Oral, mouse LD50 = 100 mg/kg; oral, rat LD50 = 255 mg/kg
A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Lomitapide | The metabolism of Lomitapide can be decreased when combined with Orphenadrine. |
| Buprenorphine | Orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Dronabinol | The serum concentration of Dronabinol can be increased when it is combined with Orphenadrine. |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Hydrocodone | Orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. |
| Magnesium sulfate | The therapeutic efficacy of Orphenadrine can be increased when used in combination with Magnesium sulfate. |
| Methotrimeprazine | Orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. |
| Metyrosine | Orphenadrine may increase the sedative activities of Metyrosine. |
| Minocycline | Minocycline may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Mirtazapine | Orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. |
| Nabilone | Nabilone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Botulinum toxin type B | Botulinum toxin type B may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Tryptophan | Tryptophan may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Fluvoxamine | Fluvoxamine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Baclofen | Baclofen may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Lorazepam | Lorazepam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Ethchlorvynol | Ethchlorvynol may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Succinylcholine | Succinylcholine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Reserpine | Reserpine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Citalopram | The risk or severity of QTc prolongation can be increased when Orphenadrine is combined with Citalopram. |
| Eletriptan | Eletriptan may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Enflurane | Enflurane may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Temazepam | Temazepam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Reboxetine | Reboxetine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Butabarbital | Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Butalbital | Butalbital may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Methysergide | Methysergide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Cabergoline | Cabergoline may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Clemastine | Clemastine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Venlafaxine | Venlafaxine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Etomidate | Etomidate may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Morphine | Morphine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Talbutal | Talbutal may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Pentobarbital | Pentobarbital may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Valproic acid | Valproic acid may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Codeine | Codeine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Dihydroergotamine | Dihydroergotamine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Tolcapone | Tolcapone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Hydromorphone | Hydromorphone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Olanzapine | Olanzapine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Cetirizine | Cetirizine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Protriptyline | Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Trimethadione | Trimethadione may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Clobazam | The risk or severity of sedation, somnolence, and CNS depression can be increased when Clobazam is combined with Orphenadrine. |
| Chlorzoxazone | Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Clozapine | The serum concentration of Clozapine can be increased when it is combined with Orphenadrine. |
| Meprobamate | Meprobamate may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Thiethylperazine | Thiethylperazine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Palonosetron | Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Sulpiride | Sulpiride may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Dexbrompheniramine | Dexbrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Loxapine | Loxapine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Remoxipride | Remoxipride may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Metocurine iodide | Metocurine iodide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Secobarbital | Secobarbital may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Promazine | Promazine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Methocarbamol | Methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Triprolidine | Triprolidine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Prochlorperazine | Prochlorperazine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Cyproheptadine | Cyproheptadine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Meperidine | Meperidine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Imipramine | Imipramine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Metharbital | Metharbital may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Quinine | Quinine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Methohexital | Methohexital may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Chlordiazepoxide | Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Duloxetine | Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Chlorpromazine | Chlorpromazine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Gallamine triethiodide | Gallamine triethiodide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Entacapone | Entacapone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Oxycodone | Oxycodone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Triflupromazine | Triflupromazine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Dextromethorphan | Dextromethorphan may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Mephenytoin | Mephenytoin may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Nortriptyline | Nortriptyline may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Amoxapine | Amoxapine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Adinazolam | Adinazolam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Lamotrigine | Lamotrigine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Carbamazepine | Carbamazepine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Cisatracurium | Cisatracurium may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Fenfluramine | Fenfluramine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Mazindol | Mazindol may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Fluticasone propionate | Fluticasone propionate may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Lisuride | Lisuride may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Ethosuximide | Ethosuximide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Thiopental | Thiopental may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Cisapride | Cisapride may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Butorphanol | Butorphanol may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Furazolidone | Furazolidone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Paramethadione | Paramethadione may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Fluphenazine | Fluphenazine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Efavirenz | Efavirenz may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Clorazepic acid | Clorazepic acid may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Dexmedetomidine | Dexmedetomidine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Dyclonine | Dyclonine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Dextropropoxyphene | Dextropropoxyphene may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Pentazocine | Pentazocine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Metaxalone | Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Trimethobenzamide | Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |