Peringatan Keamanan

Rat LD50: 826 mg/kg

Amifostine

DB01143

small molecule approved investigational

Deskripsi

A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.

Struktur Molekul 2D

Berat 214.223
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 8 minutes
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Amifostine is rapidly dephosphorylated by alkaline phosphatase in tissues primarily to the active free thiol metabolite and, subsequently, to a less active disulfide metabolite.

Rute Eliminasi

After a 10-second bolus dose of 150 mg/m2 of ETHYOL, renal excretion of the parent drug and its two metabolites was low during the hour following drug administration, averaging 0.69%, 2.64% and 2.22% of the administered dose for the parent, thiol and disulfide, respectively.

Interaksi Obat

304 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Amifostine is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Amifostine is combined with Levodopa.
Risperidone Amifostine may increase the hypotensive activities of Risperidone.
Valsartan Valsartan may increase the hypotensive activities of Amifostine.
Ramipril Ramipril may increase the hypotensive activities of Amifostine.
Esmolol Esmolol may increase the hypotensive activities of Amifostine.
Betaxolol Betaxolol may increase the hypotensive activities of Amifostine.
Reserpine Reserpine may increase the hypotensive activities of Amifostine.
Remikiren Remikiren may increase the hypotensive activities of Amifostine.
Torasemide Torasemide may increase the hypotensive activities of Amifostine.
Bethanidine Bethanidine may increase the hypotensive activities of Amifostine.
Guanadrel Guanadrel may increase the hypotensive activities of Amifostine.
Metoprolol Metoprolol may increase the hypotensive activities of Amifostine.
Isradipine Isradipine may increase the hypotensive activities of Amifostine.
Olmesartan Olmesartan may increase the hypotensive activities of Amifostine.
Chlorthalidone Chlorthalidone may increase the hypotensive activities of Amifostine.
Nitroprusside Nitroprusside may increase the hypotensive activities of Amifostine.
Atenolol Atenolol may increase the hypotensive activities of Amifostine.
Diltiazem Diltiazem may increase the hypotensive activities of Amifostine.
Minoxidil Minoxidil may increase the hypotensive activities of Amifostine.
Timolol Timolol may increase the hypotensive activities of Amifostine.
Treprostinil Treprostinil may increase the hypotensive activities of Amifostine.
Amlodipine Amlodipine may increase the hypotensive activities of Amifostine.
Nimodipine Nimodipine may increase the hypotensive activities of Amifostine.
Nisoldipine Nisoldipine may increase the hypotensive activities of Amifostine.
Bendroflumethiazide Bendroflumethiazide may increase the hypotensive activities of Amifostine.
Prazosin Prazosin may increase the hypotensive activities of Amifostine.
Fosinopril Fosinopril may increase the hypotensive activities of Amifostine.
Trandolapril Trandolapril may increase the hypotensive activities of Amifostine.
Metolazone Metolazone may increase the hypotensive activities of Amifostine.
Lercanidipine Lercanidipine may increase the hypotensive activities of Amifostine.
Benazepril Benazepril may increase the hypotensive activities of Amifostine.
Bosentan Bosentan may increase the hypotensive activities of Amifostine.
Propranolol Propranolol may increase the hypotensive activities of Amifostine.
Clonidine Clonidine may increase the hypotensive activities of Amifostine.
Enalapril Enalapril may increase the hypotensive activities of Amifostine.
Doxazosin Doxazosin may increase the hypotensive activities of Amifostine.
Labetalol Labetalol may increase the hypotensive activities of Amifostine.
Cyclothiazide Cyclothiazide may increase the hypotensive activities of Amifostine.
Bisoprolol Bisoprolol may increase the hypotensive activities of Amifostine.
Candoxatril Candoxatril may increase the hypotensive activities of Amifostine.
Nicardipine Nicardipine may increase the hypotensive activities of Amifostine.
Guanabenz Guanabenz may increase the hypotensive activities of Amifostine.
Mecamylamine Mecamylamine may increase the hypotensive activities of Amifostine.
Losartan Losartan may increase the hypotensive activities of Amifostine.
Moexipril Moexipril may increase the hypotensive activities of Amifostine.
Phentolamine Phentolamine may increase the hypotensive activities of Amifostine.
Eplerenone Eplerenone may increase the hypotensive activities of Amifostine.
Lisinopril Lisinopril may increase the hypotensive activities of Amifostine.
Nitroglycerin Nitroglycerin may increase the hypotensive activities of Amifostine.
Metyrosine Metyrosine may increase the hypotensive activities of Amifostine.
Hydroflumethiazide Hydroflumethiazide may increase the hypotensive activities of Amifostine.
Cryptenamine Cryptenamine may increase the hypotensive activities of Amifostine.
Perindopril Perindopril may increase the hypotensive activities of Amifostine.
Candesartan cilexetil Candesartan cilexetil may increase the hypotensive activities of Amifostine.
Tolazoline Tolazoline may increase the hypotensive activities of Amifostine.
Fenoldopam Fenoldopam may increase the hypotensive activities of Amifostine.
Indapamide Indapamide may increase the hypotensive activities of Amifostine.
Tadalafil Tadalafil may increase the hypotensive activities of Amifostine.
Alprenolol Alprenolol may increase the hypotensive activities of Amifostine.
Eprosartan Eprosartan may increase the hypotensive activities of Amifostine.
Chlorothiazide Chlorothiazide may increase the hypotensive activities of Amifostine.
Quinapril Quinapril may increase the hypotensive activities of Amifostine.
Omapatrilat Omapatrilat may increase the hypotensive activities of Amifostine.
Phenoxybenzamine Phenoxybenzamine may increase the hypotensive activities of Amifostine.
Pindolol Pindolol may increase the hypotensive activities of Amifostine.
Telmisartan Telmisartan may increase the hypotensive activities of Amifostine.
Methyldopa Methyldopa may increase the hypotensive activities of Amifostine.
Hydrochlorothiazide Hydrochlorothiazide may increase the hypotensive activities of Amifostine.
Guanfacine Guanfacine may increase the hypotensive activities of Amifostine.
Trichlormethiazide Trichlormethiazide may increase the hypotensive activities of Amifostine.
Felodipine Felodipine may increase the hypotensive activities of Amifostine.
Irbesartan Irbesartan may increase the hypotensive activities of Amifostine.
Nitrendipine Nitrendipine may increase the hypotensive activities of Amifostine.
Deserpidine Deserpidine may increase the hypotensive activities of Amifostine.
Pentolinium Pentolinium may increase the hypotensive activities of Amifostine.
Trimethaphan Trimethaphan may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Amifostine.
Carvedilol Carvedilol may increase the hypotensive activities of Amifostine.
Bretylium Bretylium may increase the hypotensive activities of Amifostine.
Terazosin Terazosin may increase the hypotensive activities of Amifostine.
Guanethidine Guanethidine may increase the hypotensive activities of Amifostine.
Rescinnamine Rescinnamine may increase the hypotensive activities of Amifostine.
Acebutolol Acebutolol may increase the hypotensive activities of Amifostine.
Captopril Captopril may increase the hypotensive activities of Amifostine.
Nadolol Nadolol may increase the hypotensive activities of Amifostine.
Epoprostenol Epoprostenol may increase the hypotensive activities of Amifostine.
Bepridil Bepridil may increase the hypotensive activities of Amifostine.
Hydralazine Hydralazine may increase the hypotensive activities of Amifostine.
Bevantolol Bevantolol may increase the hypotensive activities of Amifostine.
Practolol Practolol may increase the hypotensive activities of Amifostine.
Polythiazide Polythiazide may increase the hypotensive activities of Amifostine.
Cilazapril Cilazapril may increase the hypotensive activities of Amifostine.
Saprisartan Saprisartan may increase the hypotensive activities of Amifostine.
Spirapril Spirapril may increase the hypotensive activities of Amifostine.
Penbutolol Penbutolol may increase the hypotensive activities of Amifostine.
Mibefradil Mibefradil may increase the hypotensive activities of Amifostine.
Oxprenolol Oxprenolol may increase the hypotensive activities of Amifostine.
Pargyline Pargyline may increase the hypotensive activities of Amifostine.
Dexpropranolol Dexpropranolol may increase the hypotensive activities of Amifostine.

Target Protein

Alkaline phosphatase, germ cell type ALPG

Referensi & Sumber

Synthesis reference: Paul E. Kennedy, Roger A. Rajewski, John M. Baldoni, "Crystalline amifostine compositions and methods of the preparation and use of same." U.S. Patent US5424471, issued April, 1979.
Artikel (PubMed)
  • PMID: 10553165
    Santini V, Giles FJ: The potential of amifostine: from cytoprotectant to therapeutic agent. Haematologica. 1999 Nov;84(11):1035-42.

Contoh Produk & Brand

Produk: 7 • International brands: 0
Produk
  • Amifostine
    Injection, powder, lyophilized, for solution • 500 mg/10mL • Intravenous • US • Approved
  • Amifostine
    Injection, powder, lyophilized, for solution • 50 mg/1mL • Intravenous • US • Generic • Approved
  • Amifostine
    Injection, powder, lyophilized, for solution • 50 mg/1mL • Intravenous • US • Generic • Approved
  • Ethyol
    Injection, powder, lyophilized, for solution • 500 mg/10mL • Intravenous • US • Approved
  • Ethyol
    Injection, powder, lyophilized, for solution • 500 mg/10mL • Intravenous • US • Approved
  • Ethyol
    Injection, powder, lyophilized, for solution • 500 mg/10mL • Intravenous • US • Approved
  • Ethyol - Pws IV 500mg/vial
    Powder, for solution • 500 mg / vial • Intravenous • Canada • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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