Peringatan Keamanan

Side effects include virilization (masculine traits in women), acne, fluid retention, and hypercalcemia.

Fluoxymesterone

DB01185

small molecule approved illicit

Deskripsi

An anabolic steroid that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women.

Struktur Molekul 2D

Berat 336.4409
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 9.2 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Oral absorption is less than 44%.

Metabolisme

Presence of 17-alpha alkyl group reduces susceptibility to hepatic enzyme degradation, which slows metabolism and allows oral administration. Inactivation of testosterone occurs primarily in the liver

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take with food.

Interaksi Obat

169 Data
Cyclosporine The risk or severity of liver damage can be increased when Fluoxymesterone is combined with Cyclosporine.
Dicoumarol Fluoxymesterone may increase the anticoagulant activities of Dicoumarol.
Phenindione Fluoxymesterone may increase the anticoagulant activities of Phenindione.
Warfarin Fluoxymesterone may increase the anticoagulant activities of Warfarin.
Phenprocoumon Fluoxymesterone may increase the anticoagulant activities of Phenprocoumon.
Acenocoumarol Fluoxymesterone may increase the anticoagulant activities of Acenocoumarol.
4-hydroxycoumarin Fluoxymesterone may increase the anticoagulant activities of 4-hydroxycoumarin.
Coumarin Fluoxymesterone may increase the anticoagulant activities of Coumarin.
(R)-warfarin Fluoxymesterone may increase the anticoagulant activities of (R)-warfarin.
Ethyl biscoumacetate Fluoxymesterone may increase the anticoagulant activities of Ethyl biscoumacetate.
Fluindione Fluoxymesterone may increase the anticoagulant activities of Fluindione.
Clorindione Fluoxymesterone may increase the anticoagulant activities of Clorindione.
Diphenadione Fluoxymesterone may increase the anticoagulant activities of Diphenadione.
Tioclomarol Fluoxymesterone may increase the anticoagulant activities of Tioclomarol.
(S)-Warfarin Fluoxymesterone may increase the anticoagulant activities of (S)-Warfarin.
Insulin human Fluoxymesterone may increase the hypoglycemic activities of Insulin human.
Insulin lispro Fluoxymesterone may increase the hypoglycemic activities of Insulin lispro.
Insulin glargine Fluoxymesterone may increase the hypoglycemic activities of Insulin glargine.
Insulin pork Fluoxymesterone may increase the hypoglycemic activities of Insulin pork.
Troglitazone Fluoxymesterone may increase the hypoglycemic activities of Troglitazone.
Glimepiride Fluoxymesterone may increase the hypoglycemic activities of Glimepiride.
Sulfisoxazole Fluoxymesterone may increase the hypoglycemic activities of Sulfisoxazole.
Disopyramide Fluoxymesterone may increase the hypoglycemic activities of Disopyramide.
Acarbose Fluoxymesterone may increase the hypoglycemic activities of Acarbose.
Metformin Fluoxymesterone may increase the hypoglycemic activities of Metformin.
Sulfadiazine Fluoxymesterone may increase the hypoglycemic activities of Sulfadiazine.
Rosiglitazone Fluoxymesterone may increase the hypoglycemic activities of Rosiglitazone.
Acetohexamide Fluoxymesterone may increase the hypoglycemic activities of Acetohexamide.
Quinine Fluoxymesterone may increase the hypoglycemic activities of Quinine.
Miglitol Fluoxymesterone may increase the hypoglycemic activities of Miglitol.
Chlorpropamide Fluoxymesterone may increase the hypoglycemic activities of Chlorpropamide.
Nateglinide Fluoxymesterone may increase the hypoglycemic activities of Nateglinide.
Pentamidine Fluoxymesterone may increase the hypoglycemic activities of Pentamidine.
Mifepristone Fluoxymesterone may increase the hypoglycemic activities of Mifepristone.
Tolazamide Fluoxymesterone may increase the hypoglycemic activities of Tolazamide.
Repaglinide Fluoxymesterone may increase the hypoglycemic activities of Repaglinide.
Phenformin Fluoxymesterone may increase the hypoglycemic activities of Phenformin.
Sulfamethoxazole Fluoxymesterone may increase the hypoglycemic activities of Sulfamethoxazole.
Glyburide Fluoxymesterone may increase the hypoglycemic activities of Glyburide.
Glipizide Fluoxymesterone may increase the hypoglycemic activities of Glipizide.
Gliclazide Fluoxymesterone may increase the hypoglycemic activities of Gliclazide.
Tolbutamide Fluoxymesterone may increase the hypoglycemic activities of Tolbutamide.
Pioglitazone Fluoxymesterone may increase the hypoglycemic activities of Pioglitazone.
Bromocriptine Fluoxymesterone may increase the hypoglycemic activities of Bromocriptine.
Gliquidone Fluoxymesterone may increase the hypoglycemic activities of Gliquidone.
Mitiglinide Fluoxymesterone may increase the hypoglycemic activities of Mitiglinide.
Sitagliptin Fluoxymesterone may increase the hypoglycemic activities of Sitagliptin.
Sunitinib Fluoxymesterone may increase the hypoglycemic activities of Sunitinib.
Exenatide Fluoxymesterone may increase the hypoglycemic activities of Exenatide.
Mecasermin Fluoxymesterone may increase the hypoglycemic activities of Mecasermin.
Pramlintide Fluoxymesterone may increase the hypoglycemic activities of Pramlintide.
Glisoxepide Fluoxymesterone may increase the hypoglycemic activities of Glisoxepide.
Insulin aspart Fluoxymesterone may increase the hypoglycemic activities of Insulin aspart.
Insulin detemir Fluoxymesterone may increase the hypoglycemic activities of Insulin detemir.
Insulin glulisine Fluoxymesterone may increase the hypoglycemic activities of Insulin glulisine.
Glymidine Fluoxymesterone may increase the hypoglycemic activities of Glymidine.
AICA ribonucleotide Fluoxymesterone may increase the hypoglycemic activities of AICA ribonucleotide.
Buformin Fluoxymesterone may increase the hypoglycemic activities of Buformin.
Vildagliptin Fluoxymesterone may increase the hypoglycemic activities of Vildagliptin.
Voglibose Fluoxymesterone may increase the hypoglycemic activities of Voglibose.
NN344 Fluoxymesterone may increase the hypoglycemic activities of NN344.
AMG-222 Fluoxymesterone may increase the hypoglycemic activities of AMG-222.
Bisegliptin Fluoxymesterone may increase the hypoglycemic activities of Bisegliptin.
Alogliptin Fluoxymesterone may increase the hypoglycemic activities of Alogliptin.
Dapagliflozin Fluoxymesterone may increase the hypoglycemic activities of Dapagliflozin.
Saxagliptin Fluoxymesterone may increase the hypoglycemic activities of Saxagliptin.
Liraglutide Fluoxymesterone may increase the hypoglycemic activities of Liraglutide.
Gosogliptin Fluoxymesterone may increase the hypoglycemic activities of Gosogliptin.
Linagliptin Fluoxymesterone may increase the hypoglycemic activities of Linagliptin.
Canagliflozin Fluoxymesterone may increase the hypoglycemic activities of Canagliflozin.
Glibornuride Fluoxymesterone may increase the hypoglycemic activities of Glibornuride.
Benfluorex Fluoxymesterone may increase the hypoglycemic activities of Benfluorex.
Empagliflozin Fluoxymesterone may increase the hypoglycemic activities of Empagliflozin.
Albiglutide Fluoxymesterone may increase the hypoglycemic activities of Albiglutide.
Dulaglutide Fluoxymesterone may increase the hypoglycemic activities of Dulaglutide.
Lobeglitazone Fluoxymesterone may increase the hypoglycemic activities of Lobeglitazone.
Netoglitazone Fluoxymesterone may increase the hypoglycemic activities of Netoglitazone.
Rivoglitazone Fluoxymesterone may increase the hypoglycemic activities of Rivoglitazone.
Ciglitazone Fluoxymesterone may increase the hypoglycemic activities of Ciglitazone.
Lixisenatide Fluoxymesterone may increase the hypoglycemic activities of Lixisenatide.
Insulin beef Fluoxymesterone may increase the hypoglycemic activities of Insulin beef.
Insulin degludec Fluoxymesterone may increase the hypoglycemic activities of Insulin degludec.
Insulin peglispro Fluoxymesterone may increase the hypoglycemic activities of Insulin peglispro.
Insulin tregopil Fluoxymesterone may increase the hypoglycemic activities of Insulin tregopil.
Ipragliflozin Fluoxymesterone may increase the hypoglycemic activities of Ipragliflozin.
Dutogliptin Fluoxymesterone may increase the hypoglycemic activities of Dutogliptin.
Allicin Fluoxymesterone may increase the hypoglycemic activities of Allicin.
Tofogliflozin Fluoxymesterone may increase the hypoglycemic activities of Tofogliflozin.
Ertugliflozin Fluoxymesterone may increase the hypoglycemic activities of Ertugliflozin.
2,4-thiazolidinedione Fluoxymesterone may increase the hypoglycemic activities of 2,4-thiazolidinedione.
Teneligliptin Fluoxymesterone may increase the hypoglycemic activities of Teneligliptin.
Omarigliptin Fluoxymesterone may increase the hypoglycemic activities of Omarigliptin.
Carmegliptin Fluoxymesterone may increase the hypoglycemic activities of Carmegliptin.
Gemigliptin Fluoxymesterone may increase the hypoglycemic activities of Gemigliptin.
Anagliptin Fluoxymesterone may increase the hypoglycemic activities of Anagliptin.
Evogliptin Fluoxymesterone may increase the hypoglycemic activities of Evogliptin.
Sotagliflozin Fluoxymesterone may increase the hypoglycemic activities of Sotagliflozin.
Balaglitazone Fluoxymesterone may increase the hypoglycemic activities of Balaglitazone.
Remogliflozin etabonate Fluoxymesterone may increase the hypoglycemic activities of Remogliflozin etabonate.
Carbutamide Fluoxymesterone may increase the hypoglycemic activities of Carbutamide.

Target Protein

Androgen receptor AR
Estrogen receptor ESR1
Glucocorticoid receptor NR3C1
11-beta-hydroxysteroid dehydrogenase type 2 HSD11B2

Referensi & Sumber

Synthesis reference: U.S. Patent 2,793,218 U.S. Patent 2,813,881
Artikel (PubMed)
  • PMID: 17023534
    Miner JN, Chang W, Chapman MS, Finn PD, Hong MH, Lopez FJ, Marschke KB, Rosen J, Schrader W, Turner R, van Oeveren A, Viveros H, Zhi L, Negro-Vilar A: An orally active selective androgen receptor modulator is efficacious on bone, muscle, and sex function with reduced impact on prostate. Endocrinology. 2007 Jan;148(1):363-73. Epub 2006 Oct 5.

Contoh Produk & Brand

Produk: 5 • International brands: 4
Produk
  • Androxy
    Tablet • 10 mg/1 • Oral • US • Generic • Approved
  • Halotestin
    Tablet • 2 mg/1 • Oral • US • Approved
  • Halotestin
    Tablet • 5 mg/1 • Oral • US • Approved
  • Halotestin
    Tablet • 10 mg/1 • Oral • US • Approved
  • Halotestin
    Tablet • 5 mg • Oral • Canada • Approved
International Brands
  • Ora-Testryl — Bristol-Myers Squibb
  • Testoral — Midy
  • U-Gono — Upjohn
  • UItandren — Ciba

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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