Peringatan Keamanan

Toxic effects of halothane include malignant hyperthermia and hepatitis.

Halothane

DB01159

small molecule approved vet_approved

Deskripsi

A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)

Struktur Molekul 2D

Berat 197.382
Wujud liquid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Halothane is metabolized in the liver, primarily by CYP2E1, and to a lesser extent by CYP3A4 and CYP2A6.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1384 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Halothane is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Halothane is combined with Levodopa.
Risperidone Halothane may increase the hypotensive activities of Risperidone.
Furosemide Halothane may decrease the antihypertensive activities of Furosemide.
Ramipril Halothane may decrease the antihypertensive activities of Ramipril.
Esmolol Halothane may decrease the antihypertensive activities of Esmolol.
Betaxolol Halothane may decrease the antihypertensive activities of Betaxolol.
Remikiren Halothane may decrease the antihypertensive activities of Remikiren.
Bethanidine Halothane may decrease the antihypertensive activities of Bethanidine.
Guanadrel Halothane may decrease the antihypertensive activities of Guanadrel.
Olmesartan Halothane may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Halothane may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Halothane may decrease the antihypertensive activities of Nitroprusside.
Atenolol Halothane may decrease the antihypertensive activities of Atenolol.
Minoxidil Halothane may decrease the antihypertensive activities of Minoxidil.
Timolol Halothane may decrease the antihypertensive activities of Timolol.
Treprostinil Halothane may decrease the antihypertensive activities of Treprostinil.
Bendroflumethiazide Halothane may decrease the antihypertensive activities of Bendroflumethiazide.
Prazosin Halothane may decrease the antihypertensive activities of Prazosin.
Fosinopril Halothane may decrease the antihypertensive activities of Fosinopril.
Trandolapril Halothane may decrease the antihypertensive activities of Trandolapril.
Metolazone Halothane may decrease the antihypertensive activities of Metolazone.
Benazepril Halothane may decrease the antihypertensive activities of Benazepril.
Enalapril Halothane may decrease the antihypertensive activities of Enalapril.
Labetalol Halothane may decrease the antihypertensive activities of Labetalol.
Cyclothiazide Halothane may decrease the antihypertensive activities of Cyclothiazide.
Candoxatril Halothane may decrease the antihypertensive activities of Candoxatril.
Guanabenz Halothane may decrease the antihypertensive activities of Guanabenz.
Mecamylamine Halothane may decrease the antihypertensive activities of Mecamylamine.
Moexipril Halothane may decrease the antihypertensive activities of Moexipril.
Phentolamine Halothane may decrease the antihypertensive activities of Phentolamine.
Lisinopril Halothane may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Halothane may decrease the antihypertensive activities of Nitroglycerin.
Hydroflumethiazide Halothane may decrease the antihypertensive activities of Hydroflumethiazide.
Cryptenamine Halothane may decrease the antihypertensive activities of Cryptenamine.
Perindopril Halothane may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Halothane may decrease the antihypertensive activities of Candesartan cilexetil.
Tolazoline Halothane may decrease the antihypertensive activities of Tolazoline.
Fenoldopam Halothane may decrease the antihypertensive activities of Fenoldopam.
Eprosartan Halothane may decrease the antihypertensive activities of Eprosartan.
Chlorothiazide Halothane may decrease the antihypertensive activities of Chlorothiazide.
Quinapril Halothane may decrease the antihypertensive activities of Quinapril.
Omapatrilat Halothane may decrease the antihypertensive activities of Omapatrilat.
Phenoxybenzamine Halothane may decrease the antihypertensive activities of Phenoxybenzamine.
Telmisartan Halothane may decrease the antihypertensive activities of Telmisartan.
Methyldopa Halothane may decrease the antihypertensive activities of Methyldopa.
Hydrochlorothiazide Halothane may decrease the antihypertensive activities of Hydrochlorothiazide.
Trichlormethiazide Halothane may decrease the antihypertensive activities of Trichlormethiazide.
Deserpidine Halothane may decrease the antihypertensive activities of Deserpidine.
Pentolinium Halothane may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Halothane may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Halothane may decrease the antihypertensive activities of Diazoxide.
Bretylium Halothane may decrease the antihypertensive activities of Bretylium.
Terazosin Halothane may decrease the antihypertensive activities of Terazosin.
Rescinnamine Halothane may decrease the antihypertensive activities of Rescinnamine.
Acebutolol Halothane may decrease the antihypertensive activities of Acebutolol.
Captopril Halothane may decrease the antihypertensive activities of Captopril.
Nadolol Halothane may decrease the antihypertensive activities of Nadolol.
Epoprostenol Halothane may decrease the antihypertensive activities of Epoprostenol.
Bevantolol Halothane may decrease the antihypertensive activities of Bevantolol.
Practolol Halothane may decrease the antihypertensive activities of Practolol.
Polythiazide Halothane may decrease the antihypertensive activities of Polythiazide.
Cilazapril Halothane may decrease the antihypertensive activities of Cilazapril.
Saprisartan Halothane may decrease the antihypertensive activities of Saprisartan.
Spirapril Halothane may decrease the antihypertensive activities of Spirapril.
Dexpropranolol Halothane may decrease the antihypertensive activities of Dexpropranolol.
Debrisoquine Halothane may decrease the antihypertensive activities of Debrisoquine.
Celiprolol Halothane may decrease the antihypertensive activities of Celiprolol.
Diethylnorspermine Halothane may decrease the antihypertensive activities of Diethylnorspermine.
Bupranolol Halothane may decrease the antihypertensive activities of Bupranolol.
Temocapril Halothane may decrease the antihypertensive activities of Temocapril.
Indoramin Halothane may decrease the antihypertensive activities of Indoramin.
Indenolol Halothane may decrease the antihypertensive activities of Indenolol.
Trimazosin Halothane may decrease the antihypertensive activities of Trimazosin.
Moxonidine Halothane may decrease the antihypertensive activities of Moxonidine.
Rauwolfia serpentina root Halothane may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Halothane may decrease the antihypertensive activities of Enalaprilat.
Angiotensin 1-7 Halothane may decrease the antihypertensive activities of Angiotensin 1-7.
Rilmenidine Halothane may decrease the antihypertensive activities of Rilmenidine.
Talinolol Halothane may decrease the antihypertensive activities of Talinolol.
Imidapril Halothane may decrease the antihypertensive activities of Imidapril.
BQ-123 Halothane may decrease the antihypertensive activities of BQ-123.
Landiolol Halothane may decrease the antihypertensive activities of Landiolol.
Cicletanine Halothane may decrease the antihypertensive activities of Cicletanine.
Dihydralazine Halothane may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Halothane may decrease the antihypertensive activities of Zofenopril.
Guanoxan Halothane may decrease the antihypertensive activities of Guanoxan.
Delapril Halothane may decrease the antihypertensive activities of Delapril.
Vincamine Halothane may decrease the antihypertensive activities of Vincamine.
Linsidomine Halothane may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Halothane may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Halothane may decrease the antihypertensive activities of Tolonidine.
Endralazine Halothane may decrease the antihypertensive activities of Endralazine.
Esatenolol Halothane may decrease the antihypertensive activities of Esatenolol.
Cadralazine Halothane may decrease the antihypertensive activities of Cadralazine.
Cloranolol Halothane may decrease the antihypertensive activities of Cloranolol.
Cyclopenthiazide Halothane may decrease the antihypertensive activities of Cyclopenthiazide.
Bietaserpine Halothane may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Halothane may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Halothane may decrease the antihypertensive activities of Methoserpidine.

Target Protein

Potassium channel subfamily K member 3 KCNK3
Potassium channel subfamily K member 9 KCNK9
GABA(A) Receptor GABRA1
Plasma membrane calcium-transporting ATPase ATP2B1
Calcium-activated potassium channel subunit alpha-1 KCNMA1
Glutamate receptor ionotropic, NMDA 3A GRIN3A
Glutamate receptor ionotropic, NMDA 3B GRIN3B
Glutamate receptor ionotropic, NMDA 2A GRIN2A
Glycine receptor subunit alpha-1 GLRA1
Rhodopsin RHO
G protein-activated inward rectifier potassium channel 2 KCNJ6
G protein-activated inward rectifier potassium channel 1 KCNJ3
NADH-ubiquinone oxidoreductase chain 1 MT-ND1
Intermediate conductance calcium-activated potassium channel protein 4 KCNN4
Gamma-aminobutyric acid receptor subunit alpha-1 GABRA1
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 GNG2
Neuropeptide S receptor NPSR1

Referensi & Sumber

Synthesis reference: U.S. Patents 2,849,502, 2,921,098, 2,959,624, 3,082,263.
Artikel (PubMed)
  • PMID: 18175089
    Bovill JG: Inhalation anaesthesia: from diethyl ether to xenon. Handb Exp Pharmacol. 2008;(182):121-42. doi: 10.1007/978-3-540-74806-9_6.

Contoh Produk & Brand

Produk: 5 • International brands: 4
Produk
  • Fluothane Anesthetic
    Liquid • - • Respiratory (inhalation) • Canada • Approved
  • Fluothane Liq Inh 1000mg/gm
    Liquid • 1 g / g • Respiratory (inhalation) • Canada • Approved
  • Halothane
    Inhalant • 250 mL/250mL • Respiratory (inhalation) • US • Generic • Approved
  • Halothane
    Solution • 99.99 % • Respiratory (inhalation) • Canada • Approved
  • Halothane Liq 99.9%
    Liquid • 99.9 % • Respiratory (inhalation) • Canada • Approved
International Brands
  • Fluothane — Ayerst
  • Ftorotan
  • Halotan — Jugoremedija
  • Narcotan — Zentiva

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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