Diclofenamide

DB01144

small molecule approved investigational

Deskripsi

A carbonic anhydrase inhibitor that is used in the treatment of glaucoma.

Struktur Molekul 2D

Berat 305.159
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Increase consumption of potassium-rich foods. Diclofenamide may cause hypokalemia, therefore consuming more potassium-rich foods may help prevent hypokalemia.

Interaksi Obat

994 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Diclofenamide is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Diclofenamide is combined with Levodopa.
Risperidone Diclofenamide may increase the hypotensive activities of Risperidone.
Nicotine The risk or severity of adverse effects can be increased when Diclofenamide is combined with Nicotine.
Mecamylamine The risk or severity of adverse effects can be increased when Diclofenamide is combined with Mecamylamine.
Pentolinium The risk or severity of adverse effects can be increased when Diclofenamide is combined with Pentolinium.
Trimethaphan The risk or severity of adverse effects can be increased when Diclofenamide is combined with Trimethaphan.
Hexamethonium The risk or severity of adverse effects can be increased when Diclofenamide is combined with Hexamethonium.
Cyclopentamine The risk or severity of adverse effects can be increased when Diclofenamide is combined with Cyclopentamine.
Flecainide The excretion of Flecainide can be decreased when combined with Diclofenamide.
Memantine The excretion of Memantine can be decreased when combined with Diclofenamide.
Quinine The excretion of Quinine can be decreased when combined with Diclofenamide.
Quinidine The excretion of Quinidine can be decreased when combined with Diclofenamide.
Methotrexate The protein binding of Methotrexate can be increased when combined with Diclofenamide.
Lithium hydroxide The excretion of Lithium hydroxide can be increased when combined with Diclofenamide.
Lithium citrate The excretion of Lithium citrate can be increased when combined with Diclofenamide.
Metformin The risk or severity of lactic acidosis can be increased when Diclofenamide is combined with Metformin.
Aripiprazole Aripiprazole may increase the hypotensive activities of Diclofenamide.
Aripiprazole lauroxil Aripiprazole lauroxil may increase the hypotensive activities of Diclofenamide.
Nicorandil Nicorandil may increase the hypotensive activities of Diclofenamide.
Dexketoprofen The risk or severity of adverse effects can be increased when Dexketoprofen is combined with Diclofenamide.
Ketoprofen The risk or severity of adverse effects can be increased when Ketoprofen is combined with Diclofenamide.
Methenamine The serum concentration of the active metabolites of Methenamine can be reduced when Methenamine is used in combination with Diclofenamide resulting in a loss in efficacy.
Cyclosporine The risk or severity of renal failure can be increased when Diclofenamide is combined with Cyclosporine.
Triethylenetetramine The excretion of Triethylenetetramine can be increased when combined with Diclofenamide.
Linezolid Linezolid may increase the orthostatic hypotensive activities of Diclofenamide.
Furazolidone Furazolidone may increase the orthostatic hypotensive activities of Diclofenamide.
Procaine Procaine may increase the orthostatic hypotensive activities of Diclofenamide.
Tranylcypromine Tranylcypromine may increase the orthostatic hypotensive activities of Diclofenamide.
Phenelzine Phenelzine may increase the orthostatic hypotensive activities of Diclofenamide.
Minaprine Minaprine may increase the orthostatic hypotensive activities of Diclofenamide.
Selegiline Selegiline may increase the orthostatic hypotensive activities of Diclofenamide.
Procarbazine Procarbazine may increase the orthostatic hypotensive activities of Diclofenamide.
Moclobemide Moclobemide may increase the orthostatic hypotensive activities of Diclofenamide.
Isocarboxazid Isocarboxazid may increase the orthostatic hypotensive activities of Diclofenamide.
Rasagiline Rasagiline may increase the orthostatic hypotensive activities of Diclofenamide.
Pargyline Pargyline may increase the orthostatic hypotensive activities of Diclofenamide.
Clorgiline Clorgiline may increase the orthostatic hypotensive activities of Diclofenamide.
Iproniazid Iproniazid may increase the orthostatic hypotensive activities of Diclofenamide.
Nialamide Nialamide may increase the orthostatic hypotensive activities of Diclofenamide.
Safinamide Safinamide may increase the orthostatic hypotensive activities of Diclofenamide.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the orthostatic hypotensive activities of Diclofenamide.
Methylene blue Methylene blue may increase the orthostatic hypotensive activities of Diclofenamide.
Hydracarbazine Hydracarbazine may increase the orthostatic hypotensive activities of Diclofenamide.
Pirlindole Pirlindole may increase the orthostatic hypotensive activities of Diclofenamide.
Toloxatone Toloxatone may increase the orthostatic hypotensive activities of Diclofenamide.
Benmoxin Benmoxin may increase the orthostatic hypotensive activities of Diclofenamide.
Mebanazine Mebanazine may increase the orthostatic hypotensive activities of Diclofenamide.
Octamoxin Octamoxin may increase the orthostatic hypotensive activities of Diclofenamide.
Pheniprazine Pheniprazine may increase the orthostatic hypotensive activities of Diclofenamide.
Phenoxypropazine Phenoxypropazine may increase the orthostatic hypotensive activities of Diclofenamide.
Pivhydrazine Pivhydrazine may increase the orthostatic hypotensive activities of Diclofenamide.
Safrazine Safrazine may increase the orthostatic hypotensive activities of Diclofenamide.
Caroxazone Caroxazone may increase the orthostatic hypotensive activities of Diclofenamide.
