Peringatan Keamanan

Side effects include galactorrhea, gynecomastia, or menstrual irregularities.

Domperidone

DB01184

small molecule approved investigational vet_approved

Deskripsi

A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.

Struktur Molekul 2D

Berat 425.911
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 7 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take before a meal. Take 15-30 minutes before meals.

Interaksi Obat

1121 Data
Deferasirox The serum concentration of Domperidone can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Domperidone can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Domperidone can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Domperidone can be decreased when it is combined with Teriflunomide.
Mifepristone The serum concentration of Domperidone can be increased when it is combined with Mifepristone.
Linezolid The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Linezolid is combined with Domperidone.
Furazolidone The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Furazolidone is combined with Domperidone.
Procaine The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Procaine is combined with Domperidone.
Tranylcypromine The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Tranylcypromine is combined with Domperidone.
Phenelzine The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Phenelzine is combined with Domperidone.
Minaprine The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Minaprine is combined with Domperidone.
Selegiline The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Selegiline is combined with Domperidone.
Procarbazine The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Procarbazine is combined with Domperidone.
Moclobemide The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Moclobemide is combined with Domperidone.
Isocarboxazid The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Isocarboxazid is combined with Domperidone.
Rasagiline The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Rasagiline is combined with Domperidone.
Pargyline The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Pargyline is combined with Domperidone.
Clorgiline The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Clorgiline is combined with Domperidone.
Iproniazid The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Iproniazid is combined with Domperidone.
Nialamide The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Nialamide is combined with Domperidone.
Safinamide The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Safinamide is combined with Domperidone.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline is combined with Domperidone.
Methylene blue The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Methylene blue is combined with Domperidone.
Hydracarbazine The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Hydracarbazine is combined with Domperidone.
Pirlindole The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Pirlindole is combined with Domperidone.
Toloxatone The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Toloxatone is combined with Domperidone.
Benmoxin The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Benmoxin is combined with Domperidone.
Mebanazine The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Mebanazine is combined with Domperidone.
Octamoxin The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Octamoxin is combined with Domperidone.
Pheniprazine The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Pheniprazine is combined with Domperidone.
Phenoxypropazine The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Phenoxypropazine is combined with Domperidone.
Pivhydrazine The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Pivhydrazine is combined with Domperidone.
Safrazine The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Safrazine is combined with Domperidone.
Caroxazone The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Caroxazone is combined with Domperidone.
Harmaline The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Harmaline is combined with Domperidone.
Brofaromine The risk or severity of QTc prolongation, torsade de pointes, and cardiotoxicity can be increased when Brofaromine is combined with Domperidone.
Mirabegron The serum concentration of Domperidone can be increased when it is combined with Mirabegron.
Abiraterone The serum concentration of Domperidone can be increased when it is combined with Abiraterone.
Cyproterone acetate The metabolism of Domperidone can be increased when combined with Cyproterone acetate.
Leuprolide The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Domperidone.
Goserelin The risk or severity of QTc prolongation can be increased when Goserelin is combined with Domperidone.
Erythromycin The serum concentration of Domperidone can be increased when it is combined with Erythromycin.
Azithromycin The risk or severity of QTc prolongation can be increased when Azithromycin is combined with Domperidone.
Moxifloxacin The risk or severity of QTc prolongation can be increased when Moxifloxacin is combined with Domperidone.
Sulfisoxazole The risk or severity of QTc prolongation can be increased when Sulfisoxazole is combined with Domperidone.
Methadone The risk or severity of QTc prolongation can be increased when Methadone is combined with Domperidone.
Diltiazem The risk or severity of QTc prolongation can be increased when Diltiazem is combined with Domperidone.
Sulpiride The risk or severity of QTc prolongation can be increased when Sulpiride is combined with Domperidone.
Nimodipine The risk or severity of QTc prolongation can be increased when Nimodipine is combined with Domperidone.
Prochlorperazine The risk or severity of QTc prolongation can be increased when Prochlorperazine is combined with Domperidone.
Droperidol The risk or severity of QTc prolongation can be increased when Droperidol is combined with Domperidone.
Oxaliplatin The risk or severity of QTc prolongation can be increased when Oxaliplatin is combined with Domperidone.
Ciprofloxacin The risk or severity of QTc prolongation can be increased when Ciprofloxacin is combined with Domperidone.
Perflutren The risk or severity of QTc prolongation can be increased when Perflutren is combined with Domperidone.
Cinnarizine The risk or severity of QTc prolongation can be increased when Cinnarizine is combined with Domperidone.
Adenosine The risk or severity of QTc prolongation can be increased when Adenosine is combined with Domperidone.
Pentamidine The risk or severity of QTc prolongation can be increased when Pentamidine is combined with Domperidone.
Gadobenic acid The risk or severity of QTc prolongation can be increased when Gadobenic acid is combined with Domperidone.
Carbinoxamine The risk or severity of QTc prolongation can be increased when Carbinoxamine is combined with Domperidone.
Dolasetron The risk or severity of QTc prolongation can be increased when Dolasetron is combined with Domperidone.
Roxithromycin The risk or severity of QTc prolongation can be increased when Roxithromycin is combined with Domperidone.
Nalidixic acid The risk or severity of QTc prolongation can be increased when Nalidixic acid is combined with Domperidone.
Cinoxacin The risk or severity of QTc prolongation can be increased when Cinoxacin is combined with Domperidone.
Granisetron The risk or severity of QTc prolongation can be increased when Granisetron is combined with Domperidone.
Ondansetron The risk or severity of QTc prolongation can be increased when Ondansetron is combined with Domperidone.
Levosimendan The risk or severity of QTc prolongation can be increased when Levosimendan is combined with Domperidone.
Mesoridazine The risk or severity of QTc prolongation can be increased when Mesoridazine is combined with Domperidone.
Desloratadine The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Domperidone.
Lomefloxacin The risk or severity of QTc prolongation can be increased when Lomefloxacin is combined with Domperidone.
Dimenhydrinate The risk or severity of QTc prolongation can be increased when Dimenhydrinate is combined with Domperidone.
Papaverine The risk or severity of QTc prolongation can be increased when Papaverine is combined with Domperidone.
Chlorpheniramine The risk or severity of QTc prolongation can be increased when Chlorpheniramine is combined with Domperidone.
Nifedipine The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Domperidone.
Levofloxacin The risk or severity of QTc prolongation can be increased when Levofloxacin is combined with Domperidone.
Gemifloxacin The risk or severity of QTc prolongation can be increased when Gemifloxacin is combined with Domperidone.
Ofloxacin The risk or severity of QTc prolongation can be increased when Ofloxacin is combined with Domperidone.
Mibefradil The risk or severity of QTc prolongation can be increased when Mibefradil is combined with Domperidone.
Probucol The risk or severity of QTc prolongation can be increased when Probucol is combined with Domperidone.
Aceprometazine The risk or severity of QTc prolongation can be increased when Aceprometazine is combined with Domperidone.
Terlipressin The risk or severity of QTc prolongation can be increased when Terlipressin is combined with Domperidone.
Prenylamine The risk or severity of QTc prolongation can be increased when Prenylamine is combined with Domperidone.
Fluspirilene The risk or severity of QTc prolongation can be increased when Fluspirilene is combined with Domperidone.
Lofexidine The risk or severity of QTc prolongation can be increased when Lofexidine is combined with Domperidone.
Azimilide The risk or severity of QTc prolongation can be increased when Azimilide is combined with Domperidone.
Pracinostat The risk or severity of QTc prolongation can be increased when Pracinostat is combined with Domperidone.
Technetium Tc-99m ciprofloxacin The risk or severity of QTc prolongation can be increased when Technetium Tc-99m ciprofloxacin is combined with Domperidone.
Garenoxacin The risk or severity of QTc prolongation can be increased when Garenoxacin is combined with Domperidone.
Tedisamil The risk or severity of QTc prolongation can be increased when Tedisamil is combined with Domperidone.
Tucidinostat The risk or severity of QTc prolongation can be increased when Tucidinostat is combined with Domperidone.
Telavancin The risk or severity of QTc prolongation can be increased when Telavancin is combined with Domperidone.
Nemonoxacin The risk or severity of QTc prolongation can be increased when Nemonoxacin is combined with Domperidone.
Nilvadipine The risk or severity of QTc prolongation can be increased when Nilvadipine is combined with Domperidone.
Antazoline The risk or severity of QTc prolongation can be increased when Antazoline is combined with Domperidone.
Bedaquiline The risk or severity of QTc prolongation can be increased when Domperidone is combined with Bedaquiline.
Fendiline The risk or severity of QTc prolongation can be increased when Fendiline is combined with Domperidone.
Eperisone The risk or severity of QTc prolongation can be increased when Eperisone is combined with Domperidone.
Butriptyline The risk or severity of QTc prolongation can be increased when Butriptyline is combined with Domperidone.
Ceritinib The risk or severity of QTc prolongation can be increased when Ceritinib is combined with Domperidone.
Lenvatinib The risk or severity of QTc prolongation can be increased when Lenvatinib is combined with Domperidone.
Melperone The risk or severity of QTc prolongation can be increased when Melperone is combined with Domperidone.

Target Protein

D(3) dopamine receptor DRD3
D(2) dopamine receptor DRD2

Referensi & Sumber

Synthesis reference: Vanderberk, J., Kennis, L.E.J., Van der Aa, M.J.M.C. and Van Heertum, A.H.M.T.; U.S. Patents 4,066,772; January 3,1978; 4.1 10,333; August 29,1978; 4,126,687; November 21, 1978; 4,126,688; November 21,1978; 4,160,836; July 10,1979 and 4,175,129; November 20,1979; all assigned to Janssen Pharmaceutica NV (Belgium).
Artikel (PubMed)
  • PMID: 9663360
    Silvers D, Kipnes M, Broadstone V, Patterson D, Quigley EM, McCallum R, Leidy NK, Farup C, Liu Y, Joslyn A: Domperidone in the management of symptoms of diabetic gastroparesis: efficacy, tolerability, and quality-of-life outcomes in a multicenter controlled trial. DOM-USA-5 Study Group. Clin Ther. 1998 May-Jun;20(3):438-53.

Contoh Produk & Brand

Produk: 23 • International brands: 4
Produk
  • Apo-domperidone
    Tablet • 10 mg • Oral • Canada • Generic • Approved
  • Ava-domperidone
    Tablet • 10 mg • Oral • Canada • Generic • Approved
  • Bio-domperidone
    Tablet • 10 mg • Oral • Canada • Generic • Approved
  • Dom-domperidone
    Tablet • 10 mg • Oral • Canada • Generic • Approved
  • Domperidone
    Tablet • 10 mg • Oral • Canada • Approved
  • Domperidone
    Tablet • 10 mg • Oral • Canada • Approved
  • Domperidone
    Tablet • 10 mg • Oral • Canada • Approved
  • Domperidone-10
    Tablet • 10 mg • Oral • Canada • Approved
Menampilkan 8 dari 23 produk.
International Brands
  • Euciton — Roux-Ocefa
  • Moperidona — Sidus
  • Motilium — Janssen
  • Nauzelin — Kyowa Hakko Kirin

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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