may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Acebutolol.
Rituximab Acebutolol may increase the hypotensive activities of Rituximab.
Desmopressin Desmopressin may decrease the antihypertensive activities of Acebutolol.
Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Acebutolol.
Doxapram Doxapram may decrease the antihypertensive activities of Acebutolol.
Naratriptan Naratriptan may decrease the antihypertensive activities of Acebutolol.
Rizatriptan Rizatriptan may decrease the antihypertensive activities of Acebutolol.
Frovatriptan Frovatriptan may decrease the antihypertensive activities of Acebutolol.
Dutasteride Dutasteride may decrease the antihypertensive activities of Acebutolol.
Finasteride Finasteride may decrease the antihypertensive activities of Acebutolol.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Acebutolol.
1-benzylimidazole 1-benzylimidazole may decrease the antihypertensive activities of Acebutolol.
Amineptine Amineptine may decrease the antihypertensive activities of Acebutolol.
Naluzotan Naluzotan may decrease the antihypertensive activities of Acebutolol.
Nitrous oxide Nitrous oxide may decrease the antihypertensive activities of Acebutolol.
Cinitapride Cinitapride may decrease the antihypertensive activities of Acebutolol.
Ifenprodil Ifenprodil may decrease the antihypertensive activities of Acebutolol.
Dimetacrine Dimetacrine may decrease the antihypertensive activities of Acebutolol.
Moxisylyte Moxisylyte may decrease the antihypertensive activities of Acebutolol.
Tianeptine Tianeptine may decrease the antihypertensive activities of Acebutolol.
Oxaprotiline Oxaprotiline may decrease the antihypertensive activities of Acebutolol.
Atipamezole Atipamezole may decrease the antihypertensive activities of Acebutolol.
Tetrahydrocannabivarin Tetrahydrocannabivarin may decrease the antihypertensive activities of Acebutolol.
Piclozotan Piclozotan may decrease the antihypertensive activities of Acebutolol.
Siponimod Siponimod may decrease the antihypertensive activities of Acebutolol.
Idazoxan Idazoxan may decrease the antihypertensive activities of Acebutolol.
Amitriptylinoxide Amitriptylinoxide may decrease the antihypertensive activities of Acebutolol.
Dibenzepin Dibenzepin may decrease the antihypertensive activities of Acebutolol.
Quinupramine Quinupramine may decrease the antihypertensive activities of Acebutolol.
Trichloroethylene Trichloroethylene may decrease the antihypertensive activities of Acebutolol.
Melitracen Melitracen may decrease the antihypertensive activities of Acebutolol.
Lofepramine Lofepramine may decrease the antihypertensive activities of Acebutolol.
Xenon Xenon may decrease the antihypertensive activities of Acebutolol.
Iprindole Iprindole may decrease the antihypertensive activities of Acebutolol.
Buflomedil Buflomedil may decrease the antihypertensive activities of Acebutolol.
Imipramine oxide Imipramine oxide may decrease the antihypertensive activities of Acebutolol.
Quinoline Yellow WS Quinoline Yellow WS may decrease the antihypertensive activities of Acebutolol.
Solriamfetol Solriamfetol may decrease the antihypertensive activities of Acebutolol.
Sufentanil Sufentanil may decrease the antihypertensive activities of Acebutolol.
Remifentanil Remifentanil may decrease the antihypertensive activities of Acebutolol.
Halothane Halothane may decrease the antihypertensive activities of Acebutolol.
Sumatriptan Sumatriptan may decrease the antihypertensive activities of Acebutolol.
Alfentanil Alfentanil may decrease the antihypertensive activities of Acebutolol.
Fentanyl Fentanyl may decrease the antihypertensive activities of Acebutolol.
Flibanserin Flibanserin may decrease the antihypertensive activities of Acebutolol.
Diethyl ether Diethyl ether may decrease the antihypertensive activities of Acebutolol.
Selpercatinib Selpercatinib may decrease the antihypertensive activities of Acebutolol.
Naxitamab Naxitamab may decrease the antihypertensive activities of Acebutolol.
Opipramol Opipramol may decrease the antihypertensive activities of Acebutolol.
Protriptyline Protriptyline may decrease the antihypertensive activities of Acebutolol.
