Peringatan Keamanan

Oral LD50 in rat is >10 ml/kg. Symptoms of overexposure include drowsiness and headache.

Ciclopirox

DB01188

small molecule approved investigational

Deskripsi

Ciclopirox olamine (used in preparations called Batrafen, Loprox, Mycoster, Penlac and Stieprox) is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. In particular, the agent is especially effective in treating Tinea versicolor.

Struktur Molekul 2D

Berat 207.2689
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 1.7 hours for 1% topical solution.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapidly absorbed after oral administration. Mean absorption of ciclopirox after application to nails of all twenty digits and adjacent 5 millimeters of skin once daily for 6 months in patients with dermatophytic onychomycoses was less than 5% of the applied dose. Ciclopirox olamine also penetrates into hair and through the epidermis and hair follicles into sebaceous glands and dermis.

Metabolisme

Glucuronidation is the main metabolic pathway of ciclopirox.

Rute Eliminasi

Most of the compound is excreted either unchanged or as glucuronide. After oral administration of 10 mg of radiolabeled drug (14C-ciclopirox) to healthy volunteers, approximately 96% of the radioactivity was excreted renally within 12 hours of administration. Ninety-four percent of the renally excreted radioactivity was in the form of glucuronides.

Interaksi Obat

14 Data
Dicoumarol The therapeutic efficacy of Dicoumarol can be increased when used in combination with Ciclopirox.
Phenindione The therapeutic efficacy of Phenindione can be increased when used in combination with Ciclopirox.
Warfarin The therapeutic efficacy of Warfarin can be increased when used in combination with Ciclopirox.
Phenprocoumon The therapeutic efficacy of Phenprocoumon can be increased when used in combination with Ciclopirox.
Acenocoumarol The therapeutic efficacy of Acenocoumarol can be increased when used in combination with Ciclopirox.
4-hydroxycoumarin The therapeutic efficacy of 4-hydroxycoumarin can be increased when used in combination with Ciclopirox.
Coumarin The therapeutic efficacy of Coumarin can be increased when used in combination with Ciclopirox.
(R)-warfarin The therapeutic efficacy of (R)-warfarin can be increased when used in combination with Ciclopirox.
Ethyl biscoumacetate The therapeutic efficacy of Ethyl biscoumacetate can be increased when used in combination with Ciclopirox.
Fluindione The therapeutic efficacy of Fluindione can be increased when used in combination with Ciclopirox.
Clorindione The therapeutic efficacy of Clorindione can be increased when used in combination with Ciclopirox.
Diphenadione The therapeutic efficacy of Diphenadione can be increased when used in combination with Ciclopirox.
Tioclomarol The therapeutic efficacy of Tioclomarol can be increased when used in combination with Ciclopirox.
(S)-Warfarin The therapeutic efficacy of (S)-Warfarin can be increased when used in combination with Ciclopirox.

Target Protein

Sodium/potassium-transporting ATPase subunit alpha-1 ATP1A1

Referensi & Sumber

Synthesis reference: Lohaus, G.and Dittmar, W.; U.S. Patents 3,972,888; August 3, 1976; and 3,883,545; May 13, 1975; both assigned to Hoechst A .G.
Artikel (PubMed)
  • PMID: 12760852
    Niewerth M, Kunze D, Seibold M, Schaller M, Korting HC, Hube B: Ciclopirox olamine treatment affects the expression pattern of Candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factors. Antimicrob Agents Chemother. 2003 Jun;47(6):1805-17.
  • PMID: 15790671
    Sigle HC, Thewes S, Niewerth M, Korting HC, Schafer-Korting M, Hube B: Oxygen accessibility and iron levels are critical factors for the antifungal action of ciclopirox against Candida albicans. J Antimicrob Chemother. 2005 May;55(5):663-73. Epub 2005 Mar 24.

Contoh Produk & Brand

Produk: 114 • International brands: 3
Produk
  • Apo-ciclopirox
    Solution • 8 % w/w • Topical • Canada • Generic • Approved
  • Ciclodan
    Cream • 7.7 mg/1g • Topical • US • Generic • Approved
  • Ciclodan
    Kit • 7.7 mg/1g • Topical • US • Generic • Approved
  • Ciclodan
    Solution • 2.28 g/1mL • Topical • US • Generic • Approved
  • Ciclodan
    Solution • 2.28 g/1mL • Topical • US • Generic • Approved
  • Ciclomazole
    Cream; Kit; Solution • - • Topical • US
  • Ciclopirox
    Solution • 71.3 mg/1mL • Topical • US • Generic • Approved
  • Ciclopirox
    Solution • 80 mg/1mL • Topical • US • Generic • Approved
Menampilkan 8 dari 114 produk.
International Brands
  • Batrafen — Sanofi
  • Mycoster — Pierre Fabre
  • Stieprox — Stiefel

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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