Peringatan Keamanan

Symptoms of overdose include respiratory failure and cardiac arrest leading to death.

Dexfenfluramine

DB01191

small molecule approved illicit investigational withdrawn

Deskripsi

Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was withdrawn.

Struktur Molekul 2D

Berat 231.2573
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 17-20 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Well-absorbed from the gastrointestinal tract.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take with food.

Interaksi Obat

705 Data
Deferasirox The serum concentration of Dexfenfluramine can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Dexfenfluramine can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Dexfenfluramine can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Dexfenfluramine can be decreased when it is combined with Teriflunomide.
Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Dexfenfluramine.
Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Dexfenfluramine.
Mirabegron The serum concentration of Dexfenfluramine can be increased when it is combined with Mirabegron.
Abiraterone The serum concentration of Dexfenfluramine can be increased when it is combined with Abiraterone.
Mirtazapine Dexfenfluramine may increase the serotonergic activities of Mirtazapine.
Cyproterone acetate The metabolism of Dexfenfluramine can be increased when combined with Cyproterone acetate.
Methylene blue Dexfenfluramine may increase the serotonergic activities of Methylene blue.
Carbamazepine The metabolism of Dexfenfluramine can be increased when combined with Carbamazepine.
Primidone The metabolism of Dexfenfluramine can be increased when combined with Primidone.
Rifampin The metabolism of Dexfenfluramine can be increased when combined with Rifampicin.
Albendazole The metabolism of Dexfenfluramine can be increased when combined with Albendazole.
Caffeine The metabolism of Dexfenfluramine can be decreased when combined with Caffeine.
Moxifloxacin The metabolism of Dexfenfluramine can be decreased when combined with Moxifloxacin.
Lidocaine The metabolism of Dexfenfluramine can be decreased when combined with Lidocaine.
Mexiletine The metabolism of Dexfenfluramine can be decreased when combined with Mexiletine.
Alosetron The metabolism of Dexfenfluramine can be decreased when combined with Alosetron.
Gatifloxacin The metabolism of Dexfenfluramine can be decreased when combined with Gatifloxacin.
Simeprevir The metabolism of Dexfenfluramine can be decreased when combined with Simeprevir.
Lobeglitazone The metabolism of Dexfenfluramine can be decreased when combined with Lobeglitazone.
Pazufloxacin The metabolism of Dexfenfluramine can be decreased when combined with Pazufloxacin.
Osilodrostat The metabolism of Dexfenfluramine can be decreased when combined with Osilodrostat.
Venlafaxine The risk or severity of serotonin syndrome can be increased when Dexfenfluramine is combined with Venlafaxine.
Vilazodone The metabolism of Dexfenfluramine can be decreased when combined with Vilazodone.
Ritanserin The metabolism of Dexfenfluramine can be decreased when combined with Ritanserin.
Ketoconazole The metabolism of Dexfenfluramine can be decreased when combined with Ketoconazole.
Cyclosporine The metabolism of Dexfenfluramine can be decreased when combined with Cyclosporine.
Cholecalciferol The metabolism of Dexfenfluramine can be decreased when combined with Cholecalciferol.
Metoprolol The metabolism of Dexfenfluramine can be decreased when combined with Metoprolol.
Terfenadine The metabolism of Dexfenfluramine can be decreased when combined with Terfenadine.
Clobazam The serum concentration of Dexfenfluramine can be increased when it is combined with Clobazam.
Celecoxib The metabolism of Dexfenfluramine can be decreased when combined with Celecoxib.
Darifenacin The metabolism of Dexfenfluramine can be decreased when combined with Darifenacin.
Cimetidine The metabolism of Dexfenfluramine can be decreased when combined with Cimetidine.
Chloroquine The metabolism of Dexfenfluramine can be decreased when combined with Chloroquine.
Delavirdine The metabolism of Dexfenfluramine can be decreased when combined with Delavirdine.
Tipranavir The metabolism of Dexfenfluramine can be decreased when combined with Tipranavir.
Perhexiline The metabolism of Dexfenfluramine can be decreased when combined with Perhexiline.
Fusidic acid The metabolism of Dexfenfluramine can be decreased when combined with Fusidic acid.
Panobinostat The metabolism of Dexfenfluramine can be decreased when combined with Panobinostat.
Lumefantrine The metabolism of Dexfenfluramine can be decreased when combined with Lumefantrine.
Sulfaphenazole The metabolism of Dexfenfluramine can be decreased when combined with Sulfaphenazole.
Phenylbutyric acid The metabolism of Dexfenfluramine can be decreased when combined with Phenylbutyric acid.
Manidipine The metabolism of Dexfenfluramine can be decreased when combined with Manidipine.
Rolapitant The metabolism of Dexfenfluramine can be decreased when combined with Rolapitant.
Asunaprevir The metabolism of Dexfenfluramine can be decreased when combined with Asunaprevir.
Imipramine The metabolism of Dexfenfluramine can be decreased when combined with Imipramine.
Desipramine The metabolism of Dexfenfluramine can be decreased when combined with Desipramine.
Dosulepin The metabolism of Dexfenfluramine can be decreased when combined with Dosulepin.
Clozapine The serum concentration of Clozapine can be increased when it is combined with Dexfenfluramine.
Quinine The metabolism of Dexfenfluramine can be decreased when combined with Quinine.
Ritonavir The metabolism of Dexfenfluramine can be decreased when combined with Ritonavir.
Tranylcypromine The metabolism of Dexfenfluramine can be decreased when combined with Tranylcypromine.
Tegaserod The metabolism of Dexfenfluramine can be decreased when combined with Tegaserod.
Primaquine The metabolism of Dexfenfluramine can be decreased when combined with Primaquine.
Rhein The metabolism of Dexfenfluramine can be decreased when combined with Rhein.
Duloxetine The metabolism of Dexfenfluramine can be decreased when combined with Duloxetine.
Chlorpromazine The metabolism of Dexfenfluramine can be decreased when combined with Chlorpromazine.
Terbinafine The metabolism of Dexfenfluramine can be decreased when combined with Terbinafine.
Rucaparib The metabolism of Dexfenfluramine can be decreased when combined with Rucaparib.
Fluvoxamine The metabolism of Dexfenfluramine can be decreased when combined with Fluvoxamine.
Lorcaserin The metabolism of Dexfenfluramine can be decreased when combined with Lorcaserin.
Nicardipine The metabolism of Dexfenfluramine can be decreased when combined with Nicardipine.
Pitolisant The metabolism of Dexfenfluramine can be decreased when combined with Pitolisant.
Berotralstat The metabolism of Dexfenfluramine can be decreased when combined with Berotralstat.
Cisapride The metabolism of Dexfenfluramine can be decreased when combined with Cisapride.
Thioridazine The metabolism of Dexfenfluramine can be decreased when combined with Thioridazine.
Paroxetine The metabolism of Dexfenfluramine can be decreased when combined with Paroxetine.
Cinacalcet The metabolism of Dexfenfluramine can be decreased when combined with Cinacalcet.
Bupropion The metabolism of Dexfenfluramine can be decreased when combined with Bupropion.
Orphenadrine The metabolism of Dexfenfluramine can be decreased when combined with Orphenadrine.
Propafenone The metabolism of Dexfenfluramine can be decreased when combined with Propafenone.
Halofantrine The metabolism of Dexfenfluramine can be decreased when combined with Halofantrine.
Methotrimeprazine The metabolism of Dexfenfluramine can be decreased when combined with Methotrimeprazine.
Glycerol phenylbutyrate The metabolism of Dexfenfluramine can be decreased when combined with Glycerol phenylbutyrate.
Quinidine The metabolism of Dexfenfluramine can be decreased when combined with Quinidine.
Osimertinib The serum concentration of Dexfenfluramine can be decreased when it is combined with Osimertinib.
Vemurafenib The serum concentration of Dexfenfluramine can be increased when it is combined with Vemurafenib.
Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Dexfenfluramine.
Aripiprazole lauroxil The metabolism of Aripiprazole lauroxil can be decreased when combined with Dexfenfluramine.
Enflurane The metabolism of Enflurane can be decreased when combined with Dexfenfluramine.
Trimethadione The metabolism of Trimethadione can be decreased when combined with Dexfenfluramine.
Chlorzoxazone The metabolism of Chlorzoxazone can be decreased when combined with Dexfenfluramine.
Isoflurane The metabolism of Isoflurane can be decreased when combined with Dexfenfluramine.
Ethanol The metabolism of Ethanol can be decreased when combined with Dexfenfluramine.
Methoxyflurane The metabolism of Methoxyflurane can be decreased when combined with Dexfenfluramine.
Halothane The metabolism of Halothane can be decreased when combined with Dexfenfluramine.
Sevoflurane The metabolism of Sevoflurane can be decreased when combined with Dexfenfluramine.
Nilvadipine The metabolism of Nilvadipine can be decreased when combined with Dexfenfluramine.
Aniline The metabolism of Aniline can be decreased when combined with Dexfenfluramine.
Benzyl alcohol The metabolism of Benzyl alcohol can be decreased when combined with Dexfenfluramine.
Felbamate The metabolism of Felbamate can be decreased when combined with Dexfenfluramine.
Cenobamate The metabolism of Cenobamate can be decreased when combined with Dexfenfluramine.
Phenytoin The metabolism of Phenytoin can be decreased when combined with Dexfenfluramine.
Fingolimod The metabolism of Fingolimod can be decreased when combined with Dexfenfluramine.
Ethosuximide The metabolism of Ethosuximide can be decreased when combined with Dexfenfluramine.
Selumetinib The metabolism of Selumetinib can be decreased when combined with Dexfenfluramine.

Target Protein

Sodium-dependent serotonin transporter SLC6A4
5-hydroxytryptamine receptor 2C HTR2C

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 0 • International brands: 2
International Brands
  • Adifax
  • Redux

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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