Isoflurane Isoflurane may decrease the antihypertensive activities of Acebutolol.
Propofol Propofol may decrease the antihypertensive activities of Acebutolol.
Desflurane Desflurane may decrease the antihypertensive activities of Acebutolol.
Sevoflurane Sevoflurane may decrease the antihypertensive activities of Acebutolol.
Lurasidone Lurasidone may decrease the antihypertensive activities of Acebutolol.
Butriptyline Butriptyline may decrease the antihypertensive activities of Acebutolol.
Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Acebutolol.
Amiodarone The therapeutic efficacy of Acebutolol can be increased when used in combination with Amiodarone.
Bupivacaine The serum concentration of Bupivacaine can be increased when it is combined with Acebutolol.
Dipyridamole Dipyridamole may increase the bradycardic activities of Acebutolol.
Disopyramide Disopyramide may increase the bradycardic activities of Acebutolol.
Dronedarone Dronedarone may increase the bradycardic activities of Acebutolol.
Fingolimod Acebutolol may increase the bradycardic activities of Fingolimod.
Floctafenine The risk or severity of adverse effects can be increased when Acebutolol is combined with Floctafenine.
Mepivacaine The serum concentration of Mepivacaine can be increased when it is combined with Acebutolol.
Methacholine Acebutolol may increase the bronchoconstrictory activities of Methacholine.
Midodrine The therapeutic efficacy of Midodrine can be decreased when used in combination with Acebutolol.
Nifedipine The risk or severity of congestive heart failure and hypotension can be increased when Nifedipine is combined with Acebutolol.
Propafenone The risk or severity of adverse effects can be increased when Propafenone is combined with Acebutolol.
Regorafenib Regorafenib may increase the bradycardic activities of Acebutolol.
Reserpine Reserpine may increase the hypotensive activities of Acebutolol.
Deserpidine Deserpidine may increase the hypotensive activities of Acebutolol.
Guanethidine Guanethidine may increase the hypotensive activities of Acebutolol.
Rivastigmine Acebutolol may increase the bradycardic activities of Rivastigmine.
Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Acebutolol.
Mirabegron The serum concentration of Acebutolol can be increased when it is combined with Mirabegron.
Tedizolid phosphate Tedizolid phosphate may increase the hypertensive activities of Acebutolol.
Nicorandil Nicorandil may increase the hypotensive activities of Acebutolol.
Molsidomine Molsidomine may increase the hypotensive activities of Acebutolol.
Insulin argine Acebutolol may increase the hypoglycemic activities of Insulin argine.
Dorzolamide Dorzolamide may increase the hypotensive activities of Acebutolol.
Bimatoprost Bimatoprost may increase the hypotensive activities of Acebutolol.
Unoprostone Acebutolol may increase the hypotensive activities of Unoprostone.
Torasemide Torasemide may increase the hypotensive activities of Acebutolol.
Chlorthalidone Chlorthalidone may increase the hypotensive activities of Acebutolol.
Nitroprusside Nitroprusside may increase the hypotensive activities of Acebutolol.
Minoxidil Minoxidil may increase the hypotensive activities of Acebutolol.
Metolazone Metolazone may increase the hypotensive activities of Acebutolol.

Target Protein

Beta-1 adrenergic receptor ADRB1
Beta-2 adrenergic receptor ADRB2

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 67 • International brands: 1
Produk
  • Acebutolol
    Tablet • 400 mg • Oral • Canada • Approved
  • Acebutolol
    Tablet • 200 mg • Oral • Canada • Approved
  • Acebutolol
    Tablet • 100 mg • Oral • Canada • Approved
  • Acebutolol - 400
    Tablet • 400 mg • Oral • Canada • Approved
  • Acebutolol Hydrochloride
    Capsule • 200 mg/1 • Oral • US • Generic • Approved
  • Acebutolol Hydrochloride
    Capsule • 400 mg/1 • Oral • US • Generic • Approved
  • Acebutolol Hydrochloride
    Capsule • 200 mg/1 • Oral • US • Generic • Approved
  • Acebutolol Hydrochloride
    Capsule • 200 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 67 produk.
International Brands
  • Prent — Bayer

Sekuens Gen/Protein (FASTA)

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