Peringatan Keamanan

Symptoms of overdose include convulsions, muscle weakness and confusion.

Arsenic trioxide

DB01169

small molecule approved investigational

Deskripsi

Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous adverse effects. The enzyme thioredoxin reductase has recently been identified as a target for arsenic trioxide.

Struktur Molekul 2D

Berat 197.84
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Inorganic, lyophilized arsenic trioxide, when placed in solution, is immediately hydrolyzed to arsenous acid - this appears to be the pharmacologically active species of arsenic trioxide.L10007 Further metabolism involves the oxidation of arsenous acid to arsenic acid, and an oxidative methylation of arsenous acid to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) by methyltransferases in the liver. Both MMA and DMA have relatively long half-lives and can accumulate following multiple doses, the extent of which depends upon the dosing regimen in question.L10007

Rute Eliminasi

Trivalent arsenic is mostly methylated in humans and excreted in urine.

Interaksi Obat

1776 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Arsenic trioxide.
Etanercept The risk or severity of adverse effects can be increased when Etanercept is combined with Arsenic trioxide.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Arsenic trioxide.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Arsenic trioxide.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Arsenic trioxide.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Arsenic trioxide.
Anakinra The risk or severity of adverse effects can be increased when Anakinra is combined with Arsenic trioxide.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Arsenic trioxide.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Arsenic trioxide.
Aldesleukin The risk or severity of adverse effects can be increased when Aldesleukin is combined with Arsenic trioxide.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Arsenic trioxide.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Arsenic trioxide.
Pegaspargase The risk or severity of adverse effects can be increased when Pegaspargase is combined with Arsenic trioxide.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Arsenic trioxide.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Arsenic trioxide.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Arsenic trioxide.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Arsenic trioxide.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Arsenic trioxide.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Arsenic trioxide.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Arsenic trioxide.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Arsenic trioxide.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Arsenic trioxide.
Alefacept The risk or severity of adverse effects can be increased when Alefacept is combined with Arsenic trioxide.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Arsenic trioxide.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Arsenic trioxide.
Interferon alfa-2b The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Arsenic trioxide.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Arsenic trioxide.
Phenylalanine The risk or severity of adverse effects can be increased when Phenylalanine is combined with Arsenic trioxide.
Flunisolide The risk or severity of adverse effects can be increased when Flunisolide is combined with Arsenic trioxide.
Cladribine Arsenic trioxide may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Arsenic trioxide.
Amsacrine The risk or severity of adverse effects can be increased when Amsacrine is combined with Arsenic trioxide.
Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Arsenic trioxide.
Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Arsenic trioxide.
Raltitrexed The risk or severity of adverse effects can be increased when Raltitrexed is combined with Arsenic trioxide.
Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Arsenic trioxide.
Bexarotene The risk or severity of adverse effects can be increased when Bexarotene is combined with Arsenic trioxide.
Vindesine The risk or severity of adverse effects can be increased when Vindesine is combined with Arsenic trioxide.
Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Arsenic trioxide.
Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Arsenic trioxide.
Tioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Arsenic trioxide.
Vinorelbine The risk or severity of adverse effects can be increased when Vinorelbine is combined with Arsenic trioxide.
Dexrazoxane The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Arsenic trioxide.
Beclomethasone dipropionate The risk or severity of adverse effects can be increased when Beclomethasone dipropionate is combined with Arsenic trioxide.
Sorafenib The risk or severity of QTc prolongation can be increased when Arsenic trioxide is combined with Sorafenib.
Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Arsenic trioxide.
Trifluridine The risk or severity of adverse effects can be increased when Trifluridine is combined with Arsenic trioxide.
Betamethasone The risk or severity of adverse effects can be increased when Betamethasone is combined with Arsenic trioxide.
Teniposide The risk or severity of adverse effects can be increased when Teniposide is combined with Arsenic trioxide.
Chloramphenicol The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Arsenic trioxide.
Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Arsenic trioxide.
Altretamine The risk or severity of adverse effects can be increased when Altretamine is combined with Arsenic trioxide.
Zidovudine The risk or severity of adverse effects can be increased when Zidovudine is combined with Arsenic trioxide.
Cisplatin The risk or severity of adverse effects can be increased when Cisplatin is combined with Arsenic trioxide.
Oxaliplatin The risk or severity of QTc prolongation can be increased when Oxaliplatin is combined with Arsenic trioxide.
Cyclophosphamide The risk or severity of adverse effects can be increased when Cyclophosphamide is combined with Arsenic trioxide.
Fluorouracil The risk or severity of adverse effects can be increased when Fluorouracil is combined with Arsenic trioxide.
Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Arsenic trioxide.
Pentostatin The risk or severity of adverse effects can be increased when Pentostatin is combined with Arsenic trioxide.
Methotrexate The risk or severity of adverse effects can be increased when Methotrexate is combined with Arsenic trioxide.
Fluticasone propionate The risk or severity of adverse effects can be increased when Fluticasone propionate is combined with Arsenic trioxide.
Fluocinolone acetonide The risk or severity of adverse effects can be increased when Fluocinolone acetonide is combined with Arsenic trioxide.
Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Arsenic trioxide.
Imatinib The risk or severity of adverse effects can be increased when Imatinib is combined with Arsenic trioxide.
Triamcinolone The risk or severity of adverse effects can be increased when Triamcinolone is combined with Arsenic trioxide.
Clofarabine The risk or severity of adverse effects can be increased when Clofarabine is combined with Arsenic trioxide.
Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Arsenic trioxide.
Pemetrexed The risk or severity of adverse effects can be increased when Pemetrexed is combined with Arsenic trioxide.
Fludrocortisone The risk or severity of adverse effects can be increased when Fludrocortisone is combined with Arsenic trioxide.
Mycophenolate mofetil The risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with Arsenic trioxide.
Daunorubicin The risk or severity of adverse effects can be increased when Daunorubicin is combined with Arsenic trioxide.
Tretinoin The risk or severity of cardiotoxicity can be increased when Tretinoin is combined with Arsenic trioxide.
Irinotecan The risk or severity of adverse effects can be increased when Irinotecan is combined with Arsenic trioxide.
Methimazole The risk or severity of adverse effects can be increased when Methimazole is combined with Arsenic trioxide.
Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Arsenic trioxide.
Dacarbazine The risk or severity of adverse effects can be increased when Dacarbazine is combined with Arsenic trioxide.
Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Arsenic trioxide.
Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Arsenic trioxide.
Prednisolone The risk or severity of adverse effects can be increased when Prednisolone is combined with Arsenic trioxide.
Mechlorethamine The risk or severity of adverse effects can be increased when Mechlorethamine is combined with Arsenic trioxide.
Azacitidine The risk or severity of adverse effects can be increased when Azacitidine is combined with Arsenic trioxide.
Carboplatin The risk or severity of adverse effects can be increased when Carboplatin is combined with Arsenic trioxide.
Methylprednisolone The risk or severity of adverse effects can be increased when Methylprednisolone is combined with Arsenic trioxide.
Cytarabine The risk or severity of adverse effects can be increased when Cytarabine is combined with Arsenic trioxide.
Azathioprine The risk or severity of adverse effects can be increased when Azathioprine is combined with Arsenic trioxide.
Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Arsenic trioxide.
Mycophenolic acid The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Arsenic trioxide.
Mercaptopurine The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Arsenic trioxide.
Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Arsenic trioxide.
Melphalan The risk or severity of adverse effects can be increased when Melphalan is combined with Arsenic trioxide.
Fludarabine The risk or severity of adverse effects can be increased when Fludarabine is combined with Arsenic trioxide.
Flucytosine The risk or severity of adverse effects can be increased when Flucytosine is combined with Arsenic trioxide.
Capecitabine The risk or severity of adverse effects can be increased when Capecitabine is combined with Arsenic trioxide.
Trilostane The risk or severity of adverse effects can be increased when Trilostane is combined with Arsenic trioxide.
Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Arsenic trioxide.
Idarubicin The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Idarubicin.
Ifosfamide The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Ifosfamide.
Estramustine The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Estramustine.
Mitoxantrone The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Mitoxantrone.
Lomustine The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Lomustine.

Target Protein

Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB
Thioredoxin reductase 1, cytoplasmic TXNRD1
Transcription factor Jun JUN
G1/S-specific cyclin-D1 CCND1
Mitogen-activated protein kinase 3 MAPK3
Mitogen-activated protein kinase 1 MAPK1
RAC-alpha serine/threonine-protein kinase AKT1
Cyclin-dependent kinase inhibitor 1 CDKN1A
Histone deacetylase 1 HDAC1
Protein PML PML

Referensi & Sumber

Artikel (PubMed)
  • PMID: 17640917
    Lu J, Chew EH, Holmgren A: Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12288-93. Epub 2007 Jul 18.

Contoh Produk & Brand

Produk: 49 • International brands: 0
Produk
  • Arsenic trioxide
    Injection, solution • 1 mg/1mL • Intravenous • US • Generic • Approved
  • Arsenic trioxide
    Injection, solution • 1 mg/1mL • Intravenous • US • Generic • Approved
  • Arsenic Trioxide
    Injection, solution • 1 mg/1mL • Intravenous • US • Generic • Approved
  • Arsenic trioxide
    Injection, solution • 2 mg/1mL • Intravenous • US • Generic • Approved
  • Arsenic trioxide
    Injection, solution • 2 mg/1mL • Intravenous • US • Generic • Approved
  • Arsenic Trioxide
    Injection, solution • 1 mg/1mL • Intravenous • US • Generic • Approved
  • Arsenic Trioxide
    Injection • 1 mg/1mL • Intravenous • US • Generic • Approved
  • Arsenic Trioxide
    Injection, solution • 1 mg/1mL • Intravenous • US • Generic • Approved
Menampilkan 8 dari 49 produk.

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