Peringatan Keamanan

Single 5000 mg/kg oral doses of cefprozil caused no mortality or signs of toxicity in adult, weaning or neonatal rats, or adult mice. A single oral dose of 3000 mg/kg caused diarrhea and loss of appetite in cynomolgus monkeys, but no mortality.

Cefprozil

DB01150

small molecule approved

Deskripsi

Cefprozil is a cephalosporin antibiotic that is commonly employed to treat a variety of bacterial infections, including those of the ear and skin, bronchitis, and others.

Struktur Molekul 2D

Berat 389.426
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 1.3 hours
Volume Distribusi * 0.23 L/kg
Klirens (Clearance) * 3 mL/min/kg [fasting subjects]

Absorpsi

Oral bioavailability is approximately 95%.

Metabolisme

Cefprozil is eliminated primarily by the kidneys

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

796 Data
Probenecid The serum concentration of Cefprozil can be increased when it is combined with Probenecid.
Foscarnet The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Foscarnet.
Mannitol The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Cefprozil.
Tenofovir disoproxil Cefprozil may increase the nephrotoxic activities of Tenofovir disoproxil.
Tenofovir alafenamide Cefprozil may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir Cefprozil may increase the nephrotoxic activities of Tenofovir.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefprozil.
Cyclosporine The risk or severity of nephrotoxicity can be increased when Cyclosporine is combined with Cefprozil.
Icosapent The risk or severity of nephrotoxicity can be increased when Icosapent is combined with Cefprozil.
Cefotiam The risk or severity of nephrotoxicity can be increased when Cefotiam is combined with Cefprozil.
Mesalazine The risk or severity of nephrotoxicity can be increased when Mesalazine is combined with Cefprozil.
Cefmenoxime The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefprozil.
Cefmetazole The risk or severity of nephrotoxicity can be increased when Cefmetazole is combined with Cefprozil.
Indomethacin The risk or severity of nephrotoxicity can be increased when Indomethacin is combined with Cefprozil.
Triamterene The risk or severity of nephrotoxicity can be increased when Triamterene is combined with Cefprozil.
Cefpiramide The risk or severity of nephrotoxicity can be increased when Cefpiramide is combined with Cefprozil.
Loracarbef The risk or severity of nephrotoxicity can be increased when Loracarbef is combined with Cefprozil.
Cefalotin The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Cefprozil.
Nabumetone The risk or severity of nephrotoxicity can be increased when Nabumetone is combined with Cefprozil.
Ketorolac The risk or severity of nephrotoxicity can be increased when Ketorolac is combined with Cefprozil.
Tenoxicam The risk or severity of nephrotoxicity can be increased when Tenoxicam is combined with Cefprozil.
Celecoxib The risk or severity of nephrotoxicity can be increased when Celecoxib is combined with Cefprozil.
Cefotaxime The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Cefprozil.
Tolmetin The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Cefprozil.
Rofecoxib The risk or severity of nephrotoxicity can be increased when Rofecoxib is combined with Cefprozil.
Fenoprofen The risk or severity of nephrotoxicity can be increased when Fenoprofen is combined with Cefprozil.
Valdecoxib The risk or severity of nephrotoxicity can be increased when Valdecoxib is combined with Cefprozil.
Diclofenac The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Cefprozil.
Sulindac The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Cefprozil.
Bacitracin The risk or severity of nephrotoxicity can be increased when Bacitracin is combined with Cefprozil.
Amphotericin B The risk or severity of nephrotoxicity can be increased when Amphotericin B is combined with Cefprozil.
Cephaloglycin The risk or severity of nephrotoxicity can be increased when Cephaloglycin is combined with Cefprozil.
Adefovir dipivoxil The risk or severity of nephrotoxicity can be increased when Adefovir dipivoxil is combined with Cefprozil.
Pentamidine The risk or severity of nephrotoxicity can be increased when Pentamidine is combined with Cefprozil.
Mefenamic acid The risk or severity of nephrotoxicity can be increased when Mefenamic acid is combined with Cefprozil.
Naproxen The risk or severity of nephrotoxicity can be increased when Naproxen is combined with Cefprozil.
Sulfasalazine The risk or severity of nephrotoxicity can be increased when Sulfasalazine is combined with Cefprozil.
Phenylbutazone The risk or severity of nephrotoxicity can be increased when Phenylbutazone is combined with Cefprozil.
Meloxicam The risk or severity of methemoglobinemia can be increased when Cefprozil is combined with Meloxicam.
Carprofen The risk or severity of nephrotoxicity can be increased when Carprofen is combined with Cefprozil.
Tacrolimus The risk or severity of nephrotoxicity can be increased when Tacrolimus is combined with Cefprozil.
Etacrynic acid The risk or severity of nephrotoxicity can be increased when Etacrynic acid is combined with Cefprozil.
Ceforanide The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cefprozil.
Salicylic acid The risk or severity of nephrotoxicity can be increased when Salicylic acid is combined with Cefprozil.
Acetylsalicylic acid The risk or severity of nephrotoxicity can be increased when Acetylsalicylic acid is combined with Cefprozil.
Hydrochlorothiazide The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Cefprozil.
Balsalazide The risk or severity of nephrotoxicity can be increased when Balsalazide is combined with Cefprozil.
Cefditoren The risk or severity of nephrotoxicity can be increased when Cefditoren is combined with Cefprozil.
Atazanavir The risk or severity of nephrotoxicity can be increased when Atazanavir is combined with Cefprozil.
Colistimethate The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Cefprozil.
Cefuroxime The risk or severity of nephrotoxicity can be increased when Cefuroxime is combined with Cefprozil.
Cefapirin The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Cefprozil.
Olsalazine The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Olsalazine.
Lumiracoxib The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Lumiracoxib.
Cefamandole The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Cefamandole.
Cefazolin The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Cefazolin.
Cefonicid The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Cefonicid.
Cefoperazone The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Cefoperazone.
Cefoxitin The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Cefoxitin.
Ceftizoxime The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Ceftizoxime.
Magnesium salicylate The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Magnesium salicylate.
Salsalate The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Salsalate.
Choline magnesium trisalicylate The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Choline magnesium trisalicylate.
Cefepime The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Cefepime.
Cefacetrile The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Cefacetrile.
Cefpodoxime The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Cefpodoxime.
Antrafenine The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Antrafenine.
Aminophenazone The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Aminophenazone.
Antipyrine The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Antipyrine.
Tiaprofenic acid The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Tiaprofenic acid.
Lopinavir The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Lopinavir.
Etoricoxib The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Etoricoxib.
Hydrolyzed Cephalothin The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Hydrolyzed Cephalothin.
Cephalothin Group The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Cephalothin Group.
Oxyphenbutazone The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Oxyphenbutazone.
Latamoxef The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Latamoxef.
Nimesulide The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Nimesulide.
Benoxaprofen The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Benoxaprofen.
Metamizole The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Metamizole.
Zomepirac The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Zomepirac.
Ceftobiprole The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Ceftobiprole.
Cimicoxib The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Cimicoxib.
Ceftaroline fosamil The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Ceftaroline fosamil.
Lornoxicam The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Lornoxicam.
Zaltoprofen The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Zaltoprofen.
Azapropazone The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Azapropazone.
Parecoxib The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Parecoxib.
Salicylamide The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Salicylamide.
Kebuzone The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Kebuzone.
Isoxicam The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Isoxicam.
Indoprofen The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Indoprofen.
Ibuproxam The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Ibuproxam.
Floctafenine The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Floctafenine.
Fenbufen The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Fenbufen.
Etofenamate The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Etofenamate.
Epirizole The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Epirizole.
Cefaloridine The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Cefaloridine.
Cefminox The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Cefminox.
Dexibuprofen The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Dexibuprofen.
Droxicam The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Droxicam.

Target Protein

Penicillin-binding protein 1A ponA
Penicillin-binding protein 2x pbpX
Penicillin-binding protein 2B penA

Referensi & Sumber

Synthesis reference: Julia Greil, Johannes Ludescher, Siegfried Wolf, "Intermediates in cefprozil production." U.S. Patent US07355041, issued April 08, 2008.

Contoh Produk & Brand

Produk: 120 • International brands: 3
Produk
  • Apo-cefprozil
    Powder, for suspension • 125 mg / 5 mL • Oral • Canada • Generic • Approved
  • Apo-cefprozil
    Powder, for suspension • 250 mg / 5 mL • Oral • Canada • Generic • Approved
  • Apo-cefprozil
    Tablet • 500 mg • Oral • Canada • Generic • Approved
  • Apo-cefprozil
    Tablet • 250 mg • Oral • Canada • Generic • Approved
  • Auro-cefprozil
    Tablet • 250 mg • Oral • Canada • Generic • Approved
  • Auro-cefprozil
    Tablet • 500 mg • Oral • Canada • Generic • Approved
  • Auro-cefprozil
    Powder, for suspension • 125 mg / 5 mL • Oral • Canada • Generic • Approved
  • Auro-cefprozil
    Powder, for suspension • 250 mg / 5 mL • Oral • Canada • Generic • Approved
Menampilkan 8 dari 120 produk.
International Brands
  • Brisoral
  • Cronocef
  • Serozil

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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