Oral, rat LD50: 15 mg/kg. Symptoms of overdose include nausea, vomiting, convulsions, decreased blood pressure, and CNS stimulation.
Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson’s Disease. It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors. It was indicated as adjunct therapy with levodopa/carbidopa in the symptomatic treatment of parkinsonian syndrome. It was later found that pergolide increased the risk of cardiac valvulopathy. The drug was withdrawn from the US market in March 2007 and from the Canadian market in August 2007. While the use of pergolide in humans is still approved in only some countries, pergolide is mainly used for veterinary purposes.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Valsartan | Pergolide may decrease the antihypertensive activities of Valsartan. |
| Ramipril | Pergolide may decrease the antihypertensive activities of Ramipril. |
| Remikiren | Pergolide may decrease the antihypertensive activities of Remikiren. |
| Torasemide | Pergolide may decrease the antihypertensive activities of Torasemide. |
| Olmesartan | Pergolide may decrease the antihypertensive activities of Olmesartan. |
| Chlorthalidone | Pergolide may decrease the antihypertensive activities of Chlorthalidone. |
| Nitroprusside | Pergolide may decrease the antihypertensive activities of Nitroprusside. |
| Minoxidil | Pergolide may decrease the antihypertensive activities of Minoxidil. |
| Treprostinil | Pergolide may decrease the antihypertensive activities of Treprostinil. |
| Bendroflumethiazide | Pergolide may decrease the antihypertensive activities of Bendroflumethiazide. |
| Fosinopril | Pergolide may decrease the antihypertensive activities of Fosinopril. |
| Trandolapril | Pergolide may decrease the antihypertensive activities of Trandolapril. |
| Metolazone | Pergolide may decrease the antihypertensive activities of Metolazone. |
| Benazepril | Pergolide may decrease the antihypertensive activities of Benazepril. |
| Cyclothiazide | Pergolide may decrease the antihypertensive activities of Cyclothiazide. |
| Candoxatril | Pergolide may decrease the antihypertensive activities of Candoxatril. |
| Mecamylamine | Pergolide may decrease the antihypertensive activities of Mecamylamine. |
| Moexipril | Pergolide may decrease the antihypertensive activities of Moexipril. |
| Lisinopril | Pergolide may decrease the antihypertensive activities of Lisinopril. |
| Hydroflumethiazide | Pergolide may decrease the antihypertensive activities of Hydroflumethiazide. |
| Cryptenamine | Pergolide may decrease the antihypertensive activities of Cryptenamine. |
| Perindopril | Pergolide may decrease the antihypertensive activities of Perindopril. |
| Candesartan cilexetil | Pergolide may decrease the antihypertensive activities of Candesartan cilexetil. |
| Eprosartan | Pergolide may decrease the antihypertensive activities of Eprosartan. |
| Chlorothiazide | Pergolide may decrease the antihypertensive activities of Chlorothiazide. |
| Quinapril | Pergolide may decrease the antihypertensive activities of Quinapril. |
| Telmisartan | Pergolide may decrease the antihypertensive activities of Telmisartan. |
| Hydrochlorothiazide | Pergolide may decrease the antihypertensive activities of Hydrochlorothiazide. |
| Trichlormethiazide | Pergolide may decrease the antihypertensive activities of Trichlormethiazide. |
| Deserpidine | Pergolide may decrease the antihypertensive activities of Deserpidine. |
| Pentolinium | Pergolide may decrease the antihypertensive activities of Pentolinium. |
| Trimethaphan | Pergolide may decrease the antihypertensive activities of Trimethaphan. |
| Diazoxide | Pergolide may decrease the antihypertensive activities of Diazoxide. |
| Epoprostenol | Pergolide may decrease the antihypertensive activities of Epoprostenol. |
| Polythiazide | Pergolide may decrease the antihypertensive activities of Polythiazide. |
| Cilazapril | Pergolide may decrease the antihypertensive activities of Cilazapril. |
| Saprisartan | Pergolide may decrease the antihypertensive activities of Saprisartan. |
| Spirapril | Pergolide may decrease the antihypertensive activities of Spirapril. |
| Tienilic acid | Pergolide may decrease the antihypertensive activities of Tienilic acid. |
| Diethylnorspermine | Pergolide may decrease the antihypertensive activities of Diethylnorspermine. |
| Temocapril | Pergolide may decrease the antihypertensive activities of Temocapril. |
| Nicorandil | Pergolide may decrease the antihypertensive activities of Nicorandil. |
| Rauwolfia serpentina root | Pergolide may decrease the antihypertensive activities of Rauwolfia serpentina root. |
| Enalaprilat | Pergolide may decrease the antihypertensive activities of Enalaprilat. |
| Angiotensin 1-7 | Pergolide may decrease the antihypertensive activities of Angiotensin 1-7. |
| Imidapril | Pergolide may decrease the antihypertensive activities of Imidapril. |
| BQ-123 | Pergolide may decrease the antihypertensive activities of BQ-123. |
| Cicletanine | Pergolide may decrease the antihypertensive activities of Cicletanine. |
| Dihydralazine | Pergolide may decrease the antihypertensive activities of Dihydralazine. |
| Zofenopril | Pergolide may decrease the antihypertensive activities of Zofenopril. |
| Guanoxan | Pergolide may decrease the antihypertensive activities of Guanoxan. |
| Delapril | Pergolide may decrease the antihypertensive activities of Delapril. |
| Vincamine | Pergolide may decrease the antihypertensive activities of Vincamine. |
| Linsidomine | Pergolide may decrease the antihypertensive activities of Linsidomine. |
| Guanoxabenz | Pergolide may decrease the antihypertensive activities of Guanoxabenz. |
| Tolonidine | Pergolide may decrease the antihypertensive activities of Tolonidine. |
| Endralazine | Pergolide may decrease the antihypertensive activities of Endralazine. |
| Cadralazine | Pergolide may decrease the antihypertensive activities of Cadralazine. |
| Cyclopenthiazide | Pergolide may decrease the antihypertensive activities of Cyclopenthiazide. |
| Bietaserpine | Pergolide may decrease the antihypertensive activities of Bietaserpine. |
| Guanazodine | Pergolide may decrease the antihypertensive activities of Guanazodine. |
| Methoserpidine | Pergolide may decrease the antihypertensive activities of Methoserpidine. |
| Guanoclor | Pergolide may decrease the antihypertensive activities of Guanoclor. |
| Muzolimine | Pergolide may decrease the antihypertensive activities of Muzolimine. |
| Xipamide | Pergolide may decrease the antihypertensive activities of Xipamide. |
| Candesartan | Pergolide may decrease the antihypertensive activities of Candesartan. |
| Tocopherylquinone | Pergolide may decrease the antihypertensive activities of Tocopherylquinone. |
| Benazeprilat | Pergolide may decrease the antihypertensive activities of Benazeprilat. |
| Fosinoprilat | Pergolide may decrease the antihypertensive activities of Fosinoprilat. |
| Ramiprilat | Pergolide may decrease the antihypertensive activities of Ramiprilat. |
| Perindoprilat | Pergolide may decrease the antihypertensive activities of Perindoprilat. |
| Quinaprilat | Pergolide may decrease the antihypertensive activities of Quinaprilat. |
| Furosemide | Pergolide may decrease the antihypertensive activities of Furosemide. |
| Enalapril | Pergolide may decrease the antihypertensive activities of Enalapril. |
| Captopril | Pergolide may decrease the antihypertensive activities of Captopril. |
| Isradipine | Pergolide may decrease the antihypertensive activities of Isradipine. |
| Amlodipine | Pergolide may decrease the antihypertensive activities of Amlodipine. |
| Nimodipine | Pergolide may decrease the antihypertensive activities of Nimodipine. |
| Lercanidipine | Pergolide may decrease the antihypertensive activities of Lercanidipine. |
| Bosentan | Pergolide may decrease the antihypertensive activities of Bosentan. |
| Losartan | Pergolide may decrease the antihypertensive activities of Losartan. |
| Indapamide | Pergolide may decrease the antihypertensive activities of Indapamide. |
| Irbesartan | Pergolide may decrease the antihypertensive activities of Irbesartan. |
| Nitrendipine | Pergolide may decrease the antihypertensive activities of Nitrendipine. |
| Hydralazine | Pergolide may decrease the antihypertensive activities of Hydralazine. |
| Mibefradil | Pergolide may decrease the antihypertensive activities of Mibefradil. |
| Sitaxentan | Pergolide may decrease the antihypertensive activities of Sitaxentan. |
| Ambrisentan | Pergolide may decrease the antihypertensive activities of Ambrisentan. |
| Nilvadipine | Pergolide may decrease the antihypertensive activities of Nilvadipine. |
| Pinacidil | Pergolide may decrease the antihypertensive activities of Pinacidil. |
| Riociguat | Pergolide may decrease the antihypertensive activities of Riociguat. |
| Macitentan | Pergolide may decrease the antihypertensive activities of Macitentan. |
| Aliskiren | Pergolide may decrease the antihypertensive activities of Aliskiren. |
| Efonidipine | Pergolide may decrease the antihypertensive activities of Efonidipine. |
| Lacidipine | Pergolide may decrease the antihypertensive activities of Lacidipine. |
| Manidipine | Pergolide may decrease the antihypertensive activities of Manidipine. |
| Selexipag | Pergolide may decrease the antihypertensive activities of Selexipag. |
| Naftopidil | Pergolide may decrease the antihypertensive activities of Naftopidil. |
| Dexniguldipine | Pergolide may decrease the antihypertensive activities of Dexniguldipine. |
| Tadalafil | Pergolide may decrease the antihypertensive activities of Tadalafil. |