Intravenous LD50 in rats is 125mg/kg. In dogs it is >200mg/kg. No cases of overdosage have been reported. Repeated daily doses up to 8 mg/kg (maximum total dose of 896 mg) in adult patients have been administered in clinical trials with no reported dose-limiting toxicity. The minimum lethal dose is 125 mg/kg in rats, equivalent to 8.1 times the recommended human clinical dose for esophageal candidiasis based on body surface area comparisons.
Micafungin is an antifungal drug. It belongs to the antifungal class of compounds known as echinocandins and exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Tolcapone | The metabolism of Micafungin can be decreased when combined with Tolcapone. |
| Entacapone | The metabolism of Micafungin can be decreased when combined with Entacapone. |
| Testosterone propionate | The metabolism of Micafungin can be decreased when combined with Testosterone propionate. |
| 3,5-Dinitrocatechol | The metabolism of Micafungin can be decreased when combined with 3,5-Dinitrocatechol. |
| Quercetin | The metabolism of Micafungin can be decreased when combined with Quercetin. |
| Sirolimus | The metabolism of Sirolimus can be decreased when combined with Micafungin. |
| Temsirolimus | The metabolism of Temsirolimus can be decreased when combined with Micafungin. |
| Dicoumarol | The therapeutic efficacy of Dicoumarol can be increased when used in combination with Micafungin. |
| Phenindione | The therapeutic efficacy of Phenindione can be increased when used in combination with Micafungin. |
| Warfarin | The therapeutic efficacy of Warfarin can be increased when used in combination with Micafungin. |
| Phenprocoumon | The therapeutic efficacy of Phenprocoumon can be increased when used in combination with Micafungin. |
| Acenocoumarol | The therapeutic efficacy of Acenocoumarol can be increased when used in combination with Micafungin. |
| 4-hydroxycoumarin | The therapeutic efficacy of 4-hydroxycoumarin can be increased when used in combination with Micafungin. |
| Coumarin | The therapeutic efficacy of Coumarin can be increased when used in combination with Micafungin. |
| (R)-warfarin | The therapeutic efficacy of (R)-warfarin can be increased when used in combination with Micafungin. |
| Ethyl biscoumacetate | The therapeutic efficacy of Ethyl biscoumacetate can be increased when used in combination with Micafungin. |
| Fluindione | The therapeutic efficacy of Fluindione can be increased when used in combination with Micafungin. |
| Clorindione | The therapeutic efficacy of Clorindione can be increased when used in combination with Micafungin. |
| Diphenadione | The therapeutic efficacy of Diphenadione can be increased when used in combination with Micafungin. |
| Tioclomarol | The therapeutic efficacy of Tioclomarol can be increased when used in combination with Micafungin. |
| (S)-Warfarin | The therapeutic efficacy of (S)-Warfarin can be increased when used in combination with Micafungin. |
| Opicapone | The metabolism of Micafungin can be decreased when combined with Opicapone. |