Peringatan Keamanan

Oral LD50 in rat and mouse is 5000 mg/kg. Intravenous LD50 in rat is 1660 mg/kg. Symptoms of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, and swelling of face, lips, tongue, or throat.

Cloxacillin

DB01147

small molecule approved investigational vet_approved

Deskripsi

A semi-synthetic penicillin antibiotic which is a chlorinated derivative of oxacillin.

Struktur Molekul 2D

Berat 435.881
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Well absorbed from the gastrointestinal tract.

Metabolisme

Cloxacillin, like other penicillins, appears to be metabolized via breakage of the beta-lactam ring to form an inactive penicilloic acid metabolite.A233984

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take on an empty stomach. Orally administered cloxacillin should be taken 1-2 hours prior to meals as the presence of food in the stomach and intestine reduces drug absorption.

Interaksi Obat

192 Data
Methotrexate The excretion of Methotrexate can be decreased when combined with Cloxacillin.
Probenecid The excretion of Cloxacillin can be decreased when combined with Probenecid.
Doxycycline The therapeutic efficacy of Cloxacillin can be decreased when used in combination with Doxycycline.
Lymecycline The therapeutic efficacy of Cloxacillin can be decreased when used in combination with Lymecycline.
Clomocycline The therapeutic efficacy of Cloxacillin can be decreased when used in combination with Clomocycline.
Tigecycline The therapeutic efficacy of Cloxacillin can be decreased when used in combination with Tigecycline.
Oxytetracycline The therapeutic efficacy of Cloxacillin can be decreased when used in combination with Oxytetracycline.
Demeclocycline The therapeutic efficacy of Cloxacillin can be decreased when used in combination with Demeclocycline.
Tetracycline The therapeutic efficacy of Cloxacillin can be decreased when used in combination with Tetracycline.
Metacycline The therapeutic efficacy of Cloxacillin can be decreased when used in combination with Metacycline.
Minocycline The therapeutic efficacy of Cloxacillin can be decreased when used in combination with Minocycline.
Rolitetracycline The therapeutic efficacy of Cloxacillin can be decreased when used in combination with Rolitetracycline.
Sarecycline The therapeutic efficacy of Cloxacillin can be decreased when used in combination with Sarecycline.
Eravacycline The therapeutic efficacy of Cloxacillin can be decreased when used in combination with Eravacycline.
Omadacycline The therapeutic efficacy of Cloxacillin can be decreased when used in combination with Omadacycline.
Penimepicycline The therapeutic efficacy of Cloxacillin can be decreased when used in combination with Penimepicycline.
Mycophenolate mofetil The serum concentration of Mycophenolate mofetil can be decreased when it is combined with Cloxacillin.
Mycophenolic acid The serum concentration of Mycophenolic acid can be decreased when it is combined with Cloxacillin.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cloxacillin.
Dicoumarol Cloxacillin may increase the anticoagulant activities of Dicoumarol.
Phenindione Cloxacillin may increase the anticoagulant activities of Phenindione.
Warfarin Cloxacillin may increase the anticoagulant activities of Warfarin.
Phenprocoumon Cloxacillin may increase the anticoagulant activities of Phenprocoumon.
Acenocoumarol Cloxacillin may increase the anticoagulant activities of Acenocoumarol.
4-hydroxycoumarin Cloxacillin may increase the anticoagulant activities of 4-hydroxycoumarin.
Coumarin Cloxacillin may increase the anticoagulant activities of Coumarin.
(R)-warfarin Cloxacillin may increase the anticoagulant activities of (R)-warfarin.
Ethyl biscoumacetate Cloxacillin may increase the anticoagulant activities of Ethyl biscoumacetate.
Fluindione Cloxacillin may increase the anticoagulant activities of Fluindione.
Clorindione Cloxacillin may increase the anticoagulant activities of Clorindione.
Diphenadione Cloxacillin may increase the anticoagulant activities of Diphenadione.
Tioclomarol Cloxacillin may increase the anticoagulant activities of Tioclomarol.
(S)-Warfarin Cloxacillin may increase the anticoagulant activities of (S)-Warfarin.
Diethylstilbestrol The therapeutic efficacy of Diethylstilbestrol can be decreased when used in combination with Cloxacillin.
Etonogestrel The therapeutic efficacy of Etonogestrel can be decreased when used in combination with Cloxacillin.
Desogestrel The therapeutic efficacy of Desogestrel can be decreased when used in combination with Cloxacillin.
Megestrol acetate The therapeutic efficacy of Megestrol acetate can be decreased when used in combination with Cloxacillin.
Levonorgestrel The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with Cloxacillin.
Progesterone The therapeutic efficacy of Progesterone can be decreased when used in combination with Cloxacillin.
Medroxyprogesterone acetate The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with Cloxacillin.
Norethisterone The therapeutic efficacy of Norethisterone can be decreased when used in combination with Cloxacillin.
Estradiol The therapeutic efficacy of Estradiol can be decreased when used in combination with Cloxacillin.
Ethynodiol diacetate The therapeutic efficacy of Ethynodiol diacetate can be decreased when used in combination with Cloxacillin.
Mifepristone The therapeutic efficacy of Mifepristone can be decreased when used in combination with Cloxacillin.
Norgestimate The therapeutic efficacy of Norgestimate can be decreased when used in combination with Cloxacillin.
Ethinylestradiol The therapeutic efficacy of Ethinylestradiol can be decreased when used in combination with Cloxacillin.
Mestranol The therapeutic efficacy of Mestranol can be decreased when used in combination with Cloxacillin.
Drospirenone The therapeutic efficacy of Drospirenone can be decreased when used in combination with Cloxacillin.
Estrone sulfate The therapeutic efficacy of Estrone sulfate can be decreased when used in combination with Cloxacillin.
Octylphenoxy polyethoxyethanol The therapeutic efficacy of Octylphenoxy polyethoxyethanol can be decreased when used in combination with Cloxacillin.
Cyproterone acetate The therapeutic efficacy of Cyproterone acetate can be decreased when used in combination with Cloxacillin.
Trestolone The therapeutic efficacy of Trestolone can be decreased when used in combination with Cloxacillin.
Norelgestromin The therapeutic efficacy of Norelgestromin can be decreased when used in combination with Cloxacillin.
Gestodene The therapeutic efficacy of Gestodene can be decreased when used in combination with Cloxacillin.
Hydroxyprogesterone caproate The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Cloxacillin.
Ulipristal The therapeutic efficacy of Ulipristal can be decreased when used in combination with Cloxacillin.
Dienogest The therapeutic efficacy of Dienogest can be decreased when used in combination with Cloxacillin.
Norethynodrel The therapeutic efficacy of Norethynodrel can be decreased when used in combination with Cloxacillin.
Norgestrel The therapeutic efficacy of Norgestrel can be decreased when used in combination with Cloxacillin.
Cloprostenol The therapeutic efficacy of Cloprostenol can be decreased when used in combination with Cloxacillin.
Gestrinone The therapeutic efficacy of Gestrinone can be decreased when used in combination with Cloxacillin.
Nomegestrol The therapeutic efficacy of Nomegestrol can be decreased when used in combination with Cloxacillin.
Lynestrenol The therapeutic efficacy of Lynestrenol can be decreased when used in combination with Cloxacillin.
Gossypol The therapeutic efficacy of Gossypol can be decreased when used in combination with Cloxacillin.
Ormeloxifene The therapeutic efficacy of Ormeloxifene can be decreased when used in combination with Cloxacillin.
Chlormadinone The therapeutic efficacy of Chlormadinone can be decreased when used in combination with Cloxacillin.
Norgestrienone The therapeutic efficacy of Norgestrienone can be decreased when used in combination with Cloxacillin.
Quingestanol The therapeutic efficacy of Quingestanol can be decreased when used in combination with Cloxacillin.
Demegestone The therapeutic efficacy of Demegestone can be decreased when used in combination with Cloxacillin.
Etynodiol The therapeutic efficacy of Etynodiol can be decreased when used in combination with Cloxacillin.
Testosterone enanthate The therapeutic efficacy of Testosterone enanthate can be decreased when used in combination with Cloxacillin.
Estradiol benzoate The therapeutic efficacy of Estradiol benzoate can be decreased when used in combination with Cloxacillin.
Estradiol cypionate The therapeutic efficacy of Estradiol cypionate can be decreased when used in combination with Cloxacillin.
Estradiol valerate The therapeutic efficacy of Estradiol valerate can be decreased when used in combination with Cloxacillin.
Nomegestrol acetate The therapeutic efficacy of Nomegestrol acetate can be decreased when used in combination with Cloxacillin.
Norethindrone enanthate The therapeutic efficacy of Norethindrone enanthate can be decreased when used in combination with Cloxacillin.
Capreomycin The serum concentration of Capreomycin can be decreased when it is combined with Cloxacillin.
Framycetin The serum concentration of Framycetin can be decreased when it is combined with Cloxacillin.
Amikacin The serum concentration of Amikacin can be decreased when it is combined with Cloxacillin.
Tobramycin The serum concentration of Tobramycin can be decreased when it is combined with Cloxacillin.
Gentamicin The serum concentration of Gentamicin can be decreased when it is combined with Cloxacillin.
Netilmicin The serum concentration of Netilmicin can be decreased when it is combined with Cloxacillin.
Neomycin The serum concentration of Neomycin can be decreased when it is combined with Cloxacillin.
Streptomycin The serum concentration of Streptomycin can be decreased when it is combined with Cloxacillin.
Kanamycin The serum concentration of Kanamycin can be decreased when it is combined with Cloxacillin.
Paromomycin The serum concentration of Paromomycin can be decreased when it is combined with Cloxacillin.
Ribostamycin The serum concentration of Ribostamycin can be decreased when it is combined with Cloxacillin.
Geneticin The serum concentration of Geneticin can be decreased when it is combined with Cloxacillin.
Apramycin The serum concentration of Apramycin can be decreased when it is combined with Cloxacillin.
Gentamicin C1a The serum concentration of Gentamicin C1a can be decreased when it is combined with Cloxacillin.
Neamine The serum concentration of Neamine can be decreased when it is combined with Cloxacillin.
Arbekacin The serum concentration of Arbekacin can be decreased when it is combined with Cloxacillin.
Puromycin The serum concentration of Puromycin can be decreased when it is combined with Cloxacillin.
Dihydrostreptomycin The serum concentration of Dihydrostreptomycin can be decreased when it is combined with Cloxacillin.
Hygromycin B The serum concentration of Hygromycin B can be decreased when it is combined with Cloxacillin.
Sisomicin The serum concentration of Sisomicin can be decreased when it is combined with Cloxacillin.
Plazomicin The serum concentration of Plazomicin can be decreased when it is combined with Cloxacillin.
Isepamicin The serum concentration of Isepamicin can be decreased when it is combined with Cloxacillin.
Colistin The serum concentration of Colistin can be decreased when it is combined with Cloxacillin.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Cloxacillin.

Target Protein

D-alanyl-D-alanine carboxypeptidase DacA dacA
Penicillin-binding protein 2X pbpX
Penicillin-binding protein 1A pbpA

Referensi & Sumber

Synthesis reference: Doyle, F.P. and Nayler, J.H.C.; British Patent 905,778; September 12, 1962; assigned to Beecham Research Laboratories, Ltd. Doyle, F.P. and Nayler, J.H.C.; US. Patent 2,996,501; August 15, 1961.
Artikel (PubMed)
  • PMID: 32100322
    Lalanne S, Le Vee M, Lemaitre F, Le Corre P, Verdier MC, Fardel O: Differential interactions of the beta-lactam cloxacillin with human renal organic anion transporters (OATs). Fundam Clin Pharmacol. 2020 Aug;34(4):476-483. doi: 10.1111/fcp.12541. Epub 2020 Feb 25.
  • PMID: 825029
    Thijssen HH, Mattie H: Active metabolites of isoxazolylpencillins in humans. Antimicrob Agents Chemother. 1976 Sep;10(3):441-6. doi: 10.1128/aac.10.3.441.
  • PMID: 1031216
    Bratlid D, Bergan T: Displacement of albumin-bound antimicrobial agents by bilirubin. Pharmacology. 1976;14(5):464-72. doi: 10.1159/000136629.
  • PMID: 7447421
    Williamson R, Hakenbeck R, Tomasz A: In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1980 Oct;18(4):629-37.

Contoh Produk & Brand

Produk: 36 • International brands: 8
Produk
  • Apo Cloxi Cap 250mg
    Capsule • 250 mg • Oral • Canada • Generic • Approved
  • Apo Cloxi Cap 500mg
    Capsule • 500 mg • Oral • Canada • Generic • Approved
  • Apo Cloxi for Oral Soln 125mg/5ml
    Powder, for solution • 125 mg / 5 mL • Oral • Canada • Generic • Approved
  • Cloxacillin
    Capsule • 500 mg • Oral • Canada • Approved
  • Cloxacillin for Injection
    Powder, for solution • 500 mg / vial • Intramuscular; Intravenous • Canada • Approved
  • Cloxacillin for Injection
    Powder, for solution • 1 g / vial • Intravenous • Canada • Approved
  • Cloxacillin for Injection
    Powder, for solution • 2 g / vial • Intravenous • Canada • Approved
  • Cloxacillin for Injection
    Powder, for solution • 10 g / vial • Intravenous • Canada • Approved
Menampilkan 8 dari 36 produk.
International Brands
  • Aclox — Southshourne
  • Apo-Cloxi — Apotex
  • Auropen Inj. — Cirin
  • Cloxacil — Saiph
  • Cloxam — MacroPhar
  • Orbenin — GlaxoSmithKline
  • Vaclox — Atlantic
  • Vamcloxil — Vamsler

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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