Diphenylpyraline

DB01146

small molecule approved investigational

Deskripsi

Diphenylpyraline is an antihistamine. Antihistamines used in the treatment of allergy act by competing with histamine for H 1-receptor sites on effector cells. Antihistamines prevent, but do not reverse, responses mediated by histamine alone. Antihistamines antagonize, in varying degrees, most of the pharmacological effects of histamine, including urticaria and pruritus.

Struktur Molekul 2D

Berat 281.392
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Well absorbed after oral administration.

Metabolisme

Hepatic

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

36 Data
Benzylpenicilloyl polylysine Diphenylpyraline may decrease effectiveness of Benzylpenicilloyl polylysine as a diagnostic agent.
Betahistine The therapeutic efficacy of Betahistine can be decreased when used in combination with Diphenylpyraline.
Amphetamine Amphetamine may decrease the sedative activities of Diphenylpyraline.
Phentermine Phentermine may decrease the sedative activities of Diphenylpyraline.
Pseudoephedrine Pseudoephedrine may decrease the sedative activities of Diphenylpyraline.
Benzphetamine Benzphetamine may decrease the sedative activities of Diphenylpyraline.
Diethylpropion Diethylpropion may decrease the sedative activities of Diphenylpyraline.
Lisdexamfetamine Lisdexamfetamine may decrease the sedative activities of Diphenylpyraline.
Mephentermine Mephentermine may decrease the sedative activities of Diphenylpyraline.
MMDA MMDA may decrease the sedative activities of Diphenylpyraline.
Midomafetamine Midomafetamine may decrease the sedative activities of Diphenylpyraline.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Diphenylpyraline.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Diphenylpyraline.
Tenamfetamine Tenamfetamine may decrease the sedative activities of Diphenylpyraline.
Chlorphentermine Chlorphentermine may decrease the sedative activities of Diphenylpyraline.
Methylenedioxyethamphetamine Methylenedioxyethamphetamine may decrease the sedative activities of Diphenylpyraline.
Dextroamphetamine Dextroamphetamine may decrease the sedative activities of Diphenylpyraline.
Metamfetamine Metamfetamine may decrease the sedative activities of Diphenylpyraline.
Iofetamine I-123 Iofetamine I-123 may decrease the sedative activities of Diphenylpyraline.
Ritobegron Ritobegron may decrease the sedative activities of Diphenylpyraline.
Mephedrone Mephedrone may decrease the sedative activities of Diphenylpyraline.
Methoxyphenamine Methoxyphenamine may decrease the sedative activities of Diphenylpyraline.
Gepefrine Gepefrine may decrease the sedative activities of Diphenylpyraline.
2,5-Dimethoxy-4-ethylthioamphetamine 2,5-Dimethoxy-4-ethylthioamphetamine may decrease the sedative activities of Diphenylpyraline.
Phendimetrazine Phendimetrazine may decrease the sedative activities of Diphenylpyraline.
Pitolisant The therapeutic efficacy of Pitolisant can be decreased when used in combination with Diphenylpyraline.
Norepinephrine The therapeutic efficacy of Norepinephrine can be increased when used in combination with Diphenylpyraline.
Epinephrine The therapeutic efficacy of Epinephrine can be increased when used in combination with Diphenylpyraline.
Droxidopa The therapeutic efficacy of Droxidopa can be increased when used in combination with Diphenylpyraline.
Levonordefrin The therapeutic efficacy of Levonordefrin can be increased when used in combination with Diphenylpyraline.
Protokylol The therapeutic efficacy of Protokylol can be increased when used in combination with Diphenylpyraline.
Racepinephrine The therapeutic efficacy of Racepinephrine can be increased when used in combination with Diphenylpyraline.
Theodrenaline The therapeutic efficacy of Theodrenaline can be increased when used in combination with Diphenylpyraline.
Deoxyepinephrine The therapeutic efficacy of Deoxyepinephrine can be increased when used in combination with Diphenylpyraline.
Ephedrine The therapeutic efficacy of Ephedrine can be increased when used in combination with Diphenylpyraline.
Hyoscyamine Diphenylpyraline may increase the anticholinergic activities of Hyoscyamine.

Target Protein

Histamine H1 receptor HRH1
Sodium-dependent dopamine transporter SLC6A3

Referensi & Sumber

Synthesis reference: Knox, L.H. and Kapp, R.; U.S. Patent 2,479,843; August 23, 1949; assigned to Nopco Chemical Company.
Artikel (PubMed)
  • PMID: 15627433
    Lapa GB, Mathews TA, Harp J, Budygin EA, Jones SR: Diphenylpyraline, a histamine H1 receptor antagonist, has psychostimulant properties. Eur J Pharmacol. 2005 Jan 4;506(3):237-40. Epub 2004 Dec 8.
  • PMID: 11137513
    Ohno T, Kobayashi S, Hayashi M, Sakurai M, Kanazawa I: Diphenylpyraline-responsive parkinsonism in cerebrotendinous xanthomatosis: long-term follow up of three patients. J Neurol Sci. 2001 Jan 1;182(2):95-7.
  • PMID: 14039
    Puhakka H, Rantanen T, Virolainen E: Diphenylpyraline (Lergobine) in the treatment of patients suffering from allergic and vasomotor rhinitis. J Int Med Res. 1977;5(1):37-41.

Contoh Produk & Brand

Produk: 17 • International brands: 10
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    Ointment • - • Topical • Canada • OTC • Approved
Menampilkan 8 dari 17 produk.
International Brands
  • Allergen
  • Arbid
  • Belfene
  • Diafen — Riker
  • Hispril — Nopco
  • Histyn
  • Lergobine
  • Lyssipoll — Lyssia
  • Mepiben
  • Neargal

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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