Cyclizine

DB01176

small molecule approved

Deskripsi

A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)

Struktur Molekul 2D

Berat 266.3807
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 20 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Cyclizine is metabolised to its N-demethylated derivative, norcyclizine, which has little antihistaminic (H1) activity compared to Cyclizine.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol.
  • 2. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

1102 Data
Buprenorphine Cyclizine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Cyclizine.
Dronabinol The serum concentration of Dronabinol can be increased when it is combined with Cyclizine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Cyclizine.
Hydrocodone Cyclizine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Magnesium sulfate The therapeutic efficacy of Cyclizine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Cyclizine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Cyclizine may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Cyclizine.
Mirtazapine Cyclizine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Cyclizine.
Orphenadrine Cyclizine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Cyclizine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Cyclizine.
Pramipexole Cyclizine may increase the sedative activities of Pramipexole.
Ropinirole Cyclizine may increase the sedative activities of Ropinirole.
Rotigotine Cyclizine may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Cyclizine.
Sodium oxybate Cyclizine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Cyclizine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Cyclizine.
Thalidomide Cyclizine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Cyclizine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Benzylpenicilloyl polylysine Cyclizine may decrease effectiveness of Benzylpenicilloyl polylysine as a diagnostic agent.
Betahistine The therapeutic efficacy of Betahistine can be decreased when used in combination with Cyclizine.
Hyaluronidase (ovine) The therapeutic efficacy of Hyaluronidase (ovine) can be decreased when used in combination with Cyclizine.
Hyaluronidase (human recombinant) The therapeutic efficacy of Hyaluronidase (human recombinant) can be decreased when used in combination with Cyclizine.
Hyaluronidase The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Cyclizine.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Cyclizine.
Ethanol Cyclizine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Cyclizine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Cyclizine.
Fluvoxamine The risk or severity of adverse effects can be increased when Cyclizine is combined with Fluvoxamine.
Duloxetine The risk or severity of adverse effects can be increased when Cyclizine is combined with Duloxetine.
Paroxetine The risk or severity of adverse effects can be increased when Cyclizine is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Cyclizine is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Cyclizine is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when Cyclizine is combined with Nefazodone.
Zimelidine The risk or severity of adverse effects can be increased when Cyclizine is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Cyclizine is combined with Dapoxetine.
Milnacipran The risk or severity of adverse effects can be increased when Cyclizine is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Cyclizine is combined with Desvenlafaxine.
Seproxetine The risk or severity of adverse effects can be increased when Cyclizine is combined with Seproxetine.
Indalpine The risk or severity of adverse effects can be increased when Cyclizine is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Cyclizine is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Cyclizine is combined with Alaproclate.
Citalopram The risk or severity of QTc prolongation can be increased when Cyclizine is combined with Citalopram.
Escitalopram The risk or severity of adverse effects can be increased when Cyclizine is combined with Escitalopram.
Amphetamine Amphetamine may decrease the sedative activities of Cyclizine.
Phentermine Phentermine may decrease the sedative activities of Cyclizine.
Pseudoephedrine Pseudoephedrine may decrease the sedative activities of Cyclizine.
Benzphetamine Benzphetamine may decrease the sedative activities of Cyclizine.
Diethylpropion Diethylpropion may decrease the sedative activities of Cyclizine.
Lisdexamfetamine Lisdexamfetamine may decrease the sedative activities of Cyclizine.
Mephentermine Mephentermine may decrease the sedative activities of Cyclizine.
MMDA MMDA may decrease the sedative activities of Cyclizine.
Midomafetamine Midomafetamine may decrease the sedative activities of Cyclizine.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Cyclizine.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Cyclizine.
Tenamfetamine Tenamfetamine may decrease the sedative activities of Cyclizine.
Chlorphentermine Chlorphentermine may decrease the sedative activities of Cyclizine.
Methylenedioxyethamphetamine Methylenedioxyethamphetamine may decrease the sedative activities of Cyclizine.
Dextroamphetamine Dextroamphetamine may decrease the sedative activities of Cyclizine.
Metamfetamine Metamfetamine may decrease the sedative activities of Cyclizine.
Iofetamine I-123 Iofetamine I-123 may decrease the sedative activities of Cyclizine.
Ritobegron Ritobegron may decrease the sedative activities of Cyclizine.
Mephedrone Mephedrone may decrease the sedative activities of Cyclizine.
Methoxyphenamine Methoxyphenamine may decrease the sedative activities of Cyclizine.
Gepefrine Gepefrine may decrease the sedative activities of Cyclizine.
2,5-Dimethoxy-4-ethylthioamphetamine 2,5-Dimethoxy-4-ethylthioamphetamine may decrease the sedative activities of Cyclizine.
Phendimetrazine Phendimetrazine may decrease the sedative activities of Cyclizine.
Benzatropine The risk or severity of QTc prolongation can be increased when Benzatropine is combined with Cyclizine.
Amitriptyline The risk or severity of CNS depression can be increased when Amitriptyline is combined with Cyclizine.
Buclizine The risk or severity of QTc prolongation can be increased when Buclizine is combined with Cyclizine.
Cyproheptadine The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Cyclizine.
Imipramine The risk or severity of CNS depression can be increased when Imipramine is combined with Cyclizine.
Nortriptyline The risk or severity of CNS depression can be increased when Nortriptyline is combined with Cyclizine.
Amoxapine The risk or severity of CNS depression can be increased when Amoxapine is combined with Cyclizine.
Nicardipine The risk or severity of QTc prolongation can be increased when Nicardipine is combined with Cyclizine.
Propiomazine The risk or severity of CNS depression can be increased when Propiomazine is combined with Cyclizine.
Maprotiline The risk or severity of CNS depression can be increased when Maprotiline is combined with Cyclizine.
Desipramine The risk or severity of CNS depression can be increased when Desipramine is combined with Cyclizine.
Solifenacin The risk or severity of QTc prolongation can be increased when Cyclizine is combined with Solifenacin.
Pizotifen The risk or severity of CNS depression can be increased when Cyclizine is combined with Pizotifen.
Trimebutine The risk or severity of QTc prolongation can be increased when Cyclizine is combined with Trimebutine.
Dosulepin The risk or severity of CNS depression can be increased when Cyclizine is combined with Dosulepin.
Quinidine The risk or severity of QTc prolongation can be increased when Cyclizine is combined with Quinidine.
Zopiclone The risk or severity of adverse effects can be increased when Cyclizine is combined with Zopiclone.
Leuprolide The risk or severity of QTc prolongation can be increased when Cyclizine is combined with Leuprolide.
Goserelin The risk or severity of QTc prolongation can be increased when Cyclizine is combined with Goserelin.
Erythromycin The risk or severity of QTc prolongation can be increased when Cyclizine is combined with Erythromycin.
Azithromycin The risk or severity of QTc prolongation can be increased when Cyclizine is combined with Azithromycin.
Moxifloxacin The risk or severity of QTc prolongation can be increased when Cyclizine is combined with Moxifloxacin.
Ranolazine The risk or severity of QTc prolongation can be increased when Cyclizine is combined with Ranolazine.
Sulfisoxazole The risk or severity of QTc prolongation can be increased when Cyclizine is combined with Sulfisoxazole.
Diltiazem The metabolism of Diltiazem can be decreased when combined with Cyclizine.
Nimodipine The risk or severity of QTc prolongation can be increased when Cyclizine is combined with Nimodipine.
Oxaliplatin The risk or severity of QTc prolongation can be increased when Oxaliplatin is combined with Cyclizine.
Ciprofloxacin The risk or severity of QTc prolongation can be increased when Cyclizine is combined with Ciprofloxacin.
Fluorouracil The risk or severity of QTc prolongation can be increased when Cyclizine is combined with Fluorouracil.

Target Protein

Histamine H1 receptor HRH1
Sulfotransferase 1E1 SULT1E1

Referensi & Sumber

Synthesis reference: Baltzly, R. and Castillo, J.C.; U.S. Patent 2,630,435; March 3,1953; assigned to Burroughs Wellcome & Co. (U.S.A.) Inc.

Contoh Produk & Brand

Produk: 3 • International brands: 4
Produk
  • Cyclivert
    Tablet • 25 mg/25mg • Oral • US • OTC
  • Marzine Inj 50mg/ml
    Liquid • 50 mg / mL • Intramuscular; Intravenous • Canada • Approved
  • Megral Tabs
    Tablet • - • Oral • Canada • Approved
International Brands
  • Emoquil
  • Marezine
  • Marzine — GlaxoSmithKline
  • Valoid — GlaxoSmithKline

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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