Amdinocillin

DB01163

small molecule investigational withdrawn

Deskripsi

Amidinopenicillanic acid derivative with broad spectrum antibacterial action. It is poorly absorbed if given orally and is used in urinary infections and typhus. Amdinocillin is not available in the United States.

Struktur Molekul 2D

Berat 325.426
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Approximately 1 hour in patients with normal renal function. Increases to 3 to 6 hours in anephric patients.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Poorly absorbed if given orally.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

192 Data
Methotrexate The excretion of Methotrexate can be decreased when combined with Amdinocillin.
Probenecid The excretion of Amdinocillin can be decreased when combined with Probenecid.
Doxycycline The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Doxycycline.
Lymecycline The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Lymecycline.
Clomocycline The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Clomocycline.
Tigecycline The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Tigecycline.
Oxytetracycline The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Oxytetracycline.
Demeclocycline The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Demeclocycline.
Tetracycline The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Tetracycline.
Metacycline The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Metacycline.
Minocycline The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Minocycline.
Rolitetracycline The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Rolitetracycline.
Sarecycline The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Sarecycline.
Eravacycline The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Eravacycline.
Omadacycline The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Omadacycline.
Penimepicycline The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Penimepicycline.
Mycophenolate mofetil The serum concentration of Mycophenolate mofetil can be decreased when it is combined with Amdinocillin.
Mycophenolic acid The serum concentration of Mycophenolic acid can be decreased when it is combined with Amdinocillin.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Amdinocillin.
Dicoumarol Amdinocillin may increase the anticoagulant activities of Dicoumarol.
Phenindione Amdinocillin may increase the anticoagulant activities of Phenindione.
Warfarin Amdinocillin may increase the anticoagulant activities of Warfarin.
Phenprocoumon Amdinocillin may increase the anticoagulant activities of Phenprocoumon.
Acenocoumarol Amdinocillin may increase the anticoagulant activities of Acenocoumarol.
4-hydroxycoumarin Amdinocillin may increase the anticoagulant activities of 4-hydroxycoumarin.
Coumarin Amdinocillin may increase the anticoagulant activities of Coumarin.
(R)-warfarin Amdinocillin may increase the anticoagulant activities of (R)-warfarin.
Ethyl biscoumacetate Amdinocillin may increase the anticoagulant activities of Ethyl biscoumacetate.
Fluindione Amdinocillin may increase the anticoagulant activities of Fluindione.
Clorindione Amdinocillin may increase the anticoagulant activities of Clorindione.
Diphenadione Amdinocillin may increase the anticoagulant activities of Diphenadione.
Tioclomarol Amdinocillin may increase the anticoagulant activities of Tioclomarol.
(S)-Warfarin Amdinocillin may increase the anticoagulant activities of (S)-Warfarin.
Diethylstilbestrol The therapeutic efficacy of Diethylstilbestrol can be decreased when used in combination with Amdinocillin.
Etonogestrel The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Amdinocillin.
Desogestrel The therapeutic efficacy of Desogestrel can be decreased when used in combination with Amdinocillin.
Megestrol acetate The therapeutic efficacy of Megestrol acetate can be decreased when used in combination with Amdinocillin.
Levonorgestrel The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with Amdinocillin.
Progesterone The therapeutic efficacy of Progesterone can be decreased when used in combination with Amdinocillin.
Medroxyprogesterone acetate The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with Amdinocillin.
Norethisterone The therapeutic efficacy of Norethisterone can be decreased when used in combination with Amdinocillin.
Estradiol The therapeutic efficacy of Estradiol can be decreased when used in combination with Amdinocillin.
Ethynodiol diacetate The therapeutic efficacy of Ethynodiol diacetate can be decreased when used in combination with Amdinocillin.
Mifepristone The therapeutic efficacy of Mifepristone can be decreased when used in combination with Amdinocillin.
Norgestimate The therapeutic efficacy of Norgestimate can be decreased when used in combination with Amdinocillin.
Ethinylestradiol The therapeutic efficacy of Ethinylestradiol can be decreased when used in combination with Amdinocillin.
Mestranol The therapeutic efficacy of Mestranol can be decreased when used in combination with Amdinocillin.
Drospirenone The therapeutic efficacy of Drospirenone can be decreased when used in combination with Amdinocillin.
Estrone sulfate The therapeutic efficacy of Estrone sulfate can be decreased when used in combination with Amdinocillin.
Octylphenoxy polyethoxyethanol The therapeutic efficacy of Octylphenoxy polyethoxyethanol can be decreased when used in combination with Amdinocillin.
Cyproterone acetate The therapeutic efficacy of Cyproterone acetate can be decreased when used in combination with Amdinocillin.
Trestolone The therapeutic efficacy of Trestolone can be decreased when used in combination with Amdinocillin.
Norelgestromin The therapeutic efficacy of Norelgestromin can be decreased when used in combination with Amdinocillin.
Gestodene The therapeutic efficacy of Gestodene can be decreased when used in combination with Amdinocillin.
Hydroxyprogesterone caproate The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Amdinocillin.
Ulipristal The therapeutic efficacy of Ulipristal can be decreased when used in combination with Amdinocillin.
Dienogest The therapeutic efficacy of Dienogest can be decreased when used in combination with Amdinocillin.
Norethynodrel The therapeutic efficacy of Norethynodrel can be decreased when used in combination with Amdinocillin.
Norgestrel The therapeutic efficacy of Norgestrel can be decreased when used in combination with Amdinocillin.
Cloprostenol The therapeutic efficacy of Cloprostenol can be decreased when used in combination with Amdinocillin.
Gestrinone The therapeutic efficacy of Gestrinone can be decreased when used in combination with Amdinocillin.
Nomegestrol The therapeutic efficacy of Nomegestrol can be decreased when used in combination with Amdinocillin.
Lynestrenol The therapeutic efficacy of Lynestrenol can be decreased when used in combination with Amdinocillin.
Gossypol The therapeutic efficacy of Gossypol can be decreased when used in combination with Amdinocillin.
Ormeloxifene The therapeutic efficacy of Ormeloxifene can be decreased when used in combination with Amdinocillin.
Chlormadinone The therapeutic efficacy of Chlormadinone can be decreased when used in combination with Amdinocillin.
Norgestrienone The therapeutic efficacy of Norgestrienone can be decreased when used in combination with Amdinocillin.
Quingestanol The therapeutic efficacy of Quingestanol can be decreased when used in combination with Amdinocillin.
Demegestone The therapeutic efficacy of Demegestone can be decreased when used in combination with Amdinocillin.
Etynodiol The therapeutic efficacy of Etynodiol can be decreased when used in combination with Amdinocillin.
Testosterone enanthate The therapeutic efficacy of Testosterone enanthate can be decreased when used in combination with Amdinocillin.
Estradiol benzoate The therapeutic efficacy of Estradiol benzoate can be decreased when used in combination with Amdinocillin.
Estradiol cypionate The therapeutic efficacy of Estradiol cypionate can be decreased when used in combination with Amdinocillin.
Estradiol valerate The therapeutic efficacy of Estradiol valerate can be decreased when used in combination with Amdinocillin.
Nomegestrol acetate The therapeutic efficacy of Nomegestrol acetate can be decreased when used in combination with Amdinocillin.
Norethindrone enanthate The therapeutic efficacy of Norethindrone enanthate can be decreased when used in combination with Amdinocillin.
Capreomycin The serum concentration of Capreomycin can be decreased when it is combined with Amdinocillin.
Framycetin The serum concentration of Framycetin can be decreased when it is combined with Amdinocillin.
Amikacin The serum concentration of Amikacin can be decreased when it is combined with Amdinocillin.
Tobramycin The serum concentration of Tobramycin can be decreased when it is combined with Amdinocillin.
Gentamicin The serum concentration of Gentamicin can be decreased when it is combined with Amdinocillin.
Netilmicin The serum concentration of Netilmicin can be decreased when it is combined with Amdinocillin.
Neomycin The serum concentration of Neomycin can be decreased when it is combined with Amdinocillin.
Streptomycin The serum concentration of Streptomycin can be decreased when it is combined with Amdinocillin.
Kanamycin The serum concentration of Kanamycin can be decreased when it is combined with Amdinocillin.
Paromomycin The serum concentration of Paromomycin can be decreased when it is combined with Amdinocillin.
Ribostamycin The serum concentration of Ribostamycin can be decreased when it is combined with Amdinocillin.
Geneticin The serum concentration of Geneticin can be decreased when it is combined with Amdinocillin.
Apramycin The serum concentration of Apramycin can be decreased when it is combined with Amdinocillin.
Gentamicin C1a The serum concentration of Gentamicin C1a can be decreased when it is combined with Amdinocillin.
Neamine The serum concentration of Neamine can be decreased when it is combined with Amdinocillin.
Arbekacin The serum concentration of Arbekacin can be decreased when it is combined with Amdinocillin.
Puromycin The serum concentration of Puromycin can be decreased when it is combined with Amdinocillin.
Dihydrostreptomycin The serum concentration of Dihydrostreptomycin can be decreased when it is combined with Amdinocillin.
Hygromycin B The serum concentration of Hygromycin B can be decreased when it is combined with Amdinocillin.
Sisomicin The serum concentration of Sisomicin can be decreased when it is combined with Amdinocillin.
Plazomicin The serum concentration of Plazomicin can be decreased when it is combined with Amdinocillin.
Isepamicin The serum concentration of Isepamicin can be decreased when it is combined with Amdinocillin.
Colistin The serum concentration of Colistin can be decreased when it is combined with Amdinocillin.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Amdinocillin.

Target Protein

Penicillin-binding protein 2a pbp2a
Penicillin-binding protein 2 mrdA
Penicillin-binding protein 3 pbp3
Penicillin-binding protein 1A pbpA
Penicillin-binding protein 2B penA
Penicillin-binding protein 1b pbp1b

Referensi & Sumber

Synthesis reference: U.S. Patent 3,957,764.
Artikel (PubMed)
  • PMID: 6311012
    Neu HC: Penicillin-binding proteins and role of amdinocillin in causing bacterial cell death. Am J Med. 1983 Aug 29;75(2A):9-20.

Contoh Produk & Brand

Produk: 0 • International brands: 2
International Brands
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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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