Rats exposed via the oral route to cephapirin displayed low acute toxicity (LD50 = 14000 mg/kg). The most common adverse reactions are hypersensitivity reactions and alterations to liver function. Evidence of white blood cell disorders and anaemia were noted in some subjects.
Cefapirin (INN, also spelled cephapirin), commonly marketed under the trade name Cefadyl, is a first-generation cephalosporin antibiotic that is available in injectable formulations. Production for use in humans has been discontinued in the United States. Cefapirin is partly plasma-bound and is effective against gram-negative and gram-positive organisms.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Probenecid | The serum concentration of Cefapirin can be increased when it is combined with Probenecid. |
| Foscarnet | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Foscarnet. |
| Mannitol | The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Cefapirin. |
| Tenofovir disoproxil | Cefapirin may increase the nephrotoxic activities of Tenofovir disoproxil. |
| Tenofovir alafenamide | Cefapirin may increase the nephrotoxic activities of Tenofovir alafenamide. |
| Tenofovir | Cefapirin may increase the nephrotoxic activities of Tenofovir. |
| Picosulfuric acid | The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Cefapirin. |
| Cyclosporine | The risk or severity of nephrotoxicity can be increased when Cyclosporine is combined with Cefapirin. |
| Icosapent | The risk or severity of nephrotoxicity can be increased when Icosapent is combined with Cefapirin. |
| Cefotiam | The risk or severity of nephrotoxicity can be increased when Cefotiam is combined with Cefapirin. |
| Mesalazine | The risk or severity of nephrotoxicity can be increased when Mesalazine is combined with Cefapirin. |
| Cefmenoxime | The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Cefapirin. |
| Cefmetazole | The risk or severity of nephrotoxicity can be increased when Cefmetazole is combined with Cefapirin. |
| Indomethacin | The risk or severity of nephrotoxicity can be increased when Indomethacin is combined with Cefapirin. |
| Triamterene | The risk or severity of nephrotoxicity can be increased when Triamterene is combined with Cefapirin. |
| Cefpiramide | The risk or severity of nephrotoxicity can be increased when Cefpiramide is combined with Cefapirin. |
| Loracarbef | The risk or severity of nephrotoxicity can be increased when Loracarbef is combined with Cefapirin. |
| Cefalotin | The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Cefapirin. |
| Nabumetone | The risk or severity of nephrotoxicity can be increased when Nabumetone is combined with Cefapirin. |
| Ketorolac | The risk or severity of nephrotoxicity can be increased when Ketorolac is combined with Cefapirin. |
| Tenoxicam | The risk or severity of nephrotoxicity can be increased when Tenoxicam is combined with Cefapirin. |
| Celecoxib | The risk or severity of nephrotoxicity can be increased when Celecoxib is combined with Cefapirin. |
| Cefotaxime | The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Cefapirin. |
| Tolmetin | The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Cefapirin. |
| Rofecoxib | The risk or severity of nephrotoxicity can be increased when Rofecoxib is combined with Cefapirin. |
| Fenoprofen | The risk or severity of nephrotoxicity can be increased when Fenoprofen is combined with Cefapirin. |
| Valdecoxib | The risk or severity of nephrotoxicity can be increased when Valdecoxib is combined with Cefapirin. |
| Diclofenac | The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Cefapirin. |
| Sulindac | The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Cefapirin. |
| Bacitracin | The risk or severity of nephrotoxicity can be increased when Bacitracin is combined with Cefapirin. |
| Amphotericin B | The risk or severity of nephrotoxicity can be increased when Amphotericin B is combined with Cefapirin. |
| Cephaloglycin | The risk or severity of nephrotoxicity can be increased when Cephaloglycin is combined with Cefapirin. |
| Adefovir dipivoxil | The risk or severity of nephrotoxicity can be increased when Adefovir dipivoxil is combined with Cefapirin. |
| Pentamidine | The risk or severity of nephrotoxicity can be increased when Pentamidine is combined with Cefapirin. |
| Mefenamic acid | The risk or severity of nephrotoxicity can be increased when Mefenamic acid is combined with Cefapirin. |
| Naproxen | The risk or severity of nephrotoxicity can be increased when Naproxen is combined with Cefapirin. |
| Sulfasalazine | The risk or severity of nephrotoxicity can be increased when Sulfasalazine is combined with Cefapirin. |
| Phenylbutazone | The risk or severity of nephrotoxicity can be increased when Phenylbutazone is combined with Cefapirin. |
| Meloxicam | The risk or severity of methemoglobinemia can be increased when Cefapirin is combined with Meloxicam. |
| Carprofen | The risk or severity of nephrotoxicity can be increased when Carprofen is combined with Cefapirin. |
| Tacrolimus | The risk or severity of nephrotoxicity can be increased when Tacrolimus is combined with Cefapirin. |
| Etacrynic acid | The risk or severity of nephrotoxicity can be increased when Etacrynic acid is combined with Cefapirin. |
| Ceforanide | The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cefapirin. |
| Salicylic acid | The risk or severity of nephrotoxicity can be increased when Salicylic acid is combined with Cefapirin. |
| Acetylsalicylic acid | The risk or severity of nephrotoxicity can be increased when Acetylsalicylic acid is combined with Cefapirin. |
| Hydrochlorothiazide | The risk or severity of nephrotoxicity can be increased when Hydrochlorothiazide is combined with Cefapirin. |
| Balsalazide | The risk or severity of nephrotoxicity can be increased when Balsalazide is combined with Cefapirin. |
| Cefditoren | The risk or severity of nephrotoxicity can be increased when Cefditoren is combined with Cefapirin. |
| Atazanavir | The risk or severity of nephrotoxicity can be increased when Atazanavir is combined with Cefapirin. |
| Colistimethate | The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Cefapirin. |
| Cefuroxime | The risk or severity of nephrotoxicity can be increased when Cefuroxime is combined with Cefapirin. |
| Cefprozil | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Cefprozil. |
| Olsalazine | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Olsalazine. |
| Lumiracoxib | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Lumiracoxib. |
| Cefamandole | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Cefamandole. |
| Cefazolin | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Cefazolin. |
| Cefonicid | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Cefonicid. |
| Cefoperazone | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Cefoperazone. |
| Cefoxitin | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Cefoxitin. |
| Ceftizoxime | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Ceftizoxime. |
| Magnesium salicylate | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Magnesium salicylate. |
| Salsalate | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Salsalate. |
| Choline magnesium trisalicylate | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Choline magnesium trisalicylate. |
| Cefepime | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Cefepime. |
| Cefacetrile | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Cefacetrile. |
| Cefpodoxime | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Cefpodoxime. |
| Antrafenine | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Antrafenine. |
| Aminophenazone | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Aminophenazone. |
| Antipyrine | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Antipyrine. |
| Tiaprofenic acid | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Tiaprofenic acid. |
| Lopinavir | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Lopinavir. |
| Etoricoxib | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Etoricoxib. |
| Hydrolyzed Cephalothin | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Hydrolyzed Cephalothin. |
| Cephalothin Group | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Cephalothin Group. |
| Oxyphenbutazone | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Oxyphenbutazone. |
| Latamoxef | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Latamoxef. |
| Nimesulide | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Nimesulide. |
| Benoxaprofen | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Benoxaprofen. |
| Metamizole | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Metamizole. |
| Zomepirac | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Zomepirac. |
| Ceftobiprole | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Ceftobiprole. |
| Cimicoxib | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Cimicoxib. |
| Ceftaroline fosamil | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Ceftaroline fosamil. |
| Lornoxicam | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Lornoxicam. |
| Zaltoprofen | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Zaltoprofen. |
| Azapropazone | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Azapropazone. |
| Parecoxib | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Parecoxib. |
| Salicylamide | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Salicylamide. |
| Kebuzone | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Kebuzone. |
| Isoxicam | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Isoxicam. |
| Indoprofen | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Indoprofen. |
| Ibuproxam | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Ibuproxam. |
| Floctafenine | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Floctafenine. |
| Fenbufen | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Fenbufen. |
| Etofenamate | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Etofenamate. |
| Epirizole | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Epirizole. |
| Cefaloridine | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Cefaloridine. |
| Cefminox | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Cefminox. |
| Dexibuprofen | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Dexibuprofen. |
| Droxicam | The risk or severity of nephrotoxicity can be increased when Cefapirin is combined with Droxicam. |