Harmaline Harmaline may increase the orthostatic hypotensive activities of Diclofenamide.
Brofaromine Brofaromine may increase the orthostatic hypotensive activities of Diclofenamide.
Butalbital Butalbital may increase the hypotensive activities of Diclofenamide.
Pentobarbital Pentobarbital may increase the hypotensive activities of Diclofenamide.
Secobarbital Secobarbital may increase the hypotensive activities of Diclofenamide.
Methohexital Methohexital may increase the hypotensive activities of Diclofenamide.
Thiopental Thiopental may increase the hypotensive activities of Diclofenamide.
Primidone Primidone may increase the hypotensive activities of Diclofenamide.
Methylphenobarbital Methylphenobarbital may increase the hypotensive activities of Diclofenamide.
Thiamylal Thiamylal may increase the hypotensive activities of Diclofenamide.
Phenobarbital Phenobarbital may increase the hypotensive activities of Diclofenamide.
Amobarbital Amobarbital may increase the hypotensive activities of Diclofenamide.
Hexobarbital Hexobarbital may increase the hypotensive activities of Diclofenamide.
Barbital Barbital may increase the hypotensive activities of Diclofenamide.
Barbexaclone Barbexaclone may increase the hypotensive activities of Diclofenamide.
Aminosalicylic acid The risk or severity of adverse effects can be increased when Aminosalicylic acid is combined with Diclofenamide.
Mesalazine The risk or severity of adverse effects can be increased when Mesalazine is combined with Diclofenamide.
Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Diclofenamide.
Diflunisal The risk or severity of adverse effects can be increased when Diflunisal is combined with Diclofenamide.
Salicylic acid The risk or severity of adverse effects can be increased when Salicylic acid is combined with Diclofenamide.
Balsalazide The risk or severity of adverse effects can be increased when Balsalazide is combined with Diclofenamide.
Olsalazine The risk or severity of adverse effects can be increased when Olsalazine is combined with Diclofenamide.
Bismuth subsalicylate The risk or severity of adverse effects can be increased when Bismuth subsalicylate is combined with Diclofenamide.
Dersalazine The risk or severity of adverse effects can be increased when Dersalazine is combined with Diclofenamide.
Phenyl aminosalicylate The risk or severity of adverse effects can be increased when Phenyl aminosalicylate is combined with Diclofenamide.
Methyl salicylate The risk or severity of adverse effects can be increased when Methyl salicylate is combined with Diclofenamide.
Nitroaspirin The risk or severity of adverse effects can be increased when Nitroaspirin is combined with Diclofenamide.
Aloxiprin The risk or severity of adverse effects can be increased when Aloxiprin is combined with Diclofenamide.
Guacetisal The risk or severity of adverse effects can be increased when Guacetisal is combined with Diclofenamide.
Carbaspirin calcium The risk or severity of adverse effects can be increased when Carbaspirin calcium is combined with Diclofenamide.
Choline salicylate The risk or severity of adverse effects can be increased when Choline salicylate is combined with Diclofenamide.
Thiosalicylic acid The risk or severity of adverse effects can be increased when Thiosalicylic acid is combined with Diclofenamide.
Phenytoin The risk or severity of osteomalacia can be increased when Diclofenamide is combined with Phenytoin.
Fosphenytoin The risk or severity of osteomalacia can be increased when Diclofenamide is combined with Fosphenytoin.
Ethoxzolamide The risk or severity of adverse effects can be increased when Ethoxzolamide is combined with Diclofenamide.
Methazolamide The risk or severity of adverse effects can be increased when Methazolamide is combined with Diclofenamide.
Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Diclofenamide.
Zonisamide The risk or severity of adverse effects can be increased when Zonisamide is combined with Diclofenamide.
Phentermine Diclofenamide may decrease the excretion rate of Phentermine which could result in a higher serum level.
Pseudoephedrine Diclofenamide may decrease the excretion rate of Pseudoephedrine which could result in a higher serum level.
Benzphetamine Diclofenamide may decrease the excretion rate of Benzphetamine which could result in a higher serum level.
Diethylpropion Diclofenamide may decrease the excretion rate of Diethylpropion which could result in a higher serum level.
Lisdexamfetamine Diclofenamide may decrease the excretion rate of Lisdexamfetamine which could result in a higher serum level.
Mephentermine Diclofenamide may decrease the excretion rate of Mephentermine which could result in a higher serum level.
MMDA Diclofenamide may decrease the excretion rate of MMDA which could result in a higher serum level.
Midomafetamine Diclofenamide may decrease the excretion rate of Midomafetamine which could result in a higher serum level.

Target Protein

Carbonic anhydrase 2 CA2
Carbonic anhydrase 1 CA1
Carbonic anhydrase 4 CA4
Carbonic anhydrase 7 CA7
Carbonic anhydrase 3 CA3

Referensi & Sumber

Synthesis reference: Schultz,E.M.; U.S.Patent 2,835,702; May 20, 1958; assigned to Merck & Co.,Inc.
Artikel (PubMed)

Contoh Produk & Brand

Produk: 7 • International brands: 1
Produk
  • Daranide
    Tablet • 50 mg/1 • Oral • US • Approved
  • Dichlorphenamide
    Tablet • 50 mg/1 • Oral • US • Generic • Approved
  • Dichlorphenamide
    Tablet • 50 mg/1 • Oral • US • Generic • Approved
  • Keveyis
    Tablet • 50 mg/1 • Oral • US • Approved
  • Keveyis
    Tablet • 50 mg/1 • Oral • US • Approved
  • Keveyis
    Tablet • 50 mg/1 • Oral • US • Approved
  • Ormalvi
    Tablet • 50 mg/1 • Oral • US • Generic • Approved
International Brands
  • Oratrol — Alcon

